KEGG ENZYME: 2.5.1.122

ENZYME: 2.5.1.122

Entry

EC 2.5.1.122                Enzyme

Name

4-O-dimethylallyl-L-tyrosine synthase;
SirD;
dimethylallyl diphosphate:L-tyrosine 4-O-dimethylallyltransferase

Class

Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)

Sysname

prenyl-diphosphate:L-tyrosine 4-O-prenyltransferase

Reaction(IUBMB)

prenyl diphosphate + L-tyrosine = diphosphate + 4-O-prenyl-L-tyrosine [RN:R10968]

Reaction(KEGG)

R10968

Substrate

prenyl diphosphate [CPD:C00235];
L-tyrosine [CPD:C00082]

Product

diphosphate [CPD:C00013];
4-O-prenyl-L-tyrosine [CPD:C20983]

Comment

The enzyme is involved in biosynthesis of the phytotoxin sirodesmin PL by the phytopathogenic ascomycete Leptosphaeria maculans.

History

EC 2.5.1.122 created 2014

Orthology

K21339

4-O-dimethylallyl-L-tyrosine synthase

Genes

PPEI:

PpBr36_10871

PGRI:

PgNI_08061

MBRN:

26244409(tcpD)

CHIG:

CH63R_03950 CH63R_07283 CH63R_14373

CDET:

87940988(CDEST_04485) 87944463(CDEST_07960) 87949556(CDEST_13056)

TMF:	EYB26_001585

BZE:	COCCADRAFT_96963

BSC:	COCSADRAFT_41511

BOR:	COCMIDRAFT_31681

ARAB:

EKO05_0003262

E1B28_013476

» show all

Reference

1 [PMID:19762440]

Authors

Kremer A, Li SM

Title

A tyrosine O-prenyltransferase catalyses the first pathway-specific step in the biosynthesis of sirodesmin PL.

Journal

Microbiology 156:278-86 (2010)
DOI:10.1099/mic.0.033886-0

Sequence

[ag:AAS92554]

Reference

2 [PMID:21038099]

Authors

Zou HX, Xie X, Zheng XD, Li SM

Title

The tyrosine O-prenyltransferase SirD catalyzes O-, N-, and C-prenylations.

Journal

Appl Microbiol Biotechnol 89:1443-51 (2011)
DOI:10.1007/s00253-010-2956-x

Sequence

[ag:AAS92554]

Other DBs

ExplorEnz - The Enzyme Database:

2.5.1.122

IUBMB Enzyme Nomenclature:

2.5.1.122

ExPASy - ENZYME nomenclature database:

2.5.1.122

BRENDA, the Enzyme Database:

2.5.1.122

LinkDB

DBGET integrated database retrieval system