geranylfarnesyl diphosphate synthase;
(all-E) geranylfarnesyl diphosphate synthase;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
geranylgeranyl-diphosphate:isopentenyl-diphosphate transtransferase (adding 1 isopentenyl unit)
geranylgeranyl diphosphate + isopentenyl diphosphate = (2E,6E,10E,14E)-geranylfarnesyl diphosphate + diphosphate [RN:
geranylgeranyl diphosphate [CPD:
isopentenyl diphosphate [CPD:
(2E,6E,10E,14E)-geranylfarnesyl diphosphate [CPD:
The enzyme from Methanosarcina mazei is involved in biosynthesis of the polyprenyl side-chain of methanophenazine, an electron carrier utilized for methanogenesis. It prefers geranylgeranyl diphosphate and farnesyl diphosphate as allylic substrate . The enzyme from Aeropyrum pernix prefers farnesyl diphosphate as allylic substrate. The enzyme is involved in the biosynthesis of C25-C25 membrane lipids .
EC 126.96.36.199 created 2010
Ogawa T, Yoshimura T, Hemmi H
Geranylfarnesyl diphosphate synthase from Methanosarcina mazei: Different role, different evolution.
Tachibana A, Yano Y, Otani S, Nomura N, Sako Y, Taniguchi M
Novel prenyltransferase gene encoding farnesylgeranyl diphosphate synthase from a hyperthermophilic archaeon, Aeropyrum pernix. Molecularevolution with alteration in product specificity.
A novel prenyltransferase, farnesylgeranyl diphosphate synthase, from the haloalkaliphilic archaeon, Natronobacterium pharaonis.
Lee PC, Mijts BN, Petri R, Watts KT, Schmidt-Dannert C
Alteration of product specificity of Aeropyrum pernix farnesylgeranyl diphosphate synthase (Fgs) by directed evolution.
ExplorEnz - The Enzyme Database: 188.8.131.52
ExPASy - ENZYME nomenclature database: 184.108.40.206
LinkDB All DBs