KEGG   ENZYME: 2.5.1.88
Entry
EC 2.5.1.88                 Enzyme                                 
Name
trans,polycis-polyprenyl diphosphate synthase [(2Z,6E)-farnesyl diphosphate specific]
Class
Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
Sysname
(2Z,6E)-farnesyl-diphosphate:isopentenyl-diphosphate cistransferase (adding 9--11 isopentenyl units)
Reaction(IUBMB)
(2Z,6E)-farnesyl diphosphate + n isopentenyl diphosphate = n diphosphate + trans,polycis-polyprenyl diphosphate (n = 9--11) [RN:R09731]
Reaction(KEGG)
R09731
Substrate
(2Z,6E)-farnesyl diphosphate [CPD:C16826];
isopentenyl diphosphate [CPD:C00129]
Product
diphosphate [CPD:C00013];
trans,polycis-polyprenyl diphosphate [CPD:C19853]
Comment
Highest activity with (2Z,6E)-farnesyl diphosphate as allylic substrate. Broad product specificity with the major product being dodecaprenyl diphosphate. Synthesizes even C70 prenyl diphosphate as the maximum chain-length product [1].
History
EC 2.5.1.88 created 2010
Pathway
ec00900  Terpenoid backbone biosynthesis
ec01110  Biosynthesis of secondary metabolites
Orthology
K21273  trans,polycis-polyprenyl diphosphate synthase
Genes
PHWG7075_08440
BLUTEW640_02245
BCAUI6G59_13875
AUSIPK37_16425
PAUSNCTC13651_01488(uppS)
PRVG7070_00365
BRTJ4N02_06640
NSNEXE58_14895
NPCKUV85_07530
KFLKfla_2449
KQIF1D05_32195
TFUTfu_0853
THAONI17_001400
TALXFOF52_00825
NDANdas_0730
NGVCDO52_20120
NEXNE857_10750
STRREKD16_07660
SAIUJ4H86_07620
TCUTcur_3231
ACTWF7P10_35510
AGRAAGRA3207_006527
SROSros_2336
NOABKM31_32885
NOWGBF35_11800
NCXNocox_11025
NGNLCN96_12435
TBITbis_1177
STPStrop_3446
SAQSare_3825
MAUMicau_4838
MILML5_3461
MICBMicB006_3858
MTUACSH63_00310
MICHFJK98_25610
MTEMGCE86_18810
MCABHXZ27_24530
MSAGGCM10017556_10970(uppS1)
VMAVAB18032_28301
MCRAID554_22120
ASEACPL_1421
AMSAMIS_11890
ACTNL083_1597
AFSAFR_08000
ACTSACWT_1300
AIHAiant_56320(uppS1)
ACTRAsp14428_30000(uppS1)
PLKCIK06_21945
PLABC6361_31565
PLATC6W10_34995
PFLAPflav_057510(uppS1)
PSUUPsuf_017140(uppS1)
VERHUT12_29105
ATLAthai_13260(uppS_2)
ASERAsera_60570(uppS1)
PRYPrubr_07990(uppS1)
CATICS0771_00170(uppS1)
DVCDvina_46555
DFUDfulv_40965
DROSDrose_31170
DAURDaura_44720
NHYJQS43_07375
CCAZCOUCH_31645
SNASnas_2041
NAVJQS30_11505
GLYK3N28_04635
 » show all
Reference
1  [PMID:19447338]
  Authors
Ambo T, Noike M, Kurokawa H, Koyama T
  Title
Cloning and functional analysis of cis-prenyltransferase from Thermobifida fusca.
  Journal
J Biosci Bioeng 107:620-2 (2009)
DOI:10.1016/j.jbiosc.2009.02.006
  Sequence
[tfu:Tfu_0853]
Other DBs
ExplorEnz - The Enzyme Database: 2.5.1.88
IUBMB Enzyme Nomenclature: 2.5.1.88
ExPASy - ENZYME nomenclature database: 2.5.1.88
BRENDA, the Enzyme Database: 2.5.1.88
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