Entry
Name
4-amino-4-deoxychorismate synthase (2-amino-4-deoxychorismate-forming);
ADCS (ambiguous);
ADC synthase (ambiguous);
pabAB (gene names)
Class
Transferases;
Transferring nitrogenous groups;
Transaminases
BRITE hierarchy
Sysname
chorismate:L-glutamine aminotransferase (2-amino-4-deoxychorismate-forming)
Reaction(IUBMB)
chorismate + 2 L-glutamine + H2O = 4-amino-4-deoxychorismate + 2 L-glutamate + NH3 (overall reaction) [RN:
R12939 ];
(1a) 2 L-glutamine + 2 H2O = 2 L-glutamate + 2 NH3 [RN:
R00256 ];
(1b) chorismate + NH3 = (2S)-2-amino-4-deoxychorismate + H2O [RN:
R12937 ];
(1c) (2S)-2-amino-4-deoxychorismate + NH3 = 4-amino-4-deoxychorismate + NH3 [RN:
R12938 ]
Reaction(KEGG)
Substrate
Product
Comment
The enzyme, characterized from the bacterium Bacillus subtilis, is a heterodimer. The PabA subunit acts successively on two molecules of L-glutamine, hydrolysing each to L-glutamate and ammonia (cf. EC
3.5.1.2 , glutaminase). The ammonia molecules are channeled to the active site of PabB, which catalyses the formation of 4-amino-4-deoxychorismate from chorismate in two steps via the intermediate 2-amino-4-deoxychorismate. cf. EC
2.6.1.85 , aminodeoxychorismate synthase.
History
EC 2.6.1.123 created 2021
Pathway
Orthology
K25575 4-amino-4-deoxychorismate synthase (2-amino-4-deoxychorismate-forming) component II
K25578 4-amino-4-deoxychorismate synthase (2-amino-4-deoxychorismate-forming) component I
Genes
XPH : XppCFBP6546_05945(XppCFBP6546P_05945)
XHD : LMG31886_32200(pabB)
SACZ : AOT14_10320(trpE_1)
LHX : LYSHEL_02300(trpE_1)
LCAS : LYSCAS_02300(trpE_1)
LLZ : LYB30171_00978(pabB)
DYG : DYGSA30_27080(trpE_2)
TIB : THMIRHAM_08440(trpE)
TSE : THMIRHAS_16350(trpE)
TZO : THMIRHAT_15540(trpE_2)
TNI : TVNIR_1584(trpE2_[H])
THIC : TspCOW1_08130(trpE)
SPLB : SFPGR_22680(trpE_2)
SNIV : SFSGTM_18250(trpE_1)
MSD : MYSTI_01716 MYSTI_01717
MYM : A176_005392 A176_005393
MLAN : JY572_17815 JY572_17820
MFU : LILAB_00785 LILAB_00790
MMAS : MYMAC_001711 MYMAC_001712
AVM : JQX13_00315 JQX13_00320
CFUS : CYFUS_001767 CYFUS_001768
GFM : Enr17x_58250(trpG_2)
CCOS : Pan44_32500(pabA_1)
SCOR : J3U87_09635 J3U87_10815
NALL : PP769_01775 PP769_14385
NNEO : PQG83_05385 PQG83_12965
BSU : BSU00740(pabB) BSU00750(pabA)
BSR : I33_0088 I33_0089(pabA)
BSH : BSU6051_00740(pabB) BSU6051_00750(pabA)
BSY : I653_00370 I653_00375
BSUT : BSUB_00087(pabB) BSUB_00088(pabA)
BSUL : BSUA_00087(pabB) BSUA_00088(pabA)
BSUS : Q433_00455 Q433_00460
BSO : BSNT_06347(pabB) BSNT_06348(pabA)
BSN : BSn5_11940 BSn5_11945
BSQ : B657_00740(pabB) B657_00750(pabA)
BSX : C663_0075(pabB) C663_0076(pabA)
BSP : U712_00380 U712_00385
BSS : BSUW23_00380(pabB) BSUW23_00385(pabA)
BIT : BIS30_10795 BIS30_10800
BLI : BL00858(pabB) BL00859(pabA)
BLD : BLi00090(pabB) BLi00091(pabA)
BLH : BaLi_c00910(pabB) BaLi_c00920(pabA)
BAY : RBAM_000850(pabB) RBAM_000860(pabA)
BAQ : BACAU_0075(pabB) BACAU_0076(pabA)
BYA : BANAU_0074(pabB) BANAU_0075(pabA)
BQY : MUS_0082(pabB) MUS_0083(pabA)
BAMP : B938_00385 B938_00390
BAML : BAM5036_0077(pabB) BAM5036_0078(pabA)
BAMA : RBAU_0079(pabB) RBAU_0080(pabA)
BAMN : BASU_0078(pabB) BASU_0079(pabA)
BAMB : BAPNAU_0074(pabB) BAPNAU_0075(pabA)
BAMT : AJ82_00460 AJ82_00465
BAMY : V529_00760(pabB) V529_00770(pabA)
BMP : NG74_00092(pabB) NG74_00093(pabA)
BAO : BAMF_0074(pabB) BAMF_0075(pabA)
BAZ : BAMTA208_00375(pabB) BAMTA208_00380(pabA)
BQL : LL3_00076(pabB) LL3_00077(pabA)
BXH : BAXH7_00079(pabB) BAXH7_00080(pabA)
BAMI : KSO_019025 KSO_019030
BAMC : U471_00800 U471_00810
BAMF : U722_00450 U722_00455
BSIA : CWD84_21530 CWD84_21535(pabB)
BAE : BATR1942_18980 BATR1942_18985
BVM : B9C48_00445 B9C48_00450
BSON : S101395_00091(pabB) S101395_00092(pabA)
BHT : DIC78_09785 DIC78_09790
BMOJ : HC660_00870(pabB) HC660_00880(pabA)
BTEQ : G4P54_00440 G4P54_00445(pabA)
BIQ : AN935_00370 AN935_00375
BSTR : QI003_00440(pabB) QI003_00445(pabA)
BAN : BA_0068(pabB) BA_0069(pabA)
BAR : GBAA_0068(pabB) GBAA_0069(pabA)
BAH : BAMEG_0081(pabB) BAMEG_0082(pabA)
BAI : BAA_0081(pabB) BAA_0082(pabA)
BAX : H9401_0064 H9401_0065
BANT : A16_00760 A16_00770
BANR : A16R_00760 A16R_00770
BANS : BAPAT_0066 BAPAT_0067
BANH : HYU01_00390 HYU01_00395
BANV : DJ46_4463 DJ46_4464
BCA : BCE_0067(pabB) BCE_0068(pabA)
BCZ : BCE33L0064(pabB) BCE33L0065(pabA)
BCR : BCAH187_A0080(pabB) BCAH187_A0081(pabA)
BCB : BCB4264_A0076(pabB) BCB4264_A0077(pabA)
BCU : BCAH820_0077(pabB) BCAH820_0078(pabA)
BCG : BCG9842_B5239(pabA) BCG9842_B5240(pabB)
BCQ : BCQ_0078(pabB) BCQ_0079(pabA)
BCX : BCA_0081(pabB) BCA_0082(pabA)
BAL : BACI_c00800(pabB) BACI_c00810(pabA1)
BCER : BCK_07525 BCK_07530
BCEF : BcrFT9_00074 BcrFT9_00075
BCY : Bcer98_0064 Bcer98_0065
BTK : BT9727_0064(pabB) BT9727_0065(pabA)
BTL : BALH_0067(pabB) BALH_0068(pabA)
BTB : BMB171_C0064(pabB) BMB171_C0065(pabA)
BTHR : YBT1520_00320 YBT1520_00325
BTHI : BTK_00345 BTK_00350
BTC : CT43_CH0064(pabB) CT43_CH0065(pabA)
BTF : YBT020_00330 YBT020_00335
BTG : BTB_c00770(pabB) BTB_c00780(pabA)
BTN : BTF1_26370 BTF1_26375
BTHT : H175_ch0064 H175_ch0065
BTHU : YBT1518_00320 YBT1518_00325
BTHY : AQ980_01420 AQ980_01425
BWE : BcerKBAB4_0064 BcerKBAB4_0065
BWW : bwei_5698(pabB) bwei_5699(pabA)
BMYO : BG05_435 BG05_436(pabB)
BTY : Btoyo_2768 Btoyo_2769
BMYC : DJ92_2662(trpE) DJ92_2663
BBY : CY96_26945 CY96_26950
BWD : CT694_00400(trpE) CT694_00405
BTRO : FJR70_22020(pabB) FJR70_22025(pabA)
BMOB : MLA2C4_00390(trpE) MLA2C4_00395
BNT : GSN03_00390(pabB) GSN03_00395(pabA)
BPAC : LMD38_25880(pabA) LMD38_25885(pabB)
BPAN : NLJ82_00390(pabB) NLJ82_00395(pabA)
BALU : QRY64_02735(pabB) QRY64_02740(pabA)
BPUM : BW16_00450 BW16_00455
BPUS : UP12_00445 UP12_00450
BIF : N288_00460 N288_00465
BMET : BMMGA3_00415(pabB) BMMGA3_00420(pabA)
BSM : BSM4216_0971 BSM4216_0972
BGY : BGLY_0082(pabB) BGLY_0083(pabA)
BWH : A9C19_19525 A9C19_19530
BXI : BK049_07775 BK049_07780
BALT : CFN77_00455 CFN77_00460(pabA)
BAER : BAE_07985 BAE_07990
BSAF : BSL056_00455 BSL056_00460
BFD : NCTC4823_03024(pabA) NCTC4823_03025(pabB)
BSHI : LGQ02_00445 LGQ02_00450(pabA)
BBAD : K7T73_02935(pabB) K7T73_02940(pabA)
BCAB : EFK13_00445 EFK13_00450(pabA)
BRY : M0696_00440 M0696_00445(pabA)
GST : HW35_15565 HW35_15570
BACW : QR42_00445 QR42_00450
BACP : SB24_09310 SB24_09315
BACB : OY17_03175 OY17_03180
BACY : QF06_19385 QF06_19390
BACL : BS34A_00930(pabB) BS34A_00940(pabA)
BALM : BsLM_0079 BsLM_0080
BACS : AUL54_10315 AUL54_10320
BACQ : DOE78_00430 DOE78_00435
BZH : NF868_00455 NF868_00460(pabA)
BHAI : KJK41_00460(pabB) KJK41_00465(pabA)
BCAO : LC087_14165 LC087_14170(pabA)
BARD : QRY57_02035(trpE) QRY57_02040(pabA)
BAEI : RE735_00045(pabA) RE735_00050
BAFC : K3G25_19900(pabB) K3G25_19905(pabA)
BCO : Bcell_0074 Bcell_0075
BHK : B4U37_00430 B4U37_00435
BCOH : BC6307_23415 BC6307_23420
BCIR : C2I06_19155 C2I06_19160
NTX : NQZ71_01895(pabA) NQZ71_01900
NIL : L8T27_000430 L8T27_000435(pabA)
BMQ : BMQ_0095(pabB) BMQ_0096(pabA)
BMD : BMD_0093(pabB) BMD_0094(pabA)
BMH : BMWSH_5135(pabA) BMWSH_5136(pabB)
BMEG : BG04_2369(pabB) BG04_2370
BFX : BC359_00515 BC359_00520
PKS : IE339_00465(trpE) IE339_00470(pabA)
BHA : BH0090(pabB) BH0091(pabA_trpG)
BKW : BkAM31D_00470(pabB) BkAM31D_00475(pabA)
BCL : ABC0110(pabB) ABC0111(pabA)
BLE : BleG1_4097 BleG1_4098
SHUA : PQ477_08160 PQ477_08165(pabA)
BGI : BGM20_15235 BGM20_15240
BPF : BpOF4_08345(pabB) BpOF4_08350(pabA)
BON : A361_00450 A361_00455
BKO : CKF48_10420 CKF48_10425
CGOT : J1899_00435 J1899_00440(pabA)
CSUA : IM538_00445 IM538_00450(pabA)
CFIR : NAF01_00435(pabB) NAF01_00440(pabA)
CSOA : LIS82_00420(pabB) LIS82_00425(pabA)
CSPG : LS684_00440 LS684_00445(pabA)
BDA : FSZ17_00415 FSZ17_00420(pabA)
LGY : T479_00480 T479_00485
LFU : HR49_23375 HR49_23380
LYS : LBYS11_00610(pabB) LBYS11_00615
LYB : C3943_00660 C3943_00665
LYZ : DCE79_00460 DCE79_00465
LPAK : GDS87_00520 GDS87_00525(pabA)
LAGR : FJQ98_00515(pabB) FJQ98_00520(pabA)
LMAC : I6G82_18245(pabA) I6G82_18250(pabB)
LYC : FH508_0000505 FH508_0000510(pabA)
LCAP : ICJ70_23995(pabA) ICJ70_24000(pabB)
LIU : OU989_00505 OU989_00510(pabA)
LLB : R6U77_04225(pabA) R6U77_04230
LYQ : MY533_00450(pabB) MY533_00455(pabA)
FPN : ABE65_000380 ABE65_000385
FAR : ABE41_000390 ABE41_000395
FEC : QNH15_00405(pabB) QNH15_00410(pabA)
APAK : AP3564_05305 AP3564_05310
ACOP : RI196_00405(pabB) RI196_00410(pabA)
PSYH : D0S48_11890 D0S48_11895
PSYO : PB01_00420 PB01_00425
PSYB : KD050_11295 KD050_11300(pabA)
NTM : BTDUT50_01345 BTDUT50_01350(trpE)
NCM : QNK12_16365(pabB) QNK12_16370(pabA)
MEKU : HUW50_09625 HUW50_09630(pabA)
MSEM : GMB29_00440(pabB) GMB29_00445(pabA)
MDG : K8L98_00465(trpE) K8L98_00470(pabA)
MLIT : KDJ21_004840(pabA) KDJ21_004845(trpE)
MENL : MVE64_13915(trpE) MVE64_13920(pabA)
MEBZ : LPC09_00435 LPC09_00440(pabA)
AIA : AWH56_007690(pabB) AWH56_007695(pabA)
BLEN : NCTC4824_01253(pabB) NCTC4824_01254(pabA)
RMF : D5E69_00460(pabB) D5E69_00465(pabA)
RAZ : U9J35_00460(pabB) U9J35_00465(pabA)
ROD : P8596_00450(pabB) P8596_00455(pabA)
ROSS : V2W31_00460(pabB) V2W31_00465(pabA)
CTHU : HUR95_02905 HUR95_02910(pabA)
BBEV : BBEV_3307(pabA) BBEV_3308(pabB)
MCUI : G8O30_14075(pabB) G8O30_14080
GAJ : MY490_00425 MY490_00430(pabA)
PSUA : FLK61_22915 FLK61_22920(pabA)
SLMS : MM221_09185 MM221_09190(pabA)
MJO : FOF60_00445 FOF60_00450(pabA)
MSUT : LC048_22580(pabA) LC048_22585
SFOR : QNH23_10640 QNH23_10645
ECTO : MUG87_12950(trpE) MUG87_12955(pabA)
ALKL : MM271_00415 MM271_00420(pabA)
ALKG : MOJ78_00540(pabB) MOJ78_00545(pabA)
PHJ : LC071_12285 LC071_12290(pabA)
DOM : RRU94_22490(pabA) RRU94_22495
AHAL : FTX54_000375 FTX54_000380(pabA)
GTE : GTCCBUS3UF5_770 GTCCBUS3UF5_780
GTK : GT3570_00335 GT3570_00340
GTM : GT3921_01055 GT3921_01060
GLI : GLN3_10570 GLN3_10575
BCAL : CWI35_10135 CWI35_10140(pabB)
GYC : GYMC61_0066 GYMC61_0067
GYA : GYMC52_0066 GYMC52_0067
GCT : GC56T3_0065 GC56T3_0066
GMC : GY4MC1_0070 GY4MC1_0071
GGH : GHH_c00770(pabB) GHH_c00780(pabA)
GJF : M493_00605 M493_00610
GEA : GARCT_00078(pabB_1) GARCT_00079(pabA)
GEL : IB49_10550 IB49_10555
GSE : GT50_09735 GT50_09740
GSR : GS3922_15360 GS3922_15365
GZA : IC807_13870(pabB) IC807_13875(pabA)
GTH : Geoth_0089 Geoth_0090
PTL : AOT13_02665 AOT13_02670
PTB : DER53_05045(trpE) DER53_05050(pabA)
PARG : PspKH34_00690(pabB) PspKH34_00700
PCAL : BV455_01703(pabA) BV455_01704(pabB_1)
AFL : Aflv_0066(pabB) Aflv_0067(pabA)
AGN : AFK25_00395 AFK25_00400
ANM : GFC28_2606 GFC28_2607(trpE)
ANL : GFC29_2828(trpE) GFC29_2829
AND : GRQ40_00430(trpE) GRQ40_00435(pabA)
AAYD : B379_06495 B379_06500
ACAI : ISX45_16045(trpE) ISX45_16050(pabA)
AAMY : GFC30_117 GFC30_118(pabB)
EAT : EAT1b_1671 EAT1b_1672
EAN : Eab7_0058(pabB) Eab7_0059(pabA)
EXM : U719_00210 U719_00215
EXU : ESP131_02610 ESP131_02615
EAP : KB235_02115 KB235_02120(pabA)
EACE : KKI46_00420 KKI46_00425
EAUR : NMQ00_00435 NMQ00_00440(pabA)
EMM : PTI97_13820(pabA) PTI97_13825
EPF : OE059_00425 OE059_00430(pabA)
EXI : A0126_00325 A0126_00330 A0126_15885 A0126_15890
EXH : HNY42_01700 HNY42_01705
BBE : BBR47_01710(pabB) BBR47_01720(pabA)
BFM : BP422_26245 BP422_26250
BAGR : BA6348_01860 BA6348_01865(trpE)
BCHS : JNE38_01145 JNE38_01150(pabA)
BCOP : JD108_01055 JD108_01060(pabA)
BPAB : PSE45_01125(trpE) PSE45_01130(pabA)
BHUI : LOK74_21735 LOK74_21740(pabA)
BAYD : BSPP4475_19900(pabA) BSPP4475_19905
BBOR : RFB14_25680(pabA) RFB14_25685
BRUM : NDK47_01205 NDK47_01210(pabA)
BREH : HP435_01215 HP435_01220(pabA)
PJD : Pjdr2_0075 Pjdr2_0076
GYM : GYMC10_0063 GYMC10_0064
PPM : PPSC2_00325(pabB) PPSC2_00330(pabA)
PPO : PPM_0061(pabB) PPM_0062(pabA)
PPOL : X809_00340 X809_00345
PPQ : PPSQR21_000650(trpE) PPSQR21_000660(pabA)
PPOY : RE92_11365 RE92_11370
PMS : KNP414_07568(pabA) KNP414_07569
PMQ : PM3016_7112 PM3016_7113
PTA : HPL003_07810 HPL003_07815
PLV : ERIC2_c39480(pabA) ERIC2_c39490(pabB)
PSAB : PSAB_00315 PSAB_00320
PDU : PDUR_00335 PDUR_00340
PBD : PBOR_00340 PBOR_00345
PGM : PGRAT_00330 PGRAT_00335
POD : PODO_00390 PODO_00395
PAEN : P40081_00350 P40081_00355
PAEF : R50345_00400 R50345_00405
PAEQ : R50912_00340 R50912_00345
PAEA : R70723_00335 R70723_00340
PAEE : R70331_00340 R70331_00345
PAEH : H70357_00340 H70357_00345
PAEJ : H70737_00395 H70737_00400
PBJ : VN24_10625 VN24_10630
PIH : UB51_22430 UB51_22435
PRI : PRIO_0068 PRIO_0069(pabA)
PSON : JI735_08985 JI735_08990(pabA)
PPEO : ABE82_00335 ABE82_00340
PNP : IJ22_45390 IJ22_45400
POW : IJ21_02820 IJ21_02830
PBV : AR543_03150 AR543_03155
PXL : BS614_03365 BS614_03370
PYG : AWM70_18740 AWM70_18745
PSWU : SY83_06370 SY83_06375
PDH : B9T62_32455 B9T62_32460
PIB : BBD41_13905 BBD41_13910
PCX : LPB68_11625 LPB68_11630
PKB : B4V02_24905 B4V02_24910
PAIH : ASL14_11560 ASL14_11565
PVO : PVOR_02466 PVOR_02471
PLW : D5F53_29620 D5F53_29625
PLEN : EIM92_04330(pabA) EIM92_04335
PPSC : EHS13_01640 EHS13_01645(pabA)
PLUT : EI981_00340 EI981_00345(pabA)
PALB : EJC50_04055 EJC50_04060(pabA)
PCHI : PC41400_03270 PC41400_03275
PBK : Back11_46620 Back11_46630
PPRT : ET464_14495(pabA) ET464_14500
PBAC : HUB98_17415 HUB98_17420(pabA)
PRZ : GZH47_15805(pabA) GZH47_15810
PLYC : GXP70_01135 GXP70_01140(pabA)
PSOP : KP014_03590 KP014_03595(pabA)
PTRI : KDC22_00330 KDC22_00335(pabA)
PTJ : JRJ22_00340 JRJ22_00345(pabA)
PALR : HGI30_00495 HGI30_00500(pabA)
PTHI : NDS46_00350 NDS46_00355
PKA : PQ456_00270 PQ456_00275(pabA)
PUI : PUW25_00325 PUW25_00330(pabA) PUW25_15555
PMAH : PTQ21_05515 PTQ21_05520(pabA)
PAMY : P9222_04960(pabA) P9222_04965
PDY : QJQ58_22380 QJQ58_22385
PMAE : LMZ02_05900 LMZ02_05905(pabA)
PWN : QNH46_00335 QNH46_00340(pabA)
PSPN : L1F29_00345 L1F29_00350(pabA)
PPOG : QPK24_00345 QPK24_00350(pabA)
PAUN : MJA45_01080 MJA45_01085(pabA)
PHK : SK066_00285 SK066_00290(pabA)
PNK : AASFL403_18635(pabA) AASFL403_18640
PPAB : KET34_00340 KET34_00345(pabA)
PKP : SK3146_04195(pabB) SK3146_04196(pabA)
PGLU : A3958_09750 A3958_09755
PLZH : C0638_07420 C0638_07425
PEZZ : HW560_05035(pabA) HW560_05040
TCO : Theco_3665 Theco_3666
ANX : ACH33_18125 ACH33_18130
ASOC : CB4_00275(pabA) CB4_00276(pabB)
ATHE : K3F53_00670 K3F53_00675(pabA)
AUD : PO771_18880(pabA) PO771_18885
ANEU : PP175_00885 PP175_00890(pabA)
COH : EAV92_19935 EAV92_19940(pabA)
COHN : KCTCHS21_00830 KCTCHS21_00840
CCHL : FPL14_14505 FPL14_14510(pabA)
CHEB : HH215_23680 HH215_23685(pabA)
COHL : J4772_00830 J4772_00835(pabA)
SACA : FFV09_10885 FFV09_10890
PLIG : NAG76_07160 NAG76_07165(pabA)
TUM : CBW65_14520 CBW65_14525
TAB : CIG75_14490 CIG75_14495(pabB)
SSIL : SOLI23_18845 SOLI23_18850
SOB : CSE16_00420 CSE16_00425
KUR : ASO14_2817 ASO14_2818
KZO : NCTC404_00690(trpG) NCTC404_00691(pabB)
PAEK : D3873_12980 D3873_12985
PANC : E2636_18450 E2636_18455(pabA)
VIJ : JNUCC6_14160(pabA) JNUCC6_14165
SSPH : SPSPH_014030(pabA_1)
SACV : SPACI_019190(pabA_1)
ACIT : HPK19_18285 HPK19_18290(pabA)
BALA : DSM104299_03539(pabA)
SBAE : DSM104329_03905(pabA)
» show all
Taxonomy
Reference
Authors
Schadt HS, Schadt S, Oldach F, Sussmuth RD.
Title
2-Amino-2-deoxyisochorismate is a key intermediate in Bacillus subtilis p-aminobenzoic acid biosynthesis.
Journal
Reference
Authors
Bera AK, Atanasova V, Dhanda A, Ladner JE, Parsons JF.
Title
Structure of aminodeoxychorismate synthase from Stenotrophomonas maltophilia.
Journal
Sequence
Other DBs
ExPASy - ENZYME nomenclature database: 2.6.1.123
LinkDB
All DBs