KEGG ENZYME: 2.6.1.126

ENZYME: 2.6.1.126

Entry

EC 2.6.1.126                Enzyme

Name

L-aspartate:5-guanidino-3-methyl-2-oxopentanoate transaminase;
argM (gene name);
mrsB (gene name)

Class

Transferases;
Transferring nitrogenous groups;
Transaminases

Sysname

L-aspartate:5-guanidino-3-methyl-2-oxopentanoate aminotransferase

Reaction(IUBMB)

L-aspartate + (3R)-5-guanidino-3-methyl-2-oxopentanoate = oxaloacetate + (3R)-3-methyl-L-arginine [RN:R13306]

Reaction(KEGG)

R13306

Substrate

L-aspartate [CPD:C00049];
(3R)-5-guanidino-3-methyl-2-oxopentanoate [CPD:C20234]

Product

oxaloacetate [CPD:C00036];
(3R)-3-methyl-L-arginine [CPD:C22904]

Comment

Requires pyridoxal 5'-phosphate. The enzyme, characterized from several bacterial species, participates in the biosynthesis of the rare amino acid (3R)-3-methyl-L-arginine. The enzyme from Streptomyces arginensis also catalyses the activity of EC 2.6.1.125, L-arginine:2-oxoglutarate transaminase.

History

EC 2.6.1.126 created 2024

Reference

1 [PMID:20190091]

Authors

Braun SD, Hofmann J, Wensing A, Ullrich MS, Weingart H, Volksch B, Spiteller D

Title

Identification of the biosynthetic gene cluster for 3-methylarginine, a toxin produced by Pseudomonas syringae pv. syringae 22d/93.

Journal

Appl Environ Microbiol 76:2500-8 (2010)
DOI:10.1128/AEM.00666-09

Sequence

[psb:Psyr_0117]