KEGG   ENZYME: 2.6.1.40
Entry
EC 2.6.1.40                 Enzyme                                 
Name
(R)-3-amino-2-methylpropionate---pyruvate transaminase;
D-3-aminoisobutyrate---pyruvate transaminase;
beta-aminoisobutyrate-pyruvate aminotransferase;
D-3-aminoisobutyrate-pyruvate aminotransferase;
D-3-aminoisobutyrate-pyruvate transaminase;
(R)-3-amino-2-methylpropionate transaminase;
D-beta-aminoisobutyrate:pyruvate aminotransferase
Class
Transferases;
Transferring nitrogenous groups;
Transaminases
Sysname
(R)-3-amino-2-methylpropanoate:pyruvate aminotransferase
Reaction(IUBMB)
(R)-3-amino-2-methylpropanoate + pyruvate = 2-methyl-3-oxopropanoate + L-alanine [RN:R02050]
Reaction(KEGG)
R02050
Substrate
(R)-3-amino-2-methylpropanoate [CPD:C01205];
pyruvate [CPD:C00022]
Product
2-methyl-3-oxopropanoate [CPD:C00349];
L-alanine [CPD:C00041]
Comment
The two enantiomers of the 2-methyl-3-oxopropanoate formed by the enzyme interconvert by enolization, so that this enzyme, together with EC 2.6.1.22, (S)-3-amino-2-methylpropionate transaminase, provide a route for interconversion of the enantiomers of 3-amino-2-methylpropanoate.
History
EC 2.6.1.40 created 1972 (EC 2.6.1.61 created 1982, incorporated 2004) modified 2004
Pathway
ec00280  Valine, leucine and isoleucine degradation
Orthology
K00827  alanine-glyoxylate transaminase / (R)-3-amino-2-methylpropionate-pyruvate transaminase
Genes
HSA64902(AGXT2)
PTR471573(AGXT2)
PPS100982568(AGXT2)
GGO101147587(AGXT2)
PON100171524(AGXT2)
NLE100607531(AGXT2)
MCC699250(AGXT2)
MCF102140666(AGXT2)
CSAB103215117(AGXT2)
CATY105583414(AGXT2)
PANU101025018(AGXT2)
TGE112626357(AGXT2)
RRO104678746(AGXT2)
RBB108543800(AGXT2)
TFN117065012(AGXT2)
PTEH111545528(AGXT2)
CJC100403023(AGXT2)
SBQ101045858(AGXT2)
CSYR103264977(AGXT2)
MMUR105867781(AGXT2)
OGA100940834(AGXT2)
MMU268782(Agxt2)
MCAL110310555(Agxt2)
MPAH110328982(Agxt2)
RNO83784(Agxt2)
MCOC116083222(Agxt2)
MUN110566620(Agxt2)
CGE100759906(Agxt2)
PLEU114710800(Agxt2)
NGI103735910(Agxt2)
HGL101714498(Agxt2)
CPOC100714301(Agxt2)
CCAN109690881(Agxt2)
DORD105987377(Agxt2)
DSP122116999(Agxt2)
OCU100352336(AGXT2)
OPI101519119(AGXT2)
TUP102501713(AGXT2)
CFA612589(AGXT2)
VVP112908610(AGXT2)
VLG121487429(AGXT2)
AML100482092(AGXT2)
UMR103664720(AGXT2)
UAH113260880(AGXT2)
UAR123785468(AGXT2)
ELK111141161
LLV125100800
MPUF101688685(AGXT2)
ORO101375130(AGXT2)
EJU114204858(AGXT2)
ZCA113929184(AGXT2)
MLX118006359 118006488
FCA101097947(AGXT2)
PYU121041672(AGXT2)
PBG122494694(AGXT2)
PTG102966139(AGXT2)
PPAD109267716(AGXT2)
AJU106980604(AGXT2)
HHV120242473(AGXT2)
BTA521553(AGXT2)
BOM102269782(AGXT2)
BIU109575007(AGXT2)
BBUB102415414(AGXT2)
CHX102176828(AGXT2)
OAS101111660(AGXT2)
ODA120879332(AGXT2)
CCAD122454584(AGXT2)
SSC100513890(AGXT2)
CFR102515152(AGXT2)
CBAI105069421(AGXT2)
CDK105087007(AGXT2)
VPC102538895(AGXT2)
BACU103010921(AGXT2)
LVE103080731(AGXT2)
OOR101275910(AGXT2)
DLE111187642(AGXT2)
PCAD102974755(AGXT2)
PSIU116751363(AGXT2)
ECB100053849(AGXT2)
EPZ103545309(AGXT2)
EAI106824782(AGXT2)
MYB102239222(AGXT2)
MYD102773052(AGXT2)
MMYO118656733(AGXT2)
MLF102424294(AGXT2)
MNA107546352(AGXT2)
PKL118703611(AGXT2)
HAI109385510(AGXT2)
DRO112321148(AGXT2)
SHON118998768(AGXT2)
AJM119037022(AGXT2)
PDIC114508826(AGXT2)
PHAS123824867(AGXT2)
MMF118642404(AGXT2)
RFQ117025204(AGXT2)
PALE102888844(AGXT2)
PGIG120586202(AGXT2)
PVP105305880(AGXT2)
RAY107509702(AGXT2)
MJV108405850(AGXT2)
TOD119261123(AGXT2)
SARA101546708(AGXT2)
LAV100668434(AGXT2)
TMU101347029
DNM101445866(AGXT2)
MDO100020759(AGXT2)
GAS123237446(AGXT2)
SHR100917044(AGXT2)
PCW110214612(AGXT2)
OAA100078063(AGXT2)
GGA431666(AGXT2)
PCOC116238630(AGXT2)
MGP100541842(AGXT2)
CJO107305776(AGXT2)
NMEL110389481(AGXT2)
APLA101799853(AGXT2)
ACYG106036349(AGXT2)
AFUL116500789(AGXT2)
TGU100230972
LSR110482591(AGXT2)
SCAN103822879(AGXT2)
PMOA120502503(AGXT2)
OTC121343622(AGXT2)
PRUF121365751(AGXT2)
GFR102033340(AGXT2)
FAB101810573(AGXT2)
PHI102109437(AGXT2)
PMAJ107198191(AGXT2)
CCAE111941074(AGXT2)
CCW104686756(AGXT2)
ETL114066149(AGXT2)
ZAB102070123(AGXT2)
FPG101911080(AGXT2)
FCH102052632(AGXT2)
CLV102087277(AGXT2)
EGZ104133922(AGXT2)
NNI104014002(AGXT2)
ACUN113489545(AGXT2)
TALA104358771(AGXT2)
PADL103912227(AGXT2)
ACHC115336940(AGXT2)
AAM106499541(AGXT2)
AROW112976243(AGXT2)
NPD112946243(AGXT2)
DNE112982174(AGXT2)
ASN102375742(AGXT2)
AMJ102559340(AGXT2)
CPOO109307674(AGXT2)
GGN109298138(AGXT2)
PSS102449032(AGXT2)
CMY102930944(AGXT2)
CPIC101937486(AGXT2)
TST117878828(AGXT2)
CABI116833368(AGXT2)
MRV120407376(AGXT2)
ACS100565387(agxt2)
PVT110080093(AGXT2)
SUND121921476(AGXT2)
PBI103060614(AGXT2)
PMUR107296961(AGXT2) 107299675
TSR106544287(AGXT2) 106555888
PGUT117679997(AGXT2)
VKO123024135(AGXT2)
PMUA114606480(AGXT2)
ZVI118077134(AGXT2)
GJA107107502(AGXT2)
XLA108705425(agxt2.S) 108718414(agxt2.L)
XTR100491739(agxt2)
NPR108792653(AGXT2)
RTEM120927521(AGXT2)
BBUF120992187(AGXT2)
BGAR122924887(AGXT2)
DRE619269(agxt2)
SRX107719064 107739667
SANH107662137
SGH107600890
CCAR109069820(agxt2)
CAUA113038862(agxt2) 113063715
IPU108279281(agxt2)
PHYP113535665(agxt2)
SMEO124398429(agxt2)
AMEX103047265(agxt2)
EEE113584570(agxt2)
TRU101075075(agxt2)
TNGGSTEN00014411G001
LCO104928235 104928508
NCC104961016 104961017
CGOB115016801(agxt2)
ELY117269159 117270074
PLEP121960191 121960193
SLUC116062799(agxt2)
ECRA117959251(agxt2)
PFLV114571143(agxt2)
GAT120831469 120831470
PPUG119226982 119226992
MSAM119914033(agxt2)
CUD121524781 121525364
MZE101477079(agxt2)
ONL100701752 100702026
OAU116331688
OLA111948298(agxt2)
OML112163412(agxt2)
XMA102217588(agxt2)
XCO114150170(agxt2)
XHE116724194(agxt2)
PRET103473873(agxt2)
PFOR103142735(agxt2)
PLAI106952443(agxt2)
PMEI106918658(agxt2)
GAF122819621(agxt2)
CVG107085798(agxt2)
CTUL119776602(agxt2)
GMU124872599(agxt2)
NFU107374696(agxt2)
KMR108231105(agxt2)
ALIM106518182(agxt2)
NWH119425054(agxt2)
AOCE111578671(agxt2) 111587894
CSEM103390290(agxt2)
POV109626465(agxt2)
SSEN122758137(agxt2)
HHIP117771680(agxt2)
LCF108873989(agxt2) 108873991
SDU111234697(agxt2) 111234704
SLAL111664750 111664751(agxt2)
XGL120805928 120806349
HCQ109523626(agxt2)
BPEC110160563(agxt2)
MALB109960590(agxt2)
SASA106568486(agxt2)
OTW112257351(agxt2)
OMY110536779(agxt2)
OGO123999388(agxt2)
ONE115106020(agxt2)
SALP111980518(agxt2)
SNH120044878(agxt2)
ELS105007583(agxt2)
SFM108935619(agxt2)
PKI111852579(agxt2)
AANG118213290(agxt2)
LOC102682826(agxt2)
PSPA121304721(agxt2)
ARUT117420681(agxt2)
LCM102356225(AGXT2)
RTP109914961(agxt2)
BFO118417587
BBEL109473515
CIN100178847
SCLV120326226 120341470
SPU594821
APLC110989783
DMEDmel_CG11241(CG11241)
DER6544107
DSE6616589
DSIDsimw501_GD12056(Dsim_GD12056)
DYADyak_GE19492
DAN6506089
DSR110190421
DPODpse_GA10859
DPE6603439
DMN108152459
DWI6645706
DGR6557381
DMODmoj_GI11871
DNV115563732
DHE111595344
DVI6622852
CCAT101451194
BOD106623603
MDE101893078
SCAC106091501
LCQ111682457
AGAAgaP_AGAP012404
ACOZ120955850
AARA120901399
AAG5565436
AALB109426022 115268050
CQUCpipJ_CPIJ005222 CpipJ_CPIJ013562
CPII120422215
CNS116341035
AME100576186
ACER107995955
ALAB122718087
BIM100748967
BBIF117214042
BVK117236331
BVAN117166801
BTER100645336
BPYO122572915
CCAL108624048
OBB114879990
MGEN117229903
NMEA116434807
CGIG122402511
PCF106791427
PFUC122515301
VPS122635418
NVI100123739
CSOL105366494
TPRE106656953
MDL103568860
CGLO123258419
FAS105273947
DAM107036613
AGIF122857736
CCIN107267829
TCA658321
DPA109536139
SOY115887837
ATD109599134
CSET123314975
AGB108905228
LDC111503562
NVL108565425
APLN108744670 108744729
PPYR116175059
OTU111421259
BMOR101737717 101744960 101745259
BMAN114242185 114242220 114242265
MSEX115453913
DPLKGM_210383
BANY112046799
PMAC106716088 106716108
PPOT106101731 106101732
PXU106121322 106121324
PRAP111003467
ZCE119840696
HAW110375501
TNL113498037
OFU114356349
PXY105394913
API100163196
DNX107162134
AGS114130714
RMD113556264
BTAB109036563
DCI103510603
CLEC106663150
HHAL106677667
NLU111054011
PHUPhum_PHUM292860
FOC113212569
ZNE110828279
CSEC111866740
FCD110855892
DPXDAPPUDRAFT_128102
DMK116918821
PVM113819666
PJA122266894
HAME121873292
PCLA123769161
PTRU123507864
HAZT108676415
EAF111702699
ISCIscW_ISCW020823
DSV119435966
RSAN119404549
RMP119187480
VDE111249169
TUT107366508
DFR124500037
CSCU111630245
PTEP107439021
SDM118181588
CELCELE_T09B4.8(T09B4.8)
CBRCBG_12888
NAINECAME_13409
HROHELRODRAFT_185816
LGILOTGIDRAFT_132142
PCAN112577308
BGT106058632
GAE121388063 121390899
HRF124147410
HRJ124268418 124268442
CRG105338391
MYI110453623
PMAX117337550
MMER123549505
OBI106882838
OSN115216892
LAK106163654
NVE5506278
EPA110243940
ATEN116306337
ADF107345591 107346230
AMIL114958147
PDAM113666683
SPIS111324760
DGT114517030
XEN124437530
HMG100197706
TADTRIADDRAFT_63204
AQU100631942
ATHAT2G38400(AGT3) AT3G08860(PYD4) AT4G39660(AGT2)
ALY9302946 9315810 9318653
CRB17879955 17888951 17892432
CSAT104716249 104720888 104729284 104745038 104746167 104782278 104792641
EUSEUTSA_v10016589mg EUTSA_v10025073mg
BRP103835108 103851253 103857781 103859327 103865668 103867109
BNA106352999 106361359 106362305 106390423 106403302 106410980 106438152 106439151 106439231 106449228 106450358 106454645 111214132
BOE106317481 106332232 106335907 106341091
RSZ108813116 108813138 108818792 108839753 108844445 108844499 108852529 108858956 108859075
THJ104806625 104807714 104816171 104823364
CPAP110817186
CIT102615236 102618447
CICCICLE_v10011621mg CICLE_v10025514mg
PVY116108981 116125964 116126036 116131790 116139126
MINC123201646 123205448 123222782 123223069
TCC18602267 18611649
GRA105777154 105777171 105796307 105800469
GHI107896807 107903538 107914378 107914562 107928548 107935989 121206319 121208248
GAB108454044 108474449 108488629 108489650
DZI111279663 111293087 111307641 111307642
EGR104415816 104425091
GMX100170733 100170738 100780526 100797583 100804017 100819821
GSJ114380838 114394510 114406010 114413150 114416718 114421900
PVUPHAVU_002G263500g PHAVU_008G0876000 PHAVU_010G078600g
VRA106758593 106767849 106774302
VAR108323918 108328132 108346215
VUN114165730 114179367 114186135
CCAJ109813650 109816196 109816349 109816350
APRC113849699 113849938 113851640 113863270 113873831
MTRMTR_3g465800 MTR_7g072420 MTR_8g091660
CAM101488709 101493970 101494593
LJALj1g3v2444980.1(Lj1g3v2444980.1) Lj4g3v2800580.1(Lj4g3v2800580.1)
ADU107473704 107475434 107480413 107485208
AIP107625848 107631121 107639616 107644266
AHF112719918 112728127 112733266 112743801 112751474 112791240 112793367 112797146
LANG109325301 109328196 109328971 109343646 109359473 109361536
FVE101305858 101308190
RCN112174473 112186512 112194838
PPER18774709 18774891 18792092
PMUM103318900 103333451 103343315
PAVI110765776 110768398
PDUL117627762 117630011 117631023
MDM103416128 103433731 103450725
PXB103928969 103961176 103962170
ZJU107425420 107431291
MNT21403014 21404820
CSV101203709 101208662 101210304 116403551
CMO103486242 103494397 103502182
BHJ120070257 120074711
MCHA111008389 111013828 111024026
CMAX111470260 111478223 111479964 111482939
CMOS111436070 111447048 111453426 111457536
CPEP111800248 111801654 111803681 111810280
RCU8269354 8286276
JCU105636516 105648063
HBR110634155 110640903 110647166
MESC110620548 110623541 110630530
POP7456937 7460426 7468078
PEU105110289 105121878 105126463
PALZ118035601 118043619 118048146
JRE108982628 108985282 108990021 108996966
QSU111990546 112000437 112023895
QLO115950148 115952225 115984842 115984880 115994271
TWL119986541 119990079 120013516
VVI100243935 100251671 100258727
VRI117916925 117919030 117919662
SLY101247011 101268729
SPEN107017796 107032369
SOT102582419 102589300
CANN107845948 107855164
NTA107769579 107803383 107815286 107825954 107827733 107828015
NSY104228384 104231272 104246307
NTO104093720 104099804 104109792
NAU109209547 109210516 109233404
INI109157724 109164010 109172562
ITR115998616 116017305 116020666
SIND105163930 105163983 105171238 105174636 105176497
OEU111373090 111383527 111385678 111403226 111404063 111407994
EGT105953158 105960066 105973061
SSPL121742206 121745175 121745899 121775811 121787183 121806484
HAN110884572 110903697 110910958 110918713
ECAD122592627 122593836 122603434 122606897
LSV111896211 111918915 111920617
CCAV112507102 112507831 112514742
DCR108196627 108217775
CSIN114278956 114279659 114281666 114299363
BVG104890411 104898212
SOE110790222 110794781
CQI110698132 110728548 110730754 110733828 110735393
NNU104597224 104602481 104605885
MING122081585 122088751 122089942
TSS122648973 122667629 122672710
PSOM113283771 113331955 113357789
NCOL116248525 116259254
OSA4331779 4332775 4339095
DOSAOs03t0171900-01(Os03g0171900) Os03t0338000-01(Os03g0338000) Os05t0475400-01(Os05g0475400)
OBR102703014 102704498 102723055
BDI100821851 100824380 100845801 100846647
ATS109754438 109772808 109784440
TDC119283776 119284591 119291579 119296203 119348682
TAES100682403 123081930 123084763 123094831 123098594 123099923 123136936 123182362 542824
SBI8059808 8064129 8082323
ZMA100274974 100279249 100384690 103631778
SITA101763794 101780905 101784978
SVS117835958 117836932 117848334
PVIR120647153 120652427 120665169 120692741 120692838 120698374
PHAI112872622 112877983 112884662
PDA103700724 103702094 103714394
EGU105044778 105045932 105048590
MUS103968632 103984267 103989682 103994815
DCT110112395 110116619
PEQ110020129 110021374 110021412
AOF109819957 109833902 109850512
ATR18422179 18433551
SMOSELMODRAFT_143081 SELMODRAFT_235068
PPP112287430
CRECHLRE_03g182800v5
VCNVOLCADRAFT_79310
CSLCOCSUDRAFT_29200
CVRCHLNCDRAFT_143782
APROF751_4530
MBRMONBRDRAFT_26129
ACANACA1_072820
NGRNAEGRDRAFT_82452
LSHCAB17_16240
LLG44548918_01443(dgdA)
LCJNCTC11976_02502(dgdA)
LWASAMEA4504053_2397(dgdA_2)
SURSTAUR_8044
LLUAKJ09_08936
NOHG5V57_29550
RIDRIdsm_01011(dgdA)
ROMEI983_17310
PAEDG5B38_08360
BLRBRLA_c010740
BRWGOP56_21340
GYMGYMC10_0624
PLVERIC2_c05020
PSABPSAB_01945
PDUPDUR_02235
PBDPBOR_02645
PGMPGRAT_02845
PODPODO_02490
PAENP40081_02890
PAEFR50345_02405
PAEQR50912_02590
PSTEPSTEL_02775
PAEAR70723_02230
PAEER70331_02200
PAEHH70357_02490
PAEJH70737_02520
PIHUB51_24330
PRIPRIO_0619
PSONJI735_11515
PDHB9T62_34795
PVOPVOR_05433
PLWD5F53_26405
PLENEIM92_00870
PLUTEI981_03285
PSOPKP014_05440
PTRIKDC22_02505
CBVU729_2097
CGASJ1C67_11305
CLEClole_2508
CEWEKH84_15175
THEPDYI95_008985
VPYHZI73_11325
SSGSelsp_1000
SELEADJ74_07045
SELOAXE86_02480
SELTBCS37_03345
STEDSPTER_24020(argD_2)
TURAT726_02030
TSGHLK68_00345
CAPCLDAP_00250
TRATrad_1960
LCREPla8534_41840(davT)
AAGGETAA8_48580(tpa)
LPAVPLANPX_2066
PNDPla175_14200(tpa)
AMOBHG15A2_42190(dgdA)
TSPHKIH39_06075
BROCIPI25_09690
HHYHalhy_3357
 » show all
Reference
1  [PMID:5773299]
  Authors
Kakimoto Y, Taniguchi K, Sano I.
  Title
D-beta-aminoisobutyrate:pyruvate aminotransferase in mammalian liver and excretion of beta-aminoisobutyrate by man.
  Journal
J Biol Chem 244:335-40 (1969)
Reference
2  [PMID:10989446]
  Authors
Tamaki N, Sakata SF, Matsuda K
  Title
Purification, properties, and sequencing of aminoisobutyrate aminotransferases from rat liver.
  Journal
Methods Enzymol 324:376-89 (2000)
DOI:10.1016/S0076-6879(00)24247-X
  Sequence
[rno:83784]
Other DBs
ExplorEnz - The Enzyme Database: 2.6.1.40
IUBMB Enzyme Nomenclature: 2.6.1.40
ExPASy - ENZYME nomenclature database: 2.6.1.40
BRENDA, the Enzyme Database: 2.6.1.40
CAS: 37279-00-8
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