KEGG   ENZYME: 2.6.1.99
Entry
EC 2.6.1.99                 Enzyme                                 
Name
L-tryptophan---pyruvate aminotransferase;
TAA1 (gene name);
vt2 (gene name)
Class
Transferases;
Transferring nitrogenous groups;
Transaminases
Sysname
L-tryptophan:pyruvate aminotransferase
Reaction(IUBMB)
L-tryptophan + pyruvate = indole-3-pyruvate + L-alanine [RN:R10180]
Reaction(KEGG)
R10180
Substrate
L-tryptophan [CPD:C00078];
pyruvate [CPD:C00022]
Product
indole-3-pyruvate [CPD:C00331];
L-alanine [CPD:C00041]
Comment
This plant enzyme, along with EC 1.14.13.168, indole-3-pyruvate monooxygenase, is responsible for the biosynthesis of the plant hormone indole-3-acetate from L-tryptophan.
History
EC 2.6.1.99 created 2012
Pathway
ec00380  Tryptophan metabolism
ec01100  Metabolic pathways
Orthology
K16903  L-tryptophan---pyruvate aminotransferase
Genes
BANY112044543
ATHAT1G23320(TAR1) AT1G70560(TAA1) AT4G24670(TAR2)
ALY9305778 9323373 9329339
CRB17877519 17894004 17900474
CSAT104701697 104712605 104720137 104722517 104730979 104743484 104750895 104759380 104778836
EUSEUTSA_v10009685mg EUTSA_v10018719mg EUTSA_v10025236mg
BRP103831591 103840774 103840776 103852664 103862382
BNA106353777 106374472 106375778 106395273 106400436 106400463 106404922 106430840 106442204 111207310
BOE106294041 106294077 106299425 106321880 106322583 106325109
RSZ108839658 108841769 108844999 108845011
THJ104809038 104809260 104822161 104822981
CPAP110813115 110816856
CIT102612766 102617510
CICCICLE_v10020085mg CICLE_v10033774mg
PVY116118575 116124469
MINC123204446 123210603 123213225
TCC18604012 18609529
GRA105779160 105780852 105794631 105800025
GHI107886550 107890884 107898658 107898660 107909692 107933359 107933665
GAB108456650 108459859 108474874
DZI111282864 111287631 111287783 111290251
EGR104414154 104417808
GMX100777098 100801447 100803246 100807013 100818522 100820582
GSJ114380537 114392876 114400662 114409858 114411987 114416422
PVUPHAVU_002G059200g PHAVU_003G203500g PHAVU_009G175300g
VRA106753302 106761959 106776775
VAR108327681 108331054 108333707
VUN114162124 114174212 114177247
CCAJ109797027 109801329 109807609
APRC113853118 113870437 113874846
MTRMTR_3g077250 MTR_4g105220 MTR_5g033510 MTR_5g033520
CAM101489241 101508125 101514153
LJALj1g3v0318800.1(Lj1g3v0318800.1) Lj1g3v0318800.2(Lj1g3v0318800.2) Lj2g3v1415340.1(Lj2g3v1415340.1) Lj2g3v1415360.1(Lj2g3v1415360.1) Lj2g3v1415390.1(Lj2g3v1415390.1) Lj4g3v1451990.1(Lj4g3v1451990.1)
ADU107478928 107481141 107488754 107488755 107491447
AIP107609489 107632027 107633787 107640363 107641771
AHF112695941 112722318 112735514 112746944 112749973 112766026 112790455 112791756 112801160 112801162
LANG109330662 109332717 109342780 109362513
FVE101299870 101301876 101312441
RCN112176054 112180086 112199635
PPER18776298 18788121 18792031
PMUM103321820 103321907 103337916
PAVI110745862 110773598
PDUL117615674 117616625 117628571
MDM103403054 103437690 103452013 103455193
PXB103949799 103952975
ZJU107418305 107418435 107428581
MNT21397691 21410299
CSV101204502 101206126 101206363
CMO103483752 103502384 103502385
BHJ120070759 120076107 120083686
MCHA111004658 111007309 111008686
CMAX111470731 111485740 111490275 111495051 111496597
CMOS111429925 111431614 111432460 111454299 111457147
CPEP111780369 111782768 111793207 111798930 111802190
RCU8273485 8278313
JCU105640330
HBR110640704 110640705 110642579 110645893 110645901 110664765
MESC110627445 110631077
POP112324299 112328448 7456901 7492386
PEU105120045 105132347 105140228 105140872 105142072
PALZ118038235 118044886 118045457 118057452
JRE108979082 108984468 109003845
QSU111985001 111990404 112010065 112013773 112037363
QLO115963732 115979000 115986238 115986239
TWL119986048 119992145 120000883
VVI100245885 100257504 100262049
VRI117904710 117912625
SLY101246927 101253797 101262607
SPEN107012524 107019794 107020730 107021555
SOT102587670 102588233 102588841 102589167 102592266 102592610 102603358
CANN107846935 107851600 107857351 107862570
NTA107767293 107784414 107825960 107829568
NSY104224700 104244704
NTO104099725 104114980
NAU109211005 109223662
INI109160163 109177167 109190275 109190293
ITR116005080 116006812 116023589
SIND105156774 105157456 105168289 105179382
OEU111369186 111401708 111404891 111404892 111408458
EGT105950533 105967950 105975066
SSPL121766659 121768026 121785515 121785948 121799550 121800225
HAN110868545 110891139 110915440 110925437
ECAD122589916 122598580
LSV111907020 111911344
CCAV112501486 112509490
DCR108193781 108194678 108207706
CSIN114259774 114271819 114301053
BVG104894324 104897269 104897270
SOE110799231 110799637
CQI110681932 110700349 110701878 110707110 110712556 110727594
NNU104591456 104591457 104593122 104593123 104605535 104606093
MING122061412 122067247 122077154
TSS122656370 122671631 122672037
PSOM113300134 113319329 113340742 113351288 113353459 113361071
NCOL116247742
OSA4325198 4337930
DOSAOs05t0169300-01(Os05g0169300)
OBR102703686 102704576
BDI100824596 100838076
ATS109740802 109749870 109779434
TDC119267093 119269591 119274926 119276949 119328059 119328115 119331320 119341237 119365812
TAES123053434 123060273 123068780 123077285 123083178 123083188 123083217 123083248 123105817 123114279 123114319 123130433 123151276 123169461 123176510 123180651
SBI8056556 8080939 8080940
ZMA100193435 100272716 100285505 103634861 103649700
SITA101756802 101762186 101784814 101785211
SVS117850582 117855065
PVIR120664256 120667426 120676435 120697551 120701227 120705864
PHAI112887428 112892158
PDA103703781 103711568 108511861 120104136
EGU105033654 105036212
MUS103968804 103979260 103988297
DCT110097172 110100718
PEQ110019338 110031026
AOF109828906 109844997 109845497 109845735
ATR18422576
SMOSELMODRAFT_171289 SELMODRAFT_176918
PPP112274010 112278111 112294406 112295190
 » show all
Reference
1  [PMID:18394996]
  Authors
Tao Y, Ferrer JL, Ljung K, Pojer F, Hong F, Long JA, Li L, Moreno JE, Bowman ME, Ivans LJ, Cheng Y, Lim J, Zhao Y, Ballare CL, Sandberg G, Noel JP, Chory J
  Title
Rapid synthesis of auxin via a new tryptophan-dependent pathway is required for shade avoidance in plants.
  Journal
Cell 133:164-76 (2008)
DOI:10.1016/j.cell.2008.01.049
  Sequence
Reference
2  [PMID:22025724]
  Authors
Mashiguchi K, Tanaka K, Sakai T, Sugawara S, Kawaide H, Natsume M, Hanada A, Yaeno T, Shirasu K, Yao H, McSteen P, Zhao Y, Hayashi K, Kamiya Y, Kasahara H
  Title
The main auxin biosynthesis pathway in Arabidopsis.
  Journal
Proc Natl Acad Sci U S A 108:18512-7 (2011)
DOI:10.1073/pnas.1108434108
  Sequence
[ath:AT1G70560]
Reference
3  [PMID:21335375]
  Authors
Phillips KA, Skirpan AL, Liu X, Christensen A, Slewinski TL, Hudson C, Barazesh S, Cohen JD, Malcomber S, McSteen P
  Title
vanishing tassel2 encodes a grass-specific tryptophan aminotransferase required for vegetative and reproductive development in maize.
  Journal
Plant Cell 23:550-66 (2011)
DOI:10.1105/tpc.110.075267
  Sequence
[zma:103634861]
Reference
4  [PMID:22155950]
  Authors
Zhao Y
  Title
Auxin biosynthesis: a simple two-step pathway converts tryptophan to indole-3-acetic acid in plants.
  Journal
Mol Plant 5:334-8 (2012)
DOI:10.1093/mp/ssr104
Other DBs
ExplorEnz - The Enzyme Database: 2.6.1.99
IUBMB Enzyme Nomenclature: 2.6.1.99
ExPASy - ENZYME nomenclature database: 2.6.1.99
BRENDA, the Enzyme Database: 2.6.1.99
LinkDB

DBGET integrated database retrieval system