KEGG   ENZYME: 2.7.1.91
Entry
EC 2.7.1.91                 Enzyme                                 
Name
sphingosine kinase;
SPHK1 (gene name);
SPHK2 (gene name);
dihydrosphingosine kinase;
dihydrosphingosine kinase (phosphorylating);
sphingosine kinase (phosphorylating);
sphingoid base kinase;
sphinganine kinase;
ATP:sphinganine 1-phosphotransferase
Class
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor
Sysname
ATP:sphingoid base 1-phosphotransferase
Reaction(IUBMB)
ATP + a sphingoid base = ADP + a sphingoid base 1-phosphate
Reaction(KEGG)
(other) R01926 R02976
Substrate
ATP [CPD:C00002];
sphingoid base
Product
ADP [CPD:C00008];
sphingoid base 1-phosphate
Comment
The enzyme is involved in the production of sphingolipid metabolites. It phosphorylates various sphingoid long-chain bases, such as sphingosine, D-erythro-dihydrosphingosine (sphinganine), phytosphingosine (4-hydroxysphinganine), 4-hydroxy-8-sphingenine, 4,8-sphingadienine and D-threo-dihydrosphingosine and L-threo-dihydrosphingosine. The exact substrate range depends on the species.
History
EC 2.7.1.91 created 1976, modified 1980, modified 2016
Pathway
ec00600  Sphingolipid metabolism
ec01100  Metabolic pathways
Orthology
K04718  sphingosine kinase
Genes
HSA56848(SPHK2) 8877(SPHK1)
PTR468943(SPHK2) 738821(SPHK1)
PPS100977890(SPHK1) 100992056(SPHK2)
GGO101127850(SPHK1)
PON100172513(SPHK2) 100433232(SPHK1)
NLE100592000(SPHK2) 100598765(SPHK1)
MCC710441(SPHK1) 718088(SPHK2)
MCF101926057(SPHK1) 102116114(SPHK2)
CSAB103234983(SPHK2) 103242988(SPHK1)
CATY105577691(SPHK1) 105595245(SPHK2)
PANU101010713(SPHK2) 101020308(SPHK1)
TGE112608916(SPHK1) 112612325(SPHK2)
RRO104666560(SPHK2) 104681274(SPHK1)
RBB108523630(SPHK2) 108537441(SPHK1)
TFN117066720(SPHK1) 117091509(SPHK2)
PTEH111520066(SPHK2) 111542386(SPHK1)
CJC100387720(SPHK2) 100406587(SPHK1)
SBQ101029043(SPHK1) 101044895(SPHK2)
CSYR103250049(SPHK2) 103250647(SPHK1)
MMUR105865659(SPHK2) 105878971(SPHK1)
LCAT123620485(SPHK1) 123623864(SPHK2)
OGA100961067(SPHK2) 100966333(SPHK1)
MMU20698(Sphk1) 56632(Sphk2)
MCAL110297874(Sphk2) 110305526(Sphk1)
MPAH110323710(Sphk2) 110332158(Sphk1)
RNO170897(Sphk1) 308589(Sphk2)
MCOC116078345(Sphk1)
MUN110550495(Sphk2) 110564670(Sphk1)
CGE100762053(Sphk1) 100774790(Sphk2)
MAUA101822923(Sphk1) 101840320(Sphk2)
PLEU114684677(Sphk2) 114707026(Sphk1)
MORG121436240(Sphk1) 121457079(Sphk2)
AAMP119802538(Sphk2) 119812963(Sphk1)
NGI103732783(Sphk1) 103742305 103743619(Sphk2)
HGL101711606(Sphk1) 101720879(Sphk2)
CPOC100727266(Sphk1) 100730608(Sphk2)
CCAN109682695(Sphk2) 109685588(Sphk1)
DORD105994375(Sphk2) 106001315(Sphk1)
DSP122125497(Sphk2) 122128393(Sphk1)
NCAR124966668 124980283
OCU100357790(SPHK1)
OPI101522075(SPHK1) 101529238(SPHK2)
TUP102471518(SPHK1) 102476140(SPHK2)
CFA483329(SPHK1) 484401(SPHK2)
CLUD112645197(SPHK2) 112672834(SPHK1)
VVP112920827(SPHK1) 112931373(SPHK2)
VLG121474189(SPHK1) 121484099(SPHK2)
AML100473787(SPHK1) 100479407(SPHK2)
UMR103657238(SPHK2) 103665951(SPHK1)
UAH113243339(SPHK2) 113244597(SPHK1)
UAR123776264(SPHK2) 123803088(SPHK1)
ELK111160330 111160728
LLV125086829 125088644
MPUF101672769(SPHK2) 101688732(SPHK1)
ORO101375807(SPHK1) 101376404(SPHK2)
EJU114199498(SPHK2) 114216219(SPHK1)
ZCA113935283(SPHK2) 113939284(SPHK1)
MLX117998224(SPHK2) 118024239(SPHK1)
FCA101081345(SPHK2) 101084918(SPHK1)
PYU121017954(SPHK1) 121018720(SPHK2)
PBG122486120(SPHK1) 122494874(SPHK2)
PTG102961449(SPHK2) 102966392(SPHK1)
PPAD109253123(SPHK2) 109276896(SPHK1)
AJU106987762(SPHK1) 106988651(SPHK2)
HHV120228097(SPHK1) 120242882(SPHK2)
BTA533103(SPHK2) 618605(SPHK1)
BOM102284142(SPHK2) 102285123(SPHK1)
BIU109572468(SPHK2) 109573990(SPHK1)
BBUB102411106(SPHK1) 102412075(SPHK2)
CHX102168201(SPHK1) 102184187(SPHK2)
OAS101105263(SPHK1) 101106964(SPHK2) 114116817
ODA120866745(SPHK1) 120872180(SPHK2)
CCAD122420263(SPHK2) 122437088(SPHK1)
SSC100519210(SPHK1) 100738292(SPHK2)
CFR102523205(SPHK1) 102524512(SPHK2)
CBAI105062588(SPHK2) 105065623(SPHK1)
CDK105092188(SPHK1) 105102906(SPHK2)
VPC102525050(SPHK2) 102533298(SPHK1)
BACU103003972(SPHK1) 103010420(SPHK2)
LVE103072023(SPHK1) 103079519(SPHK2)
OOR101286291(SPHK1) 101289072(SPHK2)
DLE111180657(SPHK2) 111182791(SPHK1)
PCAD102982912(SPHK1) 102994529(SPHK2)
PSIU116743941(SPHK2) 116746005(SPHK1)
ECB100054066(SPHK2) 100058875(SPHK1)
EPZ103540021(SPHK2) 103541302(SPHK1)
EAI106830329(SPHK1) 106838247(SPHK2)
MYB102254173(SPHK1) 102255740(SPHK2)
MYD102762504(SPHK1) 102766668(SPHK2)
MMYO118655346(SPHK2) 118671137(SPHK1)
MLF102421251(SPHK1) 102434379(SPHK2)
MNA107531908(SPHK2) 107536591(SPHK1)
PKL118704513(SPHK1) 118721086(SPHK2)
HAI109383749(SPHK1) 109391059(SPHK2)
DRO112298798(SPHK1) 112310060(SPHK2)
SHON119000132(SPHK1)
AJM119044423(SPHK2) 119058541(SPHK1)
PDIC114503018(SPHK1) 114511602(SPHK2)
PHAS123816681(SPHK1) 123830182(SPHK2)
MMF118634564(SPHK1) 118638266(SPHK2)
RFQ117013008(SPHK1) 117035218(SPHK2)
PALE102887299(SPHK2) 102892759(SPHK1)
PGIG120600331(SPHK1) 120606967(SPHK2)
PVP105293381(SPHK1) 105301772(SPHK2)
RAY107498846(SPHK2) 107501245(SPHK1)
MJV108393157(SPHK2) 108398675(SPHK1)
TOD119232735(SPHK1) 119249520(SPHK2)
SARA101538217(SPHK2) 101554247(SPHK1)
LAV100668199(SPHK1) 100676401(SPHK2)
TMU101349439 101357482
DNM101424126(SPHK1) 101446304(SPHK2)
MDO100026664(SPHK1)
GAS123239810(SPHK2) 123245073(SPHK1)
SHR100914991(SPHK1)
PCW110219386(SPHK1) 110219899(SPHK2)
OAA100076678(SPHK1)
GGA427803(SPHK1)
PCOC116232614(SPHK1)
MGP100539320(SPHK1)
CJO107322120(SPHK1)
NMEL110407457(SPHK1)
APLA101798369(SPHK1)
ACYG106034629(SPHK1)
AFUL116496676(SPHK1)
TGU100227204(SPHK1)
LSR110476572(SPHK1)
SCAN103819871(SPHK1)
PMOA120505529(SPHK1)
OTC121338220(SPHK1)
PRUF121363901(SPHK1)
GFR102044859(SPHK1)
FAB101818075(SPHK1)
PHI102106754(SPHK1)
PMAJ107212638(SPHK1)
CCAE111937276(SPHK1)
CCW104694392(SPHK1)
ETL114058567(SPHK1)
ZAB102064646(SPHK1)
FPG101921272(SPHK1)
FCH102060119(SPHK1)
CLV102093489(SPHK1)
NNI104022872(SPHK1)
ACUN113486681(SPHK1)
TALA116964025(SPHK1)
PADL103921013(SPHK1)
ACHC115341172(SPHK1)
AROW112977766(SPHK1)
NPD112957692(SPHK1)
DNE112985338(SPHK1)
ASN102374989(SPHK2) 102385258(SPHK1)
AMJ102558563(SPHK1) 102566845(SPHK2)
CPOO109315104(SPHK1)
GGN109287761(SPHK1)
PSS102454103(SPHK1)
CMY102935501(SPHK1) 102947921(SPHK2)
CPIC101949496(SPHK1) 101953391(SPHK2)
TST117887240(SPHK2) 117887706(SPHK1)
CABI116832231(SPHK1) 116832362(SPHK2)
MRV120382966(SPHK1) 120388658(SPHK2)
ACS100553167(sphk1) 100553460(sphk2)
PVT110081807(SPHK2) 110085912(SPHK1)
SUND121921036(SPHK1) 121933175(SPHK2)
PBI103057563(SPHK2) 103060065(SPHK1)
PMUR107283100(SPHK2) 107290062(SPHK1)
TSR106538472(SPHK2) 106544340(SPHK1)
PGUT117660473(SPHK1) 117666718(SPHK2)
VKO123032209(SPHK2) 123035526(SPHK1)
PMUA114582783(SPHK2) 114590652(SPHK1)
ZVI118079862(SPHK1) 118094565(SPHK2)
GJA107111139(SPHK2) 107121147(SPHK1)
STOW125427641(SPHK1)
XLA108696679(sphk2.L) 108697745(sphk2.S) 495437(sphk1.L)
XTR100494664(sphk2) 549672(sphk1)
NPR108796856(SPHK1) 108804675(SPHK2)
RTEM120915272(SPHK2) 120918488(SPHK1)
BBUF121002845(SPHK2) 121004706(SPHK1)
BGAR122926659(SPHK2) 122942216(SPHK1)
DRE100150090(sphk2) 100331840(sphk1)
SRX107711736 107715483 107716839 107741344 107751628
SANH107677335 107696311 107700765 107702984(sphk1) 107704932
SGH107552834 107567220(sphk1) 107571948 107573493 107587860
CCAR109068914(sphk1) 109080596 109101408 109106082
CAUA113055031 113055812 113067871 113067876 113079872 113116044
PPRM120476262 120484394(sphk2)
MAMB125243043(sphk2) 125274040
IPU108264213(sphk2) 108273191
PHYP113534020 113534313 113538397(sphk1)
SMEO124381897 124384058(sphk2) 124392618
TFD113650447 113659076(sphk2) 113663689
AMEX103023393(sphk1) 103040500 103043132
EEE113573083 113580757 113587788
TRU101062830(sphk1) 101078125
TNGGSTEN00015388G001 GSTEN00032515G001
LCO104925615 104938506(sphk1) 104939955
NCC104960464 104966924(sphk1)
CGOB115010639(sphk1) 115011987 115021875
ELY117255019 117265927(sphk2) 117268127
EFO125879259 125886215 125893379(sphk2)
PLEP121942104 121945784(sphk2) 121957167
SLUC116043012 116049607(sphk2) 116065313
ECRA117946704(sphk2) 117951768 117957515
PFLV114557618 114563520(sphk1) 114569310
GAT120811037(sphk2) 120825085 120827599
PPUG119196948(sphk2) 119218087 119219867
MSAM119886066 119897529(sphk2) 119899308
CUD121503886 121508668 121514234(sphk2)
ALAT119005970(sphk2) 119013253 119026682
MZE101473156(sphk1) 101482860(sphk2) 101483399
ONL100699392(sphk1) 100708657 106096428(sphk2)
OAU116310662 116314592 116315714(sphk2)
OLA101160262 101160322 101167592(sphk1)
OML112143277(sphk2) 112146599 112157543
XMA102227445 102228021(sphk1) 106699615(sphk2)
XCO114141675 114145490(sphk1) 114160463
XHE116717124 116720844(sphk1) 116736174
PRET103469144 103469685(sphk1) 103478094(sphk2)
PFOR103136634 103136635 103136636 103151811 103153195(sphk1)
PLAI106939249 106950841(sphk1) 106953505 106957058
PMEI106909541 106914539 106918970(sphk1) 106922021(sphk2)
GAF122822302 122830248 122830556(sphk2)
CVG107088081 107088801(sphk2) 107103816(sphk1)
CTUL119771318 119783025(sphk2) 119793533
GMU124862371 124863873 124865514(sphk2) 124867716
NFU107374236 107379707(sphk2) 107382243(sphk1)
KMR108235466(sphk2) 108242955 108248787
ALIM106518760(sphk1) 106534563 106536159 106537015
NWH119409722(sphk2) 119422178 119423195
AOCE111564245 111565381 111574733
MCEP124997336 124999858 125016870(sphk2)
CSEM103383771(sphk1) 103388269 103393189
POV109627230 109633239 109639502 109644606
SSEN122770984 122774804(sphk2) 122785854
HHIP117762181 117766735 117776406(sphk2)
HSP118113612(sphk2) 118122090 118123510
LCF108875844(sphk1) 108880994 108881061 108885887
SDU111229972(sphk2) 111230210 111236346(sphk1)
SLAL111647507 111652178 111659689(sphk1)
XGL120783612(sphk2) 120788173
HCQ109514836 109515289(sphk2) 109519880(sphk1)
BPEC110160669 110162977(sphk2) 110166231(sphk1)
MALB109958866 109966257(sphk1) 109970180(sphk2)
BSPL114842665(sphk2) 114855505 114861042
SASA106564913 106577300 106588251 106601398 106605728 106605743 106606991
OTW112230322 112234610 112234899(sphk2) 112245630 112258874
OMY110485951 110486550 110493671 110520823(sphk2) 110536658 110538514
OGO123998172 124000436 124003412 124005939 124016277 124016540
ONE115103805 115104292 115110645 115117575 115121086 115142593
SALP111951624 111980109 111982461 112069107 112073208
SNH120030942 120032730 120034002 120044616 120047263 120065968
CCLU121532654 121543826(sphk2) 121551044 121570397
ELS105013154 105018992 105021624(sphk1)
SFM108925996(sphk2) 108940136(sphk1)
PKI111848492(sphk1) 111853337(sphk2)
AANG118208340(sphk2) 118219610
LOC102683742(sphk1)
PSPA121296560 121302056(sphk2)
ARUT117409982(sphk2) 117424343
LCM102350955(SPHK1) 102367258(SPHK2)
BFO118418464 118429533
BBEL109472745 109473589 109487220
CIN100183047
SCLV120341167 120341186
SPU580005
APLC110981818
SKO100377659
DMEDmel_CG1747(Sk1) Dmel_CG32484(Sk2)
DER6546465 6551618
DSE6610545 6619863
DSIDsimw501_GD13722(Dsim_GD13722) Dsimw501_GD17022(Dsim_GD17022)
DYADyak_GE15936 Dyak_GE20353
DAN6505204 6506895
DSR110185292 110191973
DPO4812196 4814588
DPE6599186 6600516
DMN108151324 108159991
DWI6644655 6646363
DGR6556482 6565471
DMODmoj_GI13895 Dmoj_GI15718
DAZ108613729 108620463
DNV108651782 115565289
DHE111597587 111601810
DVI6623175
CCAT101450021 101454265
BOD106616316 106617940
MDE101892784 101896015
SCAC106081848 106087765
LCQ111678615 111684621
LSQ119602789 119608385 119614490
HIS119648296
AGAAgaP_AGAP006995
AAG5570737
AALB109426849
CQUCpipJ_CPIJ009965 CpipJ_CPIJ009966
CPII120421539
CNS116345651
BCOO119085587
AME411349
ACER107996875
ALAB122720493
BIM100746202
BBIF117215057
BVK117231823
BVAN117160241
BTER100643842
BPYO122577726
CCAL108627556
OBB114883237
MGEN117219614
NMEA116425508
CGIG122401397
SOC105202025
MPHA105836903
AEC105146244
ACEP105627044
PBAR105422757
VEM105562570
HST105181133
DQU106746254
CFO105251817
FEX115242182
LHU105675851
PGC109859854
OBO105280727
PCF106785800
PFUC122523841
VPS122634361
NVI100123187
CSOL105361996
TPRE106648373
MDL103570708
CGLO123266326
FAS105272718
DAM107035491
AGIF122849559
LHT122509062
CCIN107267712
TCA658654
DPA109534481
SOY115880618
ATD109606128
CSET123322922
AGB108912710
LDC111507762
NVL108562198
APLN108745179
PPYR116173202
OTU111420660
BMOR101742466
BMAN114242193
MSEX115441189
DPLKGM_212979B
PMAC106718321
PPOT106109649
PXU106121444
ZCE119828176
HAW110382443
HZE124634936
TNL113498002
SLIU111358875
OFU114351171
PXY105382607 105392643
API100168375
DNX107173358
AGS114123198
RMD113553186
BTAB109033156
CLEC106671133
HHAL106682791
NLU111046614
PHUPhum_PHUM281370
FOC113207898
TPAL117650374
ZNE110833981
CSEC111866849
FCD110844143 110850940
DPXDAPPUDRAFT_307617
DMK116916703
PVM113805876
PJA122265827
PCHN125039035
HAME121856586
PCLA123761061
PTRU123507062
HAZT108665784
EAF111697768 111698791 111702704
LSM121118271
PPOI119113662
ISCIscW_ISCW021926
DSV119440191 119454031
RSAN119399918
RMP119180361
VDE111252230
VJA111263721
TUT107362739
DPTE113797929
DFR124493710
CSCU111642211
PTEP107440148
SDM118198070
CELCELE_C34C6.5(sphk-1)
CBRCBG_11121(Cbr-sphk-1)
TSPTsp_01461
HROHELRODRAFT_106711
LGILOTGIDRAFT_141816
PCAN112577320
BGT106058011
GAE121379759
HRF124132807
HRJ124282272
CRG105343802
MYI110446543
PMAX117325037
MMER123564343
OBI106875475
LAK106164905
OVIT265_03200
EGLEGR_07693
NVE5511701
EPA110253867 110253868
ATEN116295035
ADF107345603
AMIL114958221
PDAM113673662
SPIS111334045
DGT114519611
XEN124449397
HMG100197951
TADTRIADDRAFT_20947 TRIADDRAFT_51430
AQU100632946 105313400
ATHAT4G21534(SPHK2) AT4G21540(SPHK1)
ALY110226362 9305955
CRB17878499 17878619
CSAT104718177 104718178 104722903 104722904 104731385 104731386 104747506
EUSEUTSA_v10025046mg EUTSA_v10025052mg
BRP103834191 103861234
BNA106421003 106432163 106432164 106432165 106433747 111197927 111204734
BOE106301336 106327927
RSZ108822328 108852951 108852952
THJ104806277
CPAP110812605
CIT102626139
CICCICLE_v10015071mg
PVY116108000
MINC123193232 123219402
TCC18596946
GRA105768847 105777441
GHI107914002 107924409 107925234 121208545
GAB108452020 108487105
DZI111275101
EGR104445363 104447307
GMX100798935 100805656
GSJ114388253 114421308
PVUPHAVU_002G222800g PHAVU_006G191800g
VRA106766761 106775123
VAR108334448 108341077
VUN114178912 114186773
CCAJ109803185 109805027
APRC113847287 113858297
MTRMTR_2g011820
CAM101499291
LJALj6g3v2081330.1(Lj6g3v2081330.1)
ADU107468660
AIP107623332
AHF112714663 112783948
LANG109333659 109339010
FVE101311446
RCN112164982
PPER18779554
PMUM103324637
PAVI110758004
PDUL117626597
MDM103427837 103446472
PXB103964944
ZJU107422974
MNT21389821
CSV101206190
CMO103484546
BHJ120074359
MCHA111012384
CMAX111478387
CMOS111453022
CPEP111804471
RCU8289825
JCU105649467
HBR110664617
MESC110604172
POP7495267
PEU105138778
PALZ118031430
JRE109013735
QSU112009172 112012450 112014290
QLO115981866 115991626
TWL120005795
VVI100248229
VRI117924323
SLY101256244 101263975
SPEN107008754 107012868
SOT102581165 102590865
SSTN125849268 125860499
CANN107859460 107868327
NTA107771177 107799091 107803682 107831053
NSY104239972 104241636
NTO104086954 104114500
NAU109237073 109244800
INI109158937
ITR116028362
SIND105175465
OEU111370555
EGT105969076
SSPL121745176
HAN110864054 110915721
ECAD122581679 122595558
LSV111879136 111892409
CCAV112519730 112522399
DCR108196445 108197984
CSIN114260833
BVG104909115
SOE110793434
CQI110693533 110706812
NNU104605677 104612605
MING122063922 122083606
TSS122639415 122648834
PSOM113305719
NCOL116267349
OSA4327845 4343607
DOSAOs01t0782200-01(Os01g0782200)
OBR102702113 102721782
BDI100831815 100845384
ATS109731823 109751945 109764430
TDC119269213 119277211 119354137 119363323
TAES123044545 123052402 123062251 123071005 123079381 123188257
TUA125536634 125544987
SBI8054712 8081750
ZMA100284895 100383275
SITA101754408 101760848
SVS117846535 117857987
PVIR120661682 120671823 120691541
PHAI112883238
PDA103714772 103719340
EGU105032337 105032738
MUS103978421 103982878
DCT110098961 110099778 110106486
PEQ110018855 110032442 110038734
AOF109829982 109849533
ATR18431601
SMOSELMODRAFT_153855 SELMODRAFT_79159
PPP112282916 112287650
CRECHLRE_12g530550v5
CSLCOCSUDRAFT_83701
CVRCHLNCDRAFT_134482
APROF751_3234
OLUOSTLU_17414
BPGBathy13g01230
MISMICPUN_87107
MPPMICPUCDRAFT_20585
CMECYME_CMT121C
SCEYLR260W(LCB5) YOR171C(LCB4)
SEUBDI49_3771 DI49_5004
SPAOSPAR_L02850 SPAR_O02980
AGOAGOS_AGR256W
ERCEcym_3138
KLAKLLA0_F20504g
KMXKLMA_40194(LCB5)
LTHKLTH0C10406g
VPOKpol_1037p37 Kpol_1042p1
ZROZYRO0C07084g
CGRCAGL0K05995g CAGL0L04554g
NCSNCAS_0D02510(NCAS0D02510) NCAS_0F00230(NCAS0F00230)
NDINDAI_0I02370(NDAI0I02370) NDAI_0K02870(NDAI0K02870)
TPFTPHA_0F02490(TPHA0F02490) TPHA_0J00530(TPHA0J00530)
TBLTBLA_0E03180(TBLA0E03180) TBLA_0G00430(TBLA0G00430)
TDLTDEL_0G04220(TDEL0G04220)
TGBHG536_0H04320
KAFKAFR_0A05250(KAFR0A05250) KAFR_0G02620(KAFR0G02620)
KNGKNAG_0E02730(KNAG0E02730) KNAG_0M01110(KNAG0M01110)
ZMKHG535_0G02670
PPAPAS_chr3_0399
DHADEHA2B11088g
PICPICST_54239(SPH1)
PGUPGUG_01720
SPAASPAPADRAFT_55773
LELLELG_00447
CALCAALFM_C112080WA(LCB4)
CTPCTRG_03443
COTCORT_0A04990
CDUCD36_11310
CTENCANTEDRAFT_116881
YLIYALI0B11154g
CLUCLUG_03851
CLUSA9F13_01g02827
CAURCJI97_000324
SLBAWJ20_3638(LCB4)
PKZC5L36_0A00790
BNNFOA43_000981
BBRXBRETT_003732
OPAHPODL_02198
SLUDSCDLUD_000912
NCRNCU07937
NTENEUTE1DRAFT120743(NEUTE1DRAFT_120743)
SMPSMAC_01184
PANPODANSg465
TTTTHITE_2116096
MTMMYCTH_2299645
CTHRCTHT_0031500
MGRMGG_05147
PPEIPpBr36_03520
TMNUCRPA7_7104
SSCKSPSK_07175
FGRFGSG_12199
FPUFPSE_10313
FVRFVEG_08919
FOXFOXG_10270
NHENECHADRAFT_104662
TRETRIREDRAFT_68412
TRRM419DRAFT_89774
MAWMAC_09644
MAJMAA_00275
CMTCCM_00739
PLJVFPFJ_03175
VALVDBG_01425
VDAVDAG_07821
CFJCFIO01_00332
CHIGCH63R_00061
SAPOSAPIO_CDS0061
ELAUCREL1_2933
PFYPFICI_00694
SSLSS1G_01552 SS1G_09867
BFUBCIN_07g02640 BCIN_11g02340
MBEMBM_05749
PSCOLY89DRAFT_691311
GLZGLAREA_08844
ANIAN1176.2
AFMAFUA_1G10980
ACTACLA_024530
NFINFIA_014650
AORAO090038000306
ANGANI_1_458074(An08g03280)
AFVAFLA_008793
ALUCAKAW2_30695A(LCB4)
ACHEACHE_30152A(LCB4)
APUUAPUU_50567S(LCB4)
PCSPc13g13560
PDPPDIP_27490
TMFPMAA_042660
TRGTRUGW13939_03072
CIMCIMG_06936
CPWCPC735_033220
UREUREG_05912
PBLPAAG_03005
PBNPADG_02876
ABEARB_02821
TVETRV_04958
AJEHCAG_01797
BGHBDBG_00264
PNOSNOG_15083
PTEPTT_06596
BZECOCCADRAFT_101632
BSCCOCSADRAFT_129645
BORCOCMIDRAFT_90014
AALTCC77DRAFT_976530
ZTRMYCGRDRAFT_66426
PFJMYCFIDRAFT_32681
FFUCLAFUR5_00487
BCOMBAUCODRAFT_180475
NPAUCRNP2_2270
SPOSPAC4A8.07c
CNECND02910
CNBCNBD3450
CNGCNAG_01165
CGICGB_D5450C
TMSTREMEDRAFT_67509
TASAA1Q1_07643
TVSTRAVEDRAFT_175806
DSQDICSQDRAFT_77846
PCOPHACADRAFT_256300
SHSSTEHIDRAFT_169861
HIRHETIRDRAFT_311241
PSQPUNSTDRAFT_144839
ADLAURDEDRAFT_96953
FMEFOMMEDRAFT_168804
GTRGLOTRDRAFT_137011
LBCLACBIDRAFT_306015
CCICC1G_13902
ABPAGABI1DRAFT104558(AGABI1DRAFT_104558)
ABVAGABI2DRAFT176573(AGABI2DRAFT_176573)
MRRMoror_16723
MOREE1B28_008854
SCMSCHCO_02682446(SCHCODRAFT_02682446)
CPUTCONPUDRAFT_79840
SLASERLADRAFT_473900
WSEWALSEDRAFT_21414 WALSEDRAFT_61561
WICJ056_003046 J056_003047
UMAUMAG_11808
PFPPFL1_02150
MGLMGL_3927
MRTMRET_2774
MSYMMSY001_3166
PGRPGTG_01874
MLRMELLADRAFT_25264
MBRMONBRDRAFT_33671
SREPTSG_00923
DDIDDB_G0272522(sgkA) DDB_G0284545(sgkB)
DPPDICPUDRAFT_158914 DICPUDRAFT_76939
DFADFA_12044(sgkA)
EHIEHI_023410(25.t00015)
EDIEDI_063170
EIVEIN_170600
ACANACA1_068230 ACA1_176060
TETTTHERM_00459289 TTHERM_00600340
PTMGSPATT00016286001
SMINv1.2.011198.t1(symbB.v1.2.011198.t1)
PTIPHATRDRAFT_44806
FCYFRACYDRAFT_277329
TPSTHAPSDRAFT_21109
AAFAURANDRAFT_63325
PIFPITG_13546
PSOJPHYSODRAFT_289129 PHYSODRAFT_356119 PHYSODRAFT_566103
SPARSPRG_03950 SPRG_06259 SPRG_12353 SPRG_18667
EHXEMIHUDRAFT_207387 EMIHUDRAFT_246668 EMIHUDRAFT_437034
GTTGUITHDRAFT_147110
NGRNAEGRDRAFT_69820 NAEGRDRAFT_78781
AMRAM1_1694
CHONNIES4102_18350
ARPNIES39_J01510
OXYHCG48_24885
LFSHFV01_16505
 » show all
Reference
1  [PMID:4372149]
  Authors
Stoffel W, Heimann G, Hellenbroich B.
  Title
Sphingosine kinase in blood platelets.
  Journal
Hoppe Seylers Z Physiol Chem 354:562-6 (1973)
DOI:10.1515/bchm2.1973.354.1.562
Reference
2  [PMID:4373374]
  Authors
Stoffel W, Bauer E, Stahl J.
  Title
The metabolism of sphingosine bases in Tetrahymena pyriformis. Sphingosine kinase and sphingosine-1-phosphate lyase.
  Journal
Hoppe Seylers Z Physiol Chem 355:61-74 (1974)
DOI:10.1515/bchm2.1974.355.1.61
Reference
3  [PMID:9677363]
  Authors
Nagiec MM, Skrzypek M, Nagiec EE, Lester RL, Dickson RC
  Title
The LCB4 (YOR171c) and LCB5 (YLR260w) genes of Saccharomyces encode sphingoid long chain base kinases.
  Journal
J Biol Chem 273:19437-42 (1998)
DOI:10.1074/jbc.273.31.19437
  Sequence
Reference
4  [PMID:9726979]
  Authors
Kohama T, Olivera A, Edsall L, Nagiec MM, Dickson R, Spiegel S
  Title
Molecular cloning and functional characterization of murine sphingosine kinase.
  Journal
J Biol Chem 273:23722-8 (1998)
DOI:10.1074/jbc.273.37.23722
  Sequence
[mmu:20698]
Reference
5  [PMID:10751414]
  Authors
Liu H, Sugiura M, Nava VE, Edsall LC, Kono K, Poulton S, Milstien S, Kohama T, Spiegel S
  Title
Molecular cloning and functional characterization of a novel mammalian sphingosine kinase type 2 isoform.
  Journal
J Biol Chem 275:19513-20 (2000)
DOI:10.1074/jbc.M002759200
  Sequence
[hsa:56848] [mmu:56632]
Reference
6  [PMID:18557834]
  Authors
Worrall D, Liang YK, Alvarez S, Holroyd GH, Spiegel S, Panagopulos M, Gray JE, Hetherington AM
  Title
Involvement of sphingosine kinase in plant cell signalling.
  Journal
Plant J 56:64-72 (2008)
DOI:10.1111/j.1365-313X.2008.03579.x
  Sequence
[ath:AT4G21540]
Other DBs
ExplorEnz - The Enzyme Database: 2.7.1.91
IUBMB Enzyme Nomenclature: 2.7.1.91
ExPASy - ENZYME nomenclature database: 2.7.1.91
BRENDA, the Enzyme Database: 2.7.1.91
CAS: 50864-48-7
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