KEGG   ENZYME: 2.7.7.104
Entry
EC 2.7.7.104                Enzyme                                 

Name
2-hydroxyethylphosphonate cytidylyltransferase;
Fom1
Class
Transferases;
Transferring phosphorus-containing groups;
Nucleotidyltransferases
Sysname
CTP:2-hydroxyethylphosphonate cytidylyltransferase
Reaction(IUBMB)
2-hydroxyethylphosphonate + CTP = cytidine 5'-{[hydroxy(2-hydroxyethyl)phosphonoyl]phosphate} + diphosphate
Substrate
2-hydroxyethylphosphonate [CPD:C06451];
CTP [CPD:C00063]
Product
cytidine 5'-{[hydroxy(2-hydroxyethyl)phosphonoyl]phosphate} [CPD:C22216];
diphosphate [CPD:C00013]
Comment
The enzyme, isolated from the bacterium Streptomyces wedmorensis, is involved in fosfomycin biosynthesis. The enzyme also is active as EC 5.4.2.9 phosphoenolpyruvate mutase.
History
EC 2.7.7.104 created 2020
Pathway
ec00998  Biosynthesis of various secondary metabolites - part 2
ec01100  Metabolic pathways
Orthology
K23999  phosphoenolpyruvate phosphomutase / 2-hydroxyethylphosphonate cytidylyltransferase
Genes
OSG: BST96_06905
PHN: PAEH1_00300
MEU: ACJ67_08960
AZO: azo2698(pepM)
AOA: dqs_2833
HCP: HCN_1062
HCB: HCBAA847_0912
HWI: A0Z60_07480(aepX)
CHYO: CHH_1593
CHW: A2J15_004815(aepX)
CINF: CINF_1344
DAL: Dalk_1323
ECOG: FIV45_08000(aepX)
CTC: CTC_01698
CBE: Cbei_4338
CBZ: Cbs_4338
CBEI: LF65_04862
CSR: Cspa_c46190(ppm)
CSB: CLSA_c08730(ppm)
CDY: F3K33_22185(aepX)
RIX: RO1_19910
SNA: Snas_5665
NAV: JQS30_13655(aepX)
OLS: Olsu_0594
TDE: TDE_1413
TPHG: FUT81_06855(aepX)
TRI: DYE50_04590(aepX)
TPAV: HRQ91_06190(aepX)
BHC: JFL75_01540(aepX)
FSC: FSU_1439
BTH: BT_1720
BTHO: Btheta7330_01295(pphA)
BFS: BF9343_1814(aepX)
DRC: G0Q07_19260(aepX)
NLI: G3M70_12635(aepX)
PSYT: DSAG12_01622(ribL_1)
 » show all
Reference
1  [PMID:28727444]
  Authors
Cho SH, Kim SY, Tomita T, Shiraishi T, Park JS, Sato S, Kudo F, Eguchi T, Funa N, Nishiyama M, Kuzuyama T
  Title
Fosfomycin Biosynthesis via Transient Cytidylylation of 2-Hydroxyethylphosphonate by the Bifunctional Fom1 Enzyme.
  Journal
ACS Chem Biol 12:2209-2215 (2017)
DOI:10.1021/acschembio.7b00419
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 2.7.7.104
IUBMB Enzyme Nomenclature: 2.7.7.104
ExPASy - ENZYME nomenclature database: 2.7.7.104
BRENDA, the Enzyme Database: 2.7.7.104
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