KEGG   ENZYME: 2.7.7.104
Entry
EC 2.7.7.104                Enzyme                                 
Name
2-hydroxyethylphosphonate cytidylyltransferase;
Fom1
Class
Transferases;
Transferring phosphorus-containing groups;
Nucleotidyltransferases
Sysname
CTP:2-hydroxyethylphosphonate cytidylyltransferase
Reaction(IUBMB)
2-hydroxyethylphosphonate + CTP = cytidine 5'-{[hydroxy(2-hydroxyethyl)phosphonoyl]phosphate} + diphosphate [RN:R12498]
Reaction(KEGG)
R12498
Substrate
2-hydroxyethylphosphonate [CPD:C06451];
CTP [CPD:C00063]
Product
cytidine 5'-{[hydroxy(2-hydroxyethyl)phosphonoyl]phosphate} [CPD:C22216];
diphosphate [CPD:C00013]
Comment
The enzyme, isolated from the bacterium Streptomyces wedmorensis, is involved in fosfomycin biosynthesis. The enzyme also is active as EC 5.4.2.9 phosphoenolpyruvate mutase.
History
EC 2.7.7.104 created 2020
Pathway
ec00998  Biosynthesis of various antibiotics
ec01100  Metabolic pathways
Orthology
K23999  phosphoenolpyruvate phosphomutase / 2-hydroxyethylphosphonate cytidylyltransferase
Genes
PMAW: MACH26_33050
OSG: BST96_06905
MPRF: J8N69_05410(aepX)
PHN: PAEH1_00300
MEU: ACJ67_08960
AZO: azo2698(pepM)
AOA: dqs_2833
ECOG: FIV45_08000(aepX)
SNEA: NBZ79_03295(aepX)
HCP: HCN_1062
HCB: HCBAA847_0912
HWI: A0Z60_07480(aepX)
CHYO: CHH_1593
CHW: A2J15_004815(aepX)
CINF: CINF_1344
AFC: AFAEC_0069 AFAEC_0075
ANT: Arnit_2943
NSA: Nitsa_1412
DLM: DPPLL_12490
DAK: DaAHT2_1860
DAL: Dalk_1323
CTC: CTC_01698
CTET: BN906_01840
CBJ: H04402_02796
CBE: Cbei_4338
CBZ: Cbs_4338
CBEI: LF65_04862
CSR: Cspa_c46190(ppm)
CSB: CLSA_c08730(ppm)
CBUT: ATN24_05940
CARG: RSJ17_12820
CDY: F3K33_22185(aepX)
CCAA: KQH81_02885(aepX)
CNN: CNEO_1087(ppm)
CGEL: psyc5s11_47370
RAL: Rumal_1340
ALAC: JYE50_12220(aepX) JYE50_12300(aepX)
AHC: JYE49_12525(aepX)
BPEN: NQ488_09095(aepX)
CBAF: JS518_12300(aepX) JS518_12380(aepX)
RIX: RO1_19910
RRK: H8S51_002390(aepX)
HHJ: NQ487_01265(aepX) NQ487_01315(aepX)
CLE: Clole_3577
HAS: Halsa_0038
SSG: Selsp_0338
SELE: ADJ74_04700
SELO: AXE86_05255
SELT: BCS37_10905
SDIA: QU667_11285(aepX)
STIM: H1B31_02600(aepX)
LCG: L3BBH23_02720
OLS: Olsu_0594
TES: BW730_00185
SAIU: J4H86_04280(aepX)
NHY: JQS43_02325(aepX)
SNA: Snas_5665
NAV: JQS30_13655(aepX)
AYM: YM304_30130
ARP: NIES39_A00310
LMAJ: GKN94_04170(aepX)
ELUT: CKA38_13745(aepX)
TDE: TDE_1413
TBE: Trebr_0279
TPI: TREPR_2364
TPK: JO40_09715
TPHG: FUT81_06855(aepX)
TRI: DYE50_04590(aepX)
TPAV: HRQ91_06190(aepX)
TSK: HRI97_05665(aepX)
BPAA: K7I13_01580(aepX)
HPRI: P0082_09550(aepX)
SBU: SpiBuddy_0272
SGP: SpiGrapes_1560
TAZ: TREAZ_2217
SCD: Spica_1331
BHC: JFL75_01540(aepX)
FSU: Fisuc_0993
FSC: FSU_1439
BTH: BT_1720
BTHO: Btheta7330_01295(pphA)
BFR: BF1832 BF2578
BFS: BF9343_1814(aepX)
BFG: BF638R_1867
BUN: Bun01g_29040
BEG: INE88_02862
BSTE: K6V31_00385(aepX)
BDO: EL88_10435
PCOI: LK433_14490(aepX)
DRC: G0Q07_19260(aepX)
RCG: N7E81_15220(aepX)
FAX: FUAX_43910
NLI: G3M70_12635(aepX)
NVA: G3M78_13645(aepX)
METB: AW729_03845
TAR: TALC_00083
LOB: NEF87_004219
PSYT: DSAG12_01622(aepX)
ARG: QT11_C0001G0509
 » show all
Reference
1  [PMID:28727444]
  Authors
Cho SH, Kim SY, Tomita T, Shiraishi T, Park JS, Sato S, Kudo F, Eguchi T, Funa N, Nishiyama M, Kuzuyama T
  Title
Fosfomycin Biosynthesis via Transient Cytidylylation of 2-Hydroxyethylphosphonate by the Bifunctional Fom1 Enzyme.
  Journal
ACS Chem Biol 12:2209-2215 (2017)
DOI:10.1021/acschembio.7b00419
  Sequence
[ag:BAA32495]
Other DBs
ExplorEnz - The Enzyme Database: 2.7.7.104
IUBMB Enzyme Nomenclature: 2.7.7.104
ExPASy - ENZYME nomenclature database: 2.7.7.104
BRENDA, the Enzyme Database: 2.7.7.104
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