Entry
Name
2-phospho-L-lactate transferase;
cofD (gene name);
fbiA (gene name);
LPPG:Fo 2-phospho-L-lactate transferase;
LPPG:7,8-didemethyl-8-hydroxy-5-deazariboflavin 2-phospho-L-lactate transferase;
lactyl-2-diphospho-(5')guanosine:Fo 2-phospho-L-lactate transferase
Class
Transferases;
Transferring phosphorus-containing groups;
Transferases for other substituted phosphate groups
BRITE hierarchy
Sysname
(2S)-lactyl-2-diphospho-5'-guanosine:7,8-didemethyl-8-hydroxy-5-deazariboflavin 2-phospho-L-lactate transferase
Reaction(IUBMB)
(1) (2S)-lactyl-2-diphospho-5'-guanosine + 7,8-didemethyl-8-hydroxy-5-deazariboflavin = GMP + factor 420-0 [RN:
R09398 ];
(2) enolpyruvoyl-2-diphospho-5'-guanosine + 7,8-didemethyl-8-hydroxy-5-deazariboflavin = GMP + dehydro factor 420-0 [RN:
R12648 ];
(3) 3-[(R)-glyceryl]-diphospho-5'-guanosine + 7,8-didemethyl-8-hydroxy-5-deazariboflavin = GMP + 3PG-factor 420-0 [RN:
R12649 ]
Reaction(KEGG)
Substrate
(2S)-lactyl-2-diphospho-5'-guanosine [CPD:
C19155 ];
7,8-didemethyl-8-hydroxy-5-deazariboflavin [CPD:
C19154 ];
enolpyruvoyl-2-diphospho-5'-guanosine [CPD:
C22297 ];
3-[(R)-glyceryl]-diphospho-5'-guanosine [CPD:
C22298 ]
Product
Comment
This enzyme is involved in the biosynthesis of factor 420, a redox-active cofactor, in methanogenic archaea and certain bacteria. The specific reaction catalysed in vivo is determined by the availability of substrate, which in turn is determined by the enzyme present in the organism - EC
2.7.7.68 , 2-phospho-L-lactate guanylyltransferase, EC
2.7.7.105 , phosphoenolpyruvate guanylyltransferase, or EC
2.7.7.106 , 3-phospho-D-glycerate guanylyltransferase.
History
EC 2.7.8.28 created 2010, modified 2020
Pathway
ec01120 Microbial metabolism in diverse environments
Orthology
K11212 LPPG:FO 2-phospho-L-lactate transferase
Genes
THAG : CKCBHOJB_02344(cofD)
METG : HT051_05400 HT051_12620
NRE : BES08_02710 BES08_26375
SPAG : sphantq_03798(fbiA)
SPHJ : BSL82_04910 BSL82_08905
MMAE : MMARE11_12470(fbiA)
MGOR : H0P51_06360 H0P51_22655
MHEK : JMUB5695_03654(cofD)
MKY : IWGMT90018_13210(cofD)
MPHL : MPHLCCUG_01627(cofD)
MTHN : 4412656_01187(cofD)
MBUG : MU0053_003572(cofD)
MSAL : DSM43276_03405(cofD)
MTER : 4434518_02997(fbiA)
NWL : NWFMUON74_13460(cofD)
NSPU : IFM12276_09350(cofD)
RKO : JWS14_25815 JWS14_34325
RANT : RHODO2019_03500(cofD)
RHJS : OYT95_04945(cofD) OYT95_22370(cofD)
TPUL : TPB0596_34390(cofD)
SAMB : SAM23877_3078(cofD)
SLE : sle_42450(sle_42450)
SGM : GCM10017557_50180(cofD)
STUI : GCM10017668_27340(cofD)
SGOB : test1122_08555(cofD)
SXT : KPP03845_103147(cofD)
STSD : HEP87_22660(cofD) HEP87_55455(cofD)
FSB : GCM10025867_09900(cofD)
AMAU : DSM26151_27910(fbiA)
AMAV : GCM10025877_13280(cofD)
PSEK : GCM125_00150(cofD_1) GCM125_32840(cofD_2)
JTE : ASJ30_11180 ASJ30_13400
NAQU : ENKNEFLB_03314(cofD)
AEF : GEV26_02940 GEV26_12935
AWN : NQV15_02670(cofD) NQV15_04400
ABAR : AMYBAR_000935(cofD)
MSAG : GCM10017556_35210(cofD)
ACTR : Asp14428_35950(cofD)
DACT : KZZ52_32810(cofD) KZZ52_55305(cofD)
BALA : DSM104299_01950(fbiA)
PARQ : DSM112329_01798(fbiA)
SBAE : DSM104329_01287(fbiA_1) DSM104329_01863(fbiA_2)
MEM : Memar_2144 Memar_2145
MBG : BN140_1350(cofD1) BN140_1351(cofD2)
MEMA : MMAB1_1720(cofD) MMAB1_1721
MCHK : MchiMG62_24560 MchiMG62_24570
MSUM : OH143_05005 OH143_05010(cofD)
MRC : R6Y96_10040 R6Y96_10045(cofD)
MEFW : F1737_02980 F1737_02990
MESB : L1S32_00785 L1S32_00795(cofD)
MANQ : L1994_03845(cofD) L1994_06850
MJK : N2V74_00450(cofD) N2V74_05405(cofD)
HACB : Hbl1158_08300(cofD)
HJT : DVR14_19220 DVR14_23350
LOKI : Lokiarch_23950(cofD_1) Lokiarch_46980(cofD_2)
» show all
Taxonomy
Reference
Authors
Graupner M, Xu H, White RH
Title
Characterization of the 2-phospho-L-lactate transferase enzyme involved in coenzyme F(420) biosynthesis in Methanococcus jannaschii.
Journal
Sequence
Reference
Authors
Forouhar F, Abashidze M, Xu H, Grochowski LL, Seetharaman J, Hussain M, Kuzin A, Chen Y, Zhou W, Xiao R, Acton TB, Montelione GT, Galinier A, White RH, Tong L
Title
Molecular insights into the biosynthesis of the F420 coenzyme.
Journal
Sequence
Reference
Authors
Braga D, Last D, Hasan M, Guo H, Leichnitz D, Uzum Z, Richter I, Schalk F, Beemelmanns C, Hertweck C, Lackner G
Title
Metabolic Pathway Rerouting in Paraburkholderia rhizoxinica Evolved Long-Overlooked Derivatives of Coenzyme F420.
Journal
Other DBs
ExplorEnz - The Enzyme Database: 2.7.8.28
ExPASy - ENZYME nomenclature database: 2.7.8.28
LinkDB
All DBs