KEGG   ENZYME: 2.7.8.34
Entry
EC 2.7.8.34                 Enzyme                                 
Name
CDP-L-myo-inositol myo-inositolphosphotransferase;
CDP-inositol:inositol-1-phosphate transferase (bifunctional CTP:inositol-1-phosphate cytidylyltransferase/CDP-inositol:inositol-1-phosphate transferase (IPCT/DIPPS));
DIPPS (bifunctional CTP:inositol-1-phosphate cytidylyltransferase/CDP-inositol:inositol-1-phosphate transferase (IPCT/DIPPS))
Class
Transferases;
Transferring phosphorus-containing groups;
Transferases for other substituted phosphate groups
Sysname
CDP-1L-myo-inositol:1L-myo-inositol 1-phosphate myo-inositolphosphotransferase
Reaction(IUBMB)
CDP-1L-myo-inositol + 1L-myo-inositol 1-phosphate = CMP + bis(1L-myo-inositol) 3,1'-phosphate 1-phosphate [RN:R09670]
Reaction(KEGG)
R09670
Substrate
CDP-1L-myo-inositol [CPD:C19794];
1L-myo-inositol 1-phosphate [CPD:C04006]
Product
CMP [CPD:C00055];
bis(1L-myo-inositol) 3,1'-phosphate 1-phosphate
Comment
In many organisms this activity is catalysed by a bifunctional enzyme. The di-myo-inositol-1,3'-phosphate-1'-phosphate synthase domain of the bifunctional EC 2.7.7.74/EC 2.7.8.34 (CTP:inositol-1-phosphate cytidylyltransferase/CDP-inositol:inositol-1-phosphate transferase) uses only 1L-myo-inositol 1-phosphate as an alcohol acceptor, but CDP-glycerol, as well as CDP-1L-myo-inositol and CDP-D-myo-inositol, are recognized as alcohol donors. The enzyme is involved in biosynthesis of bis(1L-myo-inositol) 1,3-phosphate, a widespread organic solute in microorganisms adapted to hot environments.
History
EC 2.7.8.34 created 2011
Pathway
ec00562  Inositol phosphate metabolism
ec01100  Metabolic pathways
Orthology
K07291  CDP-L-myo-inositol myo-inositolphosphotransferase
K23992  1L-myo-inositol 1-phosphate cytidylyltransferase / CDP-L-myo-inositol myo-inositolphosphotransferase
Genes
MTHDA3224_07290
ENMEBS_0412
DBKDGMP_08060
CCROCMC5_075830
PAUUE8A73_025990
DAODesac_2272
SFUSfum_2920
BSEDDN745_05540
PCAYFRD00_02815
NARSaro_0100
NORFA702_11455
SPAPH3Z74_16915
ERYCP97_03755
PORLBG023_11496
PHZCHX26_13940
ECOGFIV45_08015
CTHUHUR95_02260
NTRB0W44_00905
TMRTmar_0126
THEFE1B22_04180
THEPDYI95_000435
TPZTph_c20790
KMEH0A61_00158(spsI)
ATLAthai_19700
RXYRxyl_1212
TBHTbon_07195
TTRTter_0472
SSMSpirs_4227
ADINH7849_05720 H7849_05725
NOBCW736_12840
AAEaq_1367(spsI)
PMXPERMA_1921
TTKTST_0884
TMMTmari_1424
TMITHEMA_07225
TMWTHMA_1448
TMQTHMB_1448
TMXTHMC_1448
TPTTpet_1375
TRQTRQ2_1311
TNACTN_1075
TNPTnap_1393
THQT2812B_07095
THZCELL2_07155
THRTRQ7_06830
NDENIDE0736
NMVNITMOv2_0605
NIONITINOP_0313
NJANSJP_1717
TIDThein_0126
TAVG4V39_06760
TMAIFVE67_04000
NLIG3M70_02610 G3M70_02615
MOXDAMO_2608
MIFMetin_0454
MIGMetig_1787
METFCFE53_00410
AFUAF_0263
AFGAFULGI_00002550
APOArcpr_0766
AVEArcve_1159 Arcve_2013
ASTAsulf_00859
FPLFerp_0148 Ferp_0859
GACGACE_2065
GAHGAH_01161
PFUPF1058
PFIPFC_04525
PHOPH1219(PH1219)
PABPAB2433
PYNPNA2_1704
PYAPYCH_00120
PYSPy04_1010
PYCTQ32_04290
TKOTK2279
TONTON_1248
TGATGAM_1853
TSITSIB_1010
TBATERMP_01130
THEGQS_09430
THATAM4_5
THMCL1_1475
TLTOCC_08385
THSTES1_1181
TNUBD01_1626
TEUTEU_00190
TCHCHITON_0904
TPEPA0127_03970
TGGA3K92_01915
TCEA3L02_05685
TBSA3L01_06850
THHCDI07_06820
TSLA3L11_01110
TTDA3L14_09240
TPRFA3L09_03245
TRLA3L10_06295
TPAFA3L08_00135
THYA3L12_02080
TCQTIRI35C_1679
PPACPAP_05835
NACAQV86_00780
APEAPE_1516.1
ACJACAM_0952
IAGIgag_0487
HBUHbut_0151
PFMPyrfu_0047
PDLPyrde_0747
KCRKcr_0184
 » show all
Reference
1  [PMID:17526717]
  Authors
Rodrigues MV, Borges N, Henriques M, Lamosa P, Ventura R, Fernandes C, Empadinhas N, Maycock C, da Costa MS, Santos H
  Title
Bifunctional CTP:inositol-1-phosphate cytidylyltransferase/CDP-inositol:inositol-1-phosphate transferase, the key enzyme for di-myo-inositol-phosphate synthesis in several (hyper)thermophiles.
  Journal
J Bacteriol 189:5405-12 (2007)
DOI:10.1128/JB.00465-07
  Sequence
[aae:aq_1367] [afu:AF_0263] [pfu:PF1058] [rxy:Rxyl_1212] [tko:TK2279]
Other DBs
ExplorEnz - The Enzyme Database: 2.7.8.34
IUBMB Enzyme Nomenclature: 2.7.8.34
ExPASy - ENZYME nomenclature database: 2.7.8.34
BRENDA, the Enzyme Database: 2.7.8.34
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