Entry |
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Name |
cardiolipin synthase (CMP-forming)
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Class |
Transferases;
Transferring phosphorus-containing groups;
Transferases for other substituted phosphate groups
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Sysname |
CDP-diacylglycerol:phosphatidylglycerol diacylglycerolphosphotransferase (CMP-forming)
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Reaction(IUBMB) |
a CDP-diacylglycerol + a phosphatidylglycerol = a cardiolipin + CMP [RN: R02030]
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Reaction(KEGG) |
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Substrate |
CDP-diacylglycerol [CPD: C00269];
phosphatidylglycerol [CPD: C00344]
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Product |
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Comment |
The eukaryotic enzyme is involved in the biosynthesis of the mitochondrial phospholipid cardiolipin. It requires divalent cations for activity.
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History |
EC 2.7.8.41 created 2014
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Pathway |
ec00564 | Glycerophospholipid metabolism |
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Orthology |
K08744 | cardiolipin synthase (CMP-forming) |
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Genes |
MNP: | 132008132 132021739(CRLS1) |
MDT: | 132230614 132239369(CRLS1) |
PKL: | 118705782 118708295(CRLS1) |
DNM: | 101424550(CRLS1) 101447986 |
AFUL: | 116488218(CRLS1) 116499914 |
PMUA: | 114593653(CRLS1) 114604220 |
PRAF: | 128410046(CRLS1) 128421039 |
SANH: | 107663140 107678734 |
CAUA: | 113060815 113071783 113117753 |
CGIB: | 127975788 128031412 |
MASI: | 127410729 127455233 |
SMEO: | 124389636 124390214(crls1) |
CCLU: | 121544814(crls1) 121559872 |
DSI: | Dsimw501_GD18179(Dsim_GD18179) |
AALB: | 109403482 109433655 115268707 115269334 |
PORN: | 139755734 139761046 |
CEL: | CELE_F23H11.9(crls-1) |
CBR: | CBG_15172(Cbr-crls-1) |
CSAT: | 104707641 104716429 104737339 |
HSYR: | 120119952 120151709 |
AHF: | 112705667 112722935 112723257 |
QSA: | O6P43_011899 O6P43_031229 |
MSYL: | 126586209 126624260 |
PCOX: | 137727107 137729706 |
SMIL: | 130985764 131022201 |
PSOM: | 113318823 113331323 113353767 |
TAES: | 123062286 123071048 123079419 |
PVIR: | 120675841 120708329 |
ACAK: | 137937716 137943157 |
SMO: | SELMODRAFT_405738 SELMODRAFT_415497 |
CGR: | 2889256(GVI51_I03509) |
NCS: | NCAS_0E03780(NCAS0E03780) |
NDI: | NDAI_0A02850(NDAI0A02850) |
TPF: | TPHA_0A03050(TPHA0A03050) |
TBL: | TBLA_0E02000(TBLA0E02000) |
TDL: | TDEL_0C02300(TDEL0C02300) |
KAF: | KAFR_0L01350(KAFR0L01350) |
KNG: | KNAG_0B02760(KNAG0B02760) |
LBG: | 92208157(LODBEIA_P29610) |
CAL: | CAALFM_C100100CA(CaO19.6100) |
CTEN: | 18247400(PSN45_004656) |
ASAU: | 88175839(PUMCH_004779) |
YLI: | 2908748(YALI2_E01036g) |
NTE: | NEUTE1DRAFT122183(NEUTE1DRAFT_122183) |
SMP: | 10808121(SMAC4_02286) |
RTHE: | 98121844(VTJ83DRAFT_1080) |
TATV: | 25783101(TrAtP1_009878) |
TASP: | 36618737(TrAFT101_011306) |
MAW: | 19246202(J3458_003756) |
PLJ: | 28886994(PLICBS_002302) |
CDET: | 87937357(CDEST_00854) |
BFU: | BCIN_03g07430(Bccrd1) |
CPW: | 9696624(D8B26_000718) |
PTRR: | 6340400(PtrM4_014790) |
ADAC: | 96088865(ACET3X_008543) |
CDEC: | 89992648(IAS62_005879) |
CTEG: | 91992994(I308_106139) |
CBAS: | 91986019(I312_105975) |
CDEP: | 91088571(L203_104361) |
KMG: | 30167672(I203_106773) |
KNE: | 92178536(IAR55_001277) |
KDJ: | 28965075(I303_101367) |
KBI: | 30207665(I302_104561) |
KPIN: | 30176262(I206_100078) |
KSH: | 87953433(IL334_001302) |
KER: | 91106567(V865_007766) |
CCAC: | CcaHIS019_0605830(CcaverHIS019_0605830) |
PPL: | POSPLDRAFT_26909 POSPLDRAFT_27949 |
ABP: | AGABI1DRAFT114250(AGABI1DRAFT_114250) |
ABV: | AGABI2DRAFT191269(AGABI2DRAFT_191269) |
SCM: | SCHCO_02619624(SCHCODRAFT_02619624) |
EHI: | EHI_035400(17.t00024) |
MANP: | EHN06_08160 EHN06_08205 |
MICC: | AUP74_00920(pgsA_1) |
LLG: | 44548918_02523(pgsA2) |
LJR: | NCTC11533_02673(pgsA2) |
LCJ: | NCTC11976_00344(pgsA2) |
LWA: | SAMEA4504053_3305(pgsA2) |
LSS: | NCTC12082_01859(pgsA2) |
LADL: | NCTC12735_01591(pgsA2) |
TNI: | TVNIR_3397(pgsA_[C]) |
URU: | DSM104443_02372(pgsA) |
UPL: | DSM104440_02115(pgsA) |
PACA: | ID47_03140 ID47_03915 |
GAGG: | Gromo_00192 Gromo_00427 |
NRH: | T8J41_17935 T8J41_19815(pgsA) |
AMIH: | CO731_04170(pgsA_1) |
RLW: | RlegWSM1455_06185(pgsA) |
RBW: | RLCC275e_06210(pgsA) |
LAS: | CLIBASIA_02435(pgsA) |
VGO: | GJW-30_1_01771(pgsA) GJW-30_1_03495(pgsA2) |
MAQU: | Maq22A_c26275(pgsA) |
HDT: | HYPDE_28443 HYPDE_37773 |
HMC: | HYPMC_2991(pgsA) HYPMC_4116 |
HNI: | W911_06570 W911_06765 |
FIL: | BN1229_v1_0075(pgsA) BN1229_v1_3935 |
FIY: | BN1229_v1_0077(pgsA) BN1229_v1_3922 |
RHZ: | RHPLAN_14650 RHPLAN_44540 |
METG: | HT051_06030(pgsA) HT051_07210 |
MROS: | EHO51_04345 EHO51_06605(pgsA) |
PLEO: | OHA_1_00211(pgsA2) OHA_1_02346(pgsA) |
TSO: | IZ6_08640(pgsA) IZ6_16040 |
BRN: | D1F64_11820 D1F64_17250(pgsA) |
PSTG: | E8M01_00055 E8M01_34810 |
TMO: | TMO_1838 TMO_c0131(pgsA) |
THET: | F1847_06005(pgsA) F1847_09020 |
TAV: | G4V39_03525 G4V39_04335 |
TMAI: | FVE67_03415 FVE67_04935 |
OBG: | Verru16b_02571(pgsA) |
LCRE: | Pla8534_41340(pgsA_1) |
ALUS: | STSP2_03330(pgsA2_2) |
LKB: | LPTSP3_g13450(pgsA_1) |
TPX: | Turpa_2077 Turpa_3868 |
MCOS: | GM418_20080 GM418_23010 GM418_23645 |
MGOS: | DIU38_008655 DIU38_030310 |
KOS: | KORDIASMS9_02119(pgsA) |
PROC: | Ptc2401_00519(pgsA_2) |
RMG: | Rhom172_0692 Rhom172_2372 |
DTH: | DICTH_0990 DICTH_1746 |
PBK: | Back11_52270(pgsA_2) |
PKP: | SK3146_03665(pgsA_1) |
COHN: | KCTCHS21_55960(pgsA) |
PABS: | JIR001_30200(pgsA_2) |
EFU: | HMPREF0351_10392(pgsA) |
MARR: | BKP56_06425 BKP56_08615 |
CCB: | Clocel_1089 Clocel_2030 |
CLT: | CM240_2235 CM240_2669 |
CCK: | Ccar_09690 Ccar_24705 |
CCOH: | SAMEA4530647_2460(pgsA_2) |
CRW: | CROST_000010(pgsA_1) CROST_038020 |
CFB: | CLFE_003000(pgsA_1) CLFE_009800 |
CAUN: | CLAUR_029960(pgsA_2) CLAUR_037250 |
HHW: | NCTC503_02715(pgsA2) |
EHA: | Ethha_1017 Ethha_1298 |
CAML: | H6X83_01975 H6X83_10535 |
SMAN: | C12CBH8_21520(pgsA_2) |
VFA: | MM35RIKEN_08140(pgsA) |
VCOP: | MM50RIKEN_14640(pgsA_2) |
CFEM: | HCR03_12205 HCR03_17445 |
BPEN: | NQ488_05420 NQ488_14445 |
CCOM: | I6K69_06410 I6K69_12210 |
BPRO: | PMF13cell1_03668(pgsA1) PMF13cell1_05160(pgsA_2) |
CSCI: | HDCHBGLK_00060(pgsA_1) |
DLO: | K5I24_10205 K5I24_15390 |
CBAR: | PATL70BA_0341 PATL70BA_2285 |
GFE: | Gferi_03535 Gferi_04350 |
TPET: | TPHSE_05890(pgsA_1) |
HALS: | D7D81_12585 D7D81_12650 |
CAD: | Curi_c05170(pgsA1) Curi_c08180(pgsA2) |
SPOA: | EQM13_00660 EQM13_06700(pgsA) |
FIT: | Fi14EGH31_06120(pgsA_2) Fi14EGH31_12850(pgsA_3) |
CDIA: | CaldiYA01_10600(pgsA) |
AAXA: | NCTC10138_01657(pgsA_2) |
MALA: | NCTC10135_00590(pgsA) |
PCAT: | Pcatena_07910(pgsA) |
DDT: | AAY81_05640 AAY81_09575 |
RTS: | CE91St31_16780(pgsA2) |
MBO: | BQ2027_MB1853(pgsA2) |
MAVM: | MAA44156_01519(pgsA) |
MMAN: | MMAN_11660(pgsA2_2) |
MMAE: | MMARE11_26200(pgsA2) |
MPSE: | MPSD_27760(pgsA1_2) |
MSHO: | MSHO_40260(pgsA2_1) |
MFJ: | MFLOJ_06490(pgsA2_1) |
MSTO: | MSTO_07750(pgsA2_1) |
MSAK: | MSAS_06980(pgsA2_1) |
MBAI: | MB901379_02496(pgsA) |
MSHJ: | MSHI_13730(pgsA1_1) |
MKY: | IWGMT90018_30240(pgsA1_1) |
MPHL: | MPHLCCUG_02349(pgsA_1) |
MTHN: | 4412656_02239(pgsA) |
MAUU: | NCTC10437_03035(pgsA_3) |
MFLV: | NCTC10271_02562(pgsA2_1) |
MSAL: | DSM43276_02117(pgsA2_1) |
MTER: | 4434518_01868(pgsA2) |
NFR: | ERS450000_01613(pgsA2_2) |
NAD: | NCTC11293_03723(pgsA2_1) |
RHU: | A3Q40_01819(pgsA1_2) |
RRT: | 4535765_02738(pgsA_2) |
RCR: | NCTC10994_00350(pgsA_1) |
GOM: | D7316_01257(pgsA1_2) |
SAMB: | SAM23877_1447(pgsA) |
SRW: | TUE45_01785(pgsA2_1) |
SLE: | sle_57090(sle_57090) |
SRN: | A4G23_00636(pgsA2_1) |
SSPB: | CP982_08165 CP982_23120 |
SXT: | KPP03845_101583(pgsA1) |
SHAU: | K9S39_30470 K9S39_37655 |
STYI: | C9F11_07195(pgsA1) C9F11_22620(pgsA3) |
LEIZ: | IT072_03460 IT072_12565 |
AMAU: | DSM26151_12810(pgsA2) |
MALK: | MalAC0309_1270(pgsA) |
PSEV: | USB125703_02031(pgsA1) |
AAGI: | NCTC2676_1_00905(pgsA_1) |
ARTM: | MN0502_11530(pgsA_1) |
CGRN: | 4412665_01261(pgsA_2) |
TLA: | TLA_TLA_00104(pgsA1) |
PROP: | QQ658_06955 QQ658_12160 |
NAQU: | ENKNEFLB_02265(pgsA1) |
NRO: | K8W59_08100 K8W59_14700 |
NBI: | SHK19_07995 SHK19_11040 |
AER: | AERYTH_08595 AERYTH_16900 |
AWS: | ACN3XK_29165 ACN3XK_30130 |
MMAR: | MODMU_2675 MODMU_4979 |
AMYZ: | HUW46_08983(pgsA1_2) |
STP: | Strop_2387 Strop_2928 |
MTEM: | GCE86_08780 GCE86_11395 |
PFLA: | Pflav_035640(pgsA_2) |
ASER: | Asera_46290(pgsA_2) |
BFK: | QN062_01675 QN062_03895 |
DPB: | BABL1_gene_945(pgsA2) |
CGW: | UR58_C0001G0495(pgsA) |
» show all
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Reference |
|
Authors |
Schlame M, Hostetler KY |
Title |
Solubilization, purification, and characterization of cardiolipin synthase from rat liver mitochondria. Demonstration of its phospholipid requirement. |
Journal |
J Biol Chem 266:22398-403 (1991) |
Reference |
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Authors |
Nowicki M, Muller F, Frentzen M |
Title |
Cardiolipin synthase of Arabidopsis thaliana. |
Journal |
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Sequence |
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Reference |
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Authors |
Houtkooper RH, Akbari H, van Lenthe H, Kulik W, Wanders RJ, Frentzen M, Vaz FM |
Title |
Identification and characterization of human cardiolipin synthase. |
Journal |
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Sequence |
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Reference |
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Authors |
Sandoval-Calderon M, Geiger O, Guan Z, Barona-Gomez F, Sohlenkamp C |
Title |
A eukaryote-like cardiolipin synthase is present in Streptomyces coelicolor and in most actinobacteria. |
Journal |
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Sequence |
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Other DBs |
ExplorEnz - The Enzyme Database: | 2.7.8.41 |
ExPASy - ENZYME nomenclature database: | 2.7.8.41 |
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LinkDB |
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