KEGG ENZYME: 3.1.1.55

ENZYME: 3.1.1.55

Entry

EC 3.1.1.55                 Enzyme

Name

acetylsalicylate deacetylase;
aspirin esterase;
aspirin esterase;
acetylsalicylic acid esterase;
aspirin hydrolase

Class

Hydrolases;
Acting on ester bonds;
Carboxylic-ester hydrolases

Sysname

acetylsalicylate O-acetylhydrolase

Reaction(IUBMB)

acetylsalicylate + H2O = salicylate + acetate [RN:R02942]

Reaction(KEGG)

R02942

Substrate

acetylsalicylate [CPD:C01405];
H2O [CPD:C00001]

Product

salicylate [CPD:C00805];
acetate [CPD:C00033]

Comment

Not identical with EC 3.1.1.1 (carboxylesterase), EC 3.1.1.2 (arylesterase), EC 3.1.1.7 (acetylcholinesterase) or EC 3.1.1.8 (cholinesterase). The activity of the liver cytosol enzyme is highest with acetyl esters of aryl alcohols, and thioesters are also hydrolysed; the microsomal enzyme also hydrolyses some other negatively charged esters, with highest activity on esters of salicylate with long-chain alcohols.

History

EC 3.1.1.55 created 1986, modified 1989

Reference

1 [PMID:6875867]

Authors

Ali B, Kaur S.

Title

Mammalian tissue acetylsalicylic acid esterase(s): identification, distribution and discrimination from other esterases.

Journal

J Pharmacol Exp Ther 226:589-94 (1983)

Reference

2 [PMID:2383281]

Authors

Kim DH, Yang YS, Jakoby WB.

Title

Aspirin hydrolyzing esterases from rat liver cytosol.

Journal

Biochem Pharmacol 40:481-7 (1990)
DOI:10.1016/0006-2952(90)90546-W

Reference

3 [PMID:6704404]

Authors

White KN, Hope DB.

Title

Partial purification and characterization of a microsomal carboxylesterase specific for salicylate esters from guinea-pig liver.

Journal

Biochim Biophys Acta 785:138-47 (1984)
DOI:10.1016/0167-4838(84)90138-9

Other DBs

ExplorEnz - The Enzyme Database:

3.1.1.55

IUBMB Enzyme Nomenclature:

3.1.1.55

ExPASy - ENZYME nomenclature database:

3.1.1.55

BRENDA, the Enzyme Database:

3.1.1.55

CAS:	87348-04-7

LinkDB

DBGET integrated database retrieval system