KEGG ORTHOLOGY: K07188

ORTHOLOGY: K07188

Entry

K07188                      KO

Symbol

LIPE, HSL

Name

hormone-sensitive lipase [EC:3.1.1.79]

Pathway

map04024

cAMP signaling pathway

map04152

AMPK signaling pathway

map04371

Apelin signaling pathway

map04714

Thermogenesis

map04910

Insulin signaling pathway

map04923

Regulation of lipolysis in adipocytes

map04925

Aldosterone synthesis and secretion

Disease

H00420

Familial partial lipodystrophy

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04371 Apelin signaling pathway
    K07188  LIPE, HSL; hormone-sensitive lipase
   04024 cAMP signaling pathway
    K07188  LIPE, HSL; hormone-sensitive lipase
   04152 AMPK signaling pathway
    K07188  LIPE, HSL; hormone-sensitive lipase
09150 Organismal Systems
  09152 Endocrine system
   04910 Insulin signaling pathway
    K07188  LIPE, HSL; hormone-sensitive lipase
   04923 Regulation of lipolysis in adipocytes
    K07188  LIPE, HSL; hormone-sensitive lipase
   04925 Aldosterone synthesis and secretion
    K07188  LIPE, HSL; hormone-sensitive lipase
  09159 Environmental adaptation
   04714 Thermogenesis
    K07188  LIPE, HSL; hormone-sensitive lipase
Enzymes [BR:ko01000]
3. Hydrolases
  3.1  Acting on ester bonds
   3.1.1  Carboxylic-ester hydrolases
    3.1.1.79  hormone-sensitive lipase
     K07188  LIPE, HSL; hormone-sensitive lipase

Other DBs

GO:

0033878

Genes

HSA:	3991(LIPE)

PTR:	456076(LIPE)

PPS:	100975071(LIPE)

GGO:	101145804(LIPE)

PON:	100445800(LIPE)

PPYG:

129019856(LIPE)

NLE:	100603864(LIPE)

HMH:	116480602(LIPE)

SSYN:

129466573(LIPE)

MCC:	707997(LIPE)

MCF:	102143368(LIPE)

MTHB:

126941743

MNI:	105495248(LIPE)

CSAB:

103234777(LIPE)

CATY:

105598066(LIPE)

PANU:

101023266(LIPE)

TGE:	112612101(LIPE)

MLEU:

105541674(LIPE)

RRO:	104658678(LIPE)

RBB:	108513895(LIPE)

TFN:	117075239(LIPE)

PTEH:

111530380

CANG:

105507879(LIPE)

CJC:	100387953(LIPE)

SBQ:	101052652(LIPE)

CIMI:

108285729(LIPE)

ANAN:

105723458

CSYR:

103264729(LIPE)

MMUR:

105868011(LIPE)

LCAT:

123624035(LIPE)

PCOQ:

105817511(LIPE)

OGA:	100952035(LIPE)

MMU:	16890(Lipe)

MCAL:

110298158(Lipe)

MPAH:

110336545(Lipe)

RNO:	25330(Lipe)

MCOC:

116101848(Lipe)

ANU:	117720546(Lipe)

MUN:	110563910(Lipe)

CGE:	100755300(Lipe)

MAUA:

101825806(Lipe)

PROB:

127238774

PLEU:

114685349(Lipe)

MORG:

121450098(Lipe)

MFOT:

126491469

AAMP:

119820308(Lipe)

NGI:	103744591(Lipe)

HGL:	101709284(Lipe)

CPOC:

100734974(Lipe)

CCAN:

109691865(Lipe)

DORD:

105997968(Lipe)

DSP:	122097600(Lipe)

PLOP:

125368426(Lipe)

NCAR:

124966648

MMMA:

107151418(Lipe)

OCU:

100339941

OPI:	101528437(LIPE)

TUP:	102477502(LIPE)

GVR:	103586114(LIPE)

CFA:	403607(LIPE)

CLUD:

112645376(LIPE)

VVP:	112931218(LIPE)

VLG:	121484344(LIPE)

NPO:	129500999(LIPE)

AML:	100479605(LIPE)

UMR:	103680155(LIPE)

UAH:	113243521(LIPE)

UAR:	123780404(LIPE)

ELK:

111161566

LLV:

125088629

MPUF:

101683381(LIPE)

MNP:	132005105(LIPE)

MLK:	131817615(LIPE)

NVS:	122912071(LIPE)

ORO:	101384261(LIPE)

EJU:	114197074(LIPE)

ZCA:	113935476(LIPE)

MLX:	117998053(LIPE)

NSU:	110586439(LIPE)

LWW:	102733724(LIPE)

FCA:	751818(LIPE)

PYU:	121018485(LIPE)

PCOO:

112851328(LIPE)

PBG:	122493988(LIPE)

PVIV:

125152692(LIPE)

LRUF:

124511087

PTG:	102952452(LIPE)

PPAD:

109257948(LIPE)

PUC:

125915427

AJU:

106987707

HHV:	120243020(LIPE)

BTA:	286879(LIPE)

BOM:	102266815(LIPE)

BIU:	109572731(LIPE)

BBUB:

102389675(LIPE)

BBIS:

104990488(LIPE)

CHX:	100860801(LIPE)

OAS:	100169699(LIPE)

BTAX:

128063156(LIPE)

ODA:	120872376(LIPE)

CCAD:

122420167(LIPE)

MBEZ:

129546774(LIPE)

SSC:	397583(LIPE)

CFR:

102520149

CBAI:

105062447(LIPE)

CDK:	105090211(LIPE)

VPC:	102531302(LIPE)

BACU:

103006716(LIPE)

BMUS:

118885038(LIPE)

LVE:	103074607(LIPE)

OOR:	101277193(LIPE)

DLE:	111180817(LIPE)

PCAD:

102989235(LIPE)

PSIU:

116743963(LIPE)

NASI:

112415393(LIPE)

ECB:	100069598(LIPE)

EPZ:	103558823(LIPE) 103563985

EAI:	106847941(LIPE)

MYB:	102247234(LIPE)

MYD:	102764534(LIPE)

MMYO:

118674384(LIPE)

MLF:	102426455(LIPE)

MDT:	132216830(LIPE)

PKL:	118702302(LIPE)

EFUS:

103303225(LIPE)

MNA:	107534157(LIPE)

DRO:	112320229(LIPE)

SHON:

119000496(LIPE)

AJM:	119060132(LIPE)

PDIC:

114511611(LIPE)

PHAS:

123818235(LIPE)

MMF:	118639408(LIPE)

PPAM:

129066147(LIPE)

HAI:	109374451(LIPE)

RFQ:	117035485(LIPE)

PALE:

102889858(LIPE)

PVP:	105307364(LIPE)

RAY:	107502572(LIPE)

MJV:	108393430(LIPE)

TOD:	119249387(LIPE)

SARA:

101540265(LIPE)

SETR:

126028546(LIPE)

LAV:	100670874(LIPE)

TMU:

101361564

ETF:	101655062(LIPE)

DNM:	101434958(LIPE)

MDO:	103104890(LIPE)

SHR:	100926393(LIPE)

AFZ:

127556374

PCW:	110219706(LIPE)

TVP:	118840433(LIPE)

OAA:	103167455(LIPE)

AGEN:

126035152

AAM:	106487870(LIPE)

AROW:

112971701(LIPE)

ASN:	102386893(LIPE)

AMJ:	102571969(LIPE)

CCAY:

125625717(LIPE)

DCC:	119847955(LIPE)

CPIC:

101953217(LIPE)

TST:	117888400(LIPE)

CABI:

116818657(LIPE)

MRV:	120390744(LIPE)

PVT:	110086763(LIPE)

SUND:

121915645(LIPE)

PBI:	103054092(LIPE)

PMUR:

107289716(LIPE)

CTIG:

120312011(LIPE)

PGUT:

117677674(LIPE)

APRI:

131204633(LIPE)

PTEX:

113445973(LIPE)

NSS:	113421205(LIPE)

VKO:	123025874(LIPE)

PMUA:

114603349(LIPE)

PRAF:

128418319(LIPE)

ZVI:	118087523(LIPE)

HCG:	128333285(LIPE)

GJA:	107106853(LIPE) 107117837

STOW:

125435512(LIPE)

EMC:	129343552(LIPE)

XLA:	100174796(lipe.L) 108697769(lipe.S)

XTR:	733899(lipe)

NPR:	108799329(LIPE)

RTEM:

120916360(LIPE)

BBUF:

120990803(LIPE)

BGAR:

122926911(LIPE)

MUO:	115476363(LIPE)

GSH:	117368797(LIPE)

DRE:	557893(lipeb) 568368(lipea)

SRX:	107706458 107723485 107739528 107748718

SANH:

107656618 107657706 107693390 107699484

SGH:	107565586 107593665 107595727 107599546

CCAR:

109105935 109111854

CAUA:

113059067 113062343 113116658 113120143

CGIB:

127935876 127975188 127979693 128030630

PTET:

122323687(lipea) 122360111(lipeb)

LROH:

127178636(lipeb) 127182269(lipea)

OMC:	131521393(lipeb) 131526328(lipea)

PPRM:

120483517(lipea) 120484659(lipeb)

RKG:	130097391(lipea) 130101863(lipeb)

MAMB:

125242790(lipeb) 125275320(lipea)

CIDE:

127497698 127500730

CERY:

137035350(lipeb) 137037589(lipea)

MASI:

127421249 127425486 127452857 127453560

TROS:

130557543(lipeb) 130567264(lipea)

TDW:	130415485(lipea) 130432801(lipeb)

MANU:

129448044(lipeb) 129455713(lipea)

IPU:	108256376(lipeb) 108272659(lipea)

IFU:	128599999(lipeb) 128615553(lipea)

PHYP:

113532968(lipe) 113535092

SMEO:

124375514(lipeb) 124382218(lipea)

TFD:	113641262(lipea) 113659674(lipeb)

TVC:	132840266(lipeb) 132842902(lipea)

TRN:	134300957(lipeb) 134329520(lipea)

AMEX:

103030794(lipeb) 103036112(lipea)

CMAO:

118798741(lipeb) 118806054(lipea)

EEE:	113571934(lipe) 113578376

CHAR:

105902027(lipea) 105910643(lipeb)

TRU:	101067661(lipe) 101070911

TFS:	130517918(lipea) 130519744(lipeb)

TNG:	GSTEN00005445G001 GSTEN00015593G001

LCO:	104927333(lipe) 104928056

NCC:	104955347 104963766

TBEN:

117477261(lipeb) 117478035(lipea)

CGOB:

115015627 115021198(lipe)

PGEO:

117455395(lipea) 117460354(lipeb)

GACU:

117549583(lipeb) 117559297(lipea)

EMAC:

134861718(lipeb) 134875241(lipea)

ELY:	117263762(lipea) 117265772(lipeb)

EFO:	125892771(lipeb) 125904660(lipea)

PLEP:

121945131(lipeb) 121958297(lipea)

SLUC:

116042460(lipeb) 116047175(lipea)

ECRA:

117945621(lipeb) 117957028(lipea)

ESP:	116691214(lipe) 116701791

PFLV:

114556966(lipe) 114567920

GAT:	120811071(lipeb) 120826336(lipea)

PPUG:

119197023(lipeb) 119218887(lipea)

AFB:	129097033(lipea) 129109404(lipeb)

CLUM:

117739107(lipea) 117745886(lipeb)

PSWI:

130207216(lipea) 130212720(lipeb)

MSAM:

119897337(lipeb) 119907925(lipea)

SCHU:

122864997(lipea) 122881968(lipeb)

CUD:	121513730(lipeb) 121524390(lipea)

ALAT:

119005801(lipeb) 119016736(lipea)

ASTR:

137601675(lipeb) 137607365(lipea)

MZE:	101473301 101485272(lipe)

ONL:	100534456(lipe) 100708083

OAU:	116309493(lipeb) 116318878(lipea)

OLA:	101157970(lipe) 101160745

OML:	112143493(lipeb) 112160867(lipea)

CSAI:

133436221(lipeb) 133460589 133460822

XMA:	102217205 102234893(lipe)

XCO:	114138258(lipe) 114156439

XHE:	116716805(lipe) 116731753

PRET:

103473021 103477914(lipe)

PFOR:

103139235(lipe) 103143485

PLAI:

106946893 106960167(lipe)

PMEI:

106916842(lipe) 106923653

GAF:	122830737(lipeb) 122843462(lipea)

PPRL:

129371269(lipeb) 129375786(lipea)

CVG:	107083574(lipe)

CTUL:

119771906(lipeb) 119781167(lipea)

GMU:	124865649(lipeb) 124879454(lipea)

NFU:	107379673(lipe) 107394884

KMR:	108229521(lipea) 108235517(lipeb)

ALIM:

106523738(lipe) 106530086

NWH:	119409953(lipeb) 119425963(lipea)

AOCE:

111564221(lipe) 111580224

MCEP:

125016201(lipeb) 125020043(lipea)

CSEM:

103388799(lipe) 103393953

POV:	109633466(lipe) 109640422

SSEN:

122774381(lipeb) 122786205(lipea)

HHIP:

117770234(lipea) 117777502(lipeb)

HSP:	118113590(lipeb) 118125101(lipea)

PPLT:

128449329(lipeb) 128461733(lipea)

SMAU:

118291618(lipea) 118303656(lipeb)

LCF:	108880754(lipeb) 108899366

SDU:	111230513 111236037(lipe)

SLAL:

111657262(lipe) 111661080

XGL:	120784156(lipeb) 120786574(lipea)

HCQ:	109513537 109531659(lipe)

SSCV:

125975658

SBIA:

133492014(lipea) 133500518(lipeb)

PEE:	133395958(lipea) 133401367(lipeb)

PTAO:

133470940(lipea) 133479302(lipeb)

BPEC:

110168856 110174235(lipe)

MALB:

109954692(lipe) 109958776

BSPL:

114842682(lipeb) 114865425(lipea)

SJO:	128365788(lipeb) 128373760(lipea)

SASA:

100380378(lips) 106570130 106577399 106605704

STRU:

115153499 115176102 115177356 115183447

OTW:	112226531(lipeb) 112230020(lipea) 112235274 112257644

OMY:	100505413(lipe1) 100505414(lipea) 110510088 110537667

OGO:	123998047 124018384 124038460 124043704(lipea)

ONE:	115112988 115120676 115131807

OKI:	109881762 109899918 109903781 109906657

OKE:	118371308 118378535 118397699 118398332(lipea)

SALP:

111955344 111958912 111978396

SNH:	120027276(lipea) 120046687 120048653 120048772

CCLU:

121575665 121586170

ELS:	105024275(lipe) 105027558 105028269

SFM:	108922191(lipe)

PKI:	111854848(tmem145)

AANG:

118229831(lipeb)

PSPA:

121299176(lipeb) 121304208

ARUT:

117434050(lipeb) 117969359

LCM:	102346636(LIPE)

HOC:	132834017(lipeb)

BFO:

BBEL:

CIN:

SCLV:

SPU:	115928003 585712

APLC:

ARUN:

AJC:

SKO:

DME:	Dmel_CG11055(Hsl)

DER:

6547758

DSE:

6610042

DSI:	Dsimw501_GD11499(Dsim_GD11499)

DYA:	Dyak_GE12096

DAN:

DSR:

DPO:

DPE:

DMN:

DWI:

DGR:

DMO:	Dmoj_GI21105

DAZ:

DNV:

DHE:

DVI:

CCAT:

BOD:

BDR:

RZE:

AOQ:

TDA:	119680198 119680953

MDE:	101899540 131801150

SCAC:

LCQ:

LSQ:

GFS:

ECOE:

HIS:

AGA:

ACOZ:

AARA:

AMER:

ASTE:

AFUN:

AMOU:

AALI:

AAG:

AALB:

ASUA:

CQU:	CpipJ_CPIJ015981

CPII:

CNS:

BCOO:

LLL:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BTER:

BPYO:

FVI:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

HST:

DQU:

CFO:	105248955 105258252

FEX:

115237774

LHU:	105676433(Hsl)

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:

CSOL:

TPRE:

LHT:

LBD:

MDL:

CGLO:

FAS:

DAM:

AGIF:

CINS:

VCAN:

CCIN:

DSM:

NPT:

NFB:

NLO:

NVG:

AROA:

TCA:

DPA:

SOY:

AGRG:

ATD:

CSET:

AGB:

LDC:

DVV:

NVL:

APLN:

PPYR:

OTU:

BMOR:

BMAN:

MSEX:

DPL:	KGM_206593

BANY:

MJU:

NIQ:

VCD:

MCIX:

PMAC:

PPOT:

PXU:

PRAP:

PBX:

PNAP:

ZCE:

CCRC:

LSIN:

AAGE:

HAW:

HZE:

TNL:

SLIU:

OFU:

ATRA:

GMW:

PXY:

PGW:

LGLY:

CCRN:

API:

DNX:

AGS:

RMD:

DVT:

BTAB:

CLEC:

HHAL:

106688498(Hsl)

NLU:

111053191

HVI:

124356720

MQU:

128987298

PHU:	Phum_PHUM288260

FOC:

TPAL:

ZNE:

CSEC:

BROR:

IEL:

FCD:

DPX:	DAPPUDRAFT_30662

DMK:

116918167

DPZ:

124342640

PVM:	113810962 113818201

PJA:

PCHN:

PMOO:

HAME:

PCLA:

PTRU:

ESN:

MNZ:

MRJ:	136829312(Hsl)

HAZT:

108668222

PPOI:

119107877

DSV:	119455920 119455921

RSAN:

119378685 119390381 119394211

RMP:	119172409 119172410

VDE:

111243951

VJA:

111271304

TUT:	107359099 107361343 107362310 107362816 107368307 107370828 107371243

DPTE:

113797455

DFR:

124498193

CSCU:

111613708

CVS:	136981410(Hsl)

PTEP:

ABRU:

UDV:

SDM:

LPOL:

PMEO:

CEL:	CELE_C46C11.1(hosl-1)

CBR:

CBG_14512

CRQ:	GCK72_024294

NAI:	NECAME_04548

TSP:

Tsp_02264

HRO:	HELRODRAFT_111475 HELRODRAFT_161006

LGI:	LOTGIDRAFT_113239

PVUL:

PCAN:

BGT:

GAE:

HRF:

HRJ:

CRG:

CANU:

CVN:

OED:

MYI:

PMAX:

RPHI:

MAEA:

OBI:

OSN:

LJP:

LAK:	106161696 106177073

SMM:	Smp_000130.1

SHX:	MS3_00005797

OVI:	T265_02504

EGL:

LLON:

NVE:

EPA:

ATEN:

ADF:	107330377 107352460

AMIL:

PDAM:

SPIS:

DGT:

XEN:

HMG:

HSY:

RES:

TAD:	TRIADDRAFT_55258

AQU:

105314138

CME:	CYME_CMF053C

GSL:	Gasu_23200

MBR:	MONBRDRAFT_25836 MONBRDRAFT_34791

SRE:	PTSG_06139 PTSG_08491

TET:	TTHERM_00185900 TTHERM_00689920 TTHERM_00827140

PTM:	GSPATT00000473001 GSPATT00006124001 GSPATT00010470001 GSPATT00014607001 GSPATT00014951001 GSPATT00015462001 GSPATT00015563001 GSPATT00020740001 GSPATT00023970001 GSPATT00027668001 GSPATT00031398001 GSPATT00032768001 GSPATT00034492001 PTMB.72

PIF:	PITG_10850

PSOJ:

PHYSODRAFT_322905

SPAR:

SPRG_01501

GTT:	GUITHDRAFT_134743

NGR:	NAEGRDRAFT_57147

» show all

Reference

PMID:21241784

Authors

Lampidonis AD, Rogdakis E, Voutsinas GE, Stravopodis DJ

Title

The resurgence of Hormone-Sensitive Lipase (HSL) in mammalian lipolysis.

Journal

Gene 477:1-11 (2011)
DOI:10.1016/j.gene.2011.01.007

Reference

PMID:8812477

Authors

Holst LS, Langin D, Mulder H, Laurell H, Grober J, Bergh A, Mohrenweiser HW, Edgren G, Holm C

Title

Molecular cloning, genomic organization, and expression of a testicular isoform of hormone-sensitive lipase.

Journal

Genomics 35:441-7 (1996)
DOI:10.1006/geno.1996.0383

Sequence

[hsa:3991]

LinkDB

DBGET integrated database retrieval system