Entry
Name
inositol-1,4-bisphosphate 1-phosphatase;
inositol-polyphosphate 1-phosphatase
Class
Hydrolases;
Acting on ester bonds;
Phosphoric-monoester hydrolases
BRITE hierarchy
Sysname
1D-myo-inositol-1,4-bisphosphate 1-phosphohydrolase
Reaction(IUBMB)
1D-myo-inositol 1,4-bisphosphate + H2O = 1D-myo-inositol 4-phosphate + phosphate [RN:
R03393 ]
Reaction(KEGG)
Substrate
1D-myo-inositol 1,4-bisphosphate [CPD:
C01220 ];
H2O [CPD:
C00001 ]
Product
1D-myo-inositol 4-phosphate [CPD:
C03546 ];
phosphate [CPD:
C00009 ]
Comment
The enzyme acts on inositol 1,4-bisphosphate and inositol 1,3,4-trisphosphate (forming inositol 3,4-bisphosphate) with similar Vmax values for both substrates, but with a five-times higher affinity for the bisphosphate. Does not act on inositol 1-phosphate, inositol 1,4,5-trisphosphate or inositol 1,3,4,5-tetrakisphosphate.
History
EC 3.1.3.57 created 1989, modified 2002
Pathway
ec00562 Inositol phosphate metabolism
Orthology
K01107 inositol polyphosphate 1-phosphatase
K15422 3'(2'), 5'-bisphosphate nucleotidase / inositol polyphosphate 1-phosphatase
Genes
RBB : 108523275 108527575(INPP1)
MORG : 121442202 121459145
GVR : 103602368(INPP1) 103609321
PSIU : 116740704 116756993(INPP1)
SETR : 126008949(INPP1) 126025706
CMY : 102940917(INPP1) 102947691
CCAY : 125627456 125645046(INPP1)
TST : 117884990(INPP1) 117888676
CABI : 116815202(INPP1) 116827757
MRV : 120374526(INPP1) 120391107
PMUR : 107293737(INPP1) 107300809
NPR : 108786717 108786723(INPP1)
MUO : 115465897 115474469(INPP1)
GSH : 117358093 117360404(INPP1)
DRE : 555899(si:ch211-160o17.2)
SGH : 107557551(inpp1) 107562242
CCAR : 109077394 109104896(inpp1)
CAUA : 113054901 113069252
CGIB : 127968186 128022648
MAMB : 125256719(inpp1) 125256990
TROS : 130548809 130549844(inpp1)
TDW : 130410126(inpp1) 130430052
CHAR : 105905670 105912196(inpp1)
SPIL : 134070890 134092857(inpp1)
SASA : 100306749(inpp) 106583335
STRU : 115150414 115208007
OGO : 124003939(inpp1) 124030750
OKE : 118388721(inpp1) 118400426
SALP : 111965037 111970240
CCLU : 121575119 121578572
SFM : 108918545 108927928(inpp1)
PKI : 111842935(inpp1) 111854764
AROT : 135238543(inpp1) 135250392
CCOG : 133110704(inpp1) 133124220
PSPA : 121309074 121323234
ARUT : 117400900(inpp1) 117403754 117427192
CPLA : 122543262 122551251
LERI : 129698639 129714750(inpp1)
DSI : Dsimw501_GD18939(Dsim_GD18939)
TDA : 119676334 119677637 119684103
AALB : 109405391 109413222
MSEX : 115444074 119189963
CFEL : 113384480 113385938
MAEA : 128229350 128237592
LAK : 106157083 106159956 106160005
ATH : AT5G09290 AT5G63980(SAL1) AT5G63990 AT5G64000(SAL2)
ALY : 9300956 9300957 9302658 9309460
CRB : 17874672 17876775 17876793 17881495
CSAT : 104727027 104727030 104729063 104734921 104741992 104742002 104742027 104762546 104762547 104769111
EUS : EUTSA_v10004312mg EUTSA_v10004421mg EUTSA_v10004505mg EUTSA_v10013884mg
BRP : 103837510 103855221 103873815 103873817 103873819
BNA : 106347966 106347988 106347997 106348088 106348090 106348091 106357655 106366259 106382921 106405023 125581587
BOE : 106327641 106328745 106331533 106335719
RSZ : 108813390 108827480 108838778 108857639 108859126
THJ : 104800114 104818427 104819342
MINC : 123199195 123205585 123223973
GRA : 105777076 105798049 105798241
GHI : 107888505 107888629 107892352 107896671 107914433 107931327 107957606
GAB : 108454499 108454552 108466233 108489423
HSYR : 120140200 120166767 120175251
RARG : 115750480 115750483
PALZ : 118030467 118040286
SSPL : 121768751 121772384
CQI : 110681994 110695157 110697645
PSOM : 113346503 113356457
OSA : 4351685 4351686(DPNPase)
DOSA : Os12g0183200 Os12g0183300
ATS : 109732486 109734469 109770883
TDC : 119287732 119300772 119330960
TAES : 123088055 123102908 123111085 123120050 123152343 123166325 123172930
MFLO : 136503266 136504369 136506719 136506768
SITA : 101764411 101764810
PVIR : 120663760 120696887 120696890
PHAI : 112884814 112887766
SMO : SELMODRAFT_234473 SELMODRAFT_97708
CCP : CHC_T00008454001 CHC_T00008808001
» show all
Taxonomy
Reference
Authors
Berridge MJ, Dawson RM, Downes CP, Heslop JP, Irvine RF.
Title
Changes in the levels of inositol phosphates after agonist-dependent hydrolysis of membrane phosphoinositides.
Journal
Reference
Authors
Connolly TM, Bansal VS, Bross TE, Irvine RF, Majerus PW.
Title
The metabolism of tris- and tetraphosphates of inositol by 5-phosphomonoesterase and 3-kinase enzymes.
Journal
J Biol Chem 262:2146-9 (1987)
Reference
Authors
Inhorn RC, Majerus PW.
Title
Inositol polyphosphate 1-phosphatase from calf brain. Purification and inhibition by Li+, Ca2+, and Mn2+.
Journal
J Biol Chem 262:15946-52 (1987)
Other DBs
ExplorEnz - The Enzyme Database: 3.1.3.57
ExPASy - ENZYME nomenclature database: 3.1.3.57
CAS: 111070-17-8 111694-13-4
LinkDB
All DBs