KEGG ORTHOLOGY: K01107

ORTHOLOGY: K01107

Entry

K01107                      KO

Symbol

INPP1

Name

inositol polyphosphate 1-phosphatase [EC:3.1.3.57]

Pathway

map00562

Inositol phosphate metabolism

map01100

Metabolic pathways

map04070

Phosphatidylinositol signaling system

Module

M00131

Inositol phosphate metabolism, Ins(1,3,4,5)P4 => Ins(1,3,4)P3 => myo-inositol

Reaction

R03393

D-myo-inositol-1,4-bisphosphate 1-phosphohydrolase

R03427

D-myo-inositol 1,3,4-trisphosphate 1-phosphohydrolase

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    K01107  INPP1; inositol polyphosphate 1-phosphatase
09130 Environmental Information Processing
  09132 Signal transduction
   04070 Phosphatidylinositol signaling system
    K01107  INPP1; inositol polyphosphate 1-phosphatase
Enzymes [BR:ko01000]
3. Hydrolases
  3.1  Acting on ester bonds
   3.1.3  Phosphoric-monoester hydrolases
    3.1.3.57  inositol-1,4-bisphosphate 1-phosphatase
     K01107  INPP1; inositol polyphosphate 1-phosphatase

Other DBs

GO:

0004441

Genes

HSA:	3628(INPP1)

PTR:	460106(INPP1)

PPS:	100967835(INPP1)

GGO:	101129850(INPP1)

PON:	100461697(INPP1)

PPYG:

129031087(INPP1)

NLE:	100592468(INPP1)

HMH:	116810540(INPP1)

SSYN:

129488173(INPP1)

MCC:	703301(INPP1)

MCF:	102129084(INPP1)

MTHB:

126932757

MNI:	105468216(INPP1)

CSAB:

103217521(INPP1)

CATY:

105579951(INPP1)

PANU:

101000049(INPP1)

TGE:	112635807(INPP1)

MLEU:

105535225(INPP1)

RRO:	104675276(INPP1)

RBB:	108523275 108527575(INPP1)

TFN:	117094721(INPP1)

PTEH:

111546263(INPP1)

CANG:

105507785(INPP1)

CJC:	100399314(INPP1)

SBQ:	101034382(INPP1)

CIMI:

108284056(INPP1)

ANAN:

105725157(INPP1)

CSYR:

103254520(INPP1)

MMUR:

105877899(INPP1)

LCAT:

123643810(INPP1)

ERUF:

138384036(INPP1)

PCOQ:

105813282(INPP1)

OGA:	100955102(INPP1)

MMU:	16329(Inpp1)

MCAL:

110297363(Inpp1)

MPAH:

110322195(Inpp1)

RNO:	316376(Inpp1)

MCOC:

116088401(Inpp1)

ANU:	117706285(Inpp1)

ASYL:

127692349(Inpp1)

MUN:	110555832(Inpp1)

CGE:

100755639

MAUA:

101826407(Inpp1)

PROB:

127226202(Inpp1)

PLEU:

114705100(Inpp1)

PMAV:

102912841(Inpp1)

MORG:

121442202 121459145

MFOT:

126511834

AAMP:

119803932(Inpp1)

CNL:	130867046(Inpp1)

NGI:	103736162(Inpp1)

HGL:	101724306(Inpp1)

CPOC:

100725526(Inpp1)

DORD:

105993739(Inpp1)

DSP:	122114999(Inpp1)

DMER:

138809200(Inpp1)

PLOP:

125350463(Inpp1)

NCAR:

124981282

MMMA:

107138546(Inpp1)

ITI:	101954996(Inpp1)

OCU:	100357992 127489834

OPI:	101526202(INPP1)

OCZ:	121150730(INPP1)

TUP:	102481098(INPP1)

GVR:	103602368(INPP1) 103609321

CFA:	478842(INPP1)

CLUD:

112656285(INPP1)

VVP:	112922928(INPP1)

VLG:	121480554(INPP1)

NPO:	129522816(INPP1)

AML:	100473008(INPP1)

UMR:	103659679(INPP1)

UAH:	113250658(INPP1)

UAR:	123798142(INPP1)

ELK:

111140882

LLV:

125094908

MPUF:

101681848(INPP1)

MNP:	132013392(INPP1)

MLK:	131827660(INPP1)

NVS:	122902122(INPP1)

ORO:	101376858(INPP1)

EJU:	114223619(INPP1)

ZCA:	113919578(INPP1)

MLX:	118012214(INPP1)

NSU:	110592377(INPP1)

LWW:	102729470(INPP1)

FCA:	101082081(INPP1)

PYU:	121030826(INPP1)

PCOO:

112872056(INPP1)

PBG:	122481570(INPP1)

PVIV:

125171882(INPP1)

LRUF:

124516574

LGF:	123599227(INPP1)

AJU:

106979728

PTG:	102951036(INPP1)

PPAD:

109274528(INPP1)

PUC:

125911462

PLEZ:

122226387(INPP1)

HHV:	120233471(INPP1)

BTA:	281869(INPP1)

BOM:	102276134(INPP1)

BIU:	109565484(INPP1)

BBUB:

102416046(INPP1)

BKE:	129646150(INPP1)

BBIS:

105005044(INPP1)

CHX:	102176832(INPP1)

OAS:	101110908(INPP1)

BTAX:

128043388(INPP1)

CSUM:

138076643(INPP1)

ODA:	120854041(INPP1)

CCAD:

122453921(INPP1)

MREE:

136165473(INPP1)

OVR:	110144351(INPP1)

MBEZ:

129538163(INPP1)

SSC:	100514878(INPP1)

CFR:	102520689(INPP1)

CBAI:

105072928(INPP1)

CDK:	105099189(INPP1)

VPC:	102532377(INPP1)

BACU:

103020750(INPP1)

BMUS:

118898380(INPP1)

LVE:	103071146(INPP1)

OOR:	101271125(INPP1)

LALB:

132522221(INPP1)

GMF:	115847665(INPP1)

DDP:	132428489(INPP1)

DLE:	111171662(INPP1)

PCAD:

102982005(INPP1)

PSIU:

116740704 116756993(INPP1)

PPHC:

136125735(INPP1)

NASI:

112392141(INPP1)

ECB:	100054603(INPP1)

EPZ:	103548647(INPP1)

EAI:	106828805(INPP1)

MYB:	102245840(INPP1)

MYD:	102766936(INPP1)

MMYO:

118661461(INPP1)

MLF:	102435148(INPP1)

MDT:	132238052(INPP1)

MYUM:

139014862(INPP1)

PKL:	118710626(INPP1)

EFUS:

103290642(INPP1)

MNA:	107539777(INPP1)

DRO:	112308010(INPP1)

SHON:

118985305(INPP1)

AJM:	119062127(INPP1)

PDIC:

114495492(INPP1)

PHAS:

123830117(INPP1)

MMF:	118625103(INPP1)

PPAM:

129061702(INPP1)

HAI:	109372960(INPP1)

RFQ:	117025735(INPP1)

PALE:

102885459(INPP1)

PGIG:

120587469(INPP1)

PVP:	105289360(INPP1)

RAY:	107511589(INPP1)

MJV:	108402009(INPP1)

TOD:	119256036(INPP1)

SARA:

101556760(INPP1)

SFUM:

130021012(INPP1)

SETR:

126008949(INPP1) 126025706

LAV:	100668984(INPP1)

TMU:

101352306

ETF:	101649478(INPP1)

DNM:	101431044(INPP1)

MDO:	100028793(INPP1)

GAS:	123242155(INPP1)

SHR:	100914455(INPP1)

AFZ:

127554464

PCW:	110213313(INPP1)

TVP:	118838327(INPP1)

PBRV:

138147619(INPP1)

MLAO:

141507632(INPP1)

OAA:	103169187(INPP1)

TACU:

119930765(INPP1)

GGA:	107049248(INPP1)

PCOC:

116235214(INPP1)

MGP:	104916077(INPP1)

CJO:	107325828(INPP1)

TPAI:

128090496(INPP1)

LMUT:

125685415(INPP1)

NMEL:

110391102(INPP1)

APLA:

119714697(INPP1)

AACU:

137845992(INPP1)

ACYG:

125181260(INPP1)

CATA:

118261007(INPP1)

AFUL:

116499954(INPP1)

LSR:	110482129(INPP1)

OTC:	121338760(INPP1)

PRUF:

121357165(INPP1)

ATRC:

139586825(INPP1)

PHI:	102109751(INPP1)

ACOE:

138100957(INPP1)

ETL:	114070097(INPP1)

ZLE:	135459057(INPP1)

SVG:	106863801(INPP1)

HRT:	120764438(INPP1)

CCIC:

134054855(INPP1)

FPG:	101914982(INPP1)

SHAB:

115618635(INPP1)

TALA:

116964443(INPP1)

ACHC:

115350877(INPP1)

HLE:	104830334(INPP1)

AGEN:

126046452

HHAR:

128152114(INPP1)

BBUT:

142041063(INPP1)

GCL:

127028464

PARX:

142048668(INPP1)

AFOR:

103905202(INPP1)

CBOR:

142073679(INPP1)

CBOY:

140644427(INPP1)

MAME:

142421030(INPP1)

CLV:	102088663(INPP1)

CNIC:

136000572(INPP1)

RTD:	128903177(INPP1)

CRID:

134526867(INPP1)

LMIC:

141733981(INPP1)

NPD:	112954222(INPP1)

ASN:	102386296(INPP1)

AMJ:	102571874(INPP1)

PSS:

102452926

CIZ:	142003337(INPP1)

CMY:	102940917(INPP1) 102947691

CCAY:

125627456 125645046(INPP1)

LKP:	140895964(INPP1) 140901098

NDS:

141975016

DCC:	122455365(INPP1)

CPIC:

101953281(INPP1)

TST:	117884990(INPP1) 117888676

CABI:

116815202(INPP1) 116827757

MRV:	120374526(INPP1) 120391107

ACS:	100556887(inpp1)

ASAO:

132768334(INPP1)

PVT:	110074857(INPP1)

SUND:

121924194(INPP1)

PBI:	103053524(INPP1)

PMUR:

107293737(INPP1) 107300809

CTIG:

120300561(INPP1)

TSR:	106548583(INPP1)

PGUT:

117662749(INPP1)

PCAE:

139310677(INPP1)

APRI:

131191313(INPP1)

PTEX:

113447319(INPP1)

NSS:	113420207(INPP1)

VKO:	123019224(INPP1)

PMUA:

114592953(INPP1)

PRAF:

128405030(INPP1)

ZVI:	118078820(INPP1)

HCG:	128342201(INPP1)

GJA:	107120900(INPP1)

STOW:

125428995(INPP1)

EMC:	129329218(INPP1)

XLA:	398838(inpp1.L)

XTR:	100144649(inpp1)

NPR:	108786717 108786723(INPP1)

RTEM:

120943702(INPP1)

ACAT:

141146708(INPP1)

PADS:

140335828(INPP1)

BBUF:

121008241(INPP1)

BGAR:

122945161(INPP1)

DTC:	141067735(INPP1)

PWL:	138285657(INPP1)

MUO:	115465897 115474469(INPP1)

GSH:	117358093 117360404(INPP1)

DRE:

555899

SRX:	107730897 107737355

SANH:

107683640

SGH:	107557551(inpp1) 107562242

CCAR:

109077394 109104896(inpp1)

CAUA:

113054901 113069252

CGIB:

127968186 128022648

PTET:

122354126(inpp1)

LROH:

127161315(inpp1)

GRF:	141293777(inpp1)

OMC:	131549425(inpp1)

PPRM:

120473441(inpp1)

RKG:	130086237(inpp1)

MAMB:

125256719(inpp1) 125256990

CIDE:

127522683

CERY:

137021762(inpp1)

MASI:

127428332

TROS:

130548809 130549844(inpp1)

TDW:	130410126(inpp1) 130430052

MANU:

129427810(inpp1)

PDAB:

135719296(inpp1)

IPU:

108255283

IFU:	128625341(inpp1)

PHYP:

113537788(inpp1)

TFD:	113656547(inpp1)

TVC:	132838328(inpp1)

CGAR:

128511183(inpp1)

NGRA:

132873962(inpp1)

TRN:	134301816(inpp1)

AMEX:

103037924(inpp1)

CMAO:

118799653(inpp1)

EEE:	113588699(inpp1)

CHAR:

105905670 105912196(inpp1)

SPIL:

134070890 134092857(inpp1)

ASAD:

121698173

TRU:	101068265(inpp1)

TFS:	130524905(inpp1)

TNG:	GSTEN00013621G001

NCC:	104954761(inpp1)

TBEN:

117489785(inpp1)

CGOB:

115008160(inpp1)

PGEO:

117447026(inpp1)

GACU:

117534191(inpp1)

EMAC:

134882500(inpp1)

ELY:	117256325(inpp1)

EFO:	125878963(inpp1)

PLEP:

121950029(inpp1)

SLUC:

116066658(inpp1)

ECRA:

117944008(inpp1)

ESP:	116688508(inpp1)

PFLV:

114553800(inpp1)

GAT:	120835252(inpp1)

PPUG:

119193950(inpp1)

AFB:	129105751(inpp1)

CLUM:

117730966(inpp1)

PSWI:

130208997(inpp1)

CANA:

137795920(inpp1)

CVE:	137879689(inpp1)

MSAM:

119886042(inpp1)

SCHU:

122867541(inpp1)

EARM:

139283170(inpp1)

CUD:	121528912(inpp1)

SPUL:

138605621(inpp1)

LMIX:

132977866(inpp1)

HTC:	141788656(inpp1)

ALAT:

119021230(inpp1)

ASTR:

137594890(inpp1)

PKLU:

139208929(inpp1)

MZE:	101464380(inpp1)

ONL:	100692058(inpp1)

OAU:	116329894(inpp1)

OLA:	101154772(inpp1)

OML:	112145722(inpp1)

CSAI:

133448686(inpp1)

XMA:	102216503(inpp1)

XCO:	114135867(inpp1)

XHE:	116711137(inpp1)

PRET:

103465287(inpp1)

PFOR:

103144301(inpp1)

PLAI:

106934496(inpp1)

PMEI:

106906103(inpp1)

GAF:	122834743(inpp1)

PPRL:

129358108(inpp1)

CVG:	107083317(inpp1)

CTUL:

119791830(inpp1)

GMU:	124856281(inpp1)

NFU:	107385611(inpp1)

KMR:	108235670(inpp1)

ALIM:

106513286(inpp1)

NWH:	119411958(inpp1)

AOCE:

111579734(inpp1)

EJA:	138202469(inpp1)

BFRE:

138627492(inpp1)

MCEP:

125006141(inpp1)

CSEM:

103386015(inpp1)

POV:	109629125(inpp1)

SSEN:

122767990(inpp1)

SSOE:

131460919(inpp1)

HHIP:

117761206(inpp1)

HSP:	118105357(inpp1)

PPLT:

128459387(inpp1)

SMAU:

118309815(inpp1)

LCF:

108898919

SDU:	111221493(inpp1)

SLAL:

111667781(inpp1)

XGL:	120807198(inpp1)

HCQ:	109522370(inpp1)

SSCV:

125976911(inpp1)

SBIA:

133507534(inpp1)

PEE:	133409201(inpp1)

PTAO:

133483320(inpp1)

BPEC:

110171309(inpp1)

ENY:	140365929(inpp1)

MALB:

109956047(inpp1)

BSPL:

114856040(inpp1)

SJO:	128355220(inpp1)

SSCO:

134003259(inpp1)

TTY:	137181746(inpp1)

GMH:	115556790(inpp1)

SASA:

100306749(inpp) 106583335

STRU:

115150414 115208007

OTW:	112215856(inpp1)

OMY:	110494163 110528263

OGO:	124003939(inpp1) 124030750

ONE:	115143033(inpp1)

OKI:	109894193(inpp1)

OKE:	118388721(inpp1) 118400426

OMM:	135539827 135541799

OCLA:

139370954

SALP:

111965037 111970240

SNH:	120062361 120065230

SFON:

129815354 129845414

CCLU:

121575119 121578572

ELS:	105017082(inpp1)

OEP:	134025184(inpp1)

SFM:	108918545 108927928(inpp1)

PKI:	111842935(inpp1) 111854764

AANG:

118211820(inpp1)

AROT:

135238543(inpp1) 135250392

CCOG:

133110704(inpp1) 133124220

LOC:

102690388

PSPA:

121309074 121323234

ARUT:

117400900(inpp1) 117403754 117427192

PSEX:

120531968(inpp1)

LCM:	102349777(INPP1)

CMK:	103176536(inpp1)

RTP:	109925469 109933224

CPLA:

122543262 122551251

CPUN:

140471235 140482072

HOC:	132805712 132817157

SCAU:

119958178(inpp1) 119961806

LERI:

129698639 129714750(inpp1)

HAKA:

140728368 140741298(inpp1)

PMRN:

116947234(INPP1)

LRJ:	133345119(INPP1)

BFO:

BBEL:

CIN:

SCLV:

CLEP:

SPU:

LPIC:

LVG:	121425963 121426670

AJJ:

APLC:

ARUN:

AAMU:

AFIL:

AJC:

SKO:

PFLL:

DME:	Dmel_CG3028(Ipp)

DER:

6553381

DSE:

6606457

DSI:	Dsimw501_GD18939(Dsim_GD18939)

DYA:	Dyak_GE26306

DAN:

DSR:

DPO:

DPE:

DMN:

DWI:

DGR:

DMO:	Dmoj_GI10045

DAZ:

108609143

DNV:

115563516

DHE:

111602750

DVI:	6629641(Ipp)

CCAT:

BOD:

BDR:

RZE:

AOQ:

ALUD:

TDA:	119676334 119677637 119684103

MDE:

SCAC:

LCQ:

LSQ:

CVJ:	135957068(Ipp)

GFS:

ECOE:

CLON:

HIS:

AGA:

ACOZ:

AARA:

AMER:

ASTE:

AMAP:

AFUN:

AMOU:

AMRS:

ANIL:

AALI:

ADAR:

ACOS:

AAG:

AALB:

ASUA:

CQU:	CpipJ_CPIJ015548

CBRI:

CNS:

BCOO:

LLL:

PPAP:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BHUN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

ACOC:

MZT:	108725727(Ipp)

CCOA:

108771845

TCZ:	108757378 108757456

TSEP:

108748575

PBAR:

105430157

VEM:

105565095

COBS:

139101327(Ipp)

TLN:	139816477(Ipp)

TAME:

143894522(Ipp)

HST:

DQU:

CFO:

FEX:

PMEC:

138932028(Ipp)

LHU:	105678194(Ipp)

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:

CSOL:

TPRE:

LHT:

LBD:

MDL:

CGLO:

CTYP:

141538558(Ipp)

FAS:

DAM:

AGIF:

CINS:

VCAN:

CCIN:

DSM:

NPT:	124215836(Ipp)

NFB:

NLO:

NVG:

AROA:

TCA:

TMOL:

138136450(Ipp)

DPA:

109539053

ESIM:

136415925(Ipp)

EFOR:

136339190(Ipp)

SOY:

115891502

RFG:	143201958(Ipp)

AGRG:

ATD:

CSET:

HAXR:

AGB:

LDC:

DVV:

NVL:

APLN:

PPYR:

OTU:

BMOR:

BMAN:

MSEX:

DPL:	KGM_211277

BANY:

MJU:

NIQ:

VCD:

MCIX:

PMAC:

PPOT:

PXU:

BPHI:

137931649(Ipp)

PRAP:

PBX:

PNAP:

ZCE:

CCRC:

LSIN:

AAGE:

HAW:

HZE:

TNL:

SLIU:

OFU:

ONU:

ATRA:

GMW:

ECLR:

140750122(Ipp)

PXY:

PGW:

LGLY:

CSTB:

CFUM:

CFEL:

CCRN:

API:	100162683 103308779

DNX:

AGS:

RMD:

ACOO:

DVT:

BTAB:

DCI:

CLEC:

HHAL:

106691324(Ipp)

NLU:

111043305

LDA:	142330256(Ipp)

HVI:

124368899

MQU:	128998564 128998568

FOC:

TPAL:

ZNE:

CSEC:

PAME:

138700035(Ipp)

SGRE:

126293447

BROR:

134531707

IEL:

124163533

HAMR:

139696685(Ipp)

FCD:

110861442

AFRA:

136030186

PVM:	113813437(Ipp)

PJA:

PCHN:

PMOO:

HAME:

PCLA:

123763711(Ipp)

CQD:	128694848(Ipp)

PTRU:

123502575

ESN:

127005617

MNZ:

135197803

MRJ:	136838518(Ipp)

PORN:

139766033(Ipp)

HAZT:

108683083

OOT:	143035119(Ipp)

EAF:

111701600

LSM:	121129229(Ipp)

TCF:

131882372

PPOI:

119114520

DSV:

119442164

DALB:

135917006(Ipp)

RSAN:

VDE:

VJA:

GOE:

DPTE:

DFR:

CSCU:

CVS:	136974098(Ipp)

PTEP:

ABRU:

UDV:

SDM:

LPOL:

PMEO:

LGI:	LOTGIDRAFT_225152

PVUL:

PCAN:

LSAX:

BARL:

BGT:

GAE:

HRF:

HASI:

HCRA:

CRG:

CANU:

OED:

MYI:

PMAX:

AIRR:

YBA:

MCAF:

MMER:

RPHI:

DPOL:

MAEA:

OBI:

OSN:

LJP:

LAK:	106157083 106159956 106160005

SMM:	Smp_017520

OVI:	T265_04718

LLON:

NVE:

ATEN:

ADF:

MCAZ:

MFOO:

PDAM:

SPIS:

TAD:	TRIADDRAFT_22251

AQU:	100633510 100637942

CCLM:

134190873

» show all

Reference

PMID:8390685

Authors

York JD, Veile RA, Donis-Keller H, Majerus PW

Title

Cloning, heterologous expression, and chromosomal localization of human inositol polyphosphate 1-phosphatase.

Journal

Proc Natl Acad Sci U S A 90:5833-7 (1993)
DOI:10.1073/pnas.90.12.5833

Sequence

[hsa:3628]

LinkDB

DBGET integrated database retrieval system