KEGG   ENZYME: 3.1.3.78
Entry
EC 3.1.3.78                 Enzyme                                 
Name
phosphatidylinositol-4,5-bisphosphate 4-phosphatase;
phosphatidylinositol-4,5-bisphosphate 4-phosphatase I;
phosphatidylinositol-4,5-bisphosphate 4-phosphatase II;
type I PtdIns-4,5-P2 4-Ptase;
type II PtdIns-4,5-P2 4-Ptase;
IpgD;
PtdIns-4,5-P2 4-phosphatase type I;
PtdIns-4,5-P2 4-phosphatase type II;
type I phosphatidylinositol-4,5-bisphosphate 4-phosphatase;
type 1 4-phosphatase
Class
Hydrolases;
Acting on ester bonds;
Phosphoric-monoester hydrolases
Sysname
1-phosphatidyl-1D-myo-inositol-4,5-bisphosphate 4-phosphohydrolase
Reaction(IUBMB)
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 5-phosphate + phosphate [RN:R08981]
Reaction(KEGG)
R08981
Substrate
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate [CPD:C04637];
H2O [CPD:C00001]
Product
1-phosphatidyl-1D-myo-inositol 5-phosphate [CPD:C11557];
phosphate [CPD:C00009]
Comment
Two pathways exist in mammalian cells to degrade 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate [PtdIns(4,5)P2] [2]. One is catalysed by this enzyme and the other by EC 3.1.3.36, phosphoinositide 5-phosphatase, where the product is PtdIns4P. The enzyme from human is specific for PtdIns(4,5)P2 as substrate, as it cannot use PtdIns(3,4,5)P3, PtdIns(3,4)P2, PtdIns(3,5)P2, PtdIns5P, PtdIns4P or PtdIns3P [2]. In humans, the enzyme is localized to late endosomal/lysosomal membranes [2]. It can control nuclear levels of PtdIns5P and thereby control p53-dependent apoptosis [3].
History
EC 3.1.3.78 created 2008
Orthology
K13084  phosphatidylinositol-4,5-bisphosphate 4-phosphatase
K13085  phosphatidylinositol-4,5-bisphosphate 4-phosphatase
Genes
HSA: 55529(PIP4P2) 90809(PIP4P1)
PTR: 464281(PIP4P2) 465201(PIP4P1)
PPS: 100968374(PIP4P2) 100988983(PIP4P1)
GGO: 101129459(PIP4P2) 101132752(PIP4P1)
PON: 100451858(PIP4P2) 100454477(PIP4P1)
NLE: 100587627(PIP4P2) 100593745(PIP4P1)
MCC: 100428001(PIP4P1) 696779(PIP4P2)
MCF: 101866619(PIP4P1) 102115056(PIP4P2)
CSAB: 103231342 103231344 103237111(TMEM55A)
CATY: 105572859(TMEM55A) 105593939(TMEM55B)
PANU: 101001652(PIP4P1) 101009781(PIP4P2)
TGE: 112629452(PIP4P1) 112630711(PIP4P2)
RRO: 104654642(PIP4P2) 104673120(PIP4P1)
RBB: 108527311(TMEM55B) 108528503(TMEM55A)
TFN: 117070090(PIP4P1) 117079004(PIP4P2)
PTEH: 111522534(PIP4P1) 111549729(PIP4P2)
CJC: 100402264(TMEM55B) 100407390(TMEM55A)
SBQ: 101027468(TMEM55B) 101033445(TMEM55A)
CSYR: 103250423(TMEM55B) 103271008(TMEM55A)
MMUR: 105864729(TMEM55B) 105869110(TMEM55A)
OGA: 100951924(PIP4P2) 100962704(PIP4P1)
MMU: 219024(Pip4p1) 72519(Pip4p2)
MCAL: 110292720(Tmem55a) 110309188(Tmem55b)
MPAH: 110325348(Tmem55b) 110338742(Tmem55a)
RNO: 362490(Pip4p2) 364298(Pip4p1)
MCOC: 116084318(Pip4p1) 116088053(Pip4p2)
MUN: 110549703(Tmem55b) 110557768(Tmem55a)
CGE: 100757444(Pip4p1) 100767770(Pip4p2)
PLEU: 114694593(Pip4p2) 114696012(Pip4p1)
NGI: 103729539(Tmem55a) 103733665(Tmem55b)
HGL: 101709122(Tmem55b) 101718072(Tmem55a)
CPOC: 100713718(Pip4p2) 100718609(Pip4p1)
CCAN: 109690515(Tmem55a) 109692126(Tmem55b)
DORD: 105982754(Tmem55a) 106000447(Tmem55b)
DSP: 122102382(Pip4p2) 122126588(Pip4p1)
NCAR: 124976820 124979632
OCU: 100349176(TMEM55B) 100353159(TMEM55A)
OPI: 101523968(PIP4P2) 101529039(PIP4P1)
TUP: 102475472(TMEM55B) 102487160 102499548(TMEM55A)
CFA: 477939(PIP4P2) 482559(PIP4P1)
VVP: 112914985(PIP4P1) 112931637(PIP4P2)
VLG: 121481490(PIP4P1) 121499023(PIP4P2)
AML: 100479476(PIP4P2) 100484149(PIP4P1)
UMR: 103656314(TMEM55B) 103661475(TMEM55A)
UAH: 113248962(PIP4P1) 113252947(PIP4P2)
UAR: 123783909(PIP4P1) 123797894(PIP4P2)
ELK: 111146677 111162295
LLV: 125098925 125103918
MPUF: 101672290(TMEM55A) 101692628(TMEM55B)
ORO: 101372920(TMEM55B) 101382006(TMEM55A)
EJU: 114216080(PIP4P2) 114221365(PIP4P1)
ZCA: 113908838(PIP4P1) 113914498(PIP4P2)
MLX: 118002964(PIP4P1) 118015002(PIP4P2)
FCA: 101080798(PIP4P1) 101088301(PIP4P2)
PYU: 121031403(PIP4P1) 121042685(PIP4P2)
PBG: 122467674(PIP4P1) 122495586(PIP4P2)
PTG: 102952164(TMEM55A) 102956222(TMEM55B)
PPAD: 109255760(TMEM55B) 109269475(TMEM55A)
AJU: 106971402(PIP4P1) 106984681(PIP4P2)
HHV: 120225955(PIP4P1) 120237341(PIP4P2) 120242017 120246391
BTA: 615077(PIP4P1) 616641(PIP4P2)
BOM: 102268358(TMEM55B) 102277826(TMEM55A)
BIU: 109564878(TMEM55B) 109568638(TMEM55A)
BBUB: 102392943(PIP4P2) 102415190(PIP4P1)
CHX: 102172557(TMEM55A) 102177240(TMEM55B)
OAS: 101111559(PIP4P2) 101117510(PIP4P1)
ODA: 120853335(PIP4P1) 120878509(PIP4P2)
CCAD: 122443317(PIP4P1) 122451301(PIP4P2)
SSC: 100155939(TMEM55B) 100156639(TMEM55A)
CFR: 102505095(PIP4P2) 102507379(PIP4P1)
CBAI: 105064674(TMEM55B) 105079632(TMEM55A)
CDK: 105085724(PIP4P2) 105097644(PIP4P1)
VPC: 102541289(PIP4P1) 102541483(PIP4P2)
BACU: 103007264(TMEM55A) 103012880(TMEM55B)
LVE: 103084248(TMEM55B) 103085248(TMEM55A)
OOR: 101273070(TMEM55A) 101273871(TMEM55B)
DLE: 111180432(PIP4P2) 111181805(PIP4P1)
PCAD: 102978742(PIP4P2) 102982773(PIP4P1)
PSIU: 116742418(PIP4P2) 116749983(PIP4P1) 116763783
ECB: 100050790(PIP4P2) 100058648(PIP4P1)
EPZ: 103559551(TMEM55B) 103564881(TMEM55A)
EAI: 106833288(PIP4P1) 106838979(PIP4P2)
MYB: 102241548(TMEM55A) 102252193(TMEM55B)
MYD: 102754867(TMEM55B) 102773968(TMEM55A)
MMYO: 118649171(PIP4P1) 118670481(PIP4P2)
MLF: 102422557(PIP4P1) 102436205(PIP4P2)
MNA: 107526961(TMEM55B)
PKL: 118718475(PIP4P2) 118724275(PIP4P1)
HAI: 109376449(TMEM55B)
DRO: 112310316(PIP4P2) 112311620(PIP4P1)
SHON: 118982616(PIP4P1) 118989291(PIP4P2)
AJM: 119036603(PIP4P1) 119047622(PIP4P2)
PDIC: 114490301(PIP4P1) 114501670(PIP4P2)
PHAS: 123808166(PIP4P1) 123820957(PIP4P2)
MMF: 118631649(PIP4P2) 118641633(PIP4P1)
RFQ: 117023446(PIP4P1) 117033621(PIP4P2)
PALE: 102898229(PIP4P2) 102898278(PIP4P1)
PGIG: 120608059(PIP4P1) 120614258(PIP4P2)
PVP: 105304152(PIP4P2) 105308945(PIP4P1)
RAY: 107507437(TMEM55A) 107521160(TMEM55B)
MJV: 108387665(TMEM55A) 108403281(TMEM55B)
TOD: 119238854(PIP4P1) 119239895(PIP4P2)
SARA: 101537201(TMEM55B) 101555869(TMEM55A)
LAV: 100660816(PIP4P1) 100664641(PIP4P2)
TMU: 101345599 101357101
DNM: 101418300(PIP4P2) 101421442(PIP4P1)
MDO: 100022045(TMEM55A) 100022893(TMEM55B)
GAS: 123231880(PIP4P2) 123236082(PIP4P1)
SHR: 100916303(PIP4P2) 100924788(PIP4P1)
PCW: 110198547(TMEM55A) 110217864(TMEM55B)
OAA: 100086066(PIP4P1) 100092908(PIP4P2)
GGA: 420221(PIP4P2)
PCOC: 116227600(PIP4P2)
MGP: 100542892(PIP4P2)
CJO: 107307004(PIP4P1) 107310378(PIP4P2)
NMEL: 110393858(TMEM55A)
APLA: 101802244(PIP4P2)
ACYG: 106030630(TMEM55A)
AFUL: 116486080(PIP4P2)
TGU: 100226950(PIP4P2)
LSR: 110477429(PIP4P2) 110481133(PIP4P1)
SCAN: 103813442(PIP4P2) 115484135(PIP4P1)
PMOA: 120500834(PIP4P2)
OTC: 121340325(PIP4P2) 121342965
PRUF: 121349816 121351993(PIP4P2)
GFR: 102040381(TMEM55A)
FAB: 101810791(TMEM55A)
PHI: 102099741(TMEM55A) 102101128(TMEM55B)
PMAJ: 107199089(TMEM55B) 107200089(TMEM55A)
CCAE: 111924560(PIP4P2)
CCW: 104692756(PIP4P2)
ETL: 114061739(PIP4P2)
ZAB: 102062275(PIP4P2)
FPG: 101922579(TMEM55A)
FCH: 102055459(PIP4P2)
CLV: 102090519(TMEM55A)
EGZ: 104125810(TMEM55A)
NNI: 104016500(TMEM55A)
ACUN: 113476160(PIP4P2)
TALA: 104359578(PIP4P2)
PADL: 103917331(TMEM55A)
ACHC: 115340537(PIP4P2)
AAM: 106496195(TMEM55A)
AROW: 112964070(PIP4P2)
NPD: 112950677(PIP4P2)
DNE: 112982968(PIP4P2)
ASN: 102373932(PIP4P2) 102374449(PIP4P1)
AMJ: 102562249(TMEM55B) 102570595(TMEM55A)
CPOO: 109320301(TMEM55A) 109320545(TMEM55B)
GGN: 109294681(TMEM55B) 109305031(TMEM55A)
PSS: 102457479(PIP4P2)
CMY: 102938814(PIP4P2) 102941676(PIP4P1)
CPIC: 101937348(PIP4P2) 101946066(PIP4P1)
TST: 117871665(PIP4P2) 117885343(PIP4P1)
CABI: 116816452(PIP4P1) 116839386(PIP4P2)
MRV: 120380995(PIP4P1) 120396740(PIP4P2)
ACS: 100556773(tmem55a) 100567084(tmem55b)
PVT: 110089558(TMEM55B) 110090207(TMEM55A)
SUND: 121930003(PIP4P2) 121934894(PIP4P1)
PBI: 103047975(PIP4P1) 103054248(PIP4P2)
PMUR: 107285754(PIP4P2) 107292313(PIP4P1)
TSR: 106545515(TMEM55A) 106549927(TMEM55B)
PGUT: 117662190(PIP4P1) 117668494(PIP4P2)
VKO: 123019493(PIP4P1) 123020326(PIP4P2)
PMUA: 114581602(PIP4P1) 114600438(PIP4P2)
ZVI: 118090061(PIP4P2) 118095026(PIP4P1)
GJA: 107105993(TMEM55A) 107116165(TMEM55B)
STOW: 125439088(PIP4P2) 125445234(PIP4P1)
XLA: 108695381(pip4p2.S) 108707045(pip4p1.S) 494834(pip4p1.L) 734343(pip4p2.L)
XTR: 100170610(pip4p1) 448483(pip4p2)
NPR: 108788678(TMEM55B) 108800143(TMEM55A)
RTEM: 120940082(PIP4P1) 120941297(PIP4P2)
BBUF: 120988956(PIP4P1) 121001674(PIP4P2)
BGAR: 122933402(PIP4P1) 122939001(PIP4P2)
DRE: 553253(pip4p1b) 556136(pip4p1a) 566642(pip4p2)
SRX: 107709255 107721780 107723169 107724355 107749147
SANH: 107659916 107665981 107692688 107692894 107696196 107702130
SGH: 107555555(tmem55a) 107565103 107576828 107584351 107590777 107600071(tmem55b)
CCAR: 109045146 109053437 109065694 109075342 109077248 109088132 109090962 109109172
CAUA: 113044494 113045079 113070034 113075861 113091867 113109880 113114327 113119590(pip4p2)
PPRM: 120463074(pip4p1b) 120484999(pip4p2) 120495422(pip4p1a)
MAMB: 125251114(pip4p1a) 125272771(pip4p1b) 125274829(pip4p2)
IPU: 108273350(pip4p2) 108274853 108280404(pip4p1a)
PHYP: 113523871 113533535(pip4p1) 113543834(pip4p2)
SMEO: 124382184(pip4p2) 124403093(pip4p1a)
TFD: 113634755(pip4p2) 113640592(pip4p1a) 113648653 125145681
AMEX: 103033991(pip4p1) 103040016(pip4p2) 103040625
EEE: 113574929 113580968(pip4p2) 113588959(pip4p1)
TRU: 101062738(pip4p1) 101068075(pip4p2) 101075194(pip4p1) 115251759
TNG: GSTEN00021192G001 GSTEN00033018G001
LCO: 104924562(pip4p2) 104926554(pip4p1) 104936244
NCC: 104947052(tmem55a) 104948613(tmem55b)
CGOB: 115016250(pip4p2)
ELY: 117245953 117263899(pip4p2) 117271648(pip4p1a)
PLEP: 121951708(pip4p1a) 121958323(pip4p2) 121962432
SLUC: 116040589(pip4p1a) 116047453(pip4p2) 116053086
ECRA: 117935074 117953665(pip4p1a) 117957036(pip4p2)
PFLV: 114545567 114565150(pip4p1) 114568780(pip4p2)
GAT: 120814228(pip4p1a) 120821340 120827077(pip4p2)
PPUG: 119207320(pip4p1a) 119219199(pip4p2) 119223022
MSAM: 119901556 119901743(pip4p1a) 119907514(pip4p2) 119913171
CUD: 121504482 121520060(pip4p1a) 121523213(pip4p2)
MZE: 101466447 101468284(pip4p2) 101479252(pip4p1)
ONL: 100693615(pip4p1) 100706272(pip4p2) 100710349
OAU: 116312075(pip4p2) 116332048 116332092(pip4p1a)
OLA: 101159467 101161334 101166147(pip4p2)
OML: 112150645(pip4p1a) 112155987 112160340(pip4p2)
XMA: 102224770 102227240(pip4p2) 102234414(pip4p1)
XCO: 114145811(pip4p1) 114156427(pip4p2) 114157811
XHE: 116722183(pip4p1) 116731725(pip4p2) 116732542
PRET: 103472397(tmem55a) 103479490(tmem55b) 103480619
PFOR: 103135131(tmem55a) 103137995(tmem55b) 103138007 103149154
PLAI: 106944687 106946254(tmem55a) 106960164(tmem55b)
PMEI: 106903481 106910744(tmem55b) 106914598 106918621(tmem55a)
GAF: 122820284 122841343(pip4p1a) 122843283(pip4p2)
CVG: 107092441(tmem55a) 107092674(tmem55b) 107095498
CTUL: 119779521(pip4p1a) 119784408 119795840(pip4p2)
GMU: 124870263(pip4p1a) 124879343(pip4p2) 124880396
NFU: 107376897 107383456(tmem55b) 107394745(tmem55a)
KMR: 108232969(pip4p1a) 108237806(pip4p2) 108248594
ALIM: 106515818(tmem55a) 106520802(tmem55b) 106523839
NWH: 119409972 119414799(pip4p1a) 119426013(pip4p2)
AOCE: 111563765(pip4p2) 111570900 111574634 111576584
CSEM: 103388924 103394417(tmem55a) 103396783(tmem55b)
POV: 109631912(tmem55a) 109645994(tmem55b) 109647653
SSEN: 122759258(pip4p1a) 122766321 122786912(pip4p2)
HHIP: 117751911 117770135(pip4p2) 117777897(pip4p1a)
LCF: 108873687 108884334 108898155(tmem55a)
SDU: 111223251(pip4p2) 111233362 111239391(pip4p1)
SLAL: 111657891 111659343(pip4p2) 111668450(pip4p1)
XGL: 120786092(pip4p2) 120797577 120799177(pip4p1a)
HCQ: 109506970 109517989(tmem55a) 109529491(tmem55b)
BPEC: 110167447(tmem55a) 110170780 110175124(tmem55b)
MALB: 109952910(tmem55a) 109974206 109974507
SASA: 106569577 106570754 106589142(tmem55a) 106600488 106608438
OTW: 112226565 112229181 112236503(pip4p1a) 112239907 112241833
OMY: 110487822(pip4p2) 110504292 110508329(pip4p1a) 110512265 110530761
OGO: 123996760 124009576 124013190 124041636(pip4p1a) 124043125
ONE: 115102832 115115331 115125483 115128057
SALP: 111974344 111979801(pip4p1) 112073639 112076069(pip4p2)
SNH: 120020656 120027946 120041077(pip4p2) 120049537 120056169
ELS: 105006704(pip4p2) 105024555(pip4p1) 105030639
SFM: 108919216(pip4p2) 108926151 108937836
PKI: 111833149 111845350 111848239(pip4p2)
AANG: 118211335 118231305 118234635(pip4p2)
LOC: 102683795(tmem55b) 102691229(tmem55a)
PSPA: 121305330 121307399 121313200 121314988 121329256
ARUT: 117395030 117398263 117398906 117399698 117425668
LCM: 102348811(TMEM55A) 102357306(TMEM55B)
CMK: 103191060(pip4p2)
RTP: 109918341(tmem55b) 109938918(tmem55a)
BFO: 118417220
BBEL: 109483241
CIN: 104266484
SPU: 588430
APLC: 110980124
SKO: 100368816
DME: Dmel_CG6707(CG6707)
DER: 6546082
DSE: 6605120
DSI: Dsimw501_GD12881(Dsim_GD12881)
DYA: Dyak_GE20289
DAN: 6506490
DSR: 110190635
DPO: Dpse_GA19800
DPE: 6600238
DMN: 108151830
DWI: 6638715
DGR: 6557366
DMO: Dmoj_GI13013
DAZ: 108613220
DNV: 108651252
DHE: 111598717
DVI: 6623987
CCAT: 101458043
BOD: 106619668
MDE: 101893850
SCAC: 106093469
LCQ: 111682675
AGA: AgaP_AGAP006243
ACOZ: 120951221
AARA: 120898884
AAG: 5574542
AALB: 109428654
CQU: CpipJ_CPIJ009913
CPII: 120418667
CNS: 116347912
AME: 408301
ACER: 108001187
ALAB: 122710420
BIM: 100749086
BBIF: 117205240
BVK: 117230173
BVAN: 117162943
BTER: 100646549
BPYO: 122571788
CCAL: 108622913
OBB: 114874660
MGEN: 117217459
NMEA: 116424096
CGIG: 122402714
SOC: 105200883
MPHA: 105839704
AEC: 105143615
ACEP: 105620209
PBAR: 105430510
VEM: 105563835
HST: 105186717
DQU: 106748938
CFO: 105255380
FEX: 115239704
LHU: 105674095
PGC: 109854987
OBO: 105282957
PCF: 106791075
PFUC: 122519801
VPS: 122630485
NVI: 100120829
CSOL: 105359276
TPRE: 106649016
MDL: 103578153 106693532
CGLO: 123264322
FAS: 105270733
DAM: 107043087
AGIF: 122860638
CCIN: 107264242
TCA: 655804
DPA: 109534456
SOY: 115877178
ATD: 109603339 109605889
CSET: 123318730
AGB: 108913856
LDC: 111504067
NVL: 108563960
APLN: 108735740
PPYR: 116174180
OTU: 111420505
BMOR: 101741980 119629095
BMAN: 114247478
MSEX: 115440024
DPL: KGM_213618 KGM_213619
BANY: 112043167
PMAC: 106719144
PPOT: 106109686
PXU: 106121436
PRAP: 110992215
ZCE: 119828288
HAW: 110370045
TNL: 113501279
SLIU: 111358774
OFU: 114361656
PXY: 105393931
API: 100164628
DNX: 107167499
AGS: 114121256
RMD: 113556156
BTAB: 109035975
DCI: 103518847 103518848
CLEC: 106665999
HHAL: 106690513
NLU: 111043649
PHU: Phum_PHUM358690 Phum_PHUM617960
FOC: 113203769
ZNE: 110834071
CSEC: 111869495
FCD: 110849352
DPX: DAPPUDRAFT_235760 DAPPUDRAFT_304652 DAPPUDRAFT_43581
DMK: 116915446 123469750
PVM: 113800971 113802341
PJA: 122250017
PCHN: 125030796
HAME: 121871871
PCLA: 123760636
PTRU: 123506685
HAZT: 108665058
EAF: 111709775
LSM: 121117358
ISC: IscW_ISCW008198
DSV: 119432683 119465627
RSAN: 119374570 119377643
RMP: 119176165 119176407
VDE: 111244394 111245807
VJA: 111265977 111272307
TUT: 107359622
DPTE: 113789342
DFR: 124495003
CSCU: 111630924 111642355
PTEP: 107452055
SDM: 118195297 118203607
CEL: CELE_Y71H2AM.2(Y71H2AM.2)
CBR: CBG_00490
BMY: BM_BM7065(Bm7065)
LOA: LOAG_02822
HRO: HELRODRAFT_187998
LGI: LOTGIDRAFT_133999
PCAN: 112576610
BGT: 106069844
GAE: 121389550
HRF: 124136840
HRJ: 124259351
CRG: 105338362
MYI: 110464767
PMAX: 117337259
MMER: 123548748
OBI: 106874795
OSN: 115220847
LAK: 106178509
SMM: Smp_022540.1
SHX: MS3_0017559
OVI: T265_09562 T265_11868
EGL: EGR_01135 EGR_09393
NVE: 5521597
EPA: 110248578
ATEN: 116304727
ADF: 107342237
AMIL: 114977192
PDAM: 113677853
SPIS: 111332610
DGT: 114516540
XEN: 124436983
HMG: 100208471
AQU: 100632025
EMA: C1192_24285
STY: STY1121(sigD)
STT: t1828(sigD)
SEX: STBHUCCB_19440
SENT: TY21A_09295
STM: STM1091(sopB)
SEO: STM14_1237(sopB)
SEV: STMMW_11031
SEY: SL1344_1030(sopB)
SEM: STMDT12_C11120
SEJ: STMUK_1060(sopB)
SEB: STM474_1083(sopB)
SEF: UMN798_1133(sigD)
SETU: STU288_01790
SETC: CFSAN001921_11720(sopB)
SENR: STMDT2_10271(sigD)
SEND: DT104_10731(sopB)
SENI: CY43_05575(sopB)
SEEN: SE451236_11305(sopB)
SPT: SPA1759(sigD)
SEK: SSPA1634
SPQ: SPAB_02464
SEI: SPC_2659(sigD)
SEC: SCH_1043(sopB)
SEH: SeHA_C1201
SHB: SU5_01724
SENH: CFSAN002069_03565(sopB)
SEEH: SEEH1578_14685
SEE: SNSL254_A1187
SENN: SN31241_21590
SEW: SeSA_A1155
SEA: SeAg_B1050
SENS: Q786_04870(sopB)
SED: SeD_A1167
SEG: SG0980(sopB)
SEL: SPUL_1966(sopB)
SEGA: SPUCDC_1952(sopB)
SET: SEN0955(sopB)
SENA: AU38_04930(sopB)
SENO: AU37_04920(sopB)
SENV: AU39_04920(sopB)
SENQ: AU40_05535(sopB)
SENL: IY59_05020(sopB)
SENJ: CFSAN001992_06185
SEEC: CFSAN002050_11850(sopB)
SEEB: SEEB0189_014115(sopB)
SEEP: I137_08940(sopB)
SENB: BN855_10450
SENE: IA1_05370(sopB)
SENC: SEET0819_12115(sopB)
SES: SARI_01910
SBG: SBG_0939(sopB)
SBZ: A464_1030
SBV: N643_04465(sopB)
SALZ: EOS98_14165
SFL: CP0133(ipgD)
SFE: SFxv_4976(ipgD)
SSN: SSON_P095(ipgD)
SBC: SbBS512_A0166(ipgD)
SDY: SDY_P171(ipgD)
SDZ: Asd1617_06366
SYM: K6K13_10905
YAL: AT01_2850(sopB)
FSM: CCS41_07775
RBAD: H2866_19305
SOD: Sant_3206(sigD) Sant_3209(sigD2)
PAY: PAU_01919
PSI: S70_12925
PSX: DR96_586(sopB)
PSTA: BGK56_15810
PVC: G3341_17095
ANS: ArsFIN_43100(sopB)
VAN: VAA_02157
LAG: N175_09340
VAU: VANGNB10_cI1105
ENW: MJO57_02340
CRZ: D1345_19490
CHAE: CH06BL_40220(sopB_sigD)
IFL: C1H71_17665(sopB)
PPK: U875_18870
PPNO: DA70_11385
PPNM: LV28_19660
LIMN: HKT17_05800
BGM: CAL15_03515
CDN: BN940_04026
PVAC: HC248_01669(ipgD)
COF: FOZ74_09105
DPG: DESPIGER_2147
STAR: G3545_19400
HMC: HYPMC_3453
PSF: PSE_2750(ipgD)
OXY: HCG48_18215
PCU: PC_RS06055
PNL: PNK_0614(ipgD)
 » show all
Reference
1  [PMID:12356723]
  Authors
Niebuhr K, Giuriato S, Pedron T, Philpott DJ, Gaits F, Sable J, Sheetz MP, Parsot C, Sansonetti PJ, Payrastre B
  Title
Conversion of PtdIns(4,5)P(2) into PtdIns(5)P by the S.flexneri effector IpgD reorganizes host cell morphology.
  Journal
EMBO J 21:5069-78 (2002)
DOI:10.1093/emboj/cdf522
  Sequence
[sfl:CP0133]
Reference
2  [PMID:16365287]
  Authors
Ungewickell A, Hugge C, Kisseleva M, Chang SC, Zou J, Feng Y, Galyov EE, Wilson M, Majerus PW
  Title
The identification and characterization of two phosphatidylinositol-4,5-bisphosphate 4-phosphatases.
  Journal
Proc Natl Acad Sci U S A 102:18854-9 (2005)
DOI:10.1073/pnas.0509740102
  Sequence
[hsa:55529 90809]
Reference
3  [PMID:17940011]
  Authors
Zou J, Marjanovic J, Kisseleva MV, Wilson M, Majerus PW
  Title
Type I phosphatidylinositol-4,5-bisphosphate 4-phosphatase regulates stress-induced apoptosis.
  Journal
Proc Natl Acad Sci U S A 104:16834-9 (2007)
DOI:10.1073/pnas.0708189104
Reference
4  [PMID:17389247]
  Authors
Mason D, Mallo GV, Terebiznik MR, Payrastre B, Finlay BB, Brumell JH, Rameh L, Grinstein S
  Title
Alteration of epithelial structure and function associated with PtdIns(4,5)P2 degradation by a bacterial phosphatase.
  Journal
J Gen Physiol 129:267-83 (2007)
DOI:10.1085/jgp.200609656
Other DBs
ExplorEnz - The Enzyme Database: 3.1.3.78
IUBMB Enzyme Nomenclature: 3.1.3.78
ExPASy - ENZYME nomenclature database: 3.1.3.78
BRENDA, the Enzyme Database: 3.1.3.78
LinkDB

DBGET integrated database retrieval system