KEGG   ENZYME: 3.1.3.78
Entry
EC 3.1.3.78                 Enzyme                                 
Name
phosphatidylinositol-4,5-bisphosphate 4-phosphatase;
phosphatidylinositol-4,5-bisphosphate 4-phosphatase I;
phosphatidylinositol-4,5-bisphosphate 4-phosphatase II;
type I PtdIns-4,5-P2 4-Ptase;
type II PtdIns-4,5-P2 4-Ptase;
IpgD;
PtdIns-4,5-P2 4-phosphatase type I;
PtdIns-4,5-P2 4-phosphatase type II;
type I phosphatidylinositol-4,5-bisphosphate 4-phosphatase;
type 1 4-phosphatase
Class
Hydrolases;
Acting on ester bonds;
Phosphoric-monoester hydrolases
Sysname
1-phosphatidyl-1D-myo-inositol-4,5-bisphosphate 4-phosphohydrolase
Reaction(IUBMB)
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 5-phosphate + phosphate [RN:R08981]
Reaction(KEGG)
R08981
Substrate
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate [CPD:C04637];
H2O [CPD:C00001]
Product
1-phosphatidyl-1D-myo-inositol 5-phosphate [CPD:C11557];
phosphate [CPD:C00009]
Comment
Two pathways exist in mammalian cells to degrade 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate [PtdIns(4,5)P2] [2]. One is catalysed by this enzyme and the other by EC 3.1.3.36, phosphoinositide 5-phosphatase, where the product is PtdIns4P. The enzyme from human is specific for PtdIns(4,5)P2 as substrate, as it cannot use PtdIns(3,4,5)P3, PtdIns(3,4)P2, PtdIns(3,5)P2, PtdIns5P, PtdIns4P or PtdIns3P [2]. In humans, the enzyme is localized to late endosomal/lysosomal membranes [2]. It can control nuclear levels of PtdIns5P and thereby control p53-dependent apoptosis [3].
History
EC 3.1.3.78 created 2008
Orthology
K13084  phosphatidylinositol-4,5-bisphosphate 4-phosphatase
K13085  phosphatidylinositol-4,5-bisphosphate 4-phosphatase
Genes
HSA: 55529(PIP4P2) 90809(PIP4P1)
PTR: 464281(PIP4P2) 465201(PIP4P1)
PPS: 100968374(PIP4P2) 100988983(PIP4P1)
GGO: 101129459(PIP4P2) 101132752(PIP4P1)
PON: 100451858(PIP4P2) 134760037(PIP4P1)
PPYG: 129012581(PIP4P1) 129042160(PIP4P2)
NLE: 100587627(PIP4P2) 100593745(PIP4P1)
HMH: 116484592(PIP4P1) 116813406(PIP4P2)
SSYN: 129486596(PIP4P2) 129487975(PIP4P1)
MCC: 100428001(PIP4P1) 696779(PIP4P2)
MCF: 101866619(PIP4P1) 102115056(PIP4P2)
MTHB: 126958302 126961846
MNI: 105497274(PIP4P2) 105499192(PIP4P1)
CSAB: 103231342 103231344 103237111(TMEM55A)
CATY: 105572859(TMEM55A) 105593939(TMEM55B)
PANU: 101001652(PIP4P1) 101009781(PIP4P2)
TGE: 112629452(PIP4P1) 112630711(PIP4P2)
MLEU: 105532033(TMEM55A) 105536724(TMEM55B)
RRO: 104654642(PIP4P2) 104673120(PIP4P1)
RBB: 108527311(TMEM55B) 108528503(TMEM55A)
TFN: 117070090(PIP4P1) 117079004(PIP4P2)
PTEH: 111522534(PIP4P1) 111549729(PIP4P2)
CANG: 105508233(TMEM55A) 105523149(TMEM55B)
CJC: 100402264(PIP4P1) 100407390(PIP4P2)
SBQ: 101027468(TMEM55B) 101033445(TMEM55A)
CIMI: 108310883(PIP4P2) 108311932(PIP4P1)
ANAN: 105725886(PIP4P2) 105726336(PIP4P1)
CSYR: 103250423(TMEM55B) 103271008(TMEM55A)
MMUR: 105864729(TMEM55B) 105869110(TMEM55A)
LCAT: 123621516(PIP4P1) 123644665(PIP4P2)
PCOQ: 105809733(TMEM55A) 105814398(TMEM55B)
OGA: 100951924(PIP4P2) 100962704(PIP4P1)
MMU: 219024(Pip4p1) 72519(Pip4p2)
MCAL: 110292720(Pip4p2) 110309188(Pip4p1)
MPAH: 110325348(Tmem55b) 110338742(Tmem55a)
RNO: 362490(Pip4p2) 364298(Pip4p1)
MCOC: 116084318(Pip4p1) 116088053(Pip4p2)
ANU: 117698715(Pip4p2) 117705197(Pip4p1)
ASYL: 127680567(Pip4p2) 127691642(Pip4p1)
MUN: 110549703(Pip4p1) 110557768(Pip4p2)
CGE: 100757444(Pip4p1) 100767770(Pip4p2)
MAUA: 101826945(Pip4p2) 101835221(Pip4p1)
PROB: 127216190(Pip4p1) 127232002(Pip4p2)
PLEU: 114694593(Pip4p2) 114696012(Pip4p1)
MORG: 121438588(Pip4p1) 121451254(Pip4p2)
MFOT: 126492851 126515920
AAMP: 119800363(Pip4p1) 119821440 119826590(Pip4p2)
NGI: 103729539(Tmem55a) 103733665(Tmem55b)
HGL: 101709122(Tmem55b) 101718072(Tmem55a)
CPOC: 100713718(Pip4p2) 100718609(Pip4p1)
CCAN: 109690515(Tmem55a) 109692126(Tmem55b)
DORD: 105982754(Tmem55a) 106000447(Tmem55b)
DSP: 122102382(Pip4p2) 122126588(Pip4p1)
PLOP: 125358523(Pip4p1) 125360907(Pip4p2)
NCAR: 124976820 124979632
MMMA: 107138264(Pip4p1) 107142308(Pip4p2)
ITI: 101957054(Pip4p2) 101961891(Pip4p1)
OCU: 100338400 100349176(PIP4P1) 100353159(PIP4P2)
OPI: 101523968(PIP4P2) 101529039(PIP4P1)
TUP: 102475472(TMEM55B) 102487160 102499548(TMEM55A)
GVR: 103599363(TMEM55A) 103605041(TMEM55B)
CFA: 477939(PIP4P2) 482559(PIP4P1)
CLUD: 112650712(PIP4P2) 112654418(PIP4P1)
VVP: 112914985(PIP4P1) 112931637(PIP4P2)
VLG: 121481490(PIP4P1) 121499023(PIP4P2)
NPO: 129495774(PIP4P2) 129520681(PIP4P1)
AML: 100479476(PIP4P2) 100484149(PIP4P1)
UMR: 103656314(PIP4P1) 103661475(PIP4P2)
UAH: 113248962(PIP4P1) 113252947(PIP4P2)
UAR: 123783909(PIP4P1) 123797894(PIP4P2)
ELK: 111146677 111162295
LLV: 125098925 125103918
MPUF: 101672290(TMEM55A) 101692628(TMEM55B)
MNP: 131999591(PIP4P1) 132014151(PIP4P2)
MLK: 131826617(PIP4P2) 131836036(PIP4P1)
NVS: 122893351(PIP4P1) 122904450(PIP4P2)
ORO: 101372920(TMEM55B) 101382006(TMEM55A)
EJU: 114216080(PIP4P2) 114221365(PIP4P1)
ZCA: 113908838(PIP4P1) 113914498(PIP4P2)
MLX: 118002964(PIP4P1) 118015002(PIP4P2)
NSU: 110578689(PIP4P2) 110585483(PIP4P1)
LWW: 102725677(PIP4P1) 102740214(PIP4P2)
FCA: 101080798(PIP4P1) 101088301(PIP4P2)
PYU: 121031403(PIP4P1) 121042685(PIP4P2)
PCOO: 112856471(PIP4P1) 112859309(PIP4P2)
PBG: 122467674(PIP4P1) 122495586(PIP4P2)
PVIV: 125156474(PIP4P2) 125168344(PIP4P1)
LRUF: 124508753 124519060
LGF: 123583266(PIP4P1) 123585804(PIP4P2)
AJU: 106971402(PIP4P1) 106984681(PIP4P2)
PTG: 102952164(TMEM55A) 102956222(TMEM55B)
PPAD: 109255760(TMEM55B) 109269475(TMEM55A)
PUC: 125909747 125924809
PLEZ: 122211022(PIP4P2) 122222266(PIP4P1)
HHV: 120225955(PIP4P1) 120237341(PIP4P2) 120242017 120246391
BTA: 615077(PIP4P1) 616641(PIP4P2)
BOM: 102268358(PIP4P1) 102277826(PIP4P2)
BIU: 109564878(TMEM55B) 109568638(TMEM55A)
BBUB: 102392943(PIP4P2) 102415190(PIP4P1)
BBIS: 104988202(TMEM55B) 105004424(TMEM55A)
CHX: 102172557(TMEM55A) 102177240(TMEM55B)
OAS: 101111559(PIP4P2) 101117510(PIP4P1)
BTAX: 128053790(PIP4P1) 128059339(PIP4P2)
CSUM: 138073419(PIP4P1) 138088511(PIP4P2)
ODA: 120853335(PIP4P1) 120878509(PIP4P2)
CCAD: 122443317(PIP4P1) 122451301(PIP4P2)
MREE: 136144871(PIP4P2) 136171778(PIP4P1)
OVR: 110122490(PIP4P2) 110133407(PIP4P1)
MBEZ: 129560119(PIP4P2) 129563108(PIP4P1)
SSC: 100155939(TMEM55B) 100156639(TMEM55A)
CFR: 102505095(PIP4P2) 102507379(PIP4P1)
CBAI: 105064674(TMEM55B) 105079632(TMEM55A)
CDK: 105085724(PIP4P2) 105097644(PIP4P1)
VPC: 102541289(PIP4P1) 102541483(PIP4P2)
BACU: 103007264(TMEM55A) 103012880(TMEM55B)
BMUS: 118883509(PIP4P2) 118891336(PIP4P1) 118905512
LVE: 103084248(TMEM55B) 103085248(TMEM55A)
OOR: 101273070(PIP4P2) 101273871(PIP4P1)
LALB: 132507891(PIP4P2) 132518615(PIP4P1) 132530827
DLE: 111180432(PIP4P2) 111181805(PIP4P1)
PCAD: 102978742(PIP4P2) 102982773(PIP4P1)
PSIU: 116742418(PIP4P2) 116749983(PIP4P1) 116763783
NASI: 112410017(PIP4P2) 112410622(PIP4P1)
ECB: 100050790(PIP4P2) 100058648(PIP4P1)
EPZ: 103559551(PIP4P1) 103564881(PIP4P2)
EAI: 106833288(PIP4P1) 106838979(PIP4P2)
MYB: 102241548(TMEM55A) 102252193(TMEM55B)
MYD: 102754867(TMEM55B) 102773968(TMEM55A)
MMYO: 118649171(PIP4P1) 118670481(PIP4P2)
MLF: 102422557(PIP4P1) 102436205(PIP4P2)
MDT: 132219678(PIP4P2) 132239553(PIP4P1)
MYUM: 138993087(PIP4P2) 139017429(PIP4P1)
PKL: 118718475(PIP4P2) 118724275(PIP4P1)
EFUS: 103301857(PIP4P2) 103303503(PIP4P1)
MNA: 107526961(TMEM55B)
DRO: 112310316(PIP4P2) 112311620(PIP4P1)
SHON: 118982616(PIP4P1) 118989291(PIP4P2)
AJM: 119036603(PIP4P1) 119047622(PIP4P2)
PDIC: 114490301(PIP4P1) 114501670(PIP4P2)
PHAS: 123808166(PIP4P1) 123820957(PIP4P2)
MMF: 118631649(PIP4P2) 118641633(PIP4P1)
PPAM: 129064397(PIP4P1) 129088362(PIP4P2)
HAI: 109376449(TMEM55B)
RFQ: 117023446(PIP4P1) 117033621(PIP4P2)
PALE: 102898229(PIP4P2) 102898278(PIP4P1)
PGIG: 120608059(PIP4P1) 120614258(PIP4P2)
PVP: 105304152(PIP4P2) 105308945(PIP4P1)
RAY: 107507437(TMEM55A) 107521160(TMEM55B)
MJV: 108387665(PIP4P2) 108395116 108403281(PIP4P1)
TOD: 119238854(PIP4P1) 119239895(PIP4P2)
SARA: 101537201(TMEM55B) 101555869(TMEM55A)
SFUM: 130041808(PIP4P1) 130044289(PIP4P2)
SETR: 126001413(PIP4P1) 126020630(PIP4P2)
LAV: 100660816(PIP4P1) 100664641(PIP4P2)
TMU: 101345599 101357101
ETF: 101650919(PIP4P1) 101656735(PIP4P2)
DNM: 101418300(PIP4P2) 101421442(PIP4P1)
MDO: 100022045(TMEM55A) 100022893(TMEM55B)
GAS: 123231880(PIP4P2) 123236082(PIP4P1)
SHR: 100916303(PIP4P2) 100924788(PIP4P1)
AFZ: 127544272 127549143
PCW: 110198547(TMEM55A) 110217864(TMEM55B)
TVP: 118830355(PIP4P1) 118833420(PIP4P2)
PBRV: 138160130(PIP4P2) 138168830(PIP4P1)
OAA: 100086066(PIP4P1) 100092908(PIP4P2)
TACU: 119920889(PIP4P1) 119926920(PIP4P2)
GGA: 420221(PIP4P2)
PCOC: 116227600(PIP4P2)
MGP: 100542892(PIP4P2)
CJO: 107307004(PIP4P1) 107310378(PIP4P2)
TPAI: 128090782(PIP4P2)
LMUT: 125690873(PIP4P2)
NMEL: 110393858(TMEM55A)
APLA: 101802244(PIP4P2)
ACYG: 106030630(PIP4P2)
CATA: 118247958(PIP4P2)
AFUL: 116486080(PIP4P2)
TGU: 100226950(PIP4P2)
LSR: 110477429(PIP4P2) 110481133(PIP4P1)
SCAN: 103813442(PIP4P2) 115484135(PIP4P1)
PMOA: 120500834(PIP4P2)
OTC: 121340325(PIP4P2) 121342965
PRUF: 121349816 121351993(PIP4P2)
ATRC: 139586678(PIP4P1) 139587362(PIP4P2)
GFR: 102040381(TMEM55A)
FAB: 101810791(TMEM55A)
OMA: 130249195(PIP4P2) 130262860(PIP4P1)
PHI: 102099741(TMEM55A) 102101128(TMEM55B)
PMAJ: 107199089(PIP4P1) 107200089(PIP4P2)
CCAE: 111924560(PIP4P2)
CCW: 104692756(PIP4P2)
CBRC: 103613447(TMEM55A)
ACOE: 138100730(PIP4P1) 138105298(PIP4P2)
ETL: 114061739(PIP4P2)
ZAB: 102062275(PIP4P2)
ZLE: 135444604(PIP4P2) 135460671(PIP4P1)
ACHL: 103806916(TMEM55A)
SVG: 106861992(TMEM55A) 106864465(TMEM55B)
MMEA: 130576023(PIP4P2) 130587493(PIP4P1)
HRT: 120748026(PIP4P1) 120760124(PIP4P2)
SATI: 136370024(PIP4P2)
CCIC: 134050053(PIP4P2) 134055940(PIP4P1)
FPG: 101922579(TMEM55A)
FCH: 102055459(PIP4P2)
CCRI: 104166516
SHAB: 115611265(PIP4P2)
ACUN: 113476160(PIP4P2)
TALA: 104359578(PIP4P2)
ACHC: 115340537(PIP4P2)
HALD: 104315809(TMEM55A)
HLE: 104828362(TMEM55A)
AGEN: 126036918 126050072
HHAR: 128138033(PIP4P1) 128142119(PIP4P2)
GCL: 127012969
CSTI: 104557491
LDI: 104341576
MNB: 103774163(TMEM55A)
DPUB: 104306048(TMEM55A)
PPUS: 135181455(PIP4P2)
AVIT: 104280036
BRHI: 104490899(TMEM55A)
EGZ: 104125810(PIP4P2)
NNI: 104016500(TMEM55A)
PCRI: 104033173(TMEM55A)
PCAO: 104052077
PADL: 103917331(TMEM55A)
FGA: 104082721
GSTE: 104256627
CLV: 102090519(TMEM55A)
MUI: 104546812(TMEM55A)
PGUU: 104467747
PLET: 104628197
EHS: 104511832(TMEM55A)
CMAC: 104484755(TMEM55A)
CUCA: 104056790(PIP4P2)
TEO: 104380322
BREG: 104633898(TMEM55A)
OHA: 104337584(TMEM55A)
ACAR: 104526135(PIP4P2)
CPEA: 104396643(TMEM55A)
CVF: 104292534(TMEM55A)
RTD: 128901846(PIP4P1) 128905701(PIP4P2)
CRID: 134512111(PIP4P2)
AAM: 106496195(TMEM55A)
AROW: 112964070(PIP4P2)
NPD: 112950677(PIP4P2)
TGT: 104571256(TMEM55A)
DNE: 112982968(PIP4P2)
SCAM: 104143960(TMEM55A)
ASN: 102373932(PIP4P2) 102374449(PIP4P1)
AMJ: 102562249(TMEM55B) 102570595(TMEM55A)
CPOO: 109320301(TMEM55A) 109320545(TMEM55B)
GGN: 109294681(TMEM55B) 109305031(TMEM55A)
PSS: 102457479(PIP4P2)
CMY: 102938814(PIP4P2) 102941676(PIP4P1)
CCAY: 125621966(PIP4P1) 125632651(PIP4P2)
DCC: 119842130(PIP4P1) 119852232(PIP4P2)
CPIC: 101937348(PIP4P2) 101946066(PIP4P1)
TST: 117871665(PIP4P2) 117885343(PIP4P1)
CABI: 116816452(PIP4P1) 116839386(PIP4P2)
MRV: 120380995(PIP4P1) 120396740(PIP4P2)
ACS: 100556773(tmem55a) 100567084(tmem55b)
ASAO: 132774975(PIP4P2) 132777717(PIP4P1)
PVT: 110089558(TMEM55B) 110090207(TMEM55A)
SUND: 121930003(PIP4P2) 121934894(PIP4P1)
PBI: 103047975(PIP4P1) 103054248(PIP4P2)
PMUR: 107285754(PIP4P2) 107292313(PIP4P1)
CTIG: 120311017(PIP4P1) 120312780(PIP4P2)
TSR: 106545515(TMEM55A) 106549927(TMEM55B)
PGUT: 117662190(PIP4P1) 117668494(PIP4P2)
APRI: 131195817(PIP4P2) 131197258(PIP4P1)
PTEX: 113439920(PIP4P2) 113449576(PIP4P1)
NSS: 113425318(PIP4P1) 113428459(PIP4P2)
VKO: 123019493(PIP4P1) 123020326(PIP4P2)
PMUA: 114581602(PIP4P1) 114600438(PIP4P2)
PRAF: 128401024(PIP4P1) 128417260(PIP4P2)
ZVI: 118090061(PIP4P2) 118095026(PIP4P1)
HCG: 128323362(PIP4P2) 128331662(PIP4P1)
GJA: 107105993(TMEM55A) 107116165(TMEM55B)
STOW: 125439088(PIP4P2) 125445234(PIP4P1)
EMC: 129333634(PIP4P2) 129338177(PIP4P1)
XLA: 108695381(pip4p2.S) 108707045(pip4p1.S) 494834(pip4p1.L) 734343(pip4p2.L)
XTR: 100170610(pip4p1) 448483(pip4p2)
NPR: 108788678(TMEM55B) 108800143(TMEM55A)
RTEM: 120940082(PIP4P1) 120941297(PIP4P2)
BBUF: 120988956(PIP4P1) 121001674(PIP4P2)
BGAR: 122933402(PIP4P1) 122939001(PIP4P2)
PWL: 138282656(PIP4P2) 138300132(PIP4P1)
MUO: 115457762(PIP4P1) 115478800(PIP4P2)
GSH: 117350613(PIP4P1) 117355152(PIP4P2)
DRE: 553253(pip4p1b) 556136(pip4p1a) 566642(pip4p2)
SRX: 107709255 107721780 107723169 107724355 107749147
SANH: 107659916 107665981 107692688 107692894 107696196 107702130
SGH: 107555555(tmem55a) 107565103 107576828 107584351 107590777 107600071(tmem55b)
CCAR: 109045146(pip4p1a) 109053437 109065694 109075342(pip4p1b) 109088132 109109172(pip4p2)
CAUA: 113044494 113045079 113070034 113075861 113091867 113109880 113114327 113119590(pip4p2)
CGIB: 127935004 127935703 127949376 127951672 127979451 127979938
PTET: 122323553(pip4p2) 122328751(pip4p1a) 122351954(pip4p1b)
LROH: 127169912(pip4p1b) 127177288(pip4p1a) 127182155(pip4p2)
OMC: 131525353(pip4p2) 131540332(pip4p1b) 131550884(pip4p1a)
PPRM: 120463074(pip4p1b) 120484999(pip4p2) 120495422(pip4p1a)
RKG: 130084677(pip4p2) 130092028(pip4p1a) 130096900(pip4p1b)
MAMB: 125251114(pip4p1a) 125272771(pip4p1b) 125274829(pip4p2)
CIDE: 127501452 127515689 127523736
CERY: 137002388(pip4p1a) 137031817(pip4p1b) 137037672(pip4p2)
MASI: 127421146 127425180 127440342 127442785 127444147 127445248
TROS: 130552951(pip4p1b) 130555054(pip4p1a) 130567312(pip4p2)
TDW: 130407090(pip4p1b) 130418517(pip4p1a)
MANU: 129443028(pip4p1a) 129444913(pip4p1b) 129455371(pip4p2)
PDAB: 135735788(pip4p1b) 135744113(pip4p1a) 135780021 135785324(pip4p2)
IPU: 108273350(pip4p2) 108274853 108280404(pip4p1a)
IFU: 128615524(pip4p2) 128618376 128623998(pip4p1a)
PHYP: 113523871 113533535(pip4p1) 113543834(pip4p2)
SMEO: 124382184(pip4p2) 124403093(pip4p1a)
TFD: 113634755(pip4p2) 113640592(pip4p1a) 113648653 125145681
TVC: 132842794(pip4p2) 132847118(pip4p1a) 132857132 132857252
CGAR: 128513450(pip4p1a) 128515562(pip4p2)
NGRA: 132870830(pip4p2) 132871650(pip4p1a)
TRN: 134302535(pip4p1a) 134304150(pip4p2) 134328666(pip4p1b)
AMEX: 103033991(pip4p1a) 103040016(pip4p2) 103040625(pip4p1b)
CMAO: 118796990(pip4p1a) 118798059(pip4p1b) 118805179 118805449(pip4p2)
EEE: 113574929 113580968(pip4p2) 113588959(pip4p1)
CHAR: 105904855 105905620(pip4p1a) 105907741(pip4p2) 122133737(pip4p1b)
SPIL: 134058554(pip4p1a) 134059377(pip4p1b) 134072245(pip4p2)
TRU: 101062738(pip4p1) 101068075(pip4p2) 101075194(pip4p1) 115251759
TFS: 130518613(pip4p2) 130522552 130539028(pip4p1a)
TNG: GSTEN00021192G001 GSTEN00033018G001
LCO: 104924562(pip4p2) 104926554(pip4p1) 104936244
NCC: 104947052(tmem55a) 104948613(tmem55b)
TBEN: 117477512(pip4p2) 117497656 117500341(pip4p1a)
CGOB: 115016250(pip4p2)
PGEO: 117443174 117455209(pip4p2) 117462430(pip4p1a)
GACU: 117538618(pip4p1a) 117561627 117563130(pip4p2)
EMAC: 134866542(pip4p1a) 134874803(pip4p2) 134876210
ELY: 117245953 117263899(pip4p2) 117271648(pip4p1a)
EFO: 125883529 125902623(pip4p1a) 125905002(pip4p2)
PLEP: 121951708(pip4p1a) 121958323(pip4p2) 121962432
SLUC: 116040589(pip4p1a) 116047453(pip4p2) 116053086
ECRA: 117935074 117953665(pip4p1a) 117957036(pip4p2)
ESP: 116669519 116698603(pip4p1) 116701796(pip4p2)
PFLV: 114545567 114565150(pip4p1) 114568780(pip4p2)
GAT: 120814228(pip4p1a) 120821340 120827077(pip4p2)
PPUG: 119207320(pip4p1a) 119219199(pip4p2) 119223022
AFB: 129088867(pip4p1a) 129093334 129097377(pip4p2)
CLUM: 117739500(pip4p2) 117746072(pip4p1a) 117747576
PSWI: 130190971(pip4p1a) 130195707(pip4p2) 130211903
CANA: 137781906(pip4p1a) 137785243(pip4p2) 137792633
CVE: 137885946 137886261(pip4p2) 137890634(pip4p1a)
MSAM: 119901556 119901743(pip4p1a) 119907514(pip4p2) 119913171
SCHU: 122863898(pip4p2) 122869707 122887462(pip4p1a)
CUD: 121504482 121520060(pip4p1a) 121523213(pip4p2)
SPUL: 138601250 138608831(pip4p2) 138612203(pip4p1a)
LMIX: 132958280 132979519(pip4p1a) 132990608(pip4p2)
ALAT: 119011575(pip4p1a) 119017362(pip4p2) 119027023
ASTR: 137590895 137607550(pip4p2) 137612099(pip4p1a)
MZE: 101466447 101468284(pip4p2) 101479252(pip4p1)
ONL: 100693615(pip4p1) 100706272(pip4p2) 100710349
OAU: 116312075(pip4p2) 116332048 116332092(pip4p1a)
OLA: 101159467 101161334 101166147(pip4p2)
OML: 112150645(pip4p1a) 112155987 112160340(pip4p2)
CSAI: 133420551 133452506(pip4p1a) 133461503(pip4p2)
XMA: 102224770 102227240(pip4p2) 102234414(pip4p1)
XCO: 114145811(pip4p1) 114156427(pip4p2) 114157811
XHE: 116722183(pip4p1) 116731725(pip4p2) 116732542
PRET: 103472397(tmem55a) 103479490(tmem55b) 103480619
PFOR: 103135131(tmem55a) 103137995(tmem55b) 103138007 103149154
PLAI: 106944687 106946254(tmem55a) 106960164(tmem55b)
PMEI: 106903481 106910744(tmem55b) 106914598 106918621(tmem55a)
GAF: 122820284 122841343(pip4p1a) 122843283(pip4p2)
PPRL: 129355687(pip4p1a) 129375172(pip4p2) 129379932
CVG: 107092441(tmem55a) 107092674(tmem55b) 107095498
CTUL: 119779521(pip4p1a) 119784408 119795840(pip4p2)
GMU: 124870263(pip4p1a) 124879343(pip4p2) 124880396
NFU: 107376897 107383456(tmem55b) 107394745(tmem55a)
KMR: 108232969(pip4p1a) 108237806(pip4p2) 108248594
ALIM: 106515818(tmem55a) 106520802(tmem55b) 106523839
NWH: 119409972 119414799(pip4p1a) 119426013(pip4p2)
AOCE: 111563765(pip4p2) 111570900 111574634(pip4p1a) 111576584
EJA: 138211965 138214359(pip4p2) 138215673(pip4p1a)
BFRE: 138620080(pip4p2) 138626929(pip4p1a) 138632439
MCEP: 125009150 125010257(pip4p1a) 125020005(pip4p2)
CSEM: 103388924 103394417(tmem55a) 103396783(tmem55b)
POV: 109631912(tmem55a) 109645994(tmem55b) 109647653
SSEN: 122759258(pip4p1a) 122766321 122786912(pip4p2)
SSOE: 131447922(pip4p2) 131456653 131473844(pip4p1a)
HHIP: 117751911 117770135(pip4p2) 117777897(pip4p1a)
HSP: 118102936 118118156(pip4p1a) 118124848(pip4p2)
PPLT: 128430296 128454955(pip4p1a) 128461765(pip4p2)
SMAU: 118285012 118292211(pip4p2) 118310349(pip4p1a)
LCF: 108873687 108884334(pip4p1a) 108898155(pip4p2)
SDU: 111223251(pip4p2) 111233362 111239391(pip4p1)
SLAL: 111657891 111659343(pip4p2) 111668450(pip4p1)
XGL: 120786092(pip4p2) 120797577 120799177(pip4p1a)
HCQ: 109506970 109517989(tmem55a) 109529491(tmem55b)
SSCV: 125985179 125985243(pip4p1a) 125987049(pip4p2)
SBIA: 133501321(pip4p2) 133511299(pip4p1a)
PEE: 133395776(pip4p2) 133397577 133411993(pip4p1a)
PTAO: 133470661(pip4p2) 133472742 133488719(pip4p1a)
BPEC: 110167447(tmem55a) 110170780 110175124(tmem55b)
ENY: 140355942(pip4p1a) 140361661(pip4p2) 140371672
MALB: 109952910(tmem55a) 109974206 109974507
BSPL: 114844543(pip4p1a) 114851071 114865653(pip4p2)
SJO: 128369350(pip4p1a) 128373672(pip4p2) 128384248
SSCO: 133990896(pip4p1a) 133996643(pip4p2) 134005723
GMH: 115529070 115535854(pip4p2) 115548793(pip4p1)
SASA: 106569577 106570754 106589142(tmem55a) 106600488 106608438
STRU: 115157487 115169315 115174163 115176274(pip4p2)
OTW: 112226565 112229181 112236503(pip4p1a) 112239907 112241833
OMY: 110487822(pip4p2) 110504292 110508329(pip4p1a) 110512265 110530761
OGO: 123996760 124009576 124013190 124041636(pip4p1a) 124043125
ONE: 115102832 115115331 115125483 115128057
OKI: 109871533 109874839 109882695 109896536 109904365(pip4p2)
OKE: 118394935 118401771 127906637 127909116 127910048(pip4p2)
OMM: 135509711 135516496 135549474 135551659(pip4p2) 135559032
OCLA: 139372801 139376363 139379511 139387109 139391837
SALP: 111974344 111979801(pip4p1) 112073639 112076069(pip4p2)
SNH: 120020656 120027946 120041077(pip4p2) 120049537 120056169
CCLU: 121534682 121571070(pip4p1b) 121572226 121581288 121586848
ELS: 105006704(pip4p2) 105024555(pip4p1) 105030639
OEP: 134016120 134037029(pip4p1a) 134041082(pip4p2)
SFM: 108919216(pip4p2) 108926151 108937836
PKI: 111833149 111845350 111848239(pip4p2)
AANG: 118211335 118231305 118234635(pip4p2)
AROT: 135258668 135261087 135261653(pip4p2)
CCOG: 133120029 133126683 133137051(pip4p2)
LOC: 102683795(tmem55b) 102691229(tmem55a)
PSPA: 121305330 121307399 121313200 121314988 121329256
ARUT: 117395030 117398263 117398906 117399698 117425668
PSEX: 120515573(pip4p2) 120522956(pip4p1a)
LCM: 102348811(TMEM55A) 102357306(TMEM55B)
CMK: 103191060(pip4p2)
RTP: 109918341(pip4p1) 109938918(pip4p2)
CPLA: 122549003(pip4p2)
HOC: 132807696(pip4p1a) 132815462(pip4p2)
LERI: 129694918 129696126(pip4p2)
PMRN: 116956136(PIP4P2)
LRJ: 133357808 133357983
BFO: 118417220
BBEL: 109483241
CIN: 104266484
SPU: 588430
LPIC: 129254032 129278085
AJJ: 139964359
APLC: 110980124
ARUN: 117289769
AAMU: 139935062
AFIL: 140135890
AJC: 117118190
SKO: 100368816
PFLL: 139147251
DME: Dmel_CG6707(CG6707)
DER: 6546082
DSE: 6605120
DSI: Dsimw501_GD12881(Dsim_GD12881)
DYA: Dyak_GE20289
DAN: 6506490
DSR: 110190635
DPO: 4813276
DPE: 6600238
DMN: 108151830
DWI: 6638715
DGR: 6557366
DMO: Dmoj_GI13013
DAZ: 108613220
DNV: 108651252
DHE: 111598717
DVI: 6623987
CCAT: 101458043
BOD: 106619668
BDR: 105231295
RZE: 108368047
AOQ: 129240984 129241589
ALUD: 128862080
TDA: 119667429
MDE: 101893850
SCAC: 106093469
LCQ: 111682675
LSQ: 119613382 119613667
CVJ: 135953447
GFS: 119631391
ECOE: 129946653
CLON: 129609136
HIS: 119647680
AGA: 1276903
ACOZ: 120951221
AARA: 120898884
AMER: 121591871
ASTE: 118509445
AMAP: 126562858
AFUN: 125771049
AMOU: 128303793
AMRS: 128712018
AALI: 118464008
ACOS: 131263558
AAG: 5574542
AALB: 109428654
ASUA: 134203063 134211444
CQU: CpipJ_CPIJ009913
CPII: 120418667
CNS: 116347912
BCOO: 119073623
LLL: 129792854
PPAP: 129801302
AME: 408301
ACER: 108001187
ALAB: 122710420
ADR: 102678254
AFLR: 100867798
BIM: 100749086
BBIF: 117205240
BVK: 117230173
BVAN: 117162943
BHUN: 126867021
BTER: 100646549
BAFF: 126923283
BPYO: 122571788
BPAS: 132908822
FVI: 122538927
CCAL: 108622913
OBB: 114874660
OLG: 117608715
MGEN: 117217459
NMEA: 116424096
CGIG: 122402714
SOC: 105200883
MPHA: 105839704
AEC: 105143615
ACEP: 105620209
PBAR: 105430510
VEM: 105563835
COBS: 139110357
TLN: 139812210 139812452
HST: 105186717
DQU: 106748938
CFO: 105255380
FEX: 115239704
PMEC: 138933069
LHU: 105674095
PGC: 109854987
OBO: 105282957
PCF: 106791075
PFUC: 122519801
VPS: 122630485
VCRB: 124424060
VVE: 124950554
NVI: 100120829
CSOL: 105359276
TPRE: 106649016
LHT: 122500596
LBD: 127279751
MDL: 103578153 106693532
CGLO: 123264322
FAS: 105270733
DAM: 107043087
AGIF: 122860638
CINS: 118072037
VCAN: 122417951
CCIN: 107264242
DSM: 124415005
NPT: 124223973
NLO: 107221332
AROA: 105691767
TCA: 655804
TMOL: 138122286
DPA: 109534456
ESIM: 136412222
EFOR: 136341004
SOY: 115877178
AGRG: 126739455
ATD: 109603339
CSET: 123318730
HAXR: 123672651
AGB: 108913856
LDC: 111504067
DVV: 114341282
NVL: 108563960
APLN: 108735740
PPYR: 116174180
OTU: 111420505
BMAN: 114247478
MSEX: 115440024
DPL: KGM_213618 KGM_213619
BANY: 112043167
MJU: 123868453
NIQ: 126774119
VCD: 124536201
MCIX: 123659859
PMAC: 106719144
PPOT: 106109686
PXU: 106121436
BPHI: 137919170
PRAP: 110992215
PBX: 123708002
PNAP: 125049331
ZCE: 119828288
CCRC: 123694651
LSIN: 126965102
AAGE: 121738408
HAW: 110370045
HZE: 124635448
TNL: 113501279
SLIU: 111358774
OFU: 114361656
ONU: 135077586
ATRA: 106135028
GMW: 113521321
PXY: 105393931
PGW: 126372376
LGLY: 125231635
CSTB: 134745179
CFEL: 113386632 113386871
CCRN: 123299341
API: 100164628
DNX: 107167499
AGS: 114121256
RMD: 113556156
ACOO: 126844334
DVT: 126897606
BTAB: 109035975
DCI: 103518847 103518848
CLEC: 106665999
HHAL: 106690513
NLU: 111043649
HVI: 124353714
MQU: 129002598 129004272
PHU: Phum_PHUM358690 Phum_PHUM617960
FOC: 113203769
TPAL: 117651370
ZNE: 110834071
CSEC: 111869495
SGRE: 126354421
BROR: 134540538
IEL: 124163472
HAMR: 139699827
FCD: 110849352
DPX: DAPPUDRAFT_235760 DAPPUDRAFT_304652 DAPPUDRAFT_43581
DMK: 116915446 123469750
DPZ: 124329188 124337736 124337737
AFRA: 136028630 136034421
PVM: 113800971 113802341
PJA: 122250017
PCHN: 125030796
PMOO: 119576374
HAME: 121871871
PCLA: 123760636
CQD: 128702865
PTRU: 123506685
ESN: 126985961
MNZ: 135216356
MRJ: 136833765
PORN: 139753831
HAZT: 108665058
EAF: 111709775
LSM: 121117358
TCF: 131885541
PPOI: 119099241
ISC: 8031937
DSV: 119432683 119465627
RSAN: 119374570 119377643
RMP: 119176165 119176407
VDE: 111244394 111245807
VJA: 111265977 111272307
TUT: 107359622
DPTE: 113789342
DFR: 124495003
CSCU: 111630924 111642355
CVS: 136984364
PTEP: 107452055
ABRU: 129971650
UDV: 129221580
SDM: 118195297 118203607
LPOL: 106457221 106468378 106474695
PMEO: 129602651
CEL: CELE_Y71H2AM.2(pipp-4P)
CBR: CBG_00490
CRQ: GCK72_010840
BMY: BM_BM7065(Bm7065)
LOA: LOAG_02822
HRO: HELRODRAFT_187998
LGI: LOTGIDRAFT_133999
PVUL: 126814235 126814236
PCAN: 112576610
LSAX: 138957338 138961982
BGT: 106069844
GAE: 121389550
HRF: 124136840
HRJ: 124259351
HASI: 137258450
HCRA: 139452137
CRG: 105338362
CANU: 128189299
CVN: 111136180
OED: 125667428
MYI: 110464767
PMAX: 117337259
AIRR: 138315884
MCAF: 127703050
MMER: 123548748
RPHI: 132725283
DPOL: 127874619
MAEA: 128209646
OBI: 106874795
OSN: 115220847
LJP: 135465798 135475820
LAK: 106178509
SMM: Smp_022540.1
SHX: MS3_00002878(PIP4P2_1)
OVI: T265_09562 T265_11868
EGL: EGR_01135 EGR_09393
LLON: 135495993
NVE: 5521597
EPA: 110248578
ATEN: 116304727
ADF: 107342237
AMIL: 114977192
MCAZ: 138021493
MFOO: 138012997
PDAM: 113677853
SPIS: 111332610
DGT: 114516540
XEN: 124436983
HMG: 100208471
HSY: 130614016
RES: 135691170
AQU: 100632025
EMA: C1192_24285
STY: STY1121(sigD)
STT: t1828(sigD)
SEX: STBHUCCB_19440
SENT: TY21A_09295
STM: STM1091(sopB)
SEO: STM14_1237(sopB)
SEV: STMMW_11031
SEY: SL1344_1030(sopB)
SEM: STMDT12_C11120
SEJ: STMUK_1060(sopB)
SEB: STM474_1083(sopB)
SEF: UMN798_1133(sigD)
SETU: STU288_01790
SETC: CFSAN001921_11720(sopB)
SENR: STMDT2_10271(sigD)
SEND: DT104_10731(sopB)
SENI: CY43_05575(sopB)
SEEN: SE451236_11305(sopB)
SPT: SPA1759(sigD)
SEK: SSPA1634
SPQ: SPAB_02464
SEI: SPC_2659(sigD)
SEC: SCH_1043(sopB)
SEH: SeHA_C1201
SHB: SU5_01724
SENH: CFSAN002069_03565(sopB)
SEEH: SEEH1578_14685
SEE: SNSL254_A1187
SENN: SN31241_21590
SEW: SeSA_A1155
SEA: SeAg_B1050
SENS: Q786_04870(sopB)
SED: SeD_A1167
SEG: SG0980(sopB)
SEL: SPUL_1966(sopB)
SEGA: SPUCDC_1952(sopB)
SET: SEN0955(sopB)
SENA: AU38_04930(sopB)
SENO: AU37_04920(sopB)
SENV: AU39_04920(sopB)
SENQ: AU40_05535(sopB)
SENL: IY59_05020(sopB)
SENJ: CFSAN001992_06185
SEEC: CFSAN002050_11850(sopB)
SEEB: SEEB0189_014115(sopB)
SEEP: I137_08940(sopB)
SENB: BN855_10450
SENE: IA1_05370(sopB)
SENC: SEET0819_12115(sopB)
SES: SARI_01910
SBG: SBG_0939(sopB)
SBZ: A464_1030
SBV: N643_04465(sopB)
SALZ: EOS98_14165
SFL: CP0133(ipgD)
SFE: SFxv_4976(ipgD)
SSN: SSON_P095(ipgD)
SBC: SbBS512_A0166(ipgD)
SDY: SDY_P171(ipgD)
SDZ: Asd1617_06366
SYM: K6K13_10905
YAL: AT01_2850(sopB)
YEG: PL78_07345
FSM: CCS41_07775
RBAD: H2866_19305
SOD: Sant_3206(sigD) Sant_3209(sigD2)
SLIG: GTU79_05195
PAY: PAU_01919
PSI: S70_12925
PSX: DR96_586(sopB)
PSTA: BGK56_15810
PTHA: OI982_10265
PVC: G3341_17095
ANS: ArsFIN_43100(sopB)
VAN: VAA_02157
LAG: N175_09340
VAU: VANGNB10_cI1105
EMP: EZMO1_3388(ipgD)
CRZ: D1345_19490
CHAE: CH06BL_40220(sopB_sigD)
IFL: C1H71_17665(sopB)
PBON: QS306_09370
PPK: U875_18870
PPNO: DA70_11385
PPNM: LV28_19660
LIMN: HKT17_05800
BGM: CAL15_03515
CDN: BN940_04026
COF: FOZ74_09105
STAR: G3545_19400
HMC: HYPMC_3453
PSF: PSE_2750(ipgD)
DPG: DESPIGER_2147
PCU: PC_RS06055
PNL: PNK_0614(ipgD)
OXY: HCG48_18215
 » show all
Reference
1  [PMID:12356723]
  Authors
Niebuhr K, Giuriato S, Pedron T, Philpott DJ, Gaits F, Sable J, Sheetz MP, Parsot C, Sansonetti PJ, Payrastre B
  Title
Conversion of PtdIns(4,5)P(2) into PtdIns(5)P by the S.flexneri effector IpgD reorganizes host cell morphology.
  Journal
EMBO J 21:5069-78 (2002)
DOI:10.1093/emboj/cdf522
  Sequence
[sfl:CP0133]
Reference
2  [PMID:16365287]
  Authors
Ungewickell A, Hugge C, Kisseleva M, Chang SC, Zou J, Feng Y, Galyov EE, Wilson M, Majerus PW
  Title
The identification and characterization of two phosphatidylinositol-4,5-bisphosphate 4-phosphatases.
  Journal
Proc Natl Acad Sci U S A 102:18854-9 (2005)
DOI:10.1073/pnas.0509740102
  Sequence
[hsa:55529 90809]
Reference
3  [PMID:17940011]
  Authors
Zou J, Marjanovic J, Kisseleva MV, Wilson M, Majerus PW
  Title
Type I phosphatidylinositol-4,5-bisphosphate 4-phosphatase regulates stress-induced apoptosis.
  Journal
Proc Natl Acad Sci U S A 104:16834-9 (2007)
DOI:10.1073/pnas.0708189104
Reference
4  [PMID:17389247]
  Authors
Mason D, Mallo GV, Terebiznik MR, Payrastre B, Finlay BB, Brumell JH, Rameh L, Grinstein S
  Title
Alteration of epithelial structure and function associated with PtdIns(4,5)P2 degradation by a bacterial phosphatase.
  Journal
J Gen Physiol 129:267-83 (2007)
DOI:10.1085/jgp.200609656
Other DBs
ExplorEnz - The Enzyme Database: 3.1.3.78
IUBMB Enzyme Nomenclature: 3.1.3.78
ExPASy - ENZYME nomenclature database: 3.1.3.78
BRENDA, the Enzyme Database: 3.1.3.78
LinkDB

DBGET integrated database retrieval system