| Entry |
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| Name |
sphingomyelin phosphodiesterase D;
sphingomyelinase D
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| Class |
Hydrolases;
Acting on ester bonds;
Phosphoric-diester hydrolases
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| Sysname |
sphingomyelin ceramide-phosphohydrolase
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| Reaction(IUBMB) |
sphingomyelin + H2O = ceramide phosphate + choline [RN: R02542]
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| Reaction(KEGG) |
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| Substrate |
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| Product |
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| Comment |
Does not act on phosphatidylcholine, but hydrolyses 2-lysophosphatidylcholine to choline and 2-lysophosphatidate.
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| History |
EC 3.1.4.41 created 1978
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| Pathway |
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| Orthology |
| K01123 | sphingomyelin phosphodiesterase D |
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| Genes |
| MBRN: | 26243344(SMASE) 26247885(SMPD3) |
| AOR: | AO090003000836 AO090102000335 AO090701000259 |
| AFV: | AFLA_000843 AFLA_004762 AFLA_011778 |
| CIM: | CIMG_06182 CIMG_09578 |
| CPW: | 9692935(D8B26_007948) 9695035(D8B26_006549) |
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| Reference |
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| Authors |
Carne HR, Onon EO. |
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| Title |
Action of Corynebacterium ovis exotoxin on endothelial cells of blood vessels. |
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| Journal |
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| Reference |
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| Authors |
Soucek A, Michalec C, Souckova A. |
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| Title |
Identification and characterization of a new enzyme of the group "phospholipase D" isolated from Corynebacterium ovis. |
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| Journal |
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| Other DBs |
| ExplorEnz - The Enzyme Database: | 3.1.4.41 |
| ExPASy - ENZYME nomenclature database: | 3.1.4.41 |
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| LinkDB |
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