Entry
Name
glucan 1,4-alpha-glucosidase;
glucoamylase;
amyloglucosidase;
gamma-amylase;
lysosomal alpha-glucosidase;
acid maltase;
exo-1,4-alpha-glucosidase;
glucose amylase;
gamma-1,4-glucan glucohydrolase;
acid maltase;
1,4-alpha-D-glucan glucohydrolase
Class
Hydrolases;
Glycosylases;
Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl compounds
BRITE hierarchy
Sysname
4-alpha-D-glucan glucohydrolase
Reaction(IUBMB)
Hydrolysis of terminal (1->4)-linked alpha-D-glucose residues successively from non-reducing ends of the chains with release of beta-D-glucose
Reaction(KEGG)
Comment
Most forms of the enzyme can rapidly hydrolyse 1,6-alpha-D-glucosidic bonds when the next bond in the sequence is 1,4, and some preparations of this enzyme hydrolyse 1,6- and 1,3-alpha-D-glucosidic bonds in other polysaccharides. This entry covers all such enzymes acting on polysaccharides more rapidly than on oligosaccharides. EC
3.2.1.20 alpha-glucosidase, from mammalian intestine, can catalyse similar reactions.
History
EC 3.2.1.3 created 1961
Pathway
ec00500 Starch and sucrose metabolism
Orthology
K21574 glucan 1,4-alpha-glucosidase
Genes
HSA : 8972(MGAM) 93432(MGAM2)
PTR : 463789(MGAM) 463790(MGAM2)
PPS : 100969608(MGAM2) 100996199(MGAM)
NLE : 100590310(MGAM) 100605801(MGAM2)
SSYN : 129484048(MGAM2) 129485099(MGAM)
MCC : 695030(MGAM) 695370(MGAM2)
MNI : 105471250(MGAM2) 105471255(MGAM)
CSAB : 103227042(MGAM) 103227409
CATY : 105589693(MGAM) 105589694(MGAM2)
PANU : 101001849(MGAM) 101002905(MGAM2)
TGE : 112620977(MGAM2) 112621698(MGAM)
MLEU : 105533558 105533559(MGAM2) 105550543(MGAM)
RRO : 104655094(MGAM2) 104659721(MGAM)
RBB : 108541550(MGAM) 108541557(MGAM2)
TFN : 117072657(MGAM2) 117073450(MGAM)
PTEH : 111521513(MGAM) 111521521(MGAM2)
CANG : 105511204(MGAM) 105511205(MGAM2)
CJC : 100397043(MGAM2) 100397416(MGAM)
SBQ : 101054069(MGAM) 101054392
CIMI : 108283438(MGAM) 108291166
ANAN : 105713652(MGAM) 105713653(MGAM2)
CSYR : 103261012(MGAM) 103261024(MGAM2)
MMUR : 105873257(MGAM) 105873269(MGAM2)
LCAT : 123646922(MGAM) 123646923(MGAM2)
MCAL : 110296574(Mgam) 110296575(Mgam2)
MPAH : 110315970 110316775 110316776
RNO : 103690059(Mgam) 312272(Mgam2)
MCOC : 116098507(Mgam) 116098783(Mgam2)
ANU : 117720542(Mgam) 117721005(Mgam2)
CGE : 100769016(Mgam) 118239532(Mgam2)
MAUA : 101844249(Mgam2) 101844514(Mgam)
PROB : 127214238 127214309
PLEU : 114684450 114684453
MORG : 121435540(Mgam) 121435541(Mgam2)
AAMP : 119806650(Mgam) 119806651(Mgam2)
NGI : 103724791(Mgam2) 103726140(Mgam)
HGL : 101711183(Mgam) 101711548(Mgam2)
CCAN : 109695405 109695424 109695435(Mgam2)
DORD : 105989478(Mgam2) 105989583(Mgam)
PLOP : 125345309 125345666 125345669
MMMA : 107148995(Mgam2) 107149112(Mgam)
TUP : 102479933(MGAM) 102480355
GVR : 103598901(MGAM) 103598903
CFA : 475523(MGAM) 482756(MGAM2)
CLUD : 112650976(MGAM2) 112650979(MGAM)
VVP : 112907034(MGAM) 112907048(MGAM2)
VLG : 121489170 121489171(MGAM)
NPO : 129515796 129515797(MGAM)
AML : 100466340(MGAM2) 100466584(MGAM)
UMR : 103669012(MGAM) 103669102
MPUF : 101672847(MGAM2) 101673126(MGAM)
MNP : 132015509(MGAM2) 132015628(MGAM)
MLK : 131829864 131829865(MGAM)
NVS : 122905146 122905147(MGAM)
ORO : 101380291(MGAM) 101381158(MGAM2)
ZCA : 113911844(MGAM2) 113912001(MGAM)
MLX : 118020576(MGAM2) 118021172(MGAM)
NSU : 110582814 110582816(MGAM)
FCA : 101094582(MGAM) 101094837
PYU : 121028218(MGAM2) 121028219(MGAM)
PCOO : 112866452(MGAM) 112866453(MGAM2)
PBG : 122488345 122488420(MGAM)
PVIV : 125151689(MGAM) 125154018
LRUF : 124523313 124523314
PTG : 102963503(MGAM) 102963785(MGAM2)
PPAD : 109269136(MGAM2) 109269137(MGAM)
HHV : 120232971 120232979(MGAM)
BTA : 100296901 100336421(MGAM)
BOM : 102265977(MGAM) 102270662(MGAM2)
BBUB : 102404728(MGAM) 102411245
BBIS : 104999396(MGAM) 104999462
CHX : 102179067(MGAM) 102180726(MGAM2)
OAS : 101113407(MGAM) 101113672
CSUM : 138079742 138080104(MGAM)
ODA : 120877553(MGAM) 120877676
MREE : 136170351(MGAM) 136170352
SSC : 100623494(MGAM2) 102160115(MGAM)
CFR : 102514558(MGAM) 102514818
CBAI : 105063006(MGAM) 105063187
CDK : 105097330(MGAM2) 105097331(MGAM)
VPC : 102541896(MGAM) 102542147(MGAM2)
BMUS : 118900603 118901203
ECB : 100064486(MGAM) 100065270(MGAM2)
EPZ : 103558278 103558279(MGAM)
EAI : 106842570(MGAM2) 106842605(MGAM)
MYB : 102255004(MGAM) 102262411(MGAM2)
MYD : 102758728(MGAM2) 102768888(MGAM)
MMYO : 118666328(MGAM) 118666609(MGAM2)
MLF : 102425458(MGAM) 102436473
MDT : 132211347 132242847(MGAM)
EFUS : 103294143(MGAM2) 103294144
MNA : 107531078(MGAM2) 107531085(MGAM)
DRO : 112299863(MGAM2) 112299904(MGAM)
SHON : 118989068(MGAM) 118989194(MGAM2)
PDIC : 114507354(MGAM) 118497205(MGAM2)
PHAS : 123829674(MGAM) 123829675(MGAM2)
MMF : 118619711(MGAM2) 118619753(MGAM)
PPAM : 129063250(MGAM2) 129063475(MGAM)
HAI : 109395594(MGAM2) 109395610(MGAM)
RFQ : 117017993(MGAM2) 117018014(MGAM)
PALE : 102878555 102897997
PGIG : 120600991(MGAM) 120600992(MGAM2)
PVP : 105291597 105291649(MGAM2)
RAY : 107514213 107516912(MGAM) 107516970
TOD : 119247910(MGAM) 119250913
SARA : 101544608(MGAM2) 101544875(MGAM)
LAV : 100661007(MGAM2) 100661293(MGAM)
ETF : 101652342(MGAM2) 101652663
DNM : 101415412(MGAM) 101415845(MGAM2)
MDO : 100009833(MGAM) 100009866
SHR : 100935157(MGAM) 105750789
PCW : 110216165 110216253(MGAM)
GGA : 425007(SI) 425545(MGAM)
CJO : 107307407 107318345(SI)
LMUT : 125687598 125697796(SI)
APLA : 101798588(SI) 119715237
CATA : 118253122 118261414 126913404(SI)
PHI : 102105067(SI) 102113603
PMAJ : 107198914 107208530(SI)
CCAE : 111933809 111933810 111943230
TALA : 104357119 104365825(SI)
ACHC : 115347679(SI) 115350190
AGEN : 126039338 126052726
HHAR : 128149523(SI) 128150332
DPUB : 104308890 104308979
PADL : 103924874 103925289(SI)
CUCA : 104056868(SI) 104059944
OHA : 104334444(SI) 104338083
CPEA : 104386435 104389475
CVF : 104285968(SI) 104289447
AAM : 106494316 106499607(SI)
AROW : 112963856(SI) 112967101
NPD : 112944324 112952404(SI)
DNE : 112986300 112986431(SI)
SCAM : 104140053(SI) 104140063
CABI : 116821366 116821459
SANH : 107660689 107687769
CAUA : 113068422 113118133
CGIB : 127934210 127935784 127977688
PTET : 122323148 122335490
LROH : 127162031 127180337(si)
OMC : 131524618(si) 131525614
PPRM : 120473722(si) 120475411
MAMB : 125253860(si) 125274221
CIDE : 127499478 127509845
CERY : 137017041 137023191(si)
MASI : 127416901 127456245
CHAR : 105894942 105897125(si)
ALIM : 106517352 106520634(si)
BSPL : 114867550 114868619
SCLV : 120327875 120328284
LPIC : 129262104 129278768
APLC : 110984420 110986798
PCLA : 123759099 123772770
ABRU : 129957601 129957645 129971512
CANU : 128166467 128182295
CVN : 111099715 111099716 111119014 111119178
LAK : 106172255 106172919 106181238
GSL : Gasu_25520 Gasu_25530
CGR : 2888278(GVI51_G02585)
NCS : NCAS_0G03900(NCAS0G03900)
NDI : NDAI_0G00580(NDAI0G00580)
TPF : TPHA_0D01570(TPHA0D01570)
TBL : TBLA_0B06900(TBLA0B06900)
TDL : TDEL_0C03860(TDEL0C03860)
KAF : KAFR_0H03370(KAFR0H03370)
KNG : KNAG_0H02080(KNAG0H02080)
LBG : 92207528(LODBEIA_P23320)
CAL : CAALFM_C301320CA(SGA1)
YLI : 2912279(YALI2_E01654g)
NTE : NEUTE1DRAFT117282(NEUTE1DRAFT_117282)
SMP : 10802966(SMAC4_06215)
PAN : PODANSg6197 PODANSg6315
PBEL : QC761_303770 QC761_304910
PPSD : QC762_303770 QC762_304910
PPSP : QC763_303770 QC763_304910
PPSA : QC764_303770 QC764_304910
TTT : THITE_164568(gla1) THITE_50690
CTHR : CTHT_0002240 CTHT_0020730
TMN : UCRPA7_2028 UCRPA7_6854
SSCK : SPSK_03169 SPSK_10517
FGR : FGSG_06278 FGSG_11326
FPU : FPSE_00991 FPSE_05684
FPOA : FPOAC1_007500 FPOAC1_009262
FVN : FVRRES_09900 FVRRES_10752
FVR : FVEG_04947 FVEG_13849
FOX : FOXG_08027 FOXG_13566
FMU : J7337_006979 J7337_010976
TATV : 25775189(TrAtP1_002547) 25777649(TrAtP1_000382)
TASP : 36607951(GLA1) 36609580(TrAFT101_000156)
MAW : 19253815(J3458_020531)
PLJ : 28886808(PLICBS_002129) 28889102(PLICBS_008427)
PTKZ : JDV02_002899 JDV02_006212
VAL : VDBG_00799 VDBG_01600 VDBG_06382
VDA : VDAG_00408 VDAG_01953 VDAG_03528
CFJ : CFIO01_00483 CFIO01_10180
CLUP : CLUP02_01169 CLUP02_17356
CHIG : CH63R_07722 CH63R_10111
CDET : 87943203(CDEST_06700) 87944935(CDEST_08432)
SAPO : SAPIO_CDS2834 SAPIO_CDS4610
PFY : PFICI_04223 PFICI_12479 PFICI_14951
SSL : SS1G_08135 SS1G_10617 SS1G_13809
BFU : BCIN_04g00030 BCIN_04g04190 BCIN_12g03390
PSCO : LY89DRAFT_591570 LY89DRAFT_602532
GLZ : GLAREA_03384 GLAREA_10627
ANI : ANIA_07402 ANIA_11143
AFM : AFUA_2G00690 AFUA_3G00610 AFUA_4G10140
ACT : ACLA_049360 ACLA_078620 ACLA_089470 ACLA_094080
NFI : NFIA_001210 NFIA_032960 NFIA_105910
AOR : AO090003000321 AO090010000746
AFV : AFLA_001365 AFLA_014248
APUU : APUU_21860A APUU_50700A
PCS : N7525_006010 N7525_011570
POU : POX_a00573 POX_b02418
TMF : EYB26_006864 EYB26_006875
TRG : TRUGW13939_01869 TRUGW13939_02511 TRUGW13939_11390
CPW : 9691152(D8B26_001658)
PNO : SNOG_14027 SNOG_15278
PTRR : 6347152(PtrM4_033390)
ARAB : EKO05_0003014 EKO05_0009383
ZTR : MYCGRDRAFT_42503(MgSGA1)
PFJ : MYCFIDRAFT_190373 MYCFIDRAFT_36361
NPA : UCRNP2_1261 UCRNP2_691
KMG : 30163356(I203_102558)
KNE : 92182177(IAR55_004919)
PPL : POSPLDRAFT_113112 POSPLDRAFT_117345
TVS : TRAVEDRAFT_28580 TRAVEDRAFT_37357 TRAVEDRAFT_54963
SHS : STEHIDRAFT_123978 STEHIDRAFT_58599
HIR : HETIRDRAFT_157474 HETIRDRAFT_36572 HETIRDRAFT_39327
PSQ : PUNSTDRAFT_105992 PUNSTDRAFT_111334 PUNSTDRAFT_55213
RSX : RhiXN_03133 RhiXN_08029 RhiXN_08281
CCI : CC1G_04997 CC1G_07201 CC1G_11695
ABP : AGABI1DRAFT112487(AGABI1DRAFT_112487)
ABV : AGABI2DRAFT192455(AGABI2DRAFT_192455)
PCUB : JR316_0007196 JR316_0007197 JR316_0012581
MPR : MPER_11147 MPER_15460
SCM : SCHCO_02631634(SCHCODRAFT_02631634) SCHCO_058306(SCHCODRAFT_058306)
PGR : PGTG_02336 PGTG_08226 PGTG_15131
PTRC : PtA15_10A345 PtA15_2A881 PtA15_6A723
PSTR : Pst134EA_002823 Pst134EA_002829 Pst134EA_005523 Pst134EA_019151
MLR : MELLADRAFT_34756 MELLADRAFT_35944 MELLADRAFT_41327 MELLADRAFT_49980
PLF : PANA5342_p10157(cga)
ACX : Achr_21940 Achr_35970
PLZ : S4054249_07080 S4054249_14090
LANT : TUM19329_04720(legY)
APRS : BI364_07990 BI364_10440
ACII : C4901_05630 C4901_07270 C4901_09820
ATY : A9R16_006770 A9R16_007260
AVV : RvVAT039_pl01560(cga)
AVF : RvVAR031_pl02260(cga)
LNE : FZC33_08555 FZC33_27980
MROS : EHO51_18520 EHO51_18780
AFR : AFE_2224 AFE_2482(cga)
AFE : Lferr_1878 Lferr_2108
AFJ : AFERRID_00830 AFERRID_29490
AFP : K1Y48_01320 K1Y48_06170
SCL : sce0768 sce4027(cga1) sce4102(cga2)
KEB : GXN75_11895 GXN75_17125
AJA : AJAP_02225 AJAP_15665
AAB : A4R43_26130 A4R43_40445
AMYY : YIM_03340(cga1) YIM_37225(cga3)
AORI : SD37_03695 SD37_23095
APRT : MUY14_14070 MUY14_40890
AROO : NQK81_28830 NQK81_42980
AMOG : QRX60_15845 QRX60_37325
ACOR : LCL61_09200 LCL61_20890
ANW : QP939_18050 QP939_40640
CYJ : Cyan7822_5640 Cyan7822_6109
NPU : Npun_F1795 Npun_R3102
TPSC : RBB77_14195 RBB77_23045
BTH : BT_3703(susB) BT_4581
BTHO : Btheta7330_03397 Btheta7330_04593
BOA : Bovatus_03808 Bovatus_04772
BCEL : BcellWH2_02435 BcellWH2_04359 BcellWH2_05314
BIS : DXK01_003445 DXK01_011200 DXK01_015630
BUN : Bun01g_20760 Bun01g_28660 Bun01g_37110
BEG : INE88_01331(susB_1) INE88_03131(susB_2)
BSTE : K6V31_05790 K6V31_11695
BFE : K6V30_06900 K6V30_11410
BNO : K8P02_02365 K8P02_03190 K8P02_14210 K8P02_14220 K8P02_16445
BHUM : JXR92_009530 JXR92_009915 JXR92_013635
BFC : BacF7301_08005 BacF7301_13160
BSAL : K6V25_01305 K6V25_10705
BFIN : BFINE_03520 BFINE_50800
BACE : H1A11_03160 H1A11_03550
BSA : Bacsa_0162 Bacsa_0701 Bacsa_2125
DYS : G7050_08340 G7050_10455 G7050_10460
DYH : G7051_08875 G7051_10825 G7051_10835
DUN : FDZ78_00855 FDZ78_07665
DUQ : E7745_03955 E7745_11650
BVS : BARVI_10590 BARVI_11740 BARVI_12960
PHER : prwr041_11830 prwr041_15160
PCOI : LK433_03565 LK433_03950
POC : NCTC13071_00460 NCTC13071_00991
SBAO : L6469_10185 L6469_11890
MBAS : ALGA_0419 ALGA_0720
FLP : LK994_07935 LK994_10625
STHA : NCTC11429_00044 NCTC11429_00103
ALM : AO498_05945 AO498_15685
SPIR : CWM47_30855 CWM47_36705
HYM : N008_16135 N008_16650
HYD : PK28_12565 PK28_17675
HYZ : AXW84_12820 AXW84_20130
HYJ : FHG12_03600 FHG12_18265
HRS : HER32_01370 HER32_04815
HBN : GUY19_06475 GUY19_12010
HTS : HMJ29_06920 HMJ29_11830
HMT : MTP16_01250 MTP16_03045
HYK : O9Z63_08710 O9Z63_09320
HSK : H4317_07030 H4317_08185
HCW : O3303_06965 O3303_07480
HSB : MWH26_02895 MWH26_09805
HCF : MUN80_03100 MUN80_03205
RUF : TH63_13785 TH63_14815
RUD : TH61_02165 TH61_05215
FLL : EI427_00700 EI427_22695
FYA : KMW28_03290 KMW28_23055
FUA : LVD17_05545 LVD17_16490
ATK : AUTU_42110 AUTU_47700(susB)
FJO : Fjoh_1209 Fjoh_1400 Fjoh_4429
FGL : EM308_03015 EM308_15050
FKI : FK004_09360 FK004_15695
FALB : HYN59_05835 HYN59_16005
FFL : HYN86_05535 HYN86_06475
FEN : J0383_08920 J0383_10145
FPB : NLJ00_06440 NLJ00_07355
FAZ : M0M57_01310 M0M57_11530
FBI : L0669_06170 L0669_07205
FCS : TRV642_1397 TRV642_1929
FPLU : NLG42_06710 NLG42_16175 NLG42_20470 NLG42_23260
FHU : M0M44_06265 M0M44_07240
FPEC : Q1W71_18245 Q1W71_19265
FFV : LNP22_06040 LNP22_06830
FLZ : GIY83_04105 GIY83_17915 GIY83_18915
COC : Coch_0626 Coch_0928 Coch_1394
COL : AM608_06705 AM608_07870
CHG : AXF12_02065 AXF12_02075 AXF12_02225
CAPN : CBG49_00400 CBG49_02325 CBG49_05000
CLK : CGC53_04745 CGC53_05705
CSPU : CGC55_07335 CGC55_08755 CGC55_11490
CCYN : CGC48_01065 CGC48_08595
CSTO : CGC58_00870 CGC58_03565
CAPF : FOC45_10570 FOC45_11625
CAPO : HW278_04480 HW278_06255 HW278_09090
ZGA : ZOBELLIA_368(susB) ZOBELLIA_3886(cgaA)
PTQ : P700755_001305 P700755_003511
PHAL : H9I45_00060 H9I45_05035 H9I45_05040
SMIS : LDL76_04485 LDL76_05970
FEK : C1H87_03925 C1H87_18490 C1H87_19170
KOS : KORDIASMS9_01037(susB)
MARF : CJ739_1662 CJ739_2459
MLIL : QLS71_002240 QLS71_013535
AFLA : FHG64_06215 FHG64_09810
SPON : HME9304_02369(malZ)
SABU : MBM09_14210 MBM09_14915
ALUT : O5O44_03540 O5O44_07395
EMN : M876_06965 M876_15815
EEN : BBD30_07985 BBD30_16980
ELB : VO54_00748 VO54_02904
EMG : BBD33_04800 BBD33_12880
EGO : BBD34_08015 BBD34_18105
EGM : AYC65_08390 AYC65_18950
ELZ : FCS00_01140 FCS00_12010
ELT : FGE20_00180 FGE20_04080
ELIZ : JCR23_11950 JCR23_17945
CIH : ATE47_05125 ATE47_06070
CIO : CEQ15_02565 CEQ15_19280
CHRY : CEY12_00090 CEY12_15655
CPIP : CJF12_07075 CJF12_13180
CTAI : NCTC12078_00320 NCTC12078_00501
CLAC : EG342_06605 EG342_14540
CNP : M0D58_00085 M0D58_01775
CHRJ : CHRYMOREF3P_4568(susB)
CFLU : ODZ84_07310 ODZ84_21930
CNR : EB819_03450 EB819_04050
LFI : LFML04_1872 LFML04_1874
LFP : Y981_09350 Y981_09360
LEG : ABH19_09920 ABH19_09930
HJE : HacjB3_05815 HacjB3_16781
HHI : HAH_2794(cga-2) HAH_2960(aglA2)
HHN : HISP_14200 HISP_15050
HALJ : G9465_05095 G9465_16565
HSN : DV733_00890 DV733_15530
HALB : EKH57_01475 EKH57_08710 EKH57_11530
HSS : J7656_01065 J7656_13085
HSAI : HPS36_03415 HPS36_06565 HPS36_15230
HAZZ : KI388_01255 KI388_13830
HSAL : JMJ58_01395 JMJ58_15605
HXA : Halxa_3685 Halxa_4123
NVR : FEJ81_22300 FEJ81_22315 FEJ81_22370
HALY : HYG82_04560 HYG82_05385
HLR : HALLA_03285 HALLA_06600
AMAN : B6F84_08550 B6F84_12075
ACIH : HS5_15420 HS5_23170
» show all
Taxonomy
Reference
Authors
FRENCH D, KNAPP DW.
Title
The maltase of Clostridium acetobutylicum; its specificity range and mode of action.
Journal
J Biol Chem 187:463-71 (1950)
Reference
Authors
Brown BI, Brown DH.
Title
The subcellular distribution of enzymes in type II glycogenosis and the occurrence of an oligo-alpha-1,4-glucan glucohydrolase in human tissues.
Journal
Reference
Authors
Jeffrey PL, Brown DH, Brown BI.
Title
Studies of lysosomal alpha-glucosidase. I. Purification and properties of the rat liver enzyme.
Journal
Reference
Authors
Kelly JJ, Alpers DH.
Title
Properties of human intestinal glucoamylase.
Journal
Reference
Authors
COPELAND WH, MILLER KD.
Title
A blood trans-alpha-glucosylase.
Journal
Reference
Authors
TSUJISAKA Y, FUKUMOTO J, YAMAMCTO T.
Title
Specificity of crystalline saccharogenic amylase of moulds.
Journal
Other DBs
ExplorEnz - The Enzyme Database: 3.2.1.3
ExPASy - ENZYME nomenclature database: 3.2.1.3
BRENDA, the Enzyme Database: 3.2.1.3
LinkDB
All DBs