Entry
Name
thymine-DNA glycosylase;
mismatch-specific thymine-DNA glycosylase;
mismatch-specific thymine-DNA N-glycosylase;
hTDG;
hsTDG;
TDG;
thymine DNA glycosylase;
G/T glycosylase;
uracil/thymine DNA glycosylase;
T:G mismatch-specific thymidine-DNA glycosylase;
G:T mismatch-specific thymine DNA-glycosylase
Class
Hydrolases;
Glycosylases;
Hydrolysing N-glycosyl compounds
BRITE hierarchy
Sysname
thymine-DNA deoxyribohydrolase (thymine-releasing)
Reaction(IUBMB)
Hydrolyses mismatched double-stranded DNA and polynucleotides, releasing free thymine.
Comment
Thymine-DNA glycosylase is part of the DNA-repair machinery. Thymine removal is fastest when it is from a G/T mismatch with a 5'-flanking C/G pair. The glycosylase removes uracil from G/U, C/U, and T/U base pairs faster than it removes thymine from G/T [3].
History
EC 3.2.2.29 created 2009
Orthology
K20813 thymine-DNA glycosylase
Genes
PTR : 112205005 452188(TDG)
PPS : 100980045(TDG) 100989432
MMU : 21665(Tdg) 545124(Tdg-ps)
MCAL : 110289134 110302718(Tdg)
ANU : 117696317(Tdg) 117701718 117718032
CGE : 100752484 100771878 100772748(Tdg)
MAUA : 101828697(Tdg) 101833826 121133556
PLEU : 114686948 114700613(Tdg)
MMMA : 107139948(Tdg) 107152259
OOR : 101280342 101289555(TDG)
PSIU : 116749477 116760048(TDG)
MJV : 108395214(TDG) 118970202
TOD : 119247359(TDG) 119247368
SETR : 126011540 126022296(TDG)
ETF : 101637963 101648943(TDG)
CLV : 102092705(TDG) 110358245
DRE : 553789(tdg.1) 558951(tdg.2)
SRX : 107716643 107716672 107753540 107753681
SANH : 107665730 107665733 107679582 107679604
SGH : 107574736 107574747 107590837 107590866
CCAR : 109065141 109065142 109074826 109112013 109112014
CAUA : 113043271(tdg) 113043272 113066764 113095310
CGIB : 127946661 128013882 128013884
PTET : 122330353(tdg.2) 122330996(tdg.1)
LROH : 127156733(tdg.1) 127156735(tdg.2)
OMC : 131533874(tdg.2) 131534179(tdg.1)
PPRM : 120459009(tdg.2) 120459087(tdg.1)
RKG : 130085341(tdg.2) 130085343(tdg.1)
MAMB : 125247087(tdg.2) 125247443(tdg.1)
CIDE : 127507201 127507287
CERY : 137014740(tdg.1) 137014942(tdg.2)
MASI : 127435649 127435651 127437705 127437706
TROS : 130551849(tdg.2) 130552213(tdg.1)
TDW : 130413758(tdg.1) 130414214(tdg.2)
MANU : 129433890(tdg.1) 129433892(tdg.2)
IPU : 108269283(tdg.1) 108269360(tdg.2)
IFU : 128611604(tdg.1) 128611606(tdg.2)
PHYP : 113546520 113546553
SMEO : 124386311(tdg.1) 124386322(tdg.2)
TFD : 113635573(tdg.2) 113636089(tdg.1)
TVC : 132855784(tdg.1) 132856230(tdg.2)
TRN : 134319083(tdg.2) 134319517(tdg.1)
AMEX : 103043944(tdg.1) 103045467(tdg.2)
CMAO : 118806738(tdg.1) 118806740(tdg.2)
CHAR : 105891516(tdg.1) 105891517(tdg.2)
TFS : 130535932(tdg.1) 130535935(tdg.2)
TNG : GSTEN00004540G001 GSTEN00004541G001
TBEN : 117497308(tdg.2) 117497310(tdg.1)
CGOB : 115010187 115010233
PGEO : 117448045(tdg.2) 117448600(tdg.1)
GACU : 117557471(tdg.2) 117557479(tdg.1)
EMAC : 134883473 134884219(tdg.2)
EFO : 125887873(tdg.1) 125887916(tdg.2)
PLEP : 121950720 121950771
SLUC : 116046808(tdg.2) 116046812
ECRA : 117948732(tdg.1) 117949310(tdg.2)
PFLV : 114560007 114560430
GAT : 120808931(tdg.2) 120809529 120812634
PPUG : 119196355(tdg.2) 119196410(tdg.1)
AFB : 129108030(tdg.2) 129108033(tdg.1)
CLUM : 117731821(tdg.1) 117731828(tdg.2)
PSWI : 130195233(tdg.2) 130195474(tdg.1)
CANA : 137799723(tdg.1) 137799725(tdg.2)
CVE : 137881656(tdg.1) 137881766(tdg.2)
MSAM : 119893480 119894164(tdg.2)
SCHU : 122874601 122874602
CUD : 121514636 121514653(tdg.2)
ALAT : 119023960(tdg.2) 119023961
ASTR : 137593934(tdg.2) 137594372(tdg.1)
ONL : 100698171(tdg) 100698435
OAU : 116313957(tdg.2) 116313959
OLA : 101155844(tdg) 101162834
CSAI : 133440325 133443644(tdg.2) 133443654(tdg.1) 133444521
XMA : 102223318 102226852(tdg)
XCO : 114133528 114156867(tdg)
PRET : 103465701 103465703(tdg)
PFOR : 103156558 103156561
PLAI : 106939000 106939003
PMEI : 106933967 106933969
GAF : 122835147(tdg.2) 122835757(tdg.1)
PPRL : 129367803(tdg.1) 129367892(tdg.2)
CVG : 107081070 107092187 107092203
CTUL : 119798191(tdg.1) 119798193(tdg.2)
GMU : 124855721(tdg.1) 124877621(tdg.2)
NFU : 107388368(tdg) 107388370
ALIM : 106522812 106522814
NWH : 119415418(tdg.2) 119415420(tdg.1)
AOCE : 111567879 111567882
EJA : 138206150(tdg.2) 138206269(tdg.1)
MCEP : 125014444(tdg.1) 125015296(tdg.2)
CSEM : 103379812 103379813
SSEN : 122776349(tdg.2) 122776371(tdg.1)
HHIP : 117763667(tdg.1) 117763672(tdg.2)
HSP : 118110123(tdg.1) 118110124(tdg.2)
PPLT : 128444324(tdg.1) 128444327(tdg.2)
SMAU : 118315324(tdg.2) 118315672(tdg.1)
LCF : 108889295(tdg.1) 108889296(tdg.2)
SLAL : 111650459(tdg) 111650466
XGL : 120792658(tdg.2) 120793792(tdg.1)
SSCV : 125970926(tdg.1) 125970931(tdg.2)
SBIA : 133501846(tdg.1) 133501848(tdg.2)
PEE : 133402742(tdg.2) 133403361(tdg.1)
PTAO : 133478253(tdg.1) 133478255(tdg.2)
BPEC : 110160314 110160346
MALB : 109973201 109975014
BSPL : 114857768(tdg.1) 114857842(tdg.2)
SJO : 128358788(tdg.2) 128359131(tdg.1)
SASA : 106561084 106561087 106584662 106584663
STRU : 115192829 115192833 115197091(tdg) 115197093
OTW : 112218271 112218273(tdg.2) 112221315 112222201
OMY : 110492132 110492152 110521257 110521258
OGO : 124037006 124037008 124039580(tdg.1) 124039602
ONE : 115134518 115134519 115144706 115144708
OKI : 109867134 109867562 109897711 109897712
OKE : 118374273 118396407 118396411(tdg.1) 127926125
SALP : 111962111 111962113 111972058 111972059
SNH : 120052301 120052302 120066620 120066621
CCLU : 121532132 121532135 121540819 121540820
ELS : 105009540(tdg) 105009541
PKI : 111844304 111844308 111847043
AANG : 118218770 118218771 118231363 118231687
PSPA : 121318478 121319620
ARUT : 117415830 117420017
DSI : Dsimw501_GD24378(Dsim_GD24378)
ACER : 107992495 107999117
ALAB : 122718843 122720041
BBIF : 117204817 117208381
BVAN : 117158113 117163389
BHUN : 126865818 126868788
BTER : 100648503 100649696
BPYO : 122570892 122577836
CCAL : 108626054 108626232 108627180
MGEN : 117224639 117225009
NMEA : 116425224 116427667
MPHA : 105833412 105838336
AEC : 105153872 105154007 105154122
ACEP : 105618145 105622736
PBAR : 105424915 105427395 105427396
LHU : 105674984(Tdg) 105679748
PFUC : 122520013 122525916
VCRB : 124426590 124428104
CSOL : 105364184 105365644
TPRE : 106657129 111694519
CGLO : 123259989 123272512
CLEC : 106667760 106669980
HHAL : 106682041 106689665
HAME : 121857233 121864623
PCLA : 123746559 138359266
HRO : HELRODRAFT_124128 HELRODRAFT_71611
AIRR : 138304985 138313701
LBG : 92208662(LODBEIA_P34660)
CAL : CAALFM_C306530WA(CaO19.7442)
CTP : CTRG_05704 CTRG_05712
YLI : 2908595(YALI2_F00094g)
SMP : 10810534(SMAC4_04996)
FVR : FVEG_00629 FVEG_08412
FMU : J7337_001351 J7337_012927
TATV : 25777163(TrAtP1_006509)
TASP : 36616481(TrAFT101_005774)
MAW : 19250538(J3458_019947)
PLJ : 28891230(PLICBS_004471)
CDET : 87948806(CDEST_12306)
CPW : 9697653(D8B26_007292)
PTRR : 6342843(PtrM4_115160)
TML : GSTUM_00001121001 GSTUM_00005557001
CDEP : 91087390(L203_103179)
KMG : 30167778(I203_100073)
KNE : 92184058(IAR55_006800)
PCO : PHACADRAFT_203182 PHACADRAFT_203552 PHACADRAFT_259229 PHACADRAFT_266509
LBC : LACBIDRAFT_298866 LACBIDRAFT_303372 LACBIDRAFT_312282 LACBIDRAFT_316334 LACBIDRAFT_316355 LACBIDRAFT_316369 LACBIDRAFT_316377
ABP : AGABI1DRAFT69564(AGABI1DRAFT_69564)
ABV : AGABI2DRAFT200628(AGABI2DRAFT_200628)
MRR : Moror_1803 Moror_7098
SCM : SCHCO_02497584(SCHCODRAFT_02497584)
RIE : OCT59_000599 OCT59_003350 OCT59_010875
» show all
Taxonomy
Reference
Authors
Waters TR, Swann PF
Title
Thymine-DNA glycosylase and G to A transition mutations at CpG sites.
Journal
Reference
Authors
Neddermann P, Jiricny J
Title
The purification of a mismatch-specific thymine-DNA glycosylase from HeLa cells.
Journal
J Biol Chem 268:21218-24 (1993)
Sequence
Reference
Authors
Waters TR, Swann PF
Title
Kinetics of the action of thymine DNA glycosylase.
Journal
Other DBs
ExplorEnz - The Enzyme Database: 3.2.2.29
ExPASy - ENZYME nomenclature database: 3.2.2.29
LinkDB
All DBs