KEGG   ENZYME: 3.3.2.15
Entry
EC 3.3.2.15                 Enzyme                                 
Name
trans-2,3-dihydro-3-hydroxyanthranilic acid synthase;
isochorismatase (ambiguous);
phzD (gene name)
Class
Hydrolases;
Acting on ether bonds;
Ether hydrolases
Sysname
(2S)-2-amino-4-deoxychorismate pyruvate-hydrolase
Reaction(IUBMB)
(2S)-2-amino-4-deoxychorismate + H2O = (5S,6S)-6-amino-5-hydroxycyclohexa-1,3-diene-1-carboxylate + pyruvate [RN:R11463]
Reaction(KEGG)
R11463
Substrate
(2S)-2-amino-4-deoxychorismate [CPD:C18054];
H2O [CPD:C00001]
Product
(5S,6S)-6-amino-5-hydroxycyclohexa-1,3-diene-1-carboxylate [CPD:C19830];
pyruvate [CPD:C00022]
Comment
Isolated from the bacterium Pseudomonas aeruginosa. Involved in phenazine biosynthesis.
History
EC 3.3.2.15 created 2016
Pathway
ec00405  Phenazine biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K20261  trans-2,3-dihydro-3-hydroxyanthranilic acid synthase
Genes
KGR: JJJ10_13560
KPAS: LUW96_21805
KLM: BWI76_15095
SFW: WN53_03390
ECA: ECA2702(ehpB)
PATR: EV46_13200
PATO: GZ59_18580(ehpB)
PPAV: LOZ86_13700
PACB: M9782_10865
LAB: LA76x_3334(phzD1)
LAQ: GLA29479_2367(phzD1)
DYG: DYGSA30_26150(phzD1)
VRU: RND59_08000
PAE: PA1902(phzD2) PA4213(phzD1)
PAEV: N297_1962 N297_4345
PAEI: N296_1962 N296_4345
PAU: PA14_09450(phzD1) PA14_39925(phzD2)
PAP: PSPA7_0886 PSPA7_3382
PAG: PLES_07141(phzD1) PLES_34221(phzD2)
PAF: PAM18_0724(phzD1) PAM18_3140(phzD2)
PAEB: NCGM1900_4587
PDK: PADK2_03605 PADK2_16140
PSG: G655_03640 G655_15605
PRP: M062_22195
PAEP: PA1S_03755 PA1S_16430
PAER: PA1R_gp2104 PA1R_gp5531
PAEM: U769_03785 U769_16145
PAEL: T223_03690 T223_17490
PAES: SCV20265_0748 SCV20265_3493
PAEU: BN889_06463(phzD1_1) BN889_06777(phzD1_3) BN889_07359(phzD1_6)
PAEG: AI22_00155 AI22_17560
PAEC: M802_1960 M802_4343
PAEO: M801_1961 M801_4211
SECH: B18_04210 B18_21400
PPAA: B7D75_03685 B7D75_15430
PAST: N015_20085
PFB: VO64_0337
POI: BOP93_12305
PCH: EY04_26285
PCP: JM49_05460
PCHP: C4K32_5262
PSET: THL1_3621
PYM: AK972_2556
PSEP: C4K39_3098
PPII: QL104_15640
PKV: QYQ93_14700
PBAM: NUH87_15860
BUU: WS70_27180
BUR: Bcep18194_B1569
BGL: bglu_2g09250
BGU: KS03_4992
TVL: FAZ95_31780
RUG: QC826_13640
BVR: BVIR_2863
MAB: MAB_0297
MMV: MYCMA_0159
MABB: MASS_0298
MABL: MMASJCM_0294
MCHE: BB28_01465
MIZ: BAB75_02015
MSAO: MYCSP_01295
MSAL: DSM43276_00252(phzD_1)
CMV: CMUST_14535
NBR: O3I_033280
NAH: F5544_33425
NHU: H0264_16225
RFA: A3L23_00644(phzD)
RHS: A3Q41_02711(phzD)
TPR: Tpau_0113
SALB: XNR_0597
SFI: SFUL_3324 SFUL_5262
SGRF: SGFS_036810
SCYE: R2B67_04370
SCB: SCAB_12041
SSX: SACTE_1752
SALS: SLNWT_4919
SGU: SGLAU_17220(phzA)
STRM: M444_18420
STRC: AA958_30770
SCZ: ABE83_19210 ABE83_26415
SRN: A4G23_05417(phzD)
STRT: A8713_24035
SGM: GCM10017557_24350(phzD1)
SCAD: DN051_13635 DN051_37360
SLS: SLINC_5468
SPLU: LK06_026280
STRD: NI25_24440
SNW: BBN63_05570
SALJ: SMD11_1729 SMD11_3253
SQZ: FQU76_00255 FQU76_33485
SAST: CD934_07145
SGZ: C0216_00425
SVN: CP980_14880
SRK: FGW37_24780
SVR: CP971_17430
SPAD: DVK44_32315
SCAV: CVT27_15340
SSEO: D0Z67_01715
SCIN: CP977_15855
SFUG: CNQ36_29865
SSPB: CP982_28280
SHUN: DWB77_04281(phzD)
SLIA: HA039_29910
SFB: CP974_28840
SROI: IAG44_13945 IAG44_38380
STRY: EQG64_08385 EQG64_16160
SMAO: CAG99_00490 CAG99_15050
SLF: JEQ17_03405
SNIG: HEK616_55590(phzD1)
SCAE: IHE65_08535
STUD: STRTU_005062
STEE: F3L20_15980
SGK: PET44_17175
SCYN: N8I84_14850 N8I84_30915
SHAU: K9S39_36110
SKG: KJK29_05880
SCOA: QU709_14165
SCHG: NRO40_23340 NRO40_27020
SINN: ABB07_25525
KBU: Q4V64_42955
SPRF: K4G22_02680
SCAJ: O1G22_43765
KSK: KSE_58300 KSE_59070
KAU: B6264_12425
KIT: CFP65_3611
KCH: O1G21_10005 O1G21_27135
STRI: C7M71_014740
ABRY: NYE86_21255
FRP: AX769_15030
RTER: IDM49_10735
RAMA: IDM48_01840
CEZ: CBP52_12015
CPAL: F1D97_01435
KRI: OX958_35230
THAO: NI17_009045
TALX: FOF52_08960 FOF52_14760
NDA: Ndas_5030
NEX: NE857_18250
NAKE: KGD83_26655
NCG: KGD84_13385
STRR: EKD16_18440(phzD)
ACTW: F7P10_05705
NOA: BKM31_19750
NGN: LCN96_24510
MHAI: OHB01_22665
FRE: Franean1_3619
SACG: FDZ84_16255
AMYC: CU254_36750
PHH: AFB00_28930
APRE: CNX65_15955
SSYI: EKG83_21240
KUT: JJ691_21740
KPHY: AOZ06_22495 AOZ06_25085
ALO: CRK58740
ACTU: Actkin_02707(dhbB_2) Actkin_02796(phzD)
MICB: MicB006_2898
MICH: FJK98_01250
MSAG: GCM10017556_11840
MCHL: PVK74_09445
PFLA: Pflav_059760
PSUU: Psuf_020500 Psuf_091090
PRY: Prubr_64680(phzD1)
DFU: Dfulv_24065
DROS: Drose_22850
DMAT: Dmats_35165
DACT: KZZ52_19515
GLY: K3N28_00720
ACTC: CHIBA101_0087
AEY: CDG81_16850
 » show all
Reference
1  [PMID:11591691]
  Authors
Mavrodi DV, Bonsall RF, Delaney SM, Soule MJ, Phillips G, Thomashow LS
  Title
Functional analysis of genes for biosynthesis of pyocyanin and phenazine-1-carboxamide from Pseudomonas aeruginosa PAO1.
  Journal
J Bacteriol 183:6454-65 (2001)
DOI:10.1128/JB.183.21.6454-6465.2001
  Sequence
[pae:PA1902 PA4213]
Reference
2  [PMID:12741825]
  Authors
Parsons JF, Calabrese K, Eisenstein E, Ladner JE
  Title
Structure and mechanism of Pseudomonas aeruginosa PhzD, an isochorismatase from the phenazine biosynthetic pathway.
  Journal
Biochemistry 42:5684-93 (2003)
DOI:10.1021/bi027385d
  Sequence
[pae:PA1902]
Other DBs
ExplorEnz - The Enzyme Database: 3.3.2.15
IUBMB Enzyme Nomenclature: 3.3.2.15
ExPASy - ENZYME nomenclature database: 3.3.2.15
BRENDA, the Enzyme Database: 3.3.2.15
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