KEGG ENZYME: 3.4.17.23

ENZYME: 3.4.17.23

Entry

EC 3.4.17.23                Enzyme

Name

angiotensin-converting enzyme 2;
ACE-2;
ACE2;
hACE2;
angiotensin converting enzyme 2;
angiotensin converting enzyme-2;
Tmem27

Class

Hydrolases;
Acting on peptide bonds (peptidases);
Metallocarboxypeptidases

Reaction(IUBMB)

angiotensin II + H2O = angiotensin-(1--7) + L-phenylalanine [RN:R09535]

Reaction(KEGG)

R09535

Substrate

angiotensin II [CPD:C02135];
H2O [CPD:C00001]

Product

angiotensin-(1--7);
L-phenylalanine [CPD:C00079]

Comment

A transmembrane glycoprotein with an extracellular catalytic domain. Angiotensin-converting enzyme 2 functions as a carboxypeptidase, cleaving a single C-terminal residue from a distinct range of substrates [2]. Catalytic efficiency is 400-fold higher with angiotensin II (1--8) as a substrate than with angiotensin I (1--10). Angiotensin-converting enzyme 2 also efficiently hydrolyses des-Arg9-bradykinin, but it does not hydrolyse bradykinin [1]. In peptidase family M2.

History

EC 3.4.17.23 created 2009

Orthology

K09708

angiotensin-converting enzyme 2

Genes

HSA:	59272(ACE2)

PTR:	465511(ACE2)

PPS:	100970340(ACE2)

GGO:	101142534(ACE2)

PON:	100171441(ACE2)

NLE:	100602708(ACE2)

MCC:	712790(ACE2)

MCF:	102130864(ACE2)

MTHB:

126946901

MNI:	105478157(ACE2)

CSAB:

103231639(ACE2)

CATY:

105574684(ACE2)

PANU:

101008749(ACE2)

TGE:	112615413(ACE2)

RRO:	104664530(ACE2)

RBB:	108539696(ACE2)

TFN:	117077264(ACE2)

PTEH:

111531712(ACE2)

CANG:

105510462

CJC:	100408882(ACE2)

SBQ:	101045190(ACE2)

CSYR:

103267011(ACE2)

MMUR:

105882317(ACE2)

LCAT:

123628560(ACE2)

PCOQ:

105805773(ACE2)

OGA:	100951881(ACE2)

MMU:	70008(Ace2)

MCAL:

110286854(Ace2)

MPAH:

110313851(Ace2)

RNO:	302668(Ace2)

MCOC:

116090418(Ace2)

MUN:	110542540 110542541

CGE:	100772552(Ace2)

MAUA:

101823817(Ace2)

PLEU:

114705723(Ace2)

MORG:

121439480(Ace2)

MFOT:

126512736

AAMP:

119804711(Ace2)

NGI:	103740288(Ace2)

HGL:	101697829(Ace2)

CPOC:

100302675(Ace2)

DORD:

105997641(Ace2)

DSP:	122108549(Ace2)

NCAR:

124971823

OCU:	100327258(ACE2)

OPI:	101526767(ACE2)

TUP:	102484728(ACE2)

GVR:

103607293

CFA:	480847(ACE2)

CLUD:

112653200(ACE2)

VVP:	112910549(ACE2)

VLG:	121483384(ACE2)

AML:	100465802(ACE2)

UMR:	103668146(ACE2)

UAH:	113240702(ACE2)

UAR:	123797272(ACE2)

ELK:

111157129

LLV:

125091709

MPUF:

101673097(ACE2)

NVS:	122897655(ACE2)

ORO:	101373514(ACE2)

EJU:	114218071(ACE2)

ZCA:	113931501(ACE2)

MLX:	118004949(ACE2)

NSU:	110572485(ACE2)

LWW:

102726269

FCA:	554349(ACE2)

PYU:	121025614(ACE2)

PBG:	122476826(ACE2)

LRUF:

124509367

PTG:	102965716(ACE2)

PPAD:

109248320(ACE2)

AJU:	106974224(ACE2)

HHV:	120232915(ACE2)

BTA:	509235(ACE2)

BOM:	102274886(ACE2)

BIU:	109555348(ACE2)

BBUB:

102409199(ACE2)

BBIS:

104984774(ACE2)

CHX:	102184608(ACE2)

OAS:	101103622(ACE2)

ODA:	120882560(ACE2)

CCAD:

122434819(ACE2)

SSC:	100144303(ACE2)

CFR:	102523304(ACE2)

CBAI:

105079297(ACE2)

CDK:	105100402(ACE2)

VPC:	102526063(ACE2)

BACU:

103009000(ACE2)

LVE:	103086585(ACE2)

OOR:	101283738(ACE2)

DLE:	111168887(ACE2)

PCAD:

102996907(ACE2)

PSIU:

116747656(ACE2)

ECB:	100055952(ACE2)

EPZ:	103568003(ACE2)

EAI:	106841569(ACE2)

MYB:	102259026(ACE2)

MYD:	102763166(ACE2)

MMYO:

118654484(ACE2)

MLF:	102419076(ACE2)

MNA:	107529512(ACE2)

PKL:	118719785(ACE2)

HAI:	109395939(ACE2)

DRO:	112313373(ACE2)

SHON:

118987251(ACE2)

AJM:	119058376(ACE2)

PDIC:

114504693(ACE2)

PHAS:

123829997(ACE2)

MMF:	118636490(ACE2)

RFQ:	117022979(ACE2)

PALE:

102888407(ACE2)

PGIG:

120611083(ACE2)

PVP:	105294000(ACE2)

RAY:	107497263(ACE2)

MJV:	108390919(ACE2)

TOD:	119246786(ACE2)

SARA:

101538370(ACE2)

LAV:	100663153(ACE2)

TMU:

101343545

ETF:	101656395(ACE2)

DNM:	101429092(ACE2)

MDO:	100031783(ACE2)

GAS:	123241705(ACE2)

SHR:	100917420(ACE2)

PCW:	110222490(ACE2)

OAA:	100085223(ACE2)

GGA:	418623(ACE2)

PCOC:

116230727(ACE2)

MGP:	100541186(ACE2)

CJO:	107325566(ACE2)

NMEL:

110392736(ACE2)

APLA:

101792697(ACE2)

ACYG:

106037784(ACE2)

AFUL:

116498237(ACE2)

TGU:	100232752(ACE2)

LSR:	110471619(ACE2)

SCAN:

103815821(ACE2)

PMOA:

120504620(ACE2)

OTC:	121342248(ACE2)

PRUF:

121356213(ACE2)

GFR:	102037445(ACE2)

FAB:	101814772(ACE2)

PHI:	102108306(ACE2)

PMAJ:

107206020(ACE2)

CCAE:

111922841(ACE2)

CCW:	104686166(ACE2)

CBRC:

103611746(ACE2)

ETL:	114066567(ACE2)

ZAB:	102067801(ACE2)

ACHL:

103810970(ACE2)

FPG:	101911905(ACE2)

FCH:	102045810(ACE2)

CLV:	102095592(ACE2)

EGZ:	104127303(ACE2)

NNI:	104022575(ACE2)

PLET:

104624367(ACE2)

PCRI:

104029332(ACE2)

PCAO:

104049988(ACE2)

ACUN:

113480767(ACE2)

TALA:

104364304(ACE2)

PADL:

103918227(ACE2)

AFOR:

103896937(ACE2)

ACHC:

115334679(ACE2)

HALD:

104310355(ACE2)

HLE:	104840548(ACE2)

AGEN:

126052875

GCL:

127026027

CCRI:

104165694(ACE2)

CSTI:

104561893(ACE2)

EHS:	104502443(ACE2)

CMAC:

104481125(ACE2)

MUI:	104537500(ACE2)

FGA:	104075932(ACE2)

GSTE:

104261683(ACE2)

LDI:	104350299(ACE2)

MNB:	103771950(ACE2)

OHA:	104334989(ACE2)

NNT:	104405453(ACE2)

PGUU:

104470941(ACE2)

ACAR:

104527265(ACE2)

CPEA:

104385382(ACE2)

AVIT:

104273417(ACE2)

CVF:	104289986(ACE2)

CUCA:

104063399(ACE2)

TEO:	104374083(ACE2)

BRHI:

104495535(ACE2)

AAM:	106490772(ACE2)

AROW:

112976192(ACE2)

NPD:	112943996(ACE2)

TGT:	104572141(ACE2)

DNE:	112995661(ACE2)

SCAM:

104140442(ACE2)

ASN:	102388701(ACE2)

AMJ:	102570994(ACE2)

CPOO:

109306030(ACE2)

GGN:	109303314(ACE2)

PSS:	102452742(ACE2)

CMY:	102938941(ACE2)

CPIC:

101950848(ACE2)

TST:	117869503(ACE2)

CABI:

116821846(ACE2)

MRV:	120375732(ACE2)

ACS:	100565298(ace2)

PVT:	110075460(ACE2)

SUND:

121925094(ACE2)

PBI:	103068164(ACE2)

PMUR:

107290068(ACE2)

CTIG:

120306512(ACE2)

TSR:	106541239 106553039(ACE2)

PGUT:

117675857(ACE2)

VKO:	123033092(ACE2)

ZVI:	118085306(ACE2)

GJA:	107115822(ACE2)

STOW:

125431331(ACE2)

XLA:	100037182(ace2.S) 108707435(ace2.L)

XTR:	100486137(ace2)

NPR:	108792313(ACE2)

RTEM:

120927763(ACE2)

BBUF:

120994623(ACE2)

BGAR:

122927935 122930372(ACE2)

DRE:	492331(ace2)

SRX:	107737258 107751135

SANH:

107691301(ace2) 107695051

SGH:	107555905 107569674

CCAR:

109101192 109101497

CAUA:

113055292 113111073(ace2)

PPRM:

120480577(ace2)

MAMB:

125256625(ace2)

IPU:	108259124(ace2)

PHYP:

113547458(ace2)

SMEO:

124380062(ace2)

TFD:	113657143(ace2)

AMEX:

103030208(ace2)

EEE:	113578258(ace2)

TRU:	101066589(ace2)

TNG:	GSTEN00018041G001

LCO:	104919764(ace2)

NCC:	104963551(ace2)

CGOB:

115005777(ace2)

ELY:	117263329(ace2)

EFO:	125878828(ace2)

PLEP:

121945388(ace2)

SLUC:

116054689(ace2)

ECRA:

117947475(ace2)

ESP:	116669656(ace2)

PFLV:

114560278(ace2)

GAT:	120808741(ace2)

PPUG:

119225508(ace2)

MSAM:

119890262(ace2)

CUD:	121521168(ace2)

ALAT:

119018333(ace2)

MZE:	101480744(ace2)

ONL:	100699386(ace2)

OAU:	116311736(ace2)

OML:	112160389(ace2)

XMA:	102218691(ace2)

XCO:	114143639(ace2)

XHE:	116719116(ace2)

PRET:

103462028(ace2)

PFOR:

103143561(ace2)

PLAI:

106952008(ace2)

PMEI:

106914635(ace2)

GAF:	122820294(ace2)

CVG:	107082518(ace2)

CTUL:

119782330(ace2)

GMU:	124867441(ace2)

NFU:	107381688(ace2)

KMR:	108250149(ace2)

ALIM:

106536269(ace2)

NWH:	119429166(ace2)

AOCE:

111567340(ace2)

MCEP:

125005739(ace2)

CSEM:

103378664(ace2)

POV:	109624773(ace2)

SSEN:

122771881(ace2)

HHIP:

117759282(ace2)

HSP:	118113077(ace2)

LCF:

108887946

SDU:	111224725(ace2)

SLAL:

111651666(ace2)

XGL:	120794742(ace2)

HCQ:	109526010(ace2)

BPEC:

110161222(ace2)

MALB:

109965722(ace2)

BSPL:

114851880(ace2)

SASA:

106595857 106609069(ace2)

STRU:

115188686 115188791

OTW:	112239661(ace2)

OMY:	110496986 110500299

OGO:

124028887

SALP:

112076415(ace2)

SNH:	120042338 120042431(ace2)

CCLU:

121562841(ace2)

ELS:	105019921(ace2)

SFM:	108920456(ace2)

PKI:	111850234(ace2)

AANG:

118213842(ace2)

LOC:	102690232(ace2)

PSPA:

121320626(ace2) 121328027

ARUT:

117406081 117407347(ace2)

PSEX:

120523603(ace2)

LCM:	102362771(ACE2)

CMK:	103177482(ace2)

RTP:	109912326 109912327

BBEL:

109476928

AJC:

117106339

SKO:	100375272 100375575 102806594

OBB:

114878034

CGIG:

122405136

SOC:

105205666

MPHA:

105827808

HST:

105186217

DQU:

106744847

LHU:

105672116

OBO:

105281396

DPX:	DAPPUDRAFT_65345

DMK:	116922098 116928362

DPZ:	124312323 124328503 124328504 124340502

HAME:

121875276

» show all

Reference

1 [PMID:11815627]

Authors

Vickers C, Hales P, Kaushik V, Dick L, Gavin J, Tang J, Godbout K, Parsons T, Baronas E, Hsieh F, Acton S, Patane M, Nichols A, Tummino P

Title

Hydrolysis of biological peptides by human angiotensin-converting enzyme-related carboxypeptidase.

Journal

J Biol Chem 277:14838-43 (2002)
DOI:10.1074/jbc.M200581200

Sequence

[hsa:59272]

Reference

2 [PMID:17897633]

Authors

Lambert DW, Hooper NM, Turner AJ

Title

Angiotensin-converting enzyme 2 and new insights into the renin-angiotensin system.

Journal

Biochem Pharmacol 75:781-6 (2008)
DOI:10.1016/j.bcp.2007.08.012

Reference

3 [PMID:14754895]

Authors

Towler P, Staker B, Prasad SG, Menon S, Tang J, Parsons T, Ryan D, Fisher M, Williams D, Dales NA, Patane MA, Pantoliano MW

Title

ACE2 X-ray structures reveal a large hinge-bending motion important for inhibitor binding and catalysis.

Journal

J Biol Chem 279:17996-8007 (2004)
DOI:10.1074/jbc.M311191200

Other DBs

ExplorEnz - The Enzyme Database:

3.4.17.23

IUBMB Enzyme Nomenclature:

3.4.17.23

ExPASy - ENZYME nomenclature database:

3.4.17.23

BRENDA, the Enzyme Database:

3.4.17.23

LinkDB

DBGET integrated database retrieval system