Entry
Name
angiotensin-converting enzyme 2;
ACE-2;
ACE2;
hACE2;
angiotensin converting enzyme 2;
angiotensin converting enzyme-2;
Tmem27
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Metallocarboxypeptidases
BRITE hierarchy
Reaction(IUBMB)
angiotensin II + H2O = angiotensin-(1--7) + L-phenylalanine [RN:
R09535 ]
Reaction(KEGG)
Substrate
Product
angiotensin-(1--7);
L-phenylalanine [CPD:
C00079 ]
Comment
A transmembrane glycoprotein with an extracellular catalytic domain. Angiotensin-converting enzyme 2 functions as a carboxypeptidase, cleaving a single C-terminal residue from a distinct range of substrates [2]. Catalytic efficiency is 400-fold higher with angiotensin II (1--8) as a substrate than with angiotensin I (1--10). Angiotensin-converting enzyme 2 also efficiently hydrolyses des-Arg9-bradykinin, but it does not hydrolyse bradykinin [1]. In peptidase family M2.
History
EC 3.4.17.23 created 2009
Orthology
K09708 angiotensin-converting enzyme 2
Genes
TSR : 106541239 106553039(ACE2)
XLA : 100037182(ace2.S) 108707435(ace2.L)
BGAR : 122927935 122930372(ACE2)
SANH : 107691301(ace2) 107695051
CCAR : 109101192 109101497
CAUA : 113055292 113111073(ace2)
CGIB : 127968584 128022223
MASI : 127426183 127428003
CHAR : 105893318(ace2) 105893961
SPIL : 134071175(ace2) 134102465
SASA : 106595857 106609069(ace2)
STRU : 115188686 115188791
OCLA : 139402523 139402659
SNH : 120042338 120042431(ace2)
PSPA : 121320626(ace2) 121328027
ARUT : 117406081 117407347(ace2)
LPIC : 129274227 129275092
ARUN : 117303157 117303241
AAMU : 139947994 139947995
AFIL : 140138783 140138813 140145805
SKO : 100375272 100375575 102806594
PFLL : 139114404 139114405
DPZ : 124312323 124328503 124328504 124340502
» show all
Taxonomy
Reference
Authors
Vickers C, Hales P, Kaushik V, Dick L, Gavin J, Tang J, Godbout K, Parsons T, Baronas E, Hsieh F, Acton S, Patane M, Nichols A, Tummino P
Title
Hydrolysis of biological peptides by human angiotensin-converting enzyme-related carboxypeptidase.
Journal
Sequence
Reference
Authors
Lambert DW, Hooper NM, Turner AJ
Title
Angiotensin-converting enzyme 2 and new insights into the renin-angiotensin system.
Journal
Reference
Authors
Towler P, Staker B, Prasad SG, Menon S, Tang J, Parsons T, Ryan D, Fisher M, Williams D, Dales NA, Patane MA, Pantoliano MW
Title
ACE2 X-ray structures reveal a large hinge-bending motion important for inhibitor binding and catalysis.
Journal
Other DBs
ExPASy - ENZYME nomenclature database: 3.4.17.23
LinkDB
All DBs