Hydrolases;
Acting on peptide bonds (peptidases);
Metallocarboxypeptidases
BRITE hierarchy

angiotensin II + H2O = angiotensin-(1--7) + L-phenylalanine [RN:R09535]

R09535
Reaction

angiotensin II [CPD:C02135];
H2O [CPD:C00001]

A transmembrane glycoprotein with an extracellular catalytic domain. Angiotensin-converting enzyme 2 functions as a carboxypeptidase, cleaving a single C-terminal residue from a distinct range of substrates [2]. Catalytic efficiency is 400-fold higher with angiotensin II (1--8) as a substrate than with angiotensin I (1--10). Angiotensin-converting enzyme 2 also efficiently hydrolyses des-Arg9-bradykinin, but it does not hydrolyse bradykinin [1]. In peptidase family M2.

EC 3.4.17.23 created 2009

1  [PMID:11815627]

Vickers C, Hales P, Kaushik V, Dick L, Gavin J, Tang J, Godbout K, Parsons T, Baronas E, Hsieh F, Acton S, Patane M, Nichols A, Tummino P

Hydrolysis of biological peptides by human angiotensin-converting enzyme-related  carboxypeptidase.

J Biol Chem 277:14838-43 (2002)
DOI:10.1074/jbc.M200581200

[hsa:59272]

2  [PMID:17897633]

Lambert DW, Hooper NM, Turner AJ

Angiotensin-converting enzyme 2 and new insights into the renin-angiotensin system.

Biochem Pharmacol 75:781-6 (2008)
DOI:10.1016/j.bcp.2007.08.012

3  [PMID:14754895]

Towler P, Staker B, Prasad SG, Menon S, Tang J, Parsons T, Ryan D, Fisher M, Williams D, Dales NA, Patane MA, Pantoliano MW

ACE2 X-ray structures reveal a large hinge-bending motion important for inhibitor binding and catalysis.

J Biol Chem 279:17996-8007 (2004)
DOI:10.1074/jbc.M311191200