KEGG   ENZYME: 3.4.21.21
Entry
EC 3.4.21.21                Enzyme                                 
Name
coagulation factor VIIa;
blood-coagulation factor VIIa;
activated blood coagulation factor VII
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Serine endopeptidases
Reaction(IUBMB)
Selective cleavage of Arg!Ile bond in factor X to form factor Xa
Comment
Formed from the precursor factor VII. The cattle enzyme is more readily inhibited by diisopropyl fluorophosphate than the human [1]. In peptidase family S1 (trypsin family)
History
EC 3.4.21.21 created 1978
Orthology
K01320  coagulation factor VII
Genes
HSA2155(F7)
PTR744785(F7)
PPS100987335(F7)
GGO101136216(F7)
PON100452636(F7)
NLE100607316(F7)
MCC721933(F7)
MCF102121077(F7)
MTHB126940187
CSAB103214833(F7)
CATY105584947(F7)
PANU100137442(F7)
TGE112617330 112617333
RRO104659908(F7)
RBB108521813(F7)
TFN117063480(F7)
PTEH111546339(F7)
CANG105505922(F7)
CJC100410381(F7)
SBQ101043113(F7)
MMUR105871938(F7)
LCAT123648811
PCOQ105825139(F7)
OGA100943078(F7)
MMU14068(F7)
MCAL110300360(F7)
MPAH110336954(F7)
RNO260320(F7)
MCOC116071158(F7)
CGE100759052(F7)
PLEU114701249(F7)
NGI103746283(F7)
HGL101706917(F7)
CPOC100727155(F7)
CCAN109686462(F7)
DORD105990379(F7)
DSP122122741(F7)
NCAR124985036
OCU100009399(F7)
OPI101527605
TUP102482034(F7)
GVR103598975(F7)
CFA607661(F7)
CLUD112656013(F7)
VVP112927508(F7)
VLG121477073(F7)
AML100471728(F7)
UMR103657528(F7)
UAH113247584(F7)
UAR123776736(F7)
ELK111147145
LLV125094855
MPUF101670299(F7)
ORO101366144(F7)
EJU114196651(F7)
ZCA113920091(F7)
MLX118009112(F7)
NSU110585853(F7)
LWW102733982(F7)
FCA101090581(F7)
PYU121037687(F7)
PBG122485003(F7)
LRUF124517231
PTG102950134(F7)
PPAD109264041(F7)
AJU106986724(F7)
HHV120228330(F7)
BTA617960(F7)
BOM102272114(F7)
BIU109567023(F7)
BBUB123464843(F7)
BBIS104982129(F7)
CHX102174404(F7)
OAS101118369(F7)
ODA120883381(F7)
CCAD122447330(F7)
SSC733661(F7)
CFR102519118(F7)
CBAI105066886(F7)
CDK105091336(F7)
LVE103076497(F7)
OOR101277688(F7)
DLE111176366(F7)
PCAD102977949(F7)
PSIU116742860(F7)
ECB100067072(F7)
EPZ103549658(F7)
EAI106839877(F7)
MYB102260786(F7)
MYD102765822(F7)
MMYO118652112(F7)
MLF102422549(F7)
MNA107536944(F7)
PKL118729785(F7)
HAI109383930(F7)
DRO112321523(F7)
SHON118984247(F7)
AJM119045897(F7)
PDIC114508703(F7)
PHAS123807543(F7)
MMF118622834(F7)
RFQ117021066(F7)
PALE102884062(F7)
PGIG120615625(F7)
RAY107514334(F7)
MJV108398704(F7)
TOD119259646(F7)
SARA101546858(F7)
LAV100655748(F7)
TMU101347612
ETF101645208 101645520(F7)
DNM101441674(F7)
MDO100022420(F7)
GAS123241780(F7)
SHR100921248(F7)
PCW110193401(F7)
GGA395086(F7)
PCOC116242799
MGP100548839(F7)
CJO107307824(F7)
NMEL110407377
APLA101796107(F7)
ACYG106046420(F7)
AFUL116500723(F7)
TGU100223776
LSR110478744
SCAN103812401
PMOA120504727
OTC121343148
PRUF121356203
GFR102035674(F7)
FAB101814835(F7)
PHI102113790
PMAJ107211187(F7)
CCAE111922719 111944764
CCW104686114
CBRC103617560
ETL114057854
ZAB102062358
ACHL103804516(F7)
FPG101911545(F7)
FCH102049587(F7)
CLV102092108(F7)
EGZ104132450(F7)
NNI104019371(F7)
PLET104618495(F7)
PCRI104034058(F7)
PCAO104048247(F7)
ACUN113485847(F7)
TALA104363232(F7)
PADL103918860(F7)
AFOR103896260
ACHC115334729(F7)
HALD104321278(F7)
HLE104836878(F7)
AGEN126052942
GCL127026128
CCRI104163703(F7)
CSTI104557028(F7)
EHS104507178
CMAC104487209
MUI104534292
FGA104070393(F7)
GSTE104257994(F7)
LDI104342655(F7)
MNB103770909(F7)
OHA104339593
NNT104411764(F7)
DPUB104298625(F7)
PGUU104458835(F7)
ACAR104520815
AVIT104268666(F7)
CVF104292717(F7)
CUCA104056613(F7)
TEO104384064(F7)
BRHI104501108(F7)
AAM106493960(F7)
AROW112960861(F7)
NPD112951596(F7)
TGT104577824(F7)
DNE112981396(F7)
ASN102375756(F7)
AMJ102560637(F7)
CPOO109306298(F7)
GGN109303320(F7)
PSS102463876(F7)
CMY102939588(F7)
CPIC101936681(F7)
TST117870785(F7)
CABI116823352(F7)
MRV120395708(F7)
ACS107982633
SUND121926339(F7)
PBI103068222
PMUR107290448(F7)
CTIG120315420
PGUT117666369(F7)
VKO123022733(F7)
PMUA114596455(F7)
ZVI118085144(F7)
GJA107110910
STOW125432180(F7)
XLA444394(f7.S)
XTR780280(f7)
NPR108791687(F7)
RTEM120926382(F7)
BBUF120995775(F7)
BGAR122932161(F7)
DRE100038778(f7l) 114423(f7)
SRX107732003 107747061 107747062 107747071 107751062
SANH107654598 107654615 107680190 107694469
SGH107551096 107551097 107570083 107570084 107572931(f7)
CCAR109064625 109065585 109102520 109102880
CAUA113044692 113044693 113087321
PPRM120458998(f7) 120458999(f7l)
MAMB125273024(f7) 125273025(f7l)
IPU100528477(f7i) 108258589(f7) 108258590(f7l)
PHYP113537544 113537687 113537688
SMEO124378655(f7i) 124378657(f7l) 124378658(f7)
TFD113648913(f7) 113648980(f7i) 125138385(f7l)
AMEX103046085 103046381
EEE113575237 113577295 113577596 113577604
TRU445940 445941 446072
TNGGSTEN00012559G001 GSTEN00012560G001 GSTEN00012561G001
LCO104936792
NCC104945669 104956115 104961578
CGOB115005340 115005341
ELY117249791(f7) 117249837(f7l)
EFO125885068(f7) 125885070(f7l)
PLEP121962692 121962693(f7i) 121962864(f7l)
SLUC116064664(f7l) 116064670(f7)
ECRA117939748 117939749(f7l)
PFLV114551521 114551525
GAT120817513(f7l) 120817566(f7i) 120817574(f7)
PPUG119212731(f7i) 119212744(f7) 119212753(f7l)
MSAM119906954 119907140 119907595(f7l) 119907870 119919371
CUD121506300 121506307
ALAT119015132 119015134 119015136(f7l)
MZE101466849 101467144 101478353
ONL100703931 100704470 100704738 109204421
OAU116325013 116325016(f7) 116325018 116325032 120432751
OLA101154762 101155013
OML112156795 112156797(f7l)
XMA102224608
XCO114140578 114140586 114140590
XHE116715684 116715686
PRET103457832 103457846 108166990
PFOR103130091 103130094
PLAI106960882 106960884
PMEI106906047 106906050
GAF122827084(f7i)
CVG107099183 107099184
CTUL119791516(f7)
GMU124861467 124861469
NFU107384573 107384576(f7)
KMR108229295(f7) 108229296(f7l) 108229769(f7i)
ALIM106517627 106517630 106517631
NWH119428797 119429037
AOCE111566045 111566046 111566047
CSEM103389797 103389800
POV109645494 109646506 109647364
SSEN122765305(f7) 122765307(f7l)
HHIP117772926 117772961(f7l)
HSP118103406(f7) 118103407(f7l)
LCF108877172 108877177
SDU111235523 111235524 111235548
SLAL111646833 111646836 111646837
XGL120797955(f7l) 120798152(f7) 120798357
HCQ109528252 109528276 109528433
BPEC110166513 110173786
MALB109971098 109971099
BSPL114848283(f7) 114848291 114848295
SASA106574661 106575728 106575739 106575751
STRU115179129 115179356 115196382
OTW112242200(f7) 112242207(f7i) 112242210(f7l)
OMY110495519 110495520(f7l) 110495524 110497014 110512308 118936561 118941031 118965220 118965221
OGO124021047(f7) 124021048(f7l)
ONE115127301
SALP112075706 112075709 112079283
SNH120033584(f7l) 120033585(f7)
CCLU121547798(f7l) 121547800(f7)
ELS105019751
SFM108937772 108937781 108938178
PKI111855725 111855729
AANG118213633 118213860(f7l) 118223459
LOC102690701 102690902(f7)
PSPA121320868 121320869 121327683
ARUT117406890 117407265
PSEX120523371
LCM102350380(F7)
CMK103183473
ASTE118513982
CGLO123270571
MSEX115450169
TPAL117639895 117644941
LSM121125440
VJA111270602
HRF124116239
ATEN116287627
 » show all
Reference
1  [PMID:4510277]
  Authors
Nemerson Y, Esnouf MP.
  Title
Activation of a proteolytic system by a membrane lipoprotein: mechanism of action of tissue factor.
  Journal
Proc Natl Acad Sci U S A 70:310-4 (1973)
DOI:10.1073/pnas.70.2.310
Reference
2  [PMID:367103]
  Authors
Davie EW, Fujikawa K, Kurachi K, Kisiel W.
  Title
The role of serine proteases in the blood coagulation cascade.
  Journal
Adv Enzymol Relat Areas Mol Biol 48:277-318 (1979)
DOI:10.1002/9780470122938.ch6
Reference
3  [PMID:6996572]
  Authors
Jackson CM, Nemerson Y.
  Title
Blood coagulation.
  Journal
Annu Rev Biochem 49:765-811 (1980)
DOI:10.1146/annurev.bi.49.070180.004001
Reference
4
  Authors
Broze, G.J., Jr. and Majerus, P.W.
  Title
Human factor VII.
  Journal
Methods Enzymol 80:228-237 (1981)
Other DBs
ExplorEnz - The Enzyme Database: 3.4.21.21
IUBMB Enzyme Nomenclature: 3.4.21.21
ExPASy - ENZYME nomenclature database: 3.4.21.21
BRENDA, the Enzyme Database: 3.4.21.21
CAS: 65312-43-8
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