ORTHOLOGY: K01320
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Entry
K01320 KO
Symbol
F7
Name
coagulation factor VII [EC:
3.4.21.21
]
Pathway
map04610
Complement and coagulation cascades
Disease
H01730
Myocardial infarction
H02256
Factor VII deficiency
Brite
KEGG Orthology (KO) [BR:
ko00001
]
09150 Organismal Systems
09151 Immune system
04610 Complement and coagulation cascades
K01320 F7; coagulation factor VII
09180 Brite Hierarchies
09181 Protein families: metabolism
01002 Peptidases and inhibitors
K01320 F7; coagulation factor VII
Enzymes [BR:
ko01000
]
3. Hydrolases
3.4 Acting on peptide bonds (peptidases)
3.4.21 Serine endopeptidases
3.4.21.21 coagulation factor VIIa
K01320 F7; coagulation factor VII
Peptidases and inhibitors [BR:
ko01002
]
Serine peptidases
Family S1: chymotrypsin family
K01320 F7; coagulation factor VII
BRITE hierarchy
Genes
HSA:
2155
(F7)
PTR:
744785
(F7)
PPS:
100987335
(F7)
GGO:
101136216
(F7)
PON:
100452636
(F7)
PPYG:
129011814
(F7)
NLE:
100607316
(F7)
HMH:
116466522
SSYN:
129464195
(F7)
MCC:
721933
(F7)
MCF:
102121077
(F7)
MTHB:
126940187
MNI:
105485261
CSAB:
103214833
(F7)
CATY:
105584947
(F7)
PANU:
100137442
(F7)
TGE:
112617330
112617333
MLEU:
105539248
(F7)
RRO:
104659908
(F7)
RBB:
108521813
(F7)
TFN:
117063480
(F7)
PTEH:
111546339
(F7)
CANG:
105505922
(F7)
CJC:
100410381
(F7)
SBQ:
101043113
(F7)
CIMI:
108285422
(F7)
ANAN:
105729782
(F7)
MMUR:
105871938
(F7)
LCAT:
123648811
PCOQ:
105825139
(F7)
OGA:
100943078
(F7)
MMU:
14068
(F7)
MCAL:
110300360
(F7)
MPAH:
110336954
(F7)
RNO:
260320
(F7)
MCOC:
116071158
(F7)
ANU:
117721861
(F7)
CGE:
100759052
(F7)
PLEU:
114701249
(F7)
NGI:
103746283
(F7)
HGL:
101706917
(F7)
CPOC:
100727155
(F7)
CCAN:
109686462
(F7)
DORD:
105990379
(F7)
DSP:
122122741
(F7)
PLOP:
125345516
125348097
(F7)
NCAR:
124985036
MMMA:
107140735
(F7)
OCU:
100009399
(F7)
OPI:
101527605
TUP:
102482034
(F7)
GVR:
103598975
(F7)
CFA:
607661
(F7)
CLUD:
112656013
(F7)
VVP:
112927508
(F7)
VLG:
121477073
(F7)
NPO:
129516322
(F7)
AML:
100471728
(F7)
UMR:
103657528
(F7)
UAH:
113247584
(F7)
UAR:
123776736
(F7)
ELK:
111147145
LLV:
125094855
MPUF:
101670299
(F7)
MNP:
132002914
MLK:
131814080
(F7)
NVS:
122907257
(F7)
ORO:
101366144
(F7)
EJU:
114196651
(F7)
ZCA:
113920091
(F7)
MLX:
118009112
(F7)
NSU:
110585853
(F7)
LWW:
102733982
(F7)
FCA:
101090581
(F7)
PYU:
121037687
(F7)
PCOO:
112860731
(F7)
PBG:
122485003
(F7)
PVIV:
125163771
(F7)
LRUF:
124517231
PTG:
102950134
(F7)
PPAD:
109264041
(F7)
PUC:
125933973
AJU:
106986724
HHV:
120228330
(F7)
BTA:
617960
(F7)
BOM:
102272114
(F7)
BIU:
109567023
(F7)
BBUB:
123464843
(F7)
BBIS:
104982129
(F7)
CHX:
102174404
(F7)
OAS:
101118369
(F7)
BTAX:
128057810
(F7)
CSUM:
138089076
(F7)
ODA:
120883381
(F7)
CCAD:
122447330
(F7)
MREE:
136144208
(F7)
MBEZ:
129556646
(F7)
SSC:
733661
(F7)
CFR:
102519118
(F7)
CBAI:
105066886
(F7)
CDK:
105091336
(F7)
BMUS:
118884197
(F7)
LVE:
103076497
(F7)
OOR:
101277688
(F7)
DLE:
111176366
(F7)
PCAD:
102977949
(F7)
PSIU:
116742860
(F7)
NASI:
112404611
(F7)
ECB:
100067072
(F7)
EPZ:
103549658
(F7)
EAI:
106839877
(F7)
MYB:
102260786
(F7)
MYD:
102765822
(F7)
MMYO:
118652112
(F7)
MLF:
102422549
(F7)
MDT:
132228554
(F7)
PKL:
118729785
(F7)
EFUS:
103288221
(F7)
MNA:
107536944
(F7)
DRO:
112321523
(F7)
SHON:
118984247
(F7)
AJM:
119045897
(F7)
PDIC:
114508703
(F7)
PHAS:
123807543
(F7)
MMF:
118622834
(F7)
PPAM:
129064669
(F7)
HAI:
109383930
(F7)
RFQ:
117021066
(F7)
PALE:
102884062
(F7)
PGIG:
120615625
(F7)
RAY:
107514334
(F7)
MJV:
108398704
(F7)
TOD:
119259646
(F7)
SARA:
101546858
(F7)
SETR:
126015568
(F7)
LAV:
100655748
(F7)
TMU:
101347612
ETF:
101645208
101645520
(F7)
DNM:
101441674
(F7)
MDO:
100022420
(F7)
GAS:
123241780
(F7)
SHR:
100921248
(F7)
AFZ:
127553485
PCW:
110193401
(F7)
TVP:
118848981
(F7)
PBRV:
138165672
(F7)
GGA:
395086
(F7)
PCOC:
116242799
MGP:
100548839
(F7)
CJO:
107307824
(F7)
TPAI:
128071555
(F7)
LMUT:
125700133
NMEL:
110407377
APLA:
101796107
(F7)
ACYG:
106046420
(F7)
CATA:
118257488
(F7)
AFUL:
116500723
(F7)
TGU:
100223776
LSR:
110478744
SCAN:
103812401
PMOA:
120504727
OTC:
121343148
PRUF:
121356203
GFR:
102035674
(F7)
FAB:
101814835
(F7)
OMA:
130249688
(F7)
PHI:
102113790
PMAJ:
107211187
(F7)
CCAE:
111922719
111944764
CCW:
104686114
CBRC:
103617560
ACOE:
138104968
(F7)
ETL:
114057854
ZAB:
102062358
ZLE:
135446052
(F7)
ACHL:
103804516
(F7)
SVG:
106858464
MMEA:
130589268
HRT:
120748692
FPG:
101911545
(F7)
FCH:
102049587
(F7)
CCRI:
104163703
(F7)
NNT:
104411764
(F7)
SHAB:
115604013
ACUN:
113485847
(F7)
TALA:
104363232
(F7)
ACHC:
115334729
(F7)
HALD:
104321278
(F7)
HLE:
104836878
(F7)
AGEN:
126052942
HHAR:
128135126
(F7)
GCL:
127026128
CSTI:
104557028
(F7)
LDI:
104342655
(F7)
MNB:
103770909
(F7)
DPUB:
104298625
(F7)
PPUS:
135175507
(F7)
AVIT:
104268666
(F7)
BRHI:
104501108
(F7)
EGZ:
104132450
(F7)
NNI:
104019371
(F7)
PCRI:
104034058
(F7)
PCAO:
104048247
(F7)
PADL:
103918860
(F7)
AFOR:
103896260
FGA:
104070393
(F7)
GSTE:
104257994
(F7)
CLV:
102092108
(F7)
MUI:
104534292
PGUU:
104458835
(F7)
PLET:
104618495
(F7)
EHS:
104507178
CMAC:
104487209
CUCA:
104056613
(F7)
TEO:
104384064
(F7)
BREG:
104632267
(F7)
OHA:
104339593
ACAR:
104520815
CVF:
104292717
(F7)
RTD:
128904162
(F7)
AAM:
106493960
(F7)
AROW:
112960861
(F7)
NPD:
112951596
(F7)
TGT:
104577824
(F7)
DNE:
112981396
(F7)
ASN:
102375756
(F7)
AMJ:
102560637
(F7)
CPOO:
109306298
(F7)
GGN:
109303320
(F7)
PSS:
102463876
(F7)
CMY:
102939588
(F7)
CCAY:
125628700
DCC:
119842005
(F7)
CPIC:
101936681
(F7)
TST:
117870785
(F7)
CABI:
116823352
(F7)
MRV:
120395708
(F7)
ACS:
107982633
ASAO:
132771516
SUND:
121926339
(F7)
PBI:
103068222
PMUR:
107290448
(F7)
CTIG:
120315420
PGUT:
117666369
(F7)
APRI:
131200251
(F7)
PTEX:
113453034
(F7)
NSS:
113429813
(F7)
VKO:
123022733
(F7)
PMUA:
114596455
(F7)
PRAF:
128411865
ZVI:
118085144
(F7)
HCG:
128348784
(F7)
GJA:
107110910
STOW:
125432180
(F7)
EMC:
129326176
(F7)
XLA:
444394
(f7.S)
XTR:
780280
(f7)
NPR:
108791687
(F7)
RTEM:
120926382
(F7)
BBUF:
120995775
(F7)
BGAR:
122932161
(F7)
MUO:
115469162
(F7)
GSH:
117362678
(F7)
DRE:
100038778
(f7l)
114423
(f7)
SRX:
107732003
107747061
107747062
107747071
107751062
SANH:
107654598
107654615
107680190
107694469
SGH:
107551096
107551097
107570083
107570084
107572931
(f7)
CCAR:
109064625
109065585
109102520
109102880
CAUA:
113044692
113044693
113087321
CGIB:
127948900
127948902
128018352
PTET:
122350341
(f7)
122350347
(f7l)
LROH:
127169461
(f7)
127169465
(f7l)
OMC:
131541811
(f7l)
131541973
(f7)
PPRM:
120458998
(f7)
120458999
(f7l)
RKG:
130082209
130082210
MAMB:
125273024
(f7)
125273025
(f7l)
CIDE:
127508916
127508928
CERY:
137033095
(f7)
137033096
(f7l)
MASI:
127443448
127443450
TROS:
130553375
(f7)
130553432
(f7l)
TDW:
130408360
130440156
(f7l)
MANU:
129445168
(f7l)
129445470
IPU:
100528477
(f7i)
108258589
(f7)
108258590
(f7l)
IFU:
128602215
(f7)
128602216
(f7l)
PHYP:
113537544
113537687
113537688
SMEO:
124378655
(f7i)
124378657
(f7l)
124378658
(f7)
TFD:
113648913
(f7)
113648980
(f7i)
125138385
(f7l)
TVC:
132839318
(f7)
132839320
(f7l)
TRN:
134328601
(f7l)
134329267
(f7)
AMEX:
103046085
(f7l)
103046381
(f7)
CMAO:
118798069
(f7l)
118798126
(f7)
EEE:
113577295
113577596
113577604
CHAR:
105896512
105896548
TRU:
445940
445941
446072
TNG:
GSTEN00012559G001
GSTEN00012560G001
GSTEN00012561G001
LCO:
104936792
NCC:
104945669
104961578
TBEN:
117469712
(f7l)
CGOB:
115005340
115005341
PGEO:
117443649
(f7)
117443651
(f7l)
GACU:
117545209
(f7)
117545236
(f7l)
EMAC:
134860727
(f7l)
134861058
(f7)
ELY:
117249791
(f7)
117249837
(f7l)
EFO:
125885068
(f7)
125885070
(f7l)
PLEP:
121962692
121962693
(f7i)
121962864
(f7l)
SLUC:
116064664
(f7l)
116064670
(f7)
ECRA:
117939748
117939749
(f7l)
PFLV:
114551521
114551525
GAT:
120817513
(f7l)
120817566
(f7i)
120817574
(f7)
PPUG:
119212731
(f7i)
119212744
(f7)
119212753
(f7l)
AFB:
129111643
(f7)
129111645
(f7l)
CLUM:
117740724
(f7l)
117745201
(f7)
PSWI:
130204481
130204483
(f7l)
CANA:
137803506
137803535
(f7l)
CVE:
137887574
(f7l)
137887592
(f7)
MSAM:
119906954
119907140
119907595
(f7l)
119907870
119919371
SCHU:
122871949
(f7)
122871955
(f7l)
CUD:
121506300
121506307
ALAT:
119015132
119015134
119015136
(f7l)
ASTR:
137591509
(f7)
137591524
(f7l)
MZE:
101466849
101467144
101478353
ONL:
100703931
100704470
100704738
109204421
OAU:
116325013
116325016
(f7)
116325018
116325032
120432751
OLA:
101154762
101155013
OML:
112156795
112156797
(f7l)
CSAI:
133425384
(f7l)
133425386
(f7)
XMA:
102224608
XCO:
114140578
114140586
114140590
XHE:
116715684
116715686
PRET:
103457832
103457846
108166990
PFOR:
103130091
103130094
PLAI:
106960882
106960884
PMEI:
106906047
106906050
GAF:
122827084
(f7i)
PPRL:
129354827
CVG:
107099183
107099184
CTUL:
119791516
(f7)
GMU:
124861467
124861469
NFU:
107384573
107384576
(f7)
KMR:
108229295
(f7)
108229296
(f7l)
108229769
(f7i)
ALIM:
106517627
106517630
106517631
NWH:
119428797
119429037
AOCE:
111566045
111566046
111566047
EJA:
138207200
138207205
(f7l)
CSEM:
103389797
103389800
POV:
109645494
109646506
109647364
SSEN:
122765305
(f7)
122765307
(f7l)
HHIP:
117772926
117772961
(f7l)
HSP:
118103406
(f7)
118103407
(f7l)
PPLT:
128430928
128430929
(f7)
SMAU:
118312394
(f7l)
118312818
(f7)
LCF:
108877172
108877177
SDU:
111235523
111235524
111235548
SLAL:
111646833
111646836
111646837
XGL:
120797955
(f7l)
120798152
(f7)
120798357
HCQ:
109528252
109528276
109528433
SSCV:
125989189
125989190
(f7l)
SBIA:
133505079
(f7l)
133507435
PEE:
133406233
133414191
PTAO:
133477353
(f7l)
133481068
BPEC:
110166513
110173786
MALB:
109971098
109971099
BSPL:
114848283
(f7)
114848291
114848295
SJO:
128354295
(f7l)
128354593
(f7)
SASA:
106574661
106575728
106575739
106575751
STRU:
115179129
115179356
115196382
OTW:
112242200
(f7)
112242207
(f7i)
112242210
(f7l)
OMY:
110495519
110495520
(f7l)
110495524
110497014
110512308
118936561
118941031
118965220
118965221
OGO:
124021047
(f7)
124021048
(f7l)
ONE:
115127301
OKI:
109883461
116354029
116354030
OKE:
118378284
(f7l)
118378287
(f7)
SALP:
112075706
112075709
112079283
SNH:
120033584
(f7l)
120033585
(f7)
CCLU:
121547798
(f7l)
121547800
(f7)
ELS:
105019751
SFM:
108937772
108937781
108938178
PKI:
111855725
111855729
AANG:
118213633
118213860
(f7l)
118223459
LOC:
102690701
102690902
(f7)
PSPA:
121320868
121320869
121327683
ARUT:
117406890
117407265
PSEX:
120523371
LCM:
102350380
(F7)
CMK:
103183473
CPLA:
122554901
PMRN:
116943708
116952364
116954595
LRJ:
133355391
133355568
133357467
MSEX:
115450169
MJU:
123865048
TPAL:
117639895
117644941
LSM:
121125440
VJA:
111270602
HRF:
124116239
HASI:
137257425
ATEN:
116287627
» show all
Taxonomy
UniProt
Reference
PMID:
23141848
Authors
Suzuki K, Sugawara T, Ishida Y, Suwabe A
Title
Compound heterozygous mutations (p.Leu13Pro and p.Tyr294*) associated with factor VII deficiency cause impaired secretion through ineffective translocation and extensive intracellular degradation of factor VII.
Journal
Thromb Res 131:166-72 (2013)
DOI:
10.1016/j.thromres.2012.10.005
Reference
PMID:
3486420
Authors
Hagen FS, Gray CL, O'Hara P, Grant FJ, Saari GC, Woodbury RG, Hart CE, Insley M, Kisiel W, Kurachi K, et al.
Title
Characterization of a cDNA coding for human factor VII.
Journal
Proc Natl Acad Sci U S A 83:2412-6 (1986)
DOI:
10.1073/pnas.83.8.2412
Sequence
[hsa:
2155
]
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