| Entry |
|
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| Name |
thrombin;
fibrinogenase;
thrombase;
thrombofort;
topical;
thrombin-C;
tropostasin;
activated blood-coagulation factor II;
blood-coagulation factor IIa;
factor IIa;
E thrombin;
beta-thrombin;
gamma-thrombin
|
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| Class |
Hydrolases;
Acting on peptide bonds (peptidases);
Serine endopeptidases
|
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| Reaction(IUBMB) |
Selective cleavage of Arg!Gly bonds in fibrinogen to form fibrin and release fibrinopeptides A and B
|
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| Comment |
Formed from prothrombin. More selective than trypsin and plasmin. In peptidase family S1 (trypsin family).
|
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| History |
EC 3.4.21.5 created 1961 as EC 3.4.4.13, transferred 1972 to EC 3.4.21.5
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| Orthology |
| K01313 | coagulation factor II (thrombin) |
|
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| Genes |
| LWW: | 102736552 102746346(F2) |
| MMYO: | 118650448 118665076(F2) |
| XLA: | 443652(f2.L) 446352(f2.S) |
| BGAR: | 122920581 122920976 122921050 |
| SANH: | 107677184 107703282 |
| CCAR: | 109081878 109081883(f2) |
| CAUA: | 113051457 113106097 |
| CGIB: | 127962215 128016815 |
| MASI: | 127443075 127452373 |
| CGOB: | 115004947 115004955 |
| EFO: | 125885041(f2) 125894740 |
| OAU: | 116325006(f2) 116325008 |
| SASA: | 106561958 106587117 |
| STRU: | 115167517 115202882 |
| OTW: | 112232253 112249021(f2) |
| OMY: | 100136077 100136616(f2) |
| OCLA: | 139385168 139411330 |
| SALP: | 111969223 111974010 |
| SNH: | 120025261 120045869(f2) |
| ARUT: | 117432060 117434678 |
| SPU: | 100890082 115924790 580206 752081 |
|
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| Reference |
1 |
|---|
| Authors |
Baughman DJ. |
|---|
| Title |
Thrombin assay. |
|---|
| Journal |
Methods Enzymol 19:145-157 (1970) |
|---|
| Reference |
2 |
|---|
| Authors |
Magnusson S. |
|---|
| Title |
Bovine prothrombin and thrombin. |
|---|
| Journal |
Methods Enzymol 19:157-184 (1970) |
|---|
| Reference |
3 |
|---|
| Authors |
Miller KD. |
|---|
| Title |
Horse prothrombin. |
|---|
| Journal |
Methods Enzymol 19:140-145 (1970) |
|---|
| Reference |
|
|---|
| Authors |
Lundblad RL, Kingdon HS, Mann KG. |
|---|
| Title |
Thrombin. |
|---|
| Journal |
|
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| Reference |
|
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| Authors |
Mann KG. |
|---|
| Title |
Prothrombin. |
|---|
| Journal |
|
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| Reference |
|
|---|
| Authors |
Davie EW, Fujikawa K, Kurachi K, Kisiel W. |
|---|
| Title |
The role of serine proteases in the blood coagulation cascade. |
|---|
| Journal |
|
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| Reference |
|
|---|
| Authors |
Cho K, Tanaka T, Cook RR, Kisiel W, Fujikawa K, Kurachi K, Powers JC. |
|---|
| Title |
Active-site mapping of bovine and human blood coagulation serine proteases using synthetic peptide 4-nitroanilide and thio ester substrates. |
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| Journal |
|
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| Reference |
|
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| Authors |
MacGillivray RT, Davie EW |
|---|
| Title |
Characterization of bovine prothrombin mRNA and its translation product. |
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| Journal |
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| Sequence |
|
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| Other DBs |
| ExplorEnz - The Enzyme Database: | 3.4.21.5 |
| ExPASy - ENZYME nomenclature database: | 3.4.21.5 |
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| LinkDB |
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