KEGG   ORTHOLOGY: K01313
Entry
K01313                      KO                                     
Symbol
F2
Name
coagulation factor II (thrombin) [EC:3.4.21.5]
Pathway
map04072  Phospholipase D signaling pathway
map04080  Neuroactive ligand-receptor interaction
map04610  Complement and coagulation cascades
map04611  Platelet activation
map04810  Regulation of actin cytoskeleton
map05130  Pathogenic Escherichia coli infection
map05171  Coronavirus disease - COVID-19
map05200  Pathways in cancer
Disease
H00223  Inherited thrombophilia
H01254  Congenital prothrombin deficiency
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04072 Phospholipase D signaling pathway
    K01313  F2; coagulation factor II (thrombin)
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    K01313  F2; coagulation factor II (thrombin)
 09140 Cellular Processes
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    K01313  F2; coagulation factor II (thrombin)
 09150 Organismal Systems
  09151 Immune system
   04610 Complement and coagulation cascades
    K01313  F2; coagulation factor II (thrombin)
   04611 Platelet activation
    K01313  F2; coagulation factor II (thrombin)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K01313  F2; coagulation factor II (thrombin)
  09172 Infectious disease: viral
   05171 Coronavirus disease - COVID-19
    K01313  F2; coagulation factor II (thrombin)
  09171 Infectious disease: bacterial
   05130 Pathogenic Escherichia coli infection
    K01313  F2; coagulation factor II (thrombin)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors
    K01313  F2; coagulation factor II (thrombin)
  09183 Protein families: signaling and cellular processes
   04147 Exosome
    K01313  F2; coagulation factor II (thrombin)
   00536 Glycosaminoglycan binding proteins
    K01313  F2; coagulation factor II (thrombin)
Enzymes [BR:ko01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.21  Serine endopeptidases
    3.4.21.5  thrombin
     K01313  F2; coagulation factor II (thrombin)
Peptidases and inhibitors [BR:ko01002]
 Serine peptidases
  Family S1: chymotrypsin family
   K01313  F2; coagulation factor II (thrombin)
Exosome [BR:ko04147]
 Exosomal proteins
  Exosomal proteins of hepatic cells
   K01313  F2; coagulation factor II (thrombin)
Glycosaminoglycan binding proteins [BR:ko00536]
 Heparan sulfate / Heparin
  Coagulation and fibrinolysis
   K01313  F2; coagulation factor II (thrombin)
Genes
HSA: 2147(F2)
PTR: 451158(F2)
PPS: 100975534(F2)
GGO: 101149905(F2)
PON: 100173859(F2)
NLE: 100595467(F2)
MCC: 712729(F2)
MCF: 102131020(F2)
CSAB: 103236354
CATY: 105592805(F2)
PANU: 101003685(F2)
TGE: 112606320(F2)
RRO: 104668398(F2)
RBB: 108521952(F2)
TFN: 117081636(F2)
PTEH: 111544903(F2)
CJC: 100386446(F2)
SBQ: 101049318(F2)
CSYR: 103267776(F2)
MMUR: 105885009(F2)
LCAT: 123642660(F2)
OGA: 100959798(F2)
MMU: 14061(F2)
MCAL: 110311945(F2)
MPAH: 110319115(F2)
RNO: 29251(F2)
MCOC: 116092238(F2)
MUN: 110549882(F2)
CGE: 100754947(F2)
MAUA: 101841138(F2)
PLEU: 114699696(F2)
MORG: 121437664(F2)
AAMP: 119814487(F2)
NGI: 103742495(F2)
HGL: 101720561(F2)
CPOC: 100725988(F2)
CCAN: 109681600(F2)
DORD: 105996039(F2)
DSP: 122104962(F2)
NCAR: 124960707
OCU: 100009146(F2)
OPI: 101528466(F2)
TUP: 102468231(F2)
CFA: 100856539(F2)
VVP: 112924085(F2)
VLG: 121471389(F2)
AML: 100472871(F2)
UMR: 103672390(F2)
UAH: 113264978(F2)
UAR: 123785006(F2)
ELK: 111149799
LLV: 125078525
MPUF: 101682635(F2)
ORO: 101381460(F2)
EJU: 114215280(F2)
ZCA: 113915371(F2)
MLX: 118015568(F2)
FCA: 101090463(F2)
PYU: 121043464(F2)
PBG: 122484430(F2)
PTG: 102950768(F2)
PPAD: 109245108(F2)
AJU: 106978029(F2)
HHV: 120228398(F2)
BTA: 280685(F2)
BOM: 102271164(F2)
BIU: 109569554(F2)
BBUB: 102415273(F2)
CHX: 102185018(F2)
OAS: 100307041(F2)
ODA: 120876939(F2)
CCAD: 122449815(F2)
SSC: 100144442(F2)
CFR: 102515763(F2)
CBAI: 105076458(F2)
CDK: 105106867(F2)
VPC: 102534618(F2)
BACU: 103013731(F2)
LVE: 103082406(F2)
OOR: 101289120(F2)
DLE: 111183976(F2)
PCAD: 102991552(F2)
PSIU: 116757330(F2)
ECB: 100057521(F2)
EPZ: 103566907(F2)
EAI: 106844001(F2)
MYB: 102252492(F2)
MYD: 102752205(F2)
MMYO: 118650448 118665076(F2)
MLF: 102428075(F2)
MNA: 107530315(F2)
PKL: 118712792(F2)
HAI: 109390173(F2)
DRO: 112303389(F2)
SHON: 118974544(F2)
AJM: 119064411(F2)
PDIC: 114499912(F2)
PHAS: 123809949(F2)
MMF: 118628654(F2)
RFQ: 117030063(F2)
PALE: 102877724(F2)
PGIG: 120606951(F2)
PVP: 105290023(F2)
RAY: 107511857(F2)
MJV: 108403296(F2)
TOD: 119254522(F2)
SARA: 101546501(F2)
LAV: 100666651(F2)
TMU: 101347713
DNM: 101420795(F2)
MDO: 100015821(F2)
GAS: 123253047(F2)
SHR: 100915186(F2)
PCW: 110223959(F2)
OAA: 100081028(F2)
GGA: 395306(F2)
PCOC: 116229164(F2)
MGP: 100549057(F2)
CJO: 107314808(F2)
NMEL: 110400969(F2)
APLA: 101792756(F2)
ACYG: 106043598(F2)
AFUL: 116490058(F2)
TGU: 100220988(F2)
LSR: 110472069(F2)
SCAN: 103826687(F2)
PMOA: 120500525(F2)
OTC: 121332682(F2)
PRUF: 121349589(F2)
GFR: 102034334(F2)
FAB: 101811384(F2)
PHI: 102114657(F2)
PMAJ: 107205921(F2)
CCAE: 111930178(F2)
CCW: 104697991(F2)
ETL: 114058944(F2)
ZAB: 102068190(F2)
FPG: 101912106(F2)
FCH: 102047000(F2)
CLV: 102087936(F2)
EGZ: 104134075(F2)
NNI: 104020379(F2)
PLET: 104624282(F2)
ACUN: 113480877(F2)
TALA: 104365891(F2)
PADL: 103921711(F2)
ACHC: 115336537(F2)
AAM: 106498225(F2)
AROW: 112973932(F2)
NPD: 112943815(F2)
DNE: 112979203(F2)
ASN: 102370968(F2)
AMJ: 102568064(F2)
CPOO: 109321079(F2)
GGN: 109298901(F2)
PSS: 102449827(F2)
CMY: 102937607(F2)
CPIC: 101938037(F2)
TST: 117876933(F2)
CABI: 116821699(F2)
MRV: 120405074(F2)
ACS: 100566916(f2)
PVT: 110081895(F2)
SUND: 121919932(F2)
PBI: 103065535(F2)
PMUR: 107294859(F2)
TSR: 106554431
PGUT: 117665523(F2)
PMUA: 114595904(F2)
ZVI: 118084964(F2)
GJA: 107106779(F2)
STOW: 125427507(F2)
XLA: 443652(f2.L) 446352(f2.S)
XTR: 548514(f2)
NPR: 108791599(F2)
RTEM: 120917137(F2)
BBUF: 120980221(F2)
DRE: 325881(f2)
SRX: 107742559
PPRM: 120492080(f2)
MAMB: 125265013(f2)
IPU: 108259272(f2)
PHYP: 113546761(f2)
SMEO: 124380054(f2)
TFD: 113634222(f2)
AMEX: 103039180(f2)
EEE: 113592322(f2)
TRU: 446073(f2)
LCO: 104936791(f2)
NCC: 104959957(f2)
ELY: 117250030(f2)
PLEP: 121963005
SLUC: 116064661(f2)
ECRA: 117940849(f2)
PFLV: 114550683(f2)
GAT: 120817458(f2)
PPUG: 119212629(f2)
MSAM: 119899034(f2)
CUD: 121506518(f2)
ALAT: 119015121(f2)
ONL: 100702313
OLA: 101170246
OML: 112156760(f2)
XMA: 102217884(f2)
XCO: 114140554(f2)
XHE: 116715665(f2)
PRET: 103480906(f2)
PFOR: 103130081(f2)
PLAI: 106960877(f2)
PMEI: 106906062(f2)
GAF: 122827062(f2)
CVG: 107099194(f2)
CTUL: 119795312(f2)
GMU: 124861454(f2)
NFU: 107384579(f2)
KMR: 108228250(f2)
ALIM: 106531261(f2)
NWH: 119428832(f2)
AOCE: 111587274(f2)
CSEM: 103389837(f2)
POV: 109648054(f2)
SSEN: 122765100(f2)
HHIP: 117777517(f2)
HSP: 118103503(f2)
SDU: 111235568(f2)
SLAL: 111646879(f2)
XGL: 120797943(f2)
HCQ: 109510409(f2)
BPEC: 110172075(f2)
MALB: 109971101(f2)
BSPL: 114845787(f2)
ELS: 105017464(f2)
SFM: 108940837(f2)
PKI: 111858234(f2)
AANG: 118215655(f2)
PSPA: 121329605
LCM: 102347036(F2)
CMK: 103186030(f2)
RTP: 109918716(f2)
BBEL: 109470513
APLC: 110974931
ASTE: 118503626
HHAL: 112211170
FOC: 113215860
LSM: 121124704
RMP: 119186596
VDE: 111246622
VJA: 111270994
SDM: 118182941
GAE: 121391255
HRF: 124117379
CRG: 105337626
PMAX: 117330388
MMER: 123548991
OBI: 106884382
NVE: 5515513
SPIS: 111328185
HMG: 100204772
 » show all
Reference
PMID:6326805
  Authors
MacGillivray RT, Davie EW
  Title
Characterization of bovine prothrombin mRNA and its translation product.
  Journal
Biochemistry 23:1626-34 (1984)
DOI:10.1021/bi00303a007
  Sequence
[bta:280685]
Reference
PMID:2856554
  Authors
Glenn KC, Frost GH, Bergmann JS, Carney DH
  Title
Synthetic peptides bind to high-affinity thrombin receptors and modulate thrombin mitogenesis.
  Journal
Pept Res 1:65-73 (1988)
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