KEGG ENZYME: 3.4.22.38

ENZYME: 3.4.22.38

Entry

EC 3.4.22.38                Enzyme

Name

cathepsin K;
cathepsin O and cathepsin X (both misleading, having been used for other enzymes);
cathepsin O2

Class

Hydrolases;
Acting on peptide bonds (peptidases);
Cysteine endopeptidases

Reaction(IUBMB)

Broad proteolytic activity. With small-molecule substrates and inhibitors, the major determinant of specificity is P2, which is preferably Leu, Met Phe, and not Arg

Comment

Prominently expressed in mammalian osteoclasts, and believed to play a role in bone resorption. In peptidase family C1 (papain family)

History

EC 3.4.22.38 created 1997

Orthology

K01371

cathepsin K

Genes

HSA:	1513(CTSK)

PTR:	457278(CTSK)

PPS:	100974656(CTSK)

GGO:	101145486(CTSK)

PON:	100432447(CTSK)

PPYG:

129029729(CTSK)

NLE:	100580351(CTSK)

HMH:	116469475(CTSK)

SSYN:

134734261(CTSK)

MCC:	574112(CTSK)

MCF:	102120416(CTSK)

MTHB:

126932254

MNI:	105497819(CTSK)

CSAB:

103247207(CTSK)

CATY:

105590201(CTSK)

PANU:

101022150(CTSK)

TGE:	112620351(CTSK)

MLEU:

105534753(CTSK)

RRO:	104681068(CTSK)

RBB:	108533261(CTSK)

TFN:	117075082(CTSK)

PTEH:

111543623(CTSK)

CANG:

105508848(CTSK)

CJC:	100410169(CTSK)

SBQ:	101045222(CTSK)

CIMI:

108316465(CTSK)

ANAN:

105724217(CTSK)

CSYR:

103251387(CTSK)

MMUR:

105873002(CTSK)

LCAT:

123633926(CTSK)

PCOQ:

105821962(CTSK)

OGA:	100950359(CTSK)

MMU:	13038(Ctsk)

MCAL:

110291053(Ctsk)

MPAH:

110320301(Ctsk)

RNO:	29175(Ctsk)

MCOC:

116093414(Ctsk)

ANU:	117707493(Ctsk)

ASYL:

127682987(Ctsk)

MUN:	110541001(Ctsk)

CGE:	100765407(Ctsk)

MAUA:

101827712(Ctsk)

PROB:

127232730(Ctsk)

PLEU:

114682409(Ctsk)

MORG:

121437982 121450816

MFOT:

126489972

AAMP:

119801328(Ctsk)

NGI:	103729102(Ctsk)

HGL:	101716993(Ctsk)

CPOC:

100718267(Ctsk)

CCAN:

109681204(Ctsk)

DORD:

105984894(Ctsk)

DSP:	122109759(Ctsk)

PLOP:

125360056(Ctsk)

NCAR:

124977877

MMMA:

107156833(Ctsk)

ITI:	101976923(Ctsk)

OCU:	100009334(CTSK)

OPI:	101525281(CTSK)

TUP:	102469152(CTSK)

GVR:

103600563

CFA:	608843(CTSK)

CLUD:

112663999(CTSK)

VVP:	112907784(CTSK)

VLG:	121490825(CTSK)

NPO:	129501301(CTSK)

AML:	100483004(CTSK)

UMR:	103667534(CTSK)

UAH:	113246211(CTSK)

UAR:	123787737(CTSK)

ELK:

111161944

LLV:

125096877

MPUF:

101682378(CTSK)

MNP:	132001450(CTSK)

MLK:	131810361(CTSK)

NVS:	122900432(CTSK)

ORO:	101371209(CTSK)

EJU:	114197248(CTSK)

ZCA:	113915477(CTSK)

MLX:	118000314(CTSK)

NSU:	110578599(CTSK)

LWW:	102747919(CTSK)

FCA:	101093379(CTSK)

PYU:	121021051(CTSK)

PCOO:

112871757(CTSK)

PBG:	122481133(CTSK)

PVIV:

125159462(CTSK)

LRUF:

124516160

LGF:	123598665(CTSK)

AJU:

106979872

PTG:	102968588(CTSK)

PPAD:

109257023(CTSK)

PUC:

125912125

PLEZ:

122228682(CTSK)

HHV:	120241249(CTSK)

BTA:	513038(CTSK)

BOM:	102287709(CTSK)

BIU:	109555331(CTSK)

BBUB:

102407535(CTSK)

BBIS:

104987657(CTSK)

CHX:	102183473(CTSK)

OAS:	101108972(CTSK)

BTAX:

128044625(CTSK)

CSUM:

138072749(CTSK)

ODA:	120855928(CTSK)

CCAD:

122434369(CTSK)

MREE:

136145964(CTSK)

OVR:	110149640(CTSK)

MBEZ:

129540299(CTSK)

SSC:	397569(CTSK)

CFR:	102511322(CTSK)

CBAI:

105071740(CTSK)

CDK:	105103193(CTSK)

VPC:	102545171(CTSK)

BACU:

103008252(CTSK)

BMUS:

118902912(CTSK)

LVE:	103075087(CTSK)

OOR:	101270188(CTSK)

LALB:

132514396(CTSK)

DLE:	111169765(CTSK)

PCAD:

102980378(CTSK)

PSIU:

116750388(CTSK)

NASI:

112411616(CTSK)

ECB:	100054991(CTSK)

EPZ:	103547638(CTSK)

EAI:	106846533(CTSK)

MYB:	102259503(CTSK)

MYD:	102771486(CTSK)

MMYO:

118672754(CTSK)

MLF:	102440408(CTSK)

MDT:	132220677(CTSK)

MYUM:

138995711(CTSK)

PKL:	118727475(CTSK)

EFUS:

103298978(CTSK)

MNA:	107539127(CTSK)

DRO:	112313792(CTSK)

AJM:	119034729(CTSK)

PDIC:

114489030(CTSK)

PHAS:

123804409(CTSK)

MMF:	118637271(CTSK)

PPAM:

129076823(CTSK) 129076831

HAI:	109372279(CTSK)

RFQ:	117014590(CTSK)

PALE:

102885198(CTSK)

PGIG:

120585212(CTSK)

PVP:	105303821(CTSK)

RAY:	107498992(CTSK)

MJV:	108408263(CTSK)

TOD:	119235951(CTSK)

SARA:

101553291(CTSK)

SFUM:

130020291(CTSK)

SETR:

125997497(CTSK)

LAV:	100673950(CTSK)

TMU:

101349596

ETF:	101656870(CTSK)

DNM:	101441026(CTSK)

MDO:	100017449(CTSK)

GAS:	123244279(CTSK)

SHR:	100917440(CTSK)

AFZ:

127559104

PCW:	110220566(CTSK)

TVP:	118858513(CTSK)

PBRV:

138162690(CTSK)

OAA:	100088286(CTSK)

TACU:

119947092(CTSK)

GGA:	395818(CTSK)

PCOC:

116238446(CTSK)

MGP:	104914440(CTSK)

TPAI:

128071928(CTSK)

LMUT:

125685749(CTSK)

APLA:

101794155(CTSK)

ACYG:

106049270(CTSK)

CATA:

118260436(CTSK)

AFUL:

116499629(CTSK)

TGU:	101233119(CTSK)

LSR:	110476861(CTSK)

SCAN:

103824024(CTSK)

PMOA:

120502594(CTSK)

OTC:	121335614(CTSK)

PRUF:

121353488(CTSK)

ATRC:

139585076(CTSK)

GFR:	102031691(CTSK)

OMA:	130263422(CTSK)

PHI:	102102166(CTSK)

PMAJ:

107214633(CTSK)

CCAE:

111939475(CTSK)

CBRC:

103619626(CTSK)

ACOE:

138098536(CTSK)

ZAB:	102060957(CTSK)

ZLE:

135457673

ACHL:

103798515(CTSK)

SVG:	106862381(CTSK)

MMEA:

130586602

HRT:	120764214(CTSK)

SATI:

136372936(CTSK)

CCIC:

134055160(CTSK)

FPG:	101919682(CTSK)

FCH:	102049655(CTSK)

NNT:	104409362(CTSK)

SHAB:

115602670(CTSK)

TALA:

116959555 122152483

ACHC:

115345553(CTSK)

HLE:	104830533(CTSK)

AGEN:

126040213

HHAR:

128146012(CTSK)

GCL:

127027057

LDI:	104348855(CTSK)

PPUS:

135192555(CTSK)

NNI:	104014432(CTSK)

AFOR:

103900499(CTSK)

CBOY:

140644293(CTSK)

CLV:	102096035(CTSK)

CMAC:

104479610(CTSK)

CUCA:

104066026(CTSK)

TEO:

104382293

BREG:

104632109

ACAR:

104527988

CPEA:

104385234(CTSK)

CVF:	104285440(CTSK)

RTD:	128900891(CTSK)

CRID:

134526000(CTSK)

AAM:	106495413(CTSK)

AROW:

112972480(CTSK)

NPD:	112952963(CTSK)

DNE:	112990056(CTSK)

SCAM:

104139546(CTSK)

ASN:	112547876(CTSK)

AMJ:	109281035(CTSK)

CPOO:

109324822(CTSK)

GGN:	109305208(CTSK)

PSS:	102447447 102459334

CMY:	102937600 102948156(CTSK)

CCAY:

125625610(CTSK) 125625765

DCC:	119847720 119847843

CPIC:

101953906 101954188

TST:

117869790

CABI:

116817633 116817658(CTSK)

MRV:	120390078(CTSK) 120390507

ACS:	100561728(ctsk)

ASAO:

132764182(CTSK)

PVT:	110081453(CTSK)

SUND:

121916255(CTSK)

PBI:	103053602(CTSK)

PMUR:

107292918(CTSK)

CTIG:

120317161(CTSK)

TSR:

106554193

PGUT:

117670136(CTSK)

APRI:

131186544(CTSK)

PTEX:

113449215(CTSK)

NSS:	113425696(CTSK)

VKO:	123032931(CTSK)

PMUA:

114586294(CTSK)

PRAF:

128403645(CTSK)

ZVI:	118076335(CTSK)

HCG:	128337698(CTSK)

GJA:	107120548(CTSK)

STOW:

125436656 125436704 125444042

EMC:	129328519(CTSK)

XLA:	100127265(ctsk.L) 108699348 108699349 108700337

XTR:	100490139 100492634 448216(ctsk) 779889(ctsk)

NPR:	108789812 108789813

RTEM:

120921060 120921061

BBUF:

120981857 120982069

BGAR:

122923215 122923216(CTSK)

PWL:

138268662

MUO:	115458068 115458069

GSH:	117350538 117350800

DRE:	550475(ctsk)

SRX:	107717769 107741754

SANH:

107663458 107689854

SGH:	107576564 107587836

CCAR:

109056407 109084523

CAUA:

113059151 113116115

CGIB:

127975145 128030028

PTET:

122359891(ctsk)

LROH:

127178601(ctsk)

OMC:	131521346(ctsk)

PPRM:

120484668(ctsk)

RKG:	130069294(ctsk)

MAMB:

125243547(ctsk)

CIDE:

127496726

CERY:

137034431(ctsk)

MASI:

127452790 127454028

TROS:

130558316(ctsk)

TDW:	130432744(ctsk) 130433069

MANU:

129448131(ctsk)

PDAB:

135727555 135788812

IPU:	100528180(ctsk) 108274827(ctss1)

IFU:	128610336(ctsk) 128618188 128618285

PHYP:

113525378 113533989

SMEO:

124384142(ctsk) 124392178(ctss1) 124392838 124392839

TFD:	113644778(ctsk)

TVC:	132845888(ctsk)

CGAR:

128520655 128520656 128520658

NGRA:

132886821(ctsk)

TRN:	134310793(ctsk)

AMEX:

103044235(ctsk)

CMAO:

118812790(ctss1) 118817493(ctsk)

EEE:	113575274 113585755

CHAR:

105891723 105891891(ctsk) 105891894 105902966 105902972 116221019

SPIL:

134082842(ctsk) 134082845

TRU:

101066261

TFS:	130518781(ctss1) 130532154(ctsk)

TNG:	GSTEN00011686G001

LCO:

104923938

NCC:	104944927 104955931

TBEN:

117478362(ctss1) 117494853(ctsk)

CGOB:

115015607 115021678

PGEO:

117460845(ctsk)

GACU:

117563199(ctsk)

EMAC:

134862311(ctsk) 134874960(ctss1)

ELY:	117263942 117266432(ctsk)

EFO:	125892610(ctsk) 125904819

PLEP:

121945418(ctsk)

SLUC:

116047396 116049094(ctsk)

ECRA:

117946035(ctsk)

ESP:

116690790

PFLV:

114556731 114567830

GAT:	120810482(ctsk)

PPUG:

119197583(ctsk) 119219160(ctss1)

AFB:	129097575(ctss1) 129110242(ctsk)

CLUM:

117745145(ctsk)

PSWI:

130187951(ctsk)

CANA:

137781002(ctsk)

CVE:

137890203

MSAM:

119882211 119897014(ctsk)

SCHU:

122864988 122882285(ctsk)

CUD:	121513705(ctsk) 121523315

SPUL:

138583563(ctsk) 138608987(ctss1)

LMIX:

132983474(ctsk) 132991026

ALAT:

119005465(ctsk) 119016605

ASTR:

137601261(ctsk)

MZE:	101486434 106675288

ONL:	102080361(ctsk) 109204084

OAU:	116333437(ctsk)

OLA:	101160005 101164922

OML:	112136686(ctsk) 112137541

CSAI:

133440252(ctsk) 133461475

XMA:

102230067

XCO:

114142267

XHE:	116717364 116731588

PRET:

103477640

PFOR:

103151583 103156711

PLAI:

106949137 106963206

PMEI:

106920373 106932691

GAF:	122831312(ctsk) 122844185(ctss1)

PPRL:

129371013(ctsk) 129375187(ctss1)

CVG:	107086845 107088362

CTUL:

119781875(ctsk) 119784812

GMU:	124865442(ctsk) 124879804

NFU:

107379225

KMR:	108243181(ctsk)

ALIM:

106524066

NWH:	119409271(ctsk)

AOCE:

111569218(ctss1) 111571631(ctsk)

EJA:	138213783(ctsk) 138214411(ctss1)

BFRE:

138628752(ctsk)

MCEP:

125016158(ctsK) 125020404

CSEM:

103388696

POV:

109633525

SSEN:

122775141(ctsk) 122786639

SSOE:

131447679(ctss1) 131471799(ctsk)

HHIP:

117770320 117770321 117776445(ctsk)

HSP:	118114030(ctsk) 124855045 124855046

PPLT:

128448909(ctsk) 128461960(ctss1)

SMAU:

118285187(ctsk) 118292023

LCF:	108883173 108884675

SDU:	111222414 111234098

SLAL:

111644723 111668412 111668430 111669222

XGL:	120784603(ctsk)

HCQ:

109512208

SSCV:

125974680(ctsk)

SBIA:

133500961(ctsk)

PEE:	133401554(ctsk)

PTAO:

133479666(ctsk)

BPEC:

110170731

ENY:	140361945 140373839

MALB:

109968905 109968961

BSPL:

114843460(ctsk) 114845304 114845306 114845307 114846125 114865357(ctss1)

SJO:	128365726 128366917 128373690

SSCO:

133983972 133984095 133995846

GMH:

115553582

SASA:

100195370(catk) 106580864

STRU:

115176788 115178886

OTW:	112222948(ctsk) 112229285

OMY:	100136757(ctsk) 110514697

OGO:	123997752(ctsk) 124006230

ONE:	115103964 115141061

OKI:	109902021 109908581

OKE:	118364447(ctsk) 118367492

OMM:	135520255 135522239

OCLA:

139364985 139392405

SALP:

111959001

SNH:	120031339 120048416(ctsk)

CCLU:

121543125 123486200

ELS:	105009269(ctsk)

OEP:	134006738 134023396(ctsk)

SFM:	108930421 108941878

PKI:	111838383 111853517 111853532 111860671

AANG:

118213555(ctsk) 118233651 118233652 118233656 118233658 118233659 118233660 118234219 118234220

AROT:

135260203 135260204 135260205 135260394 135260396 135260397

CCOG:

133125741(ctsk) 133136640

LOC:	102682459 102683074 102692644

PSPA:

121309883

ARUT:

117395492 117971318

PSEX:

120527418

LCM:	102352136(CTSK)

RTP:

109919200

CPLA:

122547102 122565168

LERI:

129711259

DME:	Dmel_CG4847(CtsK2)

DYA:	Dyak_GE11675

DGR:

6561064

CCAT:

101448435 101463270

BOD:

106618159

BDR:

105226824

RZE:

108358315

AOQ:

129245645

ALUD:

128866758

TDA:

119679230

SCAC:

106083421

LSQ:	119608035 119615828

CVJ:	135954346 135954769

GFS:

119641177

ECOE:

129945757

HIS:	119654852 119655276 119655781

CBRI:

134833241

BCOO:

119073136 119085437

AEC:

105146908

ACEP:

105627376

DQU:

106741339

CFO:

105252674

OBO:

105284231

PCF:

106790486

TCA:	658343 660669

SOY:	115877905 115879668

AGRG:

126735916

CSET:

123316309 123316315 123318474

LDC:	111502369 111511108 111511781

DVV:	114324171 114335561 126892061 126893277

CFEL:

113365622

BTAB:

109031191

HVI:

124373001

FCD:

110852181

DPX:	DAPPUDRAFT_306050 DAPPUDRAFT_312319 DAPPUDRAFT_315184 DAPPUDRAFT_320635 DAPPUDRAFT_47691 DAPPUDRAFT_8167

DMK:	116919999 116920002 116920003 116932093

AFRA:

136025426 136026904

TUT:	107367640 107371849 112538500

DPTE:

113792611

DFR:

124499318

LOA:	LOAG_18685

LGI:	LOTGIDRAFT_116870 LOTGIDRAFT_161642 LOTGIDRAFT_172091

GAE:

121381730

HRF:	124135182 124135263 124135264

HASI:

137284042 137284051

HCRA:

139455863 139455867

CRG:

105345948

OED:	125651393 130052272

MMER:

123533619 123533940 123534315 123556631

RPHI:

132744918

DPOL:

127837684 127837686 127838417 127839807 127840581 127865030

MAEA:

128208897 128211880 128217606 128218990

LAK:

106167228

EGL:

EGR_02195

DFA:

DFA_03112

EIV:	EIN_325530

PTM:	GSPATT00008837001 GSPATT00009853001

CFUS:

CYFUS_004023

HHY:	Halhy_1431

SLI:

Slin_5291

RUN:	DR864_07255

ZPR:

ZPR_4593

WIN:

WPG_0559

FBE:	FF125_17725

PSER:

ABRG53_3160

» show all

Reference

1 [PMID:7818555]

Authors

Inaoka T, Bilbe G, Ishibashi O, Tezuka K, Kumegawa M, Kokubo T.

Title

Molecular cloning of human cDNA for cathepsin K: novel cysteine proteinase predominantly expressed in bone.

Journal

Biochem Biophys Res Commun 206:89-96 (1995)
DOI:10.1006/bbrc.1995.1013

Sequence

[hsa:1513]

Reference

2 [PMID:8647860]

Authors

Bossard MJ, Tomaszek TA, Thompson SK, Amegadzie BY, Hanning CR, Jones C, Kurdyla JT, McNulty DE, Drake FH, Gowen M, Levy MA.

Title

Proteolytic activity of human osteoclast cathepsin K. Expression, purification, activation, and substrate identification.

Journal

J Biol Chem 271:12517-24 (1996)
DOI:10.1074/jbc.271.21.12517

Reference

3 [PMID:8670136]

Authors

Bromme D, Klaus JL, Okamoto K, Rasnick D, Palmer JT.

Title

Peptidyl vinyl sulphones: a new class of potent and selective cysteine protease inhibitors: S2P2 specificity of human cathepsin O2 in comparison with cathepsins S and L.

Journal

Biochem J 315 ( Pt 1):85-9 (1996)
DOI:10.1042/bj3150085

Reference

4 [PMID:9033588]

Authors

Zhao B, Janson CA, Amegadzie BY, D'Alessio K, Griffin C, Hanning CR, Jones C, Kurdyla J, McQueney M, Qiu X, Smith WW, Abdel-Meguid SS.

Title

Crystal structure of human osteoclast cathepsin K complex with E-64.

Journal

Nat Struct Biol 4:109-11 (1997)
DOI:10.1038/nsb0297-109

Reference

5 [PMID:9033587]

Authors

McGrath ME, Klaus JL, Barnes MG, Bromme D.

Title

Crystal structure of human cathepsin K complexed with a potent inhibitor.

Journal

Nat Struct Biol 4:105-9 (1997)
DOI:10.1038/nsb0297-105

Sequence

[hsa:1513]

Other DBs

ExplorEnz - The Enzyme Database:

3.4.22.38

IUBMB Enzyme Nomenclature:

3.4.22.38

ExPASy - ENZYME nomenclature database:

3.4.22.38

BRENDA, the Enzyme Database:

3.4.22.38

CAS:	94716-09-3

LinkDB

DBGET integrated database retrieval system