KEGG T01001: 1513

Homo sapiens (human): 1513

Entry

1513 CDS T01001

Gene name

CTSK, CTS02, CTSO, CTSO1, CTSO2, PKND, PYCD

Definition

(RefSeq) cathepsin K

K01371

cathepsin K [EC:3.4.22.38]

Organism

hsa Homo sapiens (human)

Pathway

hsa04142

Lysosome

hsa04210

Apoptosis

hsa04380

Osteoclast differentiation

hsa04620

Toll-like receptor signaling pathway

hsa05323

Rheumatoid arthritis

Disease

H00273

Pycnodysostosis

H00425

Lysosomal cysteine protease deficiencies

Drug target

Odanacatib:

D08955

Relacatib:

D06634

Brite

KEGG Orthology (KO) [BR:hsa00001]
09140 Cellular Processes
  09141 Transport and catabolism
   04142 Lysosome
    1513 (CTSK)
  09143 Cell growth and death
   04210 Apoptosis
    1513 (CTSK)
09150 Organismal Systems
  09151 Immune system
   04620 Toll-like receptor signaling pathway
    1513 (CTSK)
  09158 Development
   04380 Osteoclast differentiation
    1513 (CTSK)
09160 Human Diseases
  09163 Immune diseases
   05323 Rheumatoid arthritis
    1513 (CTSK)
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases [BR:hsa01002]
    1513 (CTSK)
  09182 Protein families: genetic information processing
   03110 Chaperones and folding catalysts [BR:hsa03110]
    1513 (CTSK)
Enzymes [BR:hsa01000]
3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.22  Cysteine endopeptidases
    3.4.22.38  cathepsin K
     1513 (CTSK)
Peptidases [BR:hsa01002]
Cysteine Peptidases
  Family C1: papain family
   1513 (CTSK)
Chaperones and folding catalysts [BR:hsa03110]
Intramolecular chaperones
  Papain family
   1513 (CTSK)

SSDB

Motif

Pfam:

Peptidase_C1 Inhibitor_I29 Peptidase_C1_2

Other DBs

NCBI-GeneID:

NCBI-ProteinID:

OMIM:

HGNC:

Ensembl:

Vega:

Pharos:

P43235(Tchem)

UniProt:

P43235

LinkDB

Structure

PDB:

4X6H 5TDI 6ASH 3KWZ 3KX1 4X6J 5JA7 5TUN 4DMY 3O1G 6QBS 4DMX 5JH3 1TU6 4YVA 3O0U 3KW9 3C9E 1MEM 4X6I 5Z5O 2R6N 4YV8 2BDL 2ATO 4N8W 3OVZ 3KWB 1U9X 1Q6K 1U9V 1AYU 1ATK 5J94 3H7D 2AUZ 1YT7 1U9W 1BGO 1AYV 1AU4 2AUX 1SNK 1NLJ 1AYW 1YK7 1AU3 1YK8 1BY8 1AU2 1AU0 4N79 1NL6 7PCK

Position

1q21.3

AA seq 329 aa
MWGLKVLLLPVVSFALYPEEILDTHWELWKKTHRKQYNNKVDEISRRLIWEKNLKYISIH
NLEASLGVHTYELAMNHLGDMTSEEVVQKMTGLKVPLSHSRSNDTLYIPEWEGRAPDSVD
YRKKGYVTPVKNQGQCGSCWAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSENDGCGGG
YMTNAFQYVQKNRGIDSEDAYPYVGQEESCMYNPTGKAAKCRGYREIPEGNEKALKRAVA
RVGPVSVAIDASLTSFQFYSKGVYYDESCNSDNLNHAVLAVGYGIQKGNKHWIIKNSWGE
NWGNKGYILMARNKNNACGIANLASFPKM

NT seq 990 nt +upstreamnt +downstreamnt
atgtgggggctcaaggttctgctgctacctgtggtgagctttgctctgtaccctgaggag
atactggacacccactgggagctatggaagaagacccacaggaagcaatataacaacaag
gtggatgaaatctctcggcgtttaatttgggaaaaaaacctgaagtatatttccatccat
aaccttgaggcttctcttggtgtccatacatatgaactggctatgaaccacctgggggac
atgaccagtgaagaggtggttcagaagatgactggactcaaagtacccctgtctcattcc
cgcagtaatgacaccctttatatcccagaatgggaaggtagagccccagactctgtcgac
tatcgaaagaaaggatatgttactcctgtcaaaaatcagggtcagtgtggttcctgttgg
gcttttagctctgtgggtgccctggagggccaactcaagaagaaaactggcaaactctta
aatctgagtccccagaacctagtggattgtgtgtctgagaatgatggctgtggagggggc
tacatgaccaatgccttccaatatgtgcagaagaaccggggtattgactctgaagatgcc
tacccatatgtgggacaggaagagagttgtatgtacaacccaacaggcaaggcagctaaa
tgcagagggtacagagagatccccgaggggaatgagaaagccctgaagagggcagtggcc
cgagtgggacctgtctctgtggccattgatgcaagcctgacctccttccagttttacagc
aaaggtgtgtattatgatgaaagctgcaatagcgataatctgaaccatgcagttttggca
gtgggatatggaatccagaagggaaacaagcactggataattaaaaacagctggggagaa
aactggggaaacaaaggatatatcctcatggctcgaaataagaacaacgcctgtggcatt
gccaacctggccagcttccccaagatgtga

DBGET integrated database retrieval system