Homo sapiens (human): 1513
Entry
1513 CDS
T01001
Gene name
CTSK, CTS02, CTSO, CTSO1, CTSO2, PKND, PYCD
Definition
(RefSeq) cathepsin K
KO
K01371
cathepsin K [EC:
3.4.22.38
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa04142
Lysosome
hsa04210
Apoptosis
hsa04380
Osteoclast differentiation
hsa04620
Toll-like receptor signaling pathway
hsa05323
Rheumatoid arthritis
Disease
H00273
Pycnodysostosis
H00425
Lysosomal cysteine protease deficiencies
Drug target
Odanacatib:
D08955
Relacatib:
D06634
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09140 Cellular Processes
09141 Transport and catabolism
04142 Lysosome
1513 (CTSK)
09143 Cell growth and death
04210 Apoptosis
1513 (CTSK)
09150 Organismal Systems
09151 Immune system
04620 Toll-like receptor signaling pathway
1513 (CTSK)
09158 Development
04380 Osteoclast differentiation
1513 (CTSK)
09160 Human Diseases
09163 Immune diseases
05323 Rheumatoid arthritis
1513 (CTSK)
09180 Brite Hierarchies
09181 Protein families: metabolism
01002 Peptidases [BR:
hsa01002
]
1513 (CTSK)
09182 Protein families: genetic information processing
03110 Chaperones and folding catalysts [BR:
hsa03110
]
1513 (CTSK)
Enzymes [BR:
hsa01000
]
3. Hydrolases
3.4 Acting on peptide bonds (peptidases)
3.4.22 Cysteine endopeptidases
3.4.22.38 cathepsin K
1513 (CTSK)
Peptidases [BR:
hsa01002
]
Cysteine Peptidases
Family C1: papain family
1513 (CTSK)
Chaperones and folding catalysts [BR:
hsa03110
]
Intramolecular chaperones
Papain family
1513 (CTSK)
SSDB
Motif
Pfam:
Peptidase_C1
Inhibitor_I29
Peptidase_C1_2
Other DBs
NCBI-GeneID:
1513
NCBI-ProteinID:
NP_000387
OMIM:
601105
HGNC:
2536
Ensembl:
ENSG00000143387
Vega:
OTTHUMG00000035008
Pharos:
P43235
(Tchem)
UniProt:
P43235
LinkDB
Structure
PDB:
4X6H
5TDI
6ASH
3KWZ
3KX1
4X6J
5JA7
5TUN
4DMY
3O1G
6QBS
4DMX
5JH3
1TU6
4YVA
3O0U
3KW9
3C9E
1MEM
4X6I
5Z5O
2R6N
4YV8
2BDL
2ATO
4N8W
3OVZ
3KWB
1U9X
1Q6K
1U9V
1AYU
1ATK
5J94
3H7D
2AUZ
1YT7
1U9W
1BGO
1AYV
1AU4
2AUX
1SNK
1NLJ
1AYW
1YK7
1AU3
1YK8
1BY8
1AU2
1AU0
4N79
1NL6
7PCK
Position
1q21.3
AA seq
329 aa
MWGLKVLLLPVVSFALYPEEILDTHWELWKKTHRKQYNNKVDEISRRLIWEKNLKYISIH
NLEASLGVHTYELAMNHLGDMTSEEVVQKMTGLKVPLSHSRSNDTLYIPEWEGRAPDSVD
YRKKGYVTPVKNQGQCGSCWAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSENDGCGGG
YMTNAFQYVQKNRGIDSEDAYPYVGQEESCMYNPTGKAAKCRGYREIPEGNEKALKRAVA
RVGPVSVAIDASLTSFQFYSKGVYYDESCNSDNLNHAVLAVGYGIQKGNKHWIIKNSWGE
NWGNKGYILMARNKNNACGIANLASFPKM
NT seq
990 nt
+upstream
nt +downstream
nt
atgtgggggctcaaggttctgctgctacctgtggtgagctttgctctgtaccctgaggag
atactggacacccactgggagctatggaagaagacccacaggaagcaatataacaacaag
gtggatgaaatctctcggcgtttaatttgggaaaaaaacctgaagtatatttccatccat
aaccttgaggcttctcttggtgtccatacatatgaactggctatgaaccacctgggggac
atgaccagtgaagaggtggttcagaagatgactggactcaaagtacccctgtctcattcc
cgcagtaatgacaccctttatatcccagaatgggaaggtagagccccagactctgtcgac
tatcgaaagaaaggatatgttactcctgtcaaaaatcagggtcagtgtggttcctgttgg
gcttttagctctgtgggtgccctggagggccaactcaagaagaaaactggcaaactctta
aatctgagtccccagaacctagtggattgtgtgtctgagaatgatggctgtggagggggc
tacatgaccaatgccttccaatatgtgcagaagaaccggggtattgactctgaagatgcc
tacccatatgtgggacaggaagagagttgtatgtacaacccaacaggcaaggcagctaaa
tgcagagggtacagagagatccccgaggggaatgagaaagccctgaagagggcagtggcc
cgagtgggacctgtctctgtggccattgatgcaagcctgacctccttccagttttacagc
aaaggtgtgtattatgatgaaagctgcaatagcgataatctgaaccatgcagttttggca
gtgggatatggaatccagaagggaaacaagcactggataattaaaaacagctggggagaa
aactggggaaacaaaggatatatcctcatggctcgaaataagaacaacgcctgtggcatt
gccaacctggccagcttccccaagatgtga
DBGET
integrated database retrieval system