KEGG   ENZYME: 3.4.22.63
Entry
EC 3.4.22.63                Enzyme                                 
Name
caspase-10;
FLICE2;
Mch4;
CASP-10;
ICE-like apoptotic protease 4;
apoptotic protease Mch-4;
FAS-associated death domain protein interleukin-1beta-converting enzyme 2
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Cysteine endopeptidases
Reaction(IUBMB)
Strict requirement for Asp at position P1 and has a preferred cleavage sequence of Leu-Gln-Thr-Asp!Gly
Comment
Caspase-10 is an initiator caspase, as are caspase-2 (EC 3.4.22.55), caspase-8 (EC 3.4.22.61) and caspase-9 (EC 3.4.22.62) [1]. Like caspase-8, caspase-10 contains two tandem death effector domains (DEDs) in its N-terminal prodomain, and these play a role in procaspase activation [1]. The enzyme has many overlapping substrates in common with caspase-8, such as RIP (the cleavage of which impairs NF-kappaB survival signalling and starts the cell-death process) and PAK2 (associated with some of the morphological features of apoptosis, such as cell rounding and apoptotic body formation) [2]. Bid, a Bcl2 protein, can be cleaved by caspase-3 (EC 3.4.22.56), caspase-8 and caspase-10 at Lys-Gln-Thr-Asp! to yield the pro-apoptotic p15 fragment. The p15 fragment is N-myristoylated and enhances the release of cytochrome c from mitochondria (which, in turn, initiatiates the intrinsic apoptosis pathway). Bid can be further cleaved by caspase-10 and granzyme B but not by caspase-3 or caspase-8 at Ile-Glu-Thr-Asp! to yield a p13 fragment that is not N-myristoylated [2]. Belongs in peptidase family C14.
History
EC 3.4.22.63 created 2007
Orthology
K04400  caspase 10
Genes
HSA843(CASP10)
PTR459873(CASP10)
PPS100972863(CASP10)
GGO101131419(CASP10)
PON100174433(CASP10)
PPYG129032087(CASP10)
NLE100585413(CASP10)
HMH116810460(CASP10)
SSYN129488268(CASP10)
MCC701295(CASP10)
MCF102144792(CASP10)
MTHB126932109
MNI105468106(CASP10)
CSAB103217635(CASP10)
CATY105580202(CASP10)
PANU101011831(CASP10)
TGE112636361(CASP10)
MLEU105535423(CASP10)
RRO104671862(CASP10)
RBB108532107(CASP10)
TFN117095222(CASP10)
PTEH111547163(CASP10)
CANG105517471(CASP10)
CJC100394139(CASP10)
SBQ101028043(CASP10)
CIMI108315752(CASP10)
ANAN105712653(CASP10)
CSYR103273364(CASP10)
MMUR105856963(CASP10)
LCAT123643896(CASP10)
PCOQ105819115(CASP10)
OGA100965785(CASP10)
HGL101712620(Casp10)
CPOC100717714(Casp10)
NCAR124980755
MMMA107138606(Casp10)
ITI106145327(Casp10)
OCU100101580(CASP10)
OPI101520873(CASP10)
TUP102496563(CASP10)
GVR103597793(CASP10)
CFA488472(CASP10)
CLUD112656355(CASP10)
VVP112922875(CASP10)
VLG121480767(CASP10)
NPO129522918(CASP10)
AML100475128(CASP10)
UMR103659739(CASP10)
UAH113250594(CASP10)
UAR123798198(CASP10)
ELK111141157
LLV125094997
MPUF101685031(CASP10)
MNP132013448(CASP10)
MLK131827576(CASP10)
NVS122902189(CASP10)
ORO101366538(CASP10)
EJU114223391(CASP10)
ZCA113920561(CASP10)
MLX118012154(CASP10)
NSU110592146(CASP10)
FCA101085995(CASP10)
PYU121030907(CASP10)
PCOO112872042(CASP10)
PBG122481640(CASP10)
PVIV125172183(CASP10)
LRUF124515024
LGF123599307(CASP10)
AJU106987987
PTG102962753(CASP10)
PPAD109260756(CASP10)
PUC125911770
PLEZ122226483(CASP10)
HHV120220687(CASP10)
BTA100848685
BBUB102394793
OAS101103049(CASP10)
BTAX128060900(CASP10)
CSUM138076315(CASP10)
ODA120854625
MREE136164134
MBEZ129538551(CASP10)
SSC100154896(CASP10)
CFR102514092(CASP10)
CBAI105082301(CASP10)
CDK105099180(CASP10)
VPC102540480(CASP10)
BACU103001347(CASP10)
BMUS118897930(CASP10)
LVE103076785(CASP10)
OOR101282021(CASP10)
LALB132522177(CASP10)
GMF115852276(CASP10)
DDP132428443(CASP10)
DLE111171725(CASP10)
PCAD102989304(CASP10)
PSIU116756541(CASP10)
PPHC136125731(CASP10)
NASI112407867(CASP10)
ECB100068201(CASP10)
EPZ103566002(CASP10)
EAI106823486(CASP10)
MYB102253536(CASP10)
MYD102763065(CASP10)
MMYO118661389(CASP10)
MLF102434278 102439064(CASP10)
MDT132238118(CASP10)
MYUM139014913(CASP10)
PKL118708994(CASP10)
EFUS103290617(CASP10)
MNA107533942(CASP10)
DRO112308028(CASP10)
SHON118985243(CASP10)
AJM119065494(CASP10)
PDIC114494329(CASP10)
PHAS123824433(CASP10)
MMF118625231(CASP10)
PPAM129080427(CASP10)
HAI109379185(CASP10)
RFQ117026299(CASP10)
PALE102877929(CASP10)
PGIG120587527(CASP10)
PVP105298128(CASP10)
RAY107503159(CASP10)
MJV108404750(CASP8)
TOD119256100(CASP10) 119260153
SETR126008676
LAV100663859
TMU101341837
ETF101664540(CASP10)
DNM101433860(CASP10)
MDO100016987(CASP10)
GAS123241894(CASP10)
SHR100930260(CASP10)
AFZ127553229
PCW110197140(CASP10)
TVP118848863(CASP10)
PBRV138146685(CASP10)
OAA100092695
TACU119930713(CASP10)
GGA424081(CASP10)
PCOC116233976(CASP10)
MGP100550034(CASP10)
CJO107316521(CASP10)
TPAI128077294
LMUT125696899
NMEL110400691
APLA101799731
ACYG106040000
CATA118243186
AFUL116490833
TGU100220453
LSR110484588
SCAN103814509(CASP10)
PMOA120499262(CASP10)
OTC121335317(CASP10)
PRUF121356473
ATRC139593577(CASP10)
GFR102044879(CASP10)
FAB101815409(CASP10)
OMA130255262(CASP10)
PHI102103849(CASP10)
PMAJ107207334(CASP10)
CCAE111931987(CASP10)
CCW104693775
CBRC103612146
ACOE138113622(CASP10)
ZAB102073289(CASP10)
ZLE135450166(CASP10)
SVG106855085
MMEA130579153
HRT120754974
SATI136363401(CASP10)
CCIC134047505
FPG101918719(CASP10)
FCH102057122(CASP10)
CCRI104163888(CASP10)
NNT104409388(CASP10)
SHAB115607874(CASP10)
ACUN113482525
TALA104359794
ACHC115343323(CASP10)
HALD104322667(CASP10)
HLE104830062(CASP10)
AGEN126047422
HHAR128144315(CASP10)
GCL127018711
LDI104346355(CASP10)
MNB103775951(CASP10)
DPUB104296668(CASP10)
PPUS135184702(CASP10)
AVIT104280784(CASP10)
BRHI104493619
EGZ104130512
NNI104010195(CASP10)
PCRI104026021(CASP10)
PCAO104042979(CASP10)
PADL103923449(CASP10)
AFOR103903457
FGA104082183
GSTE104255506(CASP10)
CBOY140657624
CLV102085114(CASP10)
CNIC135990328
PGUU104465712(CASP10)
PLET104623374(CASP10)
EHS104507514
CMAC104485082(CASP10)
CUCA104058322(CASP10)
TEO104375287
BREG104631028
OHA104334214(CASP10)
ACAR104523965(CASP10)
CPEA104397387
CVF104290990(CASP10)
RTD128912439(CASP10)
CRID134518270
AAM106492410
AROW112976366
NPD112956252
TGT104577125(CASP10)
DNE112987710(CASP10)
SCAM104150168
ASN102380890(CASP10)
AMJ102573990(CASP10)
CPOO109322724
GGN109301899(CASP10)
PSS102463731
CMY102931579
CCAY125644919
DCC119863323
CPIC101941379
TST117885051
CABI116836064
MRV120375092
ACS100564281(casp10)
ASAO132779600(CASP10)
PVT110089021
SUND121934703(CASP10)
PBI103052358
PMUR107296977(CASP10)
CTIG120312832(CASP10)
TSR106547531(CASP10)
PCAE139309106(CASP10)
APRI131199572
PTEX113433951(CASP10)
VKO123024246(CASP10)
PMUA114584652
PRAF128399470(CASP10)
ZVI118095885
HCG128337913(CASP10)
GJA107122423
EMC129324564
XLA397820(casp10.S) 398762(casp10.L)
XTR548432(casp10)
NPR108795087
RTEM120943729(CASP10)
ACAT141146738(CASP10)
BBUF121007625
BGAR122944468
DTC141054236(CASP10)
PWL138285742
MUO115474664
GSH117361288
SRX107752597
MALB109958095
AANG118222447(casp10)
AROT135251032(casp10)
ARUT117408574 117426544
CPLA122551461
HOC132817233 132817282
LERI129698953
HAKA140728149
PMRN116938840(CASP10)
LRJ133345825
BBEL109462052 109464410 109465186 109475257 109479913
PFLL139144073
HHAL106684022
PJA122244006 122244008 122244009 122261469 122261470
PCHN125037021 125037022 125037023 125037225
UDV129218103
SDM118205802
LGILOTGIDRAFT_53303
PVUL126808713
GAE121385161 121387653
HRJ124273712
HASI137297995
HCRA139465207 139471400 139471481
PMAX117315065 117315066
AIRR138311023 138311069
MMER123548935
OSN115223204
ADF107335801
AMIL114951335
 » show all
Reference
1  [PMID:11104820]
  Authors
Chang HY, Yang X.
  Title
Proteases for cell suicide: functions and regulation of caspases.
  Journal
Microbiol Mol Biol Rev 64:821-46 (2000)
DOI:10.1128/mmbr.64.4.821-846.2000
Reference
2  [PMID:16186808]
  Authors
Fischer U, Stroh C, Schulze-Osthoff K.
  Title
Unique and overlapping substrate specificities of caspase-8 and caspase-10.
  Journal
Oncogene 25:152-9 (2006)
DOI:10.1038/sj.onc.1209015
Reference
3  [PMID:12884866]
  Authors
Shikama Y, Yamada M, Miyashita T.
  Title
Caspase-8 and caspase-10 activate NF-kappaB through RIP, NIK and IKKalpha kinases.
  Journal
Eur J Immunol 33:1998-2006 (2003)
DOI:10.1002/eji.200324013
Reference
4  [PMID:15209560]
  Authors
Boatright KM, Deis C, Denault JB, Sutherlin DP, Salvesen GS.
  Title
Activation of caspases-8 and -10 by FLIP(L).
  Journal
Biochem J 382:651-7 (2004)
DOI:10.1042/BJ20040809
Other DBs
ExplorEnz - The Enzyme Database: 3.4.22.63
IUBMB Enzyme Nomenclature: 3.4.22.63
ExPASy - ENZYME nomenclature database: 3.4.22.63
BRENDA, the Enzyme Database: 3.4.22.63
CAS: 189088-85-5
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