Entry
Name
insulysin;
insulinase;
insulin-degrading enzyme;
insulin protease;
insulin proteinase;
insulin-degrading neutral proteinase;
insulin-specific protease;
insulin-glucagon protease;
metalloinsulinase;
IDE
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Metalloendopeptidases
BRITE hierarchy
Reaction(IUBMB)
Degradation of insulin, glucagon and other polypeptides. No action on proteins
Comment
A 110 kDa cytosolic enzyme, known from mammals and the fruit fly, Drosophila melanogaster. Inhibited by bacitracin, chelating agents EDTA and 1,10-phenanthroline, and by thiol-blocking reagents such as N-ethylmaleimide, but not by phosphoramidon. In peptidase family M16 (pitrilysin family).
History
EC 3.4.24.56 created 1972 as EC 3.4.99.10, transferred 1976 EC 3.4.22.11, transferred 1978 to EC 3.4.99.45, transferred 1993 to to EC 3.4.24.56 (EC 3.4.99.46 created 1992, incorporated 2000)
Orthology
Genes
AAMP : 119802916 119809108(Ide)
SHON : 118987983(IDE) 118993304
ACS : 100562442(ide) 103282118
GJA : 107106472(IDE) 107110237
XLA : 108696126(ide.L) 108697399(ide.S)
SRX : 107719220(ide) 107747278
SANH : 107665588 107676380
CCAR : 109067563 109100554(ide)
CAUA : 113092350 113112434
CGIB : 127970240 128025945
MASI : 127412192 127414409
CLUM : 117743828(ide) 117744323
OAU : 116309660 116318769(ide)
OLA : 101157559 101158223 101163025
OML : 112141524 112145324 112145325(ide)
SASA : 106576795 106604847
STRU : 115153037 115193970
OMY : 110502301 110526671(ide)
OMM : 135510860(ide) 135512451
OCLA : 139381086 139410065
SALP : 111951795 111977826
CCLU : 121553687 121569094(ide)
PSPA : 121321877 121325232
ARUT : 117415575 117418117
LPIC : 129273457 129273458
DSI : Dsimw501_GD12197(Dsim_GD12197)
PPAP : 129802256 129802283
MPHA : 105830806 105839814
PBAR : 105425760 105425777 105425778 105425798 105425799 105427238
VEM : 105563049 105565695 105567598
TLN : 139813796 139815653 139815723 139817361 139820402 139824853 139824855 139824856
DQU : 106741566 106742500 106750535
PMEC : 138933615 138942697(Ide)
LHU : 105667811(Ide) 105671329
PGC : 109858418 109858911 109859391
NPT : 124220466 124220467 124220470 124220471
NFB : 124182024 124183245 124183247
NLO : 107217952 107219764 107220283 124294696
DPL : KGM_211055A KGM_211055B
CFEL : 113376116 113378482 113379573
CSEC : 111864772 117282033
FCD : 110845618 110846814 110850482 110854575 110856794 110856939 110857492 110860916 110862143
VDE : 111242942 111243342 111244578 111245308 111246384 111249273 111255291
VJA : 111258856 111260626 111263062 111265757 111266466 111266586 111269255
LPOL : 106469262 106472819
CEL : CELE_C02G6.2(C02G6.2) CELE_F44E7.4(F44E7.4) CELE_Y70C5C.1(Y70C5C.1)
HASI : 137265296 137265563
HCRA : 139452441 139452508
PMAX : 117339419 117339446
AIRR : 138335086 138335418
RPHI : 132720501 132736075
SMM : Smp_011100 Smp_146010
ALY : 9314222 9314223 9316021
CRB : 17885035 17886354 17889182 17889511
CSAT : 104699389 104712420 104712421 104713937 104715299 104752120 104784127 104785199 104792037 109124581
EUS : EUTSA_v10005770mg EUTSA_v10016187mg
BRP : 103841652 103863042 103866587
BNA : 106396187 106410876 106415623 106445196 106450648 106451568 111214975
BOE : 106300306 106312439 106321110 106336575
RSZ : 108813078 108814401 108829670 108829671 108829672 108863355 130511796
CIC : CICLE_v10004240mg CICLE_v10004250mg
TCC : 18598933 18598935 18598944
GHI : 107921220 107921627 107922017 121213639
HSYR : 120124171 120154160
DZI : 111294450 111311511 111311512 111311513
EGR : 104414623 104445012 104445029 120285897 120285898 120285916
RARG : 115731771 115731803
LANG : 109340850 109356953
QSA : O6P43_006506 O6P43_010141
RCN : 112193461 112193462 112193625
PMUM : 103322039 103322040
PDUL : 117633672 117633792
MSYL : 126593826 126600659
PXB : 103946506 103946507 103968020
PCOX : 137712582 137713057 137745074
MEAN : 126679357 130014537
JCU : 105645230 105645231 105645233
HBR : 110643838 110648272 110660413 110661319 110662163 110673582
MESC : 110620723 110622746 110622795
PALZ : 118053175 118053176 118053177
JRE : 108987792 109003515 109004639
CILL : 122275122 122278982
AGLU : 133872516 133872725
SLY : 101244763 543773(ide)
SPEN : 107017808 107017877
SSTN : 125856873 125856874
SDUL : 129870667 129871444
CANN : 107870070 107870071
NTA : 107764696 107769755 107821603 107825793
INI : 109181420 109181421 109181820
SSPL : 121746983 121748336 121752292 121790165
AEW : 130788971 130789662 130789868
PSOM : 113307965 113310373 113321620
OSA : 4326432 4343659 4343660 9266542
DOSA : Os01g0778800 Os01g0779100 Os07g0570300
OBR : 102700359 102709753 102720094
OGL : 127762994 127763008 127778829 127778830 127778831
BDI : 100828166 100843556 100846895
TDC : 119269204 119277197 119354072 119363262
TAES : 123044489 123052352 123062240 123070990 123079370 123188197
LPER : 127332992 127344022
ZMA : 103633315 103636601 103651144
MFLO : 136450546 136456672 136542484 136542485 136550304
SITA : 101755850 101776553
PVIR : 120650747 120661731 120673615 120692205 120708262
PHAI : 112880219 112893810
PAUA : 133890949 133893438 133921981
ZOF : 122010200 122010201 122010203 122014126 122016351
SMO : SELMODRAFT_183357 SELMODRAFT_447027
PPP : 112282066 112287795 112291094 112293272
VCN : VOLCADRAFT_105585 VOLCADRAFT_94765
CGR : 2888706(GVI51_H06303)
NCS : NCAS_0J01470(NCAS0J01470)
NDI : NDAI_0J02240(NDAI0J02240)
TPF : TPHA_0B02260(TPHA0B02260)
TBL : TBLA_0A08050(TBLA0A08050) TBLA_0I02940(TBLA0I02940)
TDL : TDEL_0E01250(TDEL0E01250)
KAF : KAFR_0A05970(KAFR0A05970)
KNG : KNAG_0B06080(KNAG0B06080)
LBG : 92209262(LODBEIA_P40660)
CAL : CAALFM_C602860WA(STE23)
CTP : CTRG_02123 CTRG_05751 CTRG_05771
ASAU : 88172814(PUMCH_001749)
YLI : 2908439(YALI2_E00724g) 2911687(YALI2_E01409g)
NTE : NEUTE1DRAFT82494(NEUTE1DRAFT_82494)
SMP : 10806352(SMAC4_12071)
PBEL : QC761_706640(STE23)
PPSD : QC762_706640(STE23)
RTHE : 98129165(VTJ83DRAFT_834)
FOX : FOXG_01908 FOXG_06921 FOXG_12571 FOXG_12622 FOXG_13969 FOXG_16289 FOXG_17054
TATV : 25779465(TrAtP1_000541)
TASP : 36617954(TrAFT101_001837)
PLJ : 28887564(PLICBS_002804)
PTKZ : JDV02_001046(STE23)
CDET : 87937234(CDEST_00731)
PFY : PFICI_07549 PFICI_10843
PSCO : LY89DRAFT_581710 LY89DRAFT_588283 LY89DRAFT_766505
ANG : An07g06490 An16g01860
PBN : PADG_07053 PADG_11423
PTRR : 6349187(PtrM4_131560)
ADAC : 96083403(ACET3X_003081)
CDEP : 91084350(L203_100134) 91084545(L203_100329) 91086905(L203_102694)
KMG : 30163618(I203_102831)
KNE : 92182353(IAR55_005095)
CCAC : CcaHIS019_0305440(STE23)
TVS : TRAVEDRAFT_66168 TRAVEDRAFT_70638
DSQ : DICSQDRAFT_132271 DICSQDRAFT_172476
PCO : PHACADRAFT_249147 PHACADRAFT_255847
FME : FOMMEDRAFT_109506 FOMMEDRAFT_113079 FOMMEDRAFT_149732 FOMMEDRAFT_156520 FOMMEDRAFT_160675 FOMMEDRAFT_160677 FOMMEDRAFT_160684 FOMMEDRAFT_160691 FOMMEDRAFT_160811 FOMMEDRAFT_164257 FOMMEDRAFT_170571 FOMMEDRAFT_170573 FOMMEDRAFT_20973 FOMMEDRAFT_73398 FOMMEDRAFT_74907 FOMMEDRAFT_75209 FOMMEDRAFT_84908 FOMMEDRAFT_94441 FOMMEDRAFT_94516
ABP : AGABI1DRAFT68291(AGABI1DRAFT_68291)
ABV : AGABI2DRAFT199158(AGABI2DRAFT_199158)
MRR : Moror_14816 Moror_16162 Moror_8369
MORE : E1B28_006704 E1B28_009124 E1B28_009207
SCM : SCHCO_02662021(SCHCODRAFT_02662021)
SLA : SERLADRAFT_363280 SERLADRAFT_363284
RIE : OCT59_002436 OCT59_025248 OCT59_029858
CPV : cgd1_1680 cgd1_3840 cgd2_4270 cgd2_920 cgd2_930 cgd3_4180 cgd3_4200 cgd3_4210 cgd3_4220 cgd3_4240 cgd3_4250 cgd3_4260 cgd3_4270 cgd6_5520
CHO : Chro.10431 Chro.20103 Chro.20104 Chro.20459 Chro.30469 Chro.30474 Chro.30475
TGO : TGME49_257010 TGME49_269885(TLN1)
BBES : BESB_015090 BESB_077440
TET : TTHERM_000181089 TTHERM_00101300 TTHERM_00277260 TTHERM_00300360 TTHERM_00302040 TTHERM_00624110 TTHERM_00939020 TTHERM_01108740 TTHERM_01165230
PTM : GSPATT00000195001 GSPATT00000651001 GSPATT00001153001 GSPATT00002867001 GSPATT00003529001 GSPATT00003618001 GSPATT00006701001 GSPATT00011043001 GSPATT00016702001 GSPATT00021051001 GSPATT00021367001 GSPATT00025546001 GSPATT00030786001 GSPATT00036837001 PTMB.304c
PTI : PHATRDRAFT_18335 PHATRDRAFT_47985 PHATRDRAFT_50598
FCY : FRACYDRAFT_201763 FRACYDRAFT_206890 FRACYDRAFT_209078 FRACYDRAFT_248059 FRACYDRAFT_263926
TPS : THAPSDRAFT_2118 THAPSDRAFT_262412
NGD : NGA_0335320(IDE) NGA_0415400(IDE)
AAF : AURANDRAFT_62143 AURANDRAFT_71803
PIF : PITG_08991 PITG_17057
PSOJ : PHYSODRAFT_261837 PHYSODRAFT_519509
SPAR : SPRG_02382 SPRG_05446 SPRG_05468
LMAT : 92511739(LSCM1_01626)
LBZ : LBRM_31_3470(SCG5) LBRM_31_3520(SCG5)
LOI : 92359364(LSCM4_03425)
LEIS : 94177293(GH5_01726)
LEIN : 94186630(JIQ42_02939)
PHET : 94290090(JKF63_04018)
NGR : NAEGRDRAFT_35474 NAEGRDRAFT_80868
EHX : EMIHUDRAFT_110328 EMIHUDRAFT_449448 EMIHUDRAFT_449760 EMIHUDRAFT_461074 EMIHUDRAFT_471473 EMIHUDRAFT_65626 EMIHUDRAFT_74243 EMIHUDRAFT_74380 EMIHUDRAFT_97098
GTT : GUITHDRAFT_106094 GUITHDRAFT_45298 GUITHDRAFT_70428
PSHI : SAMEA2665130_0904(ptrA_1)
ALIG : NCTC10568_02300(ptrA_2)
LSD : EMK97_04385 EMK97_16295
PSEN : PNC201_14055(ptrA1)
AEL : NCTC12917_01886(ptrA_2)
CPSB : B595_0929 B595_0930
CFE : CF0202(ide1) CF0203(ide2)
OBG : Verru16b_00710(ptrA_1)
» show all
Taxonomy
Reference
Authors
Duckworth WC.
Title
Insulin degradation: mechanisms, products, and significance.
Journal
Reference
Authors
Affholter JA, Hsieh CL, Francke U, Roth RA
Title
Insulin-degrading enzyme: stable expression of the human complementary DNA, characterization of its protein product, and chromosomal mapping of the human and mouse genes.
Journal
Sequence
Reference
Authors
Duckworth WC, Hamel FG, Bennett R, Ryan MP, Roth RA.
Title
Human red blood cell insulin-degrading enzyme and rat skeletal muscle insulin protease share antigenic sites and generate identical products from insulin.
Journal
J Biol Chem 265:2984-7 (1990)
Reference
Authors
Kuo WL, Gehm BD, Rosner MR
Title
Cloning and expression of the cDNA for a Drosophila insulin-degrading enzyme.
Journal
Sequence
Reference
Authors
Ding L, Becker AB, Suzuki A, Roth RA.
Title
Comparison of the enzymatic and biochemical properties of human insulin-degrading enzyme and Escherichia coli protease III.
Journal
J Biol Chem 267:2414-20 (1992)
Other DBs
ExPASy - ENZYME nomenclature database: 3.4.24.56
LinkDB
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