KEGG   Homo sapiens (human): 3416
Entry
3416              CDS       T01001                                 
Symbol
IDE, INSULYSIN
Name
(RefSeq) insulin degrading enzyme
  KO
K01408  insulysin [EC:3.4.24.56]
Organism
hsa  Homo sapiens (human)
Pathway
hsa03266  Virion - Herpesvirus
hsa05010  Alzheimer disease
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09125 Information processing in viruses
   03266 Virion - Herpesvirus
    3416 (IDE)
 09160 Human Diseases
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    3416 (IDE)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors [BR:hsa01002]
    3416 (IDE)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.24  Metalloendopeptidases
    3.4.24.56  insulysin
     3416 (IDE)
Peptidases and inhibitors [BR:hsa01002]
 Metallo peptidases
  Family M16: pitrilysin family
   3416 (IDE)
SSDB
Motif
Pfam: Peptidase_M16_M Peptidase_M16_C Peptidase_M16 PqqF-like_C_4 Tn916-Xis PqqF_C_3
Other DBs
NCBI-GeneID: 3416
NCBI-ProteinID: NP_004960
OMIM: 146680
HGNC: 5381
Ensembl: ENSG00000119912
UniProt: P14735
Structure
LinkDB
Position
10:complement(92451684..92574093)
AA seq 1019 aa
MRYRLAWLLHPALPSTFRSVLGARLPPPERLCGFQKKTYSKMNNPAIKRIGNHITKSPED
KREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIAGLSHFCEHMLFLGTKK
YPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPLFDESCKD
REVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVRQE
LLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENKNVPLPEFPEHPFQEEHLKQ
LYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELKSKGWVNTLV
GGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQECKDLNAV
AFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEMVLDKLRPENVRVAI
VSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLPTKNEFIPTNFEILPL
EKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCNMAYLYLELL
KDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEKMATFEIDEKRFE
IIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLL
SRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQ
QRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRA
NGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQALAIRRLDKPKKL
SAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEMLAVDAPRRHKVSVHVLA
REMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRGLPLFPLVKPHINFMAAKL
NT seq 3060 nt   +upstreamnt  +downstreamnt
atgcggtaccggctagcgtggcttctgcaccccgcactgcccagcaccttccgctcagtc
ctcggcgcccgcctgccgcctccggagcgcctgtgtggtttccaaaaaaagacttacagc
aaaatgaataatccagccatcaagagaataggaaatcacattaccaagtctcctgaagac
aagcgagaatatcgagggctagagctggccaatggtatcaaagtacttcttatcagtgat
cccaccacggataagtcatcagcagcacttgatgtgcacataggttcattgtcggatcct
ccaaatattgctggcttaagtcatttttgtgaacatatgctttttttgggaacaaagaaa
taccctaaagaaaatgaatacagccagtttctcagtgagcatgcaggaagttcaaatgcc
tttactagtggagagcataccaattactattttgatgtttctcatgaacacctagaaggt
gccctagacaggtttgcacagttttttctgtgccccttgttcgatgaaagttgcaaagac
agagaggtgaatgcagttgattcagaacatgagaagaatgtgatgaatgatgcctggaga
ctctttcaattggaaaaagctacagggaatcctaaacaccccttcagtaaatttgggaca
ggtaacaaatatactctggagactagaccaaaccaagaaggcattgatgtaagacaagag
ctactgaaattccattctgcttactattcatccaacttaatggctgtttgtgttttaggt
cgagaatctttagatgacttgactaatctggtggtaaagttattttctgaagtagagaac
aaaaatgttccattgccagaatttcctgaacaccctttccaagaagaacatcttaaacaa
ctttacaaaatagtacccattaaagatattaggaatctctatgtgacatttcccatacct
gaccttcagaaatactacaaatcaaatcctggtcattatcttggtcatctcattgggcat
gaaggtcctggaagtctgttatcagaacttaagtcaaagggctgggttaatactcttgtt
ggtgggcagaaggaaggagcccgaggttttatgttttttatcattaatgtggacttgacc
gaggaaggattattacatgttgaagatataattttgcacatgtttcaatacattcagaag
ttacgtgcagaaggacctcaagaatgggttttccaagagtgcaaggacttgaatgctgtt
gcttttaggtttaaagacaaagagaggccacggggctatacatctaagattgcaggaata
ttgcattattatcccctagaagaggtgctcacagcggaatatttactggaagaatttaga
cctgacttaatagagatggttctcgataaactcagaccagaaaatgtccgggttgccata
gtttctaaatcttttgaaggaaaaactgatcgcacagaagagtggtatggaacccagtac
aaacaagaagctataccggatgaagtcatcaagaaatggcaaaatgctgacctgaatggg
aaatttaaacttcctacaaagaatgaatttattcctacgaattttgagattttaccgtta
gaaaaagaggcgacaccataccctgctcttattaaggatacagctatgagcaaactttgg
ttcaaacaagatgataagttttttttgccgaaggcttgtctcaactttgaatttttcagc
ccatttgcttatgtggaccccttgcactgtaacatggcctatttgtaccttgagctcctc
aaagactcactcaacgagtatgcatatgcagcagagctagcaggcttgagctatgatctc
caaaataccatctatgggatgtatctttcagtgaaaggttacaatgacaagcagccaatt
ttactaaagaagattattgagaaaatggctacctttgagattgatgaaaaaagatttgaa
attatcaaagaagcatatatgcgatctcttaacaatttccgggctgaacagcctcaccag
catgccatgtactacctccgcttgctgatgactgaagtggcctggactaaagatgagtta
aaagaagctctggatgatgtaacccttcctcgccttaaggccttcatacctcagctcctg
tcacggctgcacattgaagcccttctccatggaaacataacaaagcaggctgcattagga
attatgcagatggttgaagacaccctcattgaacatgctcataccaaacctctccttcca
agtcagctggttcggtatagagaagttcagctccctgacagaggatggtttgtttatcag
cagagaaatgaagttcacaataactgtggcatcgagatatactaccaaacagacatgcaa
agcacctcagagaatatgtttctggagctcttctgtcagattatctcggaaccttgcttc
aacaccctgcgcaccaaggagcagttgggctatatcgtcttcagcgggccacgtcgagct
aatggcatacagggcttgagattcatcatccagtcagaaaagccacctcactacctagaa
agcagagtggaagctttcttaattaccatggaaaagtccatagaggacatgacagaagag
gccttccaaaaacacattcaggcattagcaattcgtcgactagacaaaccaaagaagcta
tctgctgagtgtgctaaatactggggagaaatcatctcccagcaatataattttgacaga
gataacactgaggttgcatatttaaagacacttaccaaggaagatatcatcaaattctac
aaggaaatgttggcagtagatgctccaaggagacataaggtatccgtccatgttcttgcc
agggaaatggattcttgtcctgttgttggagagttcccatgtcaaaatgacataaatttg
tcacaagcaccagccttgccacaacctgaagtgattcagaacatgaccgaattcaagcgt
ggtctgccactgtttccccttgtgaaaccacatattaacttcatggctgcaaaactctga

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