KEGG ENZYME: 3.4.26.1

ENZYME: 3.4.26.1

Entry

EC 3.4.26.1                 Enzyme

Name

intramembrane prenyl-peptidase Rce1;
CaaX prenyl protease 2;
prenyl protein-specific endoprotease 2;
PPSEP 2;
alpha-factor-converting enzyme RCE1;
ras converting enzyme;
RACE;
glutamic-type intramembrane endopeptidase Rce1;
type II CAAX protease

Class

Hydrolases;
Acting on peptide bonds (peptidases);
Glutamic endopeptidases

Reaction(IUBMB)

Hydrolyses the peptide bond -P2-(S-farnesyl or geranylgeranyl)C-P1'-P2'-P3'-COOH where where P1' and P2' are amino acids with aliphatic sidechains and P3' is any C-terminal residue

Comment

The cleavage site motif is typically referred to as CaaX, where the letter a represents any amino acid, rather than alanine, and X represents the C-terminal amino acid of the target protein. The enzyme has been found in the yeast Saccharomyces cerevisiae and homologues exist in humans and several other species. Although the cleavage site is similar to that of the metallo-peptidase Ste24 endopeptidase (EC 3.4.24.84), there appear to be specificity differences in the proteins hydrolysed by these two enzymes, with amino-acid substitution studies indicating activity of the yeast enzyme towards substrates with a hydrophylic residue at (P1') that are not hydrolysed by EC 3.4.24.84 [4].

History

EC 3.4.26.1 created 2023

Pathway

ec00900

Terpenoid backbone biosynthesis

ec01110

Biosynthesis of secondary metabolites

Orthology

K08658

intramembrane prenyl-peptidase

Genes

HSA:	9986(RCE1)

PTR:	451355(RCE1)

PPS:	100981621(RCE1)

GGO:	101125752(RCE1)

PON:	100432288(RCE1)

PPYG:

129009062(RCE1)

NLE:	100585301(RCE1)

HMH:	116469062(RCE1)

SSYN:

129477494(RCE1)

MCC:	713224(RCE1)

MCF:	102116161(RCE1)

MTHB:

126935391

MNI:	105469653(RCE1)

CATY:

105577375(RCE1)

PANU:

101021805(RCE1)

MLEU:

105544449(RCE1)

RRO:	104664758(RCE1)

TFN:	117081550(RCE1)

CANG:

105512105(RCE1)

CJC:	100401419(RCE1)

SBQ:	101037989(RCE1)

CIMI:

108310195(RCE1)

ANAN:

105706497(RCE1)

CSYR:

103268323(RCE1)

MMUR:

105867463(RCE1)

LCAT:

123642873(RCE1)

PCOQ:

105827257(RCE1)

OGA:	100945932(RCE1)

MMU:	19671(Rce1)

MCAL:

110285251(Rce1)

MPAH:

110323840(Rce1)

RNO:	309153(Rce1)

MCOC:

116103342(Rce1)

ANU:	117696712(Rce1)

ASYL:

127692772(Rce1)

MUN:	110556493(Rce1)

CGE:	100758680(Rce1)

MAUA:

101823505(Rce1)

PROB:

127228653(Rce1)

PLEU:

114685995 114709129(Rce1)

MORG:

121454655(Rce1)

MFOT:

126498699

AAMP:

119817412(Rce1)

NGI:	103725567(Rce1)

HGL:	101713597(Rce1)

CPOC:

100719218(Rce1)

CCAN:

109687116(Rce1)

DORD:

105989036(Rce1)

DSP:	122105283(Rce1)

PLOP:

125361277(Rce1)

NCAR:

124958307

MMMA:

107156989(Rce1)

ITI:	101975710(Rce1)

OCU:

100338882

OPI:	101522761(RCE1)

TUP:	102485354(RCE1)

GVR:	103605406(RCE1)

CFA:	483705(RCE1)

CLUD:

112659508(RCE1)

VVP:	112924200(RCE1)

VLG:	121471279(RCE1)

NPO:	129503068(RCE1)

AML:	100482882(RCE1)

UMR:	103679502(RCE1)

UAH:	113244049(RCE1)

UAR:	123778432(RCE1)

ELK:

111150284

LLV:

125079512

MPUF:

101685013(RCE1)

MNP:	132018076(RCE1)

MLK:	131816198(RCE1)

NVS:	122913170(RCE1)

ORO:	101362277(RCE1)

EJU:	114220548(RCE1)

ZCA:	113915506(RCE1)

MLX:	118016111(RCE1)

NSU:	110576378(RCE1)

LWW:	102732421(RCE1)

FCA:	101100334(RCE1)

PYU:	121023838(RCE1)

PCOO:

112852146(RCE1)

PBG:	122484035(RCE1)

PVIV:

125177013(RCE1)

LRUF:

124505101

LGF:	123601974(RCE1)

AJU:

106971191

PTG:	102959980(RCE1)

PPAD:

109246823(RCE1)

PUC:

125911863

PLEZ:

122199689(RCE1)

HHV:	120233872(RCE1)

BTA:	539539(RCE1)

BOM:	102284443(RCE1)

BIU:	109554512(RCE1)

BBIS:

104986980(RCE1)

OAS:	101107239(RCE1)

BTAX:

128068829(RCE1)

CSUM:

138083872(RCE1)

ODA:	120874759(RCE1)

OVR:	110145990(RCE1)

MBEZ:

129548713(RCE1)

SSC:	100514389(RCE1)

CFR:	102524590(RCE1)

CBAI:

105070315(RCE1)

CDK:	105104445(RCE1)

VPC:	102540907(RCE1)

BACU:

103016654(RCE1)

LVE:	103070485(RCE1)

OOR:	101281520(RCE1)

LALB:

132525587(RCE1)

DLE:	111183692(RCE1)

PCAD:

102993963(RCE1)

PSIU:

116758606(RCE1)

NASI:

112402318(RCE1)

ECB:	100052803(RCE1)

EAI:

106833513

MYB:	102245506(RCE1)

MYD:	102770598(RCE1)

MMYO:

118665240(RCE1)

MLF:	102417330(RCE1)

MDT:	132241360(RCE1)

MYUM:

139018800(RCE1)

PKL:	118706986(RCE1) 118711113

EFUS:

103290939(RCE1)

MNA:	107533561(RCE1)

DRO:	112317056(RCE1)

SHON:

118991795(RCE1)

AJM:	119041931(RCE1)

PDIC:

114499528(RCE1)

PHAS:

123829558(RCE1)

MMF:	118628033(RCE1)

PPAM:

129068367(RCE1)

HAI:	109384200(RCE1)

RFQ:	117031255(RCE1)

PALE:

102894737(RCE1)

PGIG:

120584782(RCE1)

PVP:	105297958(RCE1)

RAY:	107503858(RCE1)

MJV:	108399819(RCE1)

TOD:	119249924(RCE1)

SARA:

101546754(RCE1)

SFUM:

130039950(RCE1)

SETR:

126018102(RCE1)

LAV:	100673035(RCE1)

TMU:

101348285

ETF:	101649871(RCE1)

DNM:	101420699(RCE1)

MDO:	100015109(RCE1)

GAS:	123251278(RCE1)

SHR:	111721560(RCE1)

AFZ:

127541893

PCW:	110195281(RCE1)

TVP:	118853698(RCE1)

PBRV:

138144905(RCE1)

OAA:	100088666(RCE1)

TACU:

119943571(RCE1)

ACYG:

136788545 136789232

AFUL:

116501697(RCE1)

TGU:	115491947(RCE1)

LSR:	110478831(RCE1)

ATRC:

139586315(RCE1)

OMA:	130262801(RCE1)

PHI:	102105034(RCE1)

PMAJ:

107199595(RCE1)

ACOE:

138100284(RCE1)

ZLE:	135460283(RCE1)

CCIC:

134055612(RCE1)

SHAB:

115614681(RCE1)

ACHC:

115338324(RCE1)

AGEN:

126033861

CUCA:

128849846(RCE1)

RTD:	128901809(RCE1)

CRID:

134508089(RCE1)

NPD:	112958138(RCE1)

ASN:	112551819(RCE1)

AMJ:	102562400(RCE1)

PSS:	102446822(RCE1)

CMY:	102940344(RCE1)

CCAY:

125639392(RCE1)

DCC:	119858260(RCE1)

CPIC:

101941067(RCE1)

TST:	117877815 117880816(RCE1)

CABI:

116817709 116835702(RCE1)

MRV:	120369477(RCE1) 120406527

ACS:	100556866(rce1)

ASAO:

132764379(RCE1)

PVT:	110089976(RCE1)

SUND:

121915371(RCE1)

PBI:	103057848(RCE1)

PMUR:

107302626(RCE1)

CTIG:

120318529(RCE1)

TSR:	106538032 106547455

PGUT:

117669722(RCE1)

APRI:

131186431(RCE1)

PTEX:

113446689(RCE1)

NSS:	113426672(RCE1)

VKO:	123032655(RCE1)

PMUA:

114586218(RCE1)

PRAF:

128403459(RCE1)

ZVI:	118076588(RCE1)

HCG:	128337075(RCE1)

GJA:	107111047(RCE1)

STOW:

125443158(RCE1)

EMC:	129336790(RCE1) 129337742

XLA:	444550(rce1.S)

XTR:	549000(rce1)

NPR:	108800616(RCE1)

RTEM:

120917481(RCE1)

BBUF:

120980940(RCE1)

BGAR:

122920125(RCE1)

PWL:	138259869(RCE1)

MUO:	115481041(RCE1)

GSH:	117365055(RCE1)

DRE:	557720(rce1a) 566908(rce1b)

SRX:	107710076 107731886

SANH:

107679240 107683501 107699980

SGH:	107597889(rce1)

CCAR:

109092999 109093995

CAUA:

113049014 113105516

CGIB:

127962624 128017279

PTET:

122349432(rce1a)

LROH:

127152388 127168142(rce1a)

OMC:	131529090 131543421(rce1a)

PPRM:

120469936(rce1a)

RKG:	130091393(rce1a)

MAMB:

125252195 125265457(rce1a)

CIDE:

127503503 127515212

CERY:

137012786 137030552(rce1a)

MASI:

127415176 127453067

TROS:

130568199(rce1a)

MANU:

129438237(rce1a)

PDAB:

135750733 135764763

IPU:	108268100(rce1a)

IFU:	128609911(rce1a)

PHYP:

113540580(rce1)

SMEO:

124387765(rce1a)

TFD:	113657520(rce1a)

TVC:	132848490(rce1a)

CGAR:

128530768(rce1a)

NGRA:

132894187(rce1a)

TRN:	134311493(rce1a)

AMEX:

103027039(rce1a) 103028746

CMAO:

118820036 118826403(rce1a)

EEE:	113581805(rce1)

CHAR:

105904836(rce1a) 122131812

SPIL:

134059888(rce1a) 134079856

TRU:	101077933(rce1) 101079461

TFS:	130523199(rce1a)

TNG:	GSTEN00006678G001 GSTEN00010157G001

LCO:	104935875(rce1)

NCC:	104967330(rce1)

TBEN:

117482675(rce1a) 117490659

CGOB:

115018509 115023581

PGEO:

117459025 117463947(rce1a)

GACU:

117540230 117551798(rce1a)

EMAC:

134872460 134875989(rce1a)

ELY:	117272713(rce1a)

EFO:	125883541(rce1a) 125898387

PLEP:

121952939 121962026(rce1a)

SLUC:

116036905 116043781(rce1a)

ECRA:

117934823(rce1a) 117955029

ESP:	116700690 116707199

PFLV:

114545793(rce1) 114566230

GAT:	120821801 120822326(rce1a)

PPUG:

119215784 119222194(rce1a)

AFB:	129093203(rce1a) 129113912

CLUM:

117742337 117747653(rce1a)

PSWI:

130211667(rce1a)

CANA:

137792456(rce1a) 137802973

CVE:	137871520 137876812

MSAM:

119896136 119912263(rce1a)

SCHU:

122870755(rce1a) 122888047

CUD:	121506658(rce1a) 121518499

SPUL:

138600551(rce1a) 138600935

LMIX:

132958233(rce1a) 132988736

ALAT:

119027293(rce1a) 119030810

ASTR:

137590776(rce1a)

MZE:	101469070 101478769(rce1)

ONL:	100695797 100709339

OAU:	116310425(rce1a) 116319717

OLA:	101174702(rce1)

OML:	112155873(rce1a)

CSAI:

133420348(rce1a) 133459510

XMA:	102231599 102235810(rce1)

XCO:	114153209 114153210 114156774(rce1)

XHE:	116728999 116732884(rce1)

PRET:

103480142(rce1)

PFOR:

103138797 103148907

PLAI:

106946964(rce1)

PMEI:

106917265(rce1)

GAF:	122820468(rce1a) 122844585

PPRL:

129373378 129378355(rce1a)

CVG:	107084180 107103812(rce1)

CTUL:

119775011(rce1a)

GMU:	124876635 124880184(rce1a)

NFU:	107384707(rce1)

KMR:	108242254(rce1a)

ALIM:

106533202

NWH:	119415167(rce1a)

AOCE:

111577208(rce1a)

EJA:	138195985 138203981(rce1a)

BFRE:

138626434(rce1a) 138634897

MCEP:

125003449(rce1a)

CSEM:

103385544(rce1)

POV:	109642747(rce1) 109644482

SSEN:

122766478(rce1a)

SSOE:

131456924(rce1a)

HHIP:

117751814(rce1a) 117774827

HSP:	118102708(rce1a)

PPLT:

128430066(rce1a) 128457400

SMAU:

118301286 118307241(rce1a)

LCF:	108879729(rce1a) 108893236 108895254

SDU:	111217044 111223593

SLAL:

111667962 111672089

XGL:	120797178(rce1a)

HCQ:	109516593(rce1)

SSCV:

125973742(rce1a)

SBIA:

133494707(rce1a)

PEE:	133397923(rce1a)

PTAO:

133472972(rce1a)

BPEC:

110170730(rce1)

ENY:	140371796(rce1a)

MALB:

109957242(rce1)

BSPL:

114849384(rce1a)

SJO:	128370873 128384325(rce1a)

SSCO:

133994298 134005956(rce1a)

GMH:	115529321(rce1)

SASA:

106577518 106608582

STRU:

115194130 115198139

OTW:	112214806 112260084

OMY:	110500724 110531865

OGO:	124008544 124014165

ONE:	115133653 115138189

OKI:	109896470 109906602

OKE:	118368646 118391880

OMM:	135510722 135516421

OCLA:

139379078 139416187

SALP:

111955327 111960327

SNH:	120030404 120049208(rce1a)

CCLU:

121554327 121572695

ELS:	105022128(rce1)

OEP:	134009654(rce1a)

SFM:	108934137(rce1)

PKI:	111858523(rce1)

AANG:

118222157 118234866

AROT:

135249986 135263537

CCOG:

133123986(rce1a) 133132803

LOC:	102688688(rce1)

PSPA:

121306238(rce1a) 121310463

ARUT:

117398689 117967816

PSEX:

120539279(rce1a)

CMK:	103172575(rce1a)

RTP:	109936897(rce1a)

CPLA:

122543850(rce1a)

HOC:	132836243(rce1a)

LERI:

129714972(rce1a)

PMRN:

116947798(RCE1)

LRJ:	133341361(RCE1)

BFO:

118417527

BBEL:

109472323

CIN:

100184780

SCLV:

120331499 120331500

SPU:

105444035

LPIC:

129264419

AJJ:

139970768

APLC:

110979271

ARUN:

117297339

AAMU:

139944226

AFIL:

140153022

AJC:

117108486

SKO:

102808340

PFLL:

139149456 139150598

DME:	Dmel_CG4852(Sras)

DER:

6544359

DSE:

6610886

DSI:	Dsimw501_GD13889(Dsim_GD13889)

DYA:	Dyak_GE21494

DAN:

6506617

DSR:

110176183

DPO:

4813878

DPE:

6600306

DMN:

108150913

DWI:

6638803

DGR:

6557337

DMO:	Dmoj_GI12131

DAZ:

108613511

DNV:

108651516

DHE:

111593089

DVI:	6623964(Sras)

CCAT:

101453819

BOD:

106615902

BDR:

105229752

RZE:

108382296

AOQ:

129238849

ALUD:

128857947

TDA:	119670844 119672855

MDE:

101899205

SCAC:

106086818

LCQ:

111677413

LSQ:

119604427

CVJ:	135957102(Sras)

GFS:

119635393

ECOE:

129941126

CLON:

129611425

HIS:

119650949

AGA:

1270883

ACOZ:

120961673

AARA:

120901522

AMER:

121587791

ASTE:

118502885

AMAP:

126558640

AFUN:

125763319

AMOU:

128297053

AMRS:

128707779

AALI:

118460160

ACOS:

131272815

AAG:

5565703

AALB:

109623054

ASUA:

134204959

CQU:	CpipJ_CPIJ002690

CNS:

116337461

BCOO:

119068174

LLL:

129788018

PPAP:

129798592

AME:

409333

ACER:

107994363

ALAB:

122715311

ADR:

102681092

AFLR:

100864371

BIM:

100748778

BBIF:

117205095

BVK:

117231089

BVAN:

117157597

BHUN:

126871630

BTER:

100645944

BAFF:

126921987

BPYO:

122567779

BPAS:

132912721

FVI:

122538633

CCAL:

108631033

OBB:

114877556

OLG:

117603047

MGEN:

117219333

NMEA:

116434146

CGIG:

122399087

SOC:

105203231

MPHA:

105829025

AEC:

105144814

ACEP:

105624087

PBAR:

105425872

VEM:

105567947

COBS:

139105915(Sras)

TLN:	139822513(Sras)

DQU:

106745850

CFO:

105253623

FEX:

115237138

PMEC:

138941091(Sras)

LHU:	105670725(Sras)

PGC:

109857733

OBO:

105278801

PCF:

106787059

PFUC:

122523275

VPS:

122636319

VCRB:

124432132

VVE:

124956802

NVI:

100115515

CSOL:

105360906

TPRE:

106653850

LHT:

122511843

LBD:

127281357

MDL:

103576652

CGLO:

123275164

FAS:

105266815

DAM:

107043005

AGIF:

122854850

CINS:

118068948

VCAN:

122408815

CCIN:

107264552

DSM:

124408353

NPT:	124217890(Sras)

NFB:

124179387

NLO:

107224033

NVG:

124302227

AROA:

105683389

TCA:

656195

TMOL:

138124621(Sras)

DPA:

109536252

ESIM:

136408682(Sras)

EFOR:

136343957(Sras)

SOY:

115880356

AGRG:

126739619

ATD:

109609221

CSET:

123308354

HAXR:

123671325

AGB:

108905471

LDC:

111517622

NVL:

108562852

APLN:

108739149

PPYR:

116174462

BMOR:

101735415

BMAN:

114243914

MSEX:

115446916 119192558

DPL:	KGM_202245

BANY:

112044379

MJU:

123874921

NIQ:

126775778

VCD:

124538388

MCIX:

123662321

PMAC:

106721661

PPOT:

106101028

PXU:

106120113

BPHI:

137919852(Sras)

PRAP:

110994314

PBX:

123718221

PNAP:

125054585

ZCE:

119828496

CCRC:

123699605

LSIN:

126972363

AAGE:

121726508

HAW:

110373462

HZE:

124640229

TNL:	113504748 113504815 113506742

SLIU:

111350379

OFU:

114360058

ONU:

135080383

ATRA:

106129746

GMW:

113519725

PXY:

105380824

PGW:

126375171

LGLY:

125232520

CSTB:

134748452

CFEL:

113378258 113382973

CCRN:

123291647

API:

100167262

DNX:

107162139

AGS:

114130722

RMD:

113555459

ACOO:

126841335

DVT:

126908683

BTAB:

109041411

DCI:

103519699

CLEC:

106665428

HHAL:

106687764(Sras)

NLU:	111046216 120350785

HVI:

124370697

MQU:

128987738

PHU:	Phum_PHUM444940

FOC:

113207533

TPAL:

117643668

ZNE:

110838861

CSEC:

111870130

SGRE:

126268190

BROR:

134536162

IEL:

124167860

HAMR:

139698843(Sras)

FCD:

110844992

DPX:	DAPPUDRAFT_188721

DMK:

116931357

DPZ:

124310951

AFRA:

136042257

PVM:	113811367(Sras)

PJA:

122249627

PCHN:

125026446

PMOO:

119580137

HAME:

121859134

CQD:	128698314(Sras)

PTRU:

123514728

ESN:	126995334 126995373

MNZ:

135206124

MRJ:	136834262(Sras)

PORN:

139760311(Sras)

HAZT:

108683032

EAF:

111696832

LSM:	121116372 121118624

TCF:

131885884

PPOI:

119109576

DSV:

119457676

RSAN:

119374075

RMP:

119167907

VDE:

111254470

VJA:

111273645

TUT:	107364876 107364977 107364978 107367463

DPTE:

113797033

DFR:

124498646

CSCU:

111624354

CVS:	136978292(Sras)

PTEP:

107454563

ABRU:

129965835

UDV:

129220126

SDM:

118184668

LPOL:

106471285

PMEO:

129580895

CEL:	CELE_F48F5.5(fce-2)

CBR:	CBG_17836 CBG_17837(Cbr-fce-2)

CRQ:	GCK72_021336

BMY:	BM_BM4212(Bma-fce-2)

LOA:	LOAG_09521

TSP:

Tsp_08637

HRO:	HELRODRAFT_70936

LGI:	LOTGIDRAFT_111054

PCAN:

112570073

LSAX:

138952050

BGT:

106055484

GAE:

121372360

HRF:

124127357

HRJ:

124265162

HASI:

137294840

HCRA:

139442700

CRG:

105330791

CVN:	111128863 111129201

OED:

125652420

MYI:

110462813

PMAX:

117323751

AIRR:

138318777

MCAF:

127738829

MMER:

128555593

RPHI:

132760185

DPOL:

127871853 127871928

MAEA:

128208294

OBI:

106884353

OSN:

115228090

LJP:

135468280

LAK:	106157490 106159848 112042727

SMM:	Smp_017650.1

SHX:	MS3_00004112(RCE1)

EGL:

EGR_07255

LLON:

135484334

NVE:

5503266

EPA:

110235660

ATEN:

116305096

ADF:

107357050

AMIL:

114956370 122947950

MCAZ:

138027882

MFOO:

137980036

PDAM:

113671925

SPIS:

111343505

DGT:

114520108

XEN:

124442364

HMG:

100201694

HSY:

130653756

RES:

135686346

TAD:	TRIADDRAFT_57211

AQU:

100641475

ATH:	AT2G36305(FACE2)

ALY:

9317504

CRB:

17887826

CSAT:

104782046 104785902 104792403

EUS:	EUTSA_v10016950mg

BRP:

103857613

BNA:	106388128 106437904

BOE:

106331957

RSZ:	108838465 130505082

THJ:

104807091

CPAP:

110822660

CIT:

102629770

CIC:	CICLE_v10012247mg

PVY:

116129228

MINC:

123226928

TCC:

18598216

GRA:	105766682 105797708

GHI:	107899223 107948290

GAB:

108458290

HSYR:

120142986 120180864 120181051 120188080

DZI:

111311729

EGR:

104438127

RARG:

115742346

GMX:	100783290 100790273

GSJ:	114370186 114373730

PVU:

137830344

VRA:

106769742

VAR:

108324125

VUN:

114192432

VUM:

124836387

CCAJ:

109818330

APRC:

113872875

MTR:

25483841

TPRA:

123903223

CAM:

101514895

PSAT:

127091342

VVO:	131639303 131644699

ADU:

107473883

AIP:

107625093

AHF:	112727138 112741047

LANG:

109338667

PCIN:

129318807

QSA:	O6P43_005928

FVE:

101296682

AANS:

126799270

RCN:

112193269

PPER:

18771726

PMUM:

103339696

PAVI:

110753503

PDUL:

117634520

MDM:	103427532 103449451

MSYL:

126593231 126599691

PXB:	103956480 103963626

PCOX:

137713535 137746054

ZJU:

107432181

MNT:

21398510

CSAV:

115708811

CSV:

101206885

CMO:

103486598

BHJ:

120091625

MCHA:

111014343

CMAX:

111498632

CMOS:

111433731

CPEP:

111801146

RCU:

8267177

MEAN:

126679479

JCU:

105629485

HBR:

110657233

MESC:

110621925

POP:

7487248

PEU:

105122482

PALZ:

118053359

PNZ:

133688361

JRE:

108985707

CILL:

122276344

CAVE:

132191973

AGLU:

133872857

QSU:

112001793

QLO:

115951354

TWL:	119998258 120013135

VVI:

100247667

VRI:

117920826

SLY:

101259663

SPEN:

107029701

SOT:

102580679

SSTN:

125871733

SDUL:

129882131

CANN:

107843222

LBB:

132629849

NTA:	107763027 107812696

NSY:

104222669

NTO:

104106761

NAU:

109229748

INI:

109155223

ITR:

116024583

SIND:

105174080

OEU:

111388434

EGT:

105960079

SSPL:

121792174 121795519 121798694 121799832

SMIL:

130996590

APAN:

127251128

HAN:	110886601 110886602 110886610 110886611 110890529 110900237

ECAD:

122581758

LSV:

111905036

CCAV:

112519371

DCR:

108211722

CSIN:

114307141

RVL:

131319415

AEW:

130788922

DLT:

127788787

BVG:	104886301 104898380

SOE:

110788513

CQI:	110695753 110729321

ATRI:

130812849

MOF:

131165853

NNU:

104588363

MING:

122073794

TSS:

122648618

PSOM:

113309743 113323180

OSA:

9268853

OBR:

102721448

OGL:

127773665

BDI:

100834096

ATS:

109735878

TDC:	119276368 119276386 119340357

TAES:

123052928 123129312 123181747

TUA:

125514366

LPER:

127317746

LRD:	124706752 124707724

SBI:

8073597

ZMA:

100192945

MFLO:

136451128 136451143

SITA:

101784292

SVS:

117848600

PVIR:

120665765 120699005

PHAI:

112887661

PAUA:

133928744

PDA:

103706002

EGU:	105033869 105038234

MUS:	135584105 135625583

ZOF:	122020787 122025540

DCT:

110096655

PEQ:

110025408

AOF:	109823816 109835377

MSIN:

131234488

ACAK:

137959759

NCOL:

116264042

ATR:

18422575

CJF:

131061303

SMO:	SELMODRAFT_110711 SELMODRAFT_427203

PPP:

112281244

CRE:	CHLRE_01g042150v5

VCN:	VOLCADRAFT_32069

CSL:	COCSUDRAFT_14314

CVR:	CHLNCDRAFT_139494

APRO:

F751_6361

OLU:	OSTLU_16795

OTA:	OT_ostta09g02460

BPG:	Bathy10g02080

MIS:	MICPUN_76762

MPP:	MICPUCDRAFT_38670

GSL:	Gasu_06680

CCP:	CHC_T00002173001

SCE:	YMR274C(RCE1)

SEUB:

DI49_4360

SPAO:

SPAR_M03890

AGO:	AGOS_AAL186W

ERC:

Ecym_2709

KLA:	KLLA0_D01705g

KMX:	KLMA_10580(RCE1)

LTH:	KLTH0C04026g

ZRO:	ZYRO0G14014g

CGR:	2887873(GVI51_F03157)

NCS:	NCAS_0C00460(NCAS0C00460)

NDI:	NDAI_0K00460(NDAI0K00460)

TPF:	TPHA_0I00210(TPHA0I00210)

TBL:	TBLA_0D03200(TBLA0D03200)

TGB:	HG536_0H00660

TDL:	TDEL_0B00650(TDEL0B00650)

KAF:	KAFR_0B03870(KAFR0B03870)

KNG:	KNAG_0J00310(KNAG0J00310)

ZMK:	HG535_0F00350

DHA:	DEHA2F07260g

PGU:	PGUG_01421

SPAA:

SPAPADRAFT_58781

LEL:	PVL30_004323(RCE1)

LBG:	92210433(LODBEIA_P52370)

CAL:	CAALFM_C404570WA(RCE1)

COT:	CORT_0B00860

CDU:	CD36_44260

CLU:	CLUG_00675

CLUS:

A9F13_17g00572

ASAU:

88175731(PUMCH_004671)

PPA:	PAS_chr4_0834

PKZ:	C5L36_0B10150

BBRX:

BRETT_001619

OPA:	HPODL_05367

YLI:	2908438(YALI2_F00838g)

NCR:

NCU11314

NTE:	NEUTE1DRAFT121990(NEUTE1DRAFT_121990)

SMP:	10803854(SMAC4_05369)

PAN:	PODANSg4823

PBEL:

QC761_702280(RCE1)

PPSD:

QC762_702280(RCE1)

PPSP:

QC763_702280(RCE1)

PPSA:

QC764_702280(RCE1)

TTT:	THITE_44263

MTM:	MYCTH_49425

CTHR:

CTHT_0023940

RTHE:

98121815(VTJ83DRAFT_1054)

MGR:

MGG_08854

PPEI:

PpBr36_00527

PGRI:

PgNI_04553

TMN:	UCRPA7_1647

SSCK:

SPSK_02648

FGR:	FGSG_02597

FPU:	FPSE_11933

FPOA:

FPOAC1_002723

FVN:	FVRRES_03027

FVR:	FVEG_09156

FOX:	FOXG_10504

NHE:	NECHADRAFT_44179

FFC:	NCS54_00848400

FKR:	NCS57_00891300

FMU:	J7337_005241

TRE:	TRIREDRAFT_124222

TRR:	M419DRAFT_139491

TATV:

25778373(TrAtP1_009800)

TASP:

36611198(TrAFT101_011366)

PCHM:

VFPPC_14155

CMT:

CCM_05829

AMUS:

LMH87_008195

PTKZ:

JDV02_002706(RCE1)

VAL:	VDBG_08631

VDA:	VDAG_06292

CFJ:	CFIO01_10650

CLUP:

CLUP02_03532

CHIG:

CH63R_02612

CDET:

87937353(CDEST_00850)

ELA:	UCREL1_4904

PFY:	PFICI_12628

SSL:	SS1G_00428

BFU:	BCIN_03g04260(Bcrce1)

MBE:

MBM_08218

PSCO:

LY89DRAFT_688953

GLZ:	GLAREA_00858

ANI:	ANIA_06528

AFM:	AFUA_6G04890

ACT:	ACLA_095650

NFI:	NFIA_051440

AOR:	AO090701000050

ANG:	An14g03420

AFV:	AFLA_004538

ALUC:

AKAW2_41024A

ACHE:

ACHE_50229S

APUU:

APUU_10756S

PCS:	N7525_002095

PDP:	PDIP_18420

POU:	POX_c04502

TMF:	EYB26_009656

TRG:	TRUGW13939_07226

CIM:	CIMG_02653

CPW:	9696639(D8B26_000739)

PBL:	PAAG_03593

PBN:	PADG_12065

AJE:	HCAG_06839

BGH:	BDBG_07699

PNO:	SNOG_01345

PTE:

PTT_18673

PTRR:

6341760(PtrM4_098030)

BZE:	COCCADRAFT_4596

BSC:	COCSADRAFT_101488

BOR:	COCMIDRAFT_102513

AALT:

CC77DRAFT_965113

ADAC:

96086262(ACET3X_005940)

ARAB:

EKO05_0008625

ZTR:	MYCGRDRAFT_76260

PFJ:	MYCFIDRAFT_88452

FFU:	CLAFUR5_03644

CBET:

CB0940_03104

BCOM:

BAUCODRAFT_148289

NPA:

UCRNP2_86

TML:	GSTUM_00005185001

SPO:	2542754(rce1)

SOM:	SOMG_01720(rce1)

CNE:

CNK03110

CNB:

CNBK0370

CNG:	CNAG_01978

CGI:	CGB_K0490W

CDEU:

CNBG_2975

CDEP:

91089568(L203_105359)

KMG:	30161458(I203_105834)

KNE:	92183280(IAR55_006022)

TMS:	TREMEDRAFT_15682

TASA:

A1Q1_03507

CCAC:

CcaHIS019_0302880(RCE1)

TVS:	TRAVEDRAFT_130870

DSQ:	DICSQDRAFT_112441

SHS:	STEHIDRAFT_55231

HIR:	HETIRDRAFT_240649

PSQ:	PUNSTDRAFT_111105

ADL:	AURDEDRAFT_61361

FME:	FOMMEDRAFT_168421

GTR:	GLOTRDRAFT_77508

RSX:	RhiXN_07369

LBC:	LACBIDRAFT_310467 LACBIDRAFT_332961

CCI:	CC1G_03088

ABP:	AGABI1DRAFT79847(AGABI1DRAFT_79847)

ABV:	AGABI2DRAFT213114(AGABI2DRAFT_213114)

MRR:	Moror_7546

E1B28_004807

SCM:	SCHCO_02614015(SCHCODRAFT_02614015)

CPUT:

CONPUDRAFT_105000

SLA:	SERLADRAFT_469174

WSE:	WALSEDRAFT_61414

UMA:	UMAG_11228

PFP:	PFL1_06643

SGRA:

EX895_003695

MGL:

MGL_3383

MRT:

MRET_1844

MSYM:

MSY001_1585

PGR:	PGTG_10585

PTRC:

PtA15_5A838

PSTR:

Pst134EA_009543 Pst134EA_031688

MLR:	MELLADRAFT_117057

RIE:	OCT59_017356

SRE:	PTSG_00300

DDI:	DDB_G0292570

DPP:	DICPUDRAFT_147553

EHI:	EHI_187200(12.t00005)

EIV:	EIN_043950

ACAN:

ACA1_085940 ACA1_255370

PTM:	GSPATT00011590001

PTI:	PHATRDRAFT_7108

FCY:	FRACYDRAFT_165906

TPS:	THAPSDRAFT_269387

AAF:	AURANDRAFT_19189

PIF:	PITG_04001

PSOJ:

PHYSODRAFT_551240

SPAR:

SPRG_10771

TBR:	Tb927.3.1540

TBG:	TbgDal_III1300

TCR:	510089.39 510421.29

LMA:	LMJF_26_2690

LIF:	LINJ_26_2720

LDO:	LDBPK_262720

LMI:	LMXM_26_2690

LMAT:

92514310(LSCM1_04286)

LBZ:	LBRM_26_2620

LPAN:

LPMP_262660

LOI:	92361162(LSCM4_05280)

LEIS:

94180682(GH5_05302)

LENR:

94171269(CUR178_04045)

LEIN:

94188842(JIQ42_05204)

PHET:

94290390(JKF63_04327)

NGR:	NAEGRDRAFT_74579

GLA:	GL50803_007029

EHX:	EMIHUDRAFT_47218 EMIHUDRAFT_47221

GTT:	GUITHDRAFT_104593

» show all

Reference

1 [PMID:10085068]

Authors

Otto JC, Kim E, Young SG, Casey PJ.

Title

Cloning and characterization of a mammalian prenyl protein-specific protease.

Journal

J Biol Chem 274:8379-82 (1999)
DOI:10.1074/jbc.274.13.8379

Sequence

[hsa:9986]

Reference

2 [PMID:24291792]

Authors

Manolaridis I, Kulkarni K, Dodd RB, Ogasawara S, Zhang Z, Bineva G, Reilly NO, Hanrahan SJ, Thompson AJ, Cronin N, Iwata S, Barford D

Title

Mechanism of farnesylated CAAX protein processing by the intramembrane protease Rce1.

Journal

Nature 504:301-5 (2013)
DOI:10.1038/nature12754

Sequence

[mmp:MMP0485]

Reference

3 [PMID:21570408]

Authors

Pei J, Mitchell DA, Dixon JE, Grishin NV.

Title

Expansion of type II CAAX proteases reveals evolutionary origin of gamma-secretase subunit APH-1.

Journal

J Mol Biol 410:18-26 (2011)
DOI:10.1016/j.jmb.2011.04.066

Reference

4 [PMID:10825201]

Authors

Trueblood CE, Boyartchuk VL, Picologlou EA, Rozema D, Poulter CD, Rine J.

Title

The CaaX proteases, Afc1p and Rce1p, have overlapping but distinct substrate specificities.

Journal

Mol Cell Biol 20:4381-92 (2000)
DOI:10.1128/MCB.20.12.4381-4392.2000

Sequence

[sce:YMR274C]

Reference

5 [PMID:16361710]

Authors

Plummer LJ, Hildebrandt ER, Porter SB, Rogers VA, McCracken J, Schmidt WK.

Title

Mutational analysis of the ras converting enzyme reveals a requirement for glutamate and histidine residues.

Journal

J Biol Chem 281:4596-605 (2006)
DOI:10.1074/jbc.M506284200

Other DBs

ExplorEnz - The Enzyme Database:

3.4.26.1

IUBMB Enzyme Nomenclature:

3.4.26.1

ExPASy - ENZYME nomenclature database:

3.4.26.1

BRENDA, the Enzyme Database:

3.4.26.1

LinkDB

DBGET integrated database retrieval system