Entry
Name
phosphoribosyl-AMP cyclohydrolase;
PRAMP-cyclohydrolase;
phosphoribosyladenosine monophosphate cyclohydrolase;
1-(5-phospho-D-ribosyl)-AMP 1,6-hydrolase
Class
Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In cyclic amidines
BRITE hierarchy
Sysname
1-(5-phospho-beta-D-ribosyl)-AMP 1,6-hydrolase
Reaction(IUBMB)
1-(5-phospho-beta-D-ribosyl)-AMP + H2O = 1-(5-phospho-beta-D-ribosyl)-5-[(5-phospho-beta-D-ribosylamino)methylideneamino]imidazole-4-carboxamide [RN:
R04037 ]
Reaction(KEGG)
Substrate
1-(5-phospho-beta-D-ribosyl)-AMP [CPD:
C02741 ];
H2O [CPD:
C00001 ]
Product
1-(5-phospho-beta-D-ribosyl)-5-[(5-phospho-beta-D-ribosylamino)methylideneamino]imidazole-4-carboxamide [CPD:
C04896 ]
Comment
The Neurospora crassa enzyme also catalyses the reactions of EC
1.1.1.23 (histidinol dehydrogenase) and EC
3.6.1.31 (phosphoribosyl-ATP diphosphatase).
History
EC 3.5.4.19 created 1972, modified 1976, modified 1981, modified 2000
Pathway
ec01110 Biosynthesis of secondary metabolites
Orthology
K01496 phosphoribosyl-AMP cyclohydrolase
K11755 phosphoribosyl-AMP cyclohydrolase / phosphoribosyl-ATP pyrophosphohydrolase
K14152 phosphoribosyl-ATP pyrophosphohydrolase / phosphoribosyl-AMP cyclohydrolase / histidinol dehydrogenase
Genes
CSAT : 104741789 104757554 104777221
BNA : 106365613 106367164 106451798 125608753
PVY : 116129805 116135159 116141912
GRA : 105763505 105785904 105798642 105804188
GHI : 107888797 107922436 107945840
HSYR : 120124827 120163016
CCAJ : 109789639 109794896 109802925
AHF : 112697078 112743567 112754968
PCIN : 129303512 129308760
QSA : O6P43_001373 O6P43_006112
AANS : 126787485 126788507
MDM : 103413049 103418845 103427209
MSYL : 126590918 126615730
PXB : 103930643 103934311 103948885
CPEP : 111783531 111805641
QSU : 111990777 111992172 112036579
SSPL : 121794985 121800288
APAN : 127249039 127259516
MING : 122066053 122093268
PSOM : 113271416 113281309
TAES : 123061105 123069691 123078177
MFLO : 136449828 136451982 136505499 136505725 136508118
PVIR : 120673506 120706544
ZOF : 121992585 121994065 121996542 122031364
SMO : SELMODRAFT_409257 SELMODRAFT_411322
NCS : NCAS_0B08820(NCAS0B08820)
NDI : NDAI_0A00450(NDAI0A00450)
TPF : TPHA_0E03690(TPHA0E03690)
TDL : TDEL_0C06570(TDEL0C06570)
KAF : KAFR_0D00420(KAFR0D00420)
KNG : KNAG_0C00510(KNAG0C00510)
SPAA : SPAPADRAFT_141809(HIS2)
LBG : 92210178(LODBEIA_P49820)
CAL : CAALFM_C400140CA(HIS4)
YLI : 2905745(YALI2_A00250g)
NTE : NEUTE1DRAFT150173(NEUTE1DRAFT_150173)
SMP : 10805831(SMAC4_02870)
FPOA : FPOAC1_000917(HIS3)
TATV : 25774999(TrAtP1_006517)
PLJ : 28891237(PLICBS_004464)
CDET : 87948785(CDEST_12285)
BFU : BCIN_05g05260(Bchis4)
PTRR : 6342900(PtrM4_115850)
TML : GSTUM_00010427001 GSTUM_00010428001
SPO : 2539650(his2) 2540290(his7)
SOM : SOMG_01601(his7) SOMG_02196(his2)
CDEP : 91088063(L203_103853)
KMG : 30166319(I203_102385)
KNE : 92179906(IAR55_002648)
CCAC : CcaHIS019_0202180(HIS4)
ABP : AGABI1DRAFT72979(AGABI1DRAFT_72979)
ABV : AGABI2DRAFT184772(AGABI2DRAFT_184772)
SCM : SCHCO_02621953(SCHCODRAFT_02621953)
PSTR : Pst134EA_005041 Pst134EA_032370
ECF : ECH74115_2959(hisIE)
ECOO : ECRM13514_2747(hisI)
ECOH : ECRM13516_2615(hisI)
ECW : EcE24377A_2317(hisIE)
EDJ : ECDH1ME8569_1962(hisI)
ECOI : ECOPMV1_02181(hisE)
EAL : EAKF1_ch3988c(hisIE)
SBC : SbBS512_E1206(hisIE)
ECLS : LI67_011410 LI67_015750
KPU : KP1_3687(hisI) KP1_p080
KPO : KPN2242_15470 KPN2242_25651
KPR : KPR_1620(hisI) KPR_3432(hisI2)
KPNK : BN49_3575(hisI2) BN49_3699(hisI)
REE : electrica_01700(hisE)
RTG : NCTC13098_02351(hisE) NCTC13098_02538
CTEL : GBC03_12220 GBC03_14095
CLAP : NCTC11466_01528(hisE)
KIE : NCTC12125_00642(hisE)
AHN : NCTC12129_03338(hisI)
METY : MRY16398_18190(hisE)
PSHI : SAMEA2665130_2145(hisE)
YPG : YpAngola_A3176(hisIE)
YPI : YpsIP31758_2435(hisI)
SMW : SMWW4_v1c15920(hisI)
SFJ : SAMEA4384070_1651(hisE)
SOF : NCTC11214_05307(hisE)
SSAR : SSARUM_001546(hisIE)
PAQU : DMB82_0008960(hisIE)
PARL : PEC302110_17320(hisIE)
BAPF : BUMPF009_CDS00489(hisi)
BAPG : BUMPG002_CDS00490(hisi)
BAPU : BUMPUSDA_CDS00488(hisi)
BAPW : BUMPW106_CDS00489(hisi)
TPTY : NCTC11468_02380(hisE)
PHEI : NCTC12003_02830(hisE)
PRJ : NCTC6933_01243(hisE)
LRI : NCTC12151_01564(hisE)
HIC : NTHIC486_00511(hisE)
HPIT : NCTC13334_01117(hisE)
HAEG : NCTC8502_00659(hisE)
PDAG : 4362423_02102(hisI)
ALIG : NCTC10568_02428(hisI)
AVT : NCTC3438_00672(hisE)
RPNE : NCTC8284_00204(hisI)
PAET : NCTC13378_01333(hisI)
XFU : XFF4834R_chr19800(hisIE)
XPH : XppCFBP6546_19975(XppCFBP6546P_19975)
XHD : LMG31886_24700(hisI)
LAUX : LA521A_23350(hisIE)
LLZ : LYB30171_01623(hisI)
VAU : VANGNB10_cI1074(hisI)
VIB : VspSTUT11_18990(hisI)
VIS : VspSTUT16_19930(hisI)
PHOT : L4174_011025(hisIE)
POJ : PtoMrB4_47710 PtoMrB4_52290(hisI)
PAEB : NCGM1900_5822(hisI)
PSAV : PSA3335_25405(hisI)
PVD : CFBP1590__4942(hisI)
PFL : PFL_0424(hisI1) PFL_6181(hisI2)
PPRC : PFLCHA0_c04310(hisI1) PFLCHA0_c61420(hisI2)
PPRO : PPC_0438(hisI) PPC_6135
PFN : HZ99_17390 HZ99_20015(hisI)
PFS : PFLU_0386 PFLU_6092(hisI)
PAZO : AYR47_06635 AYR47_09075(hisI)
PMUD : NCTC8068_00394(hisI_1) NCTC8068_05399(hisI_2)
PTOL : I7845_01995(hisI) I7845_28745(hisI)
PMAB : U0037_01935(hisI) U0037_30600(hisI)
PBRE : QDY63_00755(hisI) QDY63_03260(hisI)
PFW : PF1751_v1c03620(hisI) PF1751_v1c55060(hisI)
PFF : PFLUOLIPICF706385(hisI) PFLUOLIPICF708475
PFX : A7318_01650(hisI) A7318_27150
PPUU : PputUW4_00323(hisI)
PCH : EY04_01490(hisI) EY04_29770
PCZ : PCL1606_00380 PCL1606_56610
PCP : JM49_00450 JM49_28220(hisI)
PCHP : C4K32_0436 C4K32_6250
PSEM : TO66_02065(hisI) TO66_31370
PSOS : POS17_0415(hisI) POS17_6143
PANR : A7J50_0375 A7J50_5828
PYM : AK972_5531 AK972_5981
PSEJ : HNQ25_01975(hisI) HNQ25_21920(hisI)
PSEP : C4K39_0427 C4K39_3482
PPII : QL104_02165(hisI) QL104_31310(hisI)
PVW : HU752_000780(hisI) HU752_002920(hisI)
PTRT : HU722_0002845(hisI)
PSHH : HU773_000765(hisI) HU773_002640(hisI)
PASG : KSS96_00670(hisI) KSS96_02850(hisI)
PTW : TUM18999_51640 TUM18999_56350(hisI)
PTAE : NCTC10697_04212(hisI)
PPEG : KUA23_01940(hisI) KUA23_29825(hisI)
PSOA : PSm6_11560(hisI_1) PSm6_15980(hisI_2)
PHYG : JTY93_01745(hisI) JTY93_27250(hisI)
PSLP : BHQ29_19870(hisI) BHQ29_22900
PSNC : C0058_01940 C0058_32275
PDEU : QEP73_07175(hisI) QEP73_15065(hisI)
PKH : JLK41_02485(hisI) JLK41_24910(hisI)
PTY : JWV26_13240(hisI) JWV26_24010(hisI)
PBB : AKN87_06030(hisI) AKN87_09295
MALL : PBN92_14645(hisI) PBN92_17235(hisI)
MSHE : MAALD49_29260(hisI) MAALD49_33850(hisI)
PSYC : DABAL43B_2617(hisI)
AHL : AHTJS_06140 AHTJS_14750
ASJ : AsACE_CH02622(hisIE)
ACHI : CDG60_01220 CDG60_02595
AGYL : FPL18_05040 FPL18_16420(hisI)
AVZ : HWI77_10125(hisI) HWI77_15195
ASUE : F2A31_06010(hisI) F2A31_13925
MCAT : MC25239_00165(hisE)
MCUN : NCTC10297_00529(hisE)
SCAA : TUM17387_18080(hisI)
AMC : MADE_000001022230 MADE_1005555
CEB : B0D95_18220(hisI) B0D95_19460
GIL : NHM04_08475(hisI) NHM04_13820(hisI)
SNAN : I6N98_03610(hisI) I6N98_14060(hisI)
MTHD : A3224_12565 A3224_15565(hisI)
LLG : 44548918_01232(hisI)
LJR : NCTC11533_01699(hisE)
LCJ : NCTC11976_02571(hisI)
LWA : SAMEA4504053_1416(hisE)
LSS : NCTC12082_00885(hisI)
LANT : TUM19329_14920(hisI)
MRP : NM686_006700(hisI) NM686_020450(hisI)
MAH : MEALZ_0077(hisI) MEALZ_0824(hisI)
MBUR : EQU24_00445(hisI) EQU24_16935(hisI)
MISZ : MishRS11D_04900(hisI)
MCAU : MIT9_P1583 MIT9_P1945
MMAF : GCM100_05160 GCM100_14780(hisI)
CYQ : Q91_1150(hisI2) Q91_2122
CZA : CYCME_0303 CYCME_1378(hisI)
CYY : CPC19_02200 CPC19_06855
TIB : THMIRHAM_02640(hisI)
TSE : THMIRHAS_02710(hisI)
TZO : THMIRHAT_03920(hisI)
TSB : HMY34_02105(hisI) HMY34_10820(hisI)
THIP : N838_09160(hisI) N838_21725(hisI)
TLR : Thiosp_02733 Thiosp_02912
TNI : TVNIR_0885(hisI_[H])
GAI : IMCC3135_32135(hisI)
THIC : TspCOW1_23590(hisI)
HCH : HCH_01079(hisI1) HCH_10001(hisI2)
HBE : BEI_1337(hisI1) BEI_1825(hisI2)
HAG : BB497_12520 BB497_12675
HASO : B2G49_00940 B2G49_07270
HAAH : HALA3H3_880082(hisI)
HVN : EI420_03850(hisI) EI420_09645(hisI)
HAXI : HAALTHF_37750n(hisI)
ALCA : ASALC70_03134(hisI)
MGEO : CFI10_00635 CFI10_03865
NCU : F0U83_06710(hisI) F0U83_16530(hisI)
NJP : NEJAP_2812 NEJAP_3634
AJP : AMJAP_2419 AMJAP_3311
BACZ : KFF03_00440(hisI) KFF03_06870(hisI)
AEL : NCTC12917_02044(hisE)
CDIZ : CEDIAZO_01930(hisI)
NMQ : NMBM04240196_1539(hisI)
NMZ : NMBNZ0533_0670(hisI)
NMX : NMA510612_0937(hisI)
NWE : SAMEA3174300_0046(hisI)
NZO : SAMEA4504057_1452(hisI)
NCI : NCTC10296_00204(hisI)
NANI : NCTC12227_01335(hisI)
CCUP : BKK81_00095 BKK81_18465
BMV : BMASAVP1_A3246(hisI)
BML : BMA10229_A1795(hisI)
BPM : BURPS1710b_3686(hisI)
BPL : BURPS1106A_3717(hisI)
BGD : bgla_1g03830 bgla_2g01560
BUE : BRPE67_ACDS24460(hisI)
PLG : NCTC10937_00579(hisI)
BUO : BRPE64_ACDS25000(hisI)
VTR : MYVALT_E_00500(hisI)
BTRM : SAMEA390648701080(hisI)
BOJ : CBF45_10630 CBF45_16755(hisI)
AFA : UZ73_12105(hisI) UZ73_17210
AFQ : AFA_08040 AFA_17175(hisI)
AAQU : D3M96_09230 D3M96_18420
AAMM : FE795_07330(hisI) FE795_15975(hisI)
ALCN : MID00_09380(hisI) MID00_19365(hisI)
DLA : I6G47_26105(hisI) I6G47_28015(hisI)
CRJ : QMY55_03830(hisI) QMY55_19215(hisI) QMY55_22235(hisI)
LIM : L103DPR2_00742(hisI)
LIH : L63ED372_02582(hisI)
SMIO : CATMQ487_39300(hisI)
URU : DSM104443_03678(hisI)
UPL : DSM104440_03206(hisI)
THAG : CKCBHOJB_00635(hisI)
FPHO : SHINM1_013260(hisI)
APP : CAP2UW1_2994 CAP2UW1_4039 CAP2UW1_4269
RBS : RHODOSMS8_01508(hisI)
SMEL : SM2011_c01004(hisI)
SFD : USDA257_c34540(hisI)
SAME : SAMCFNEI73_Ch1547(hisI)
EGI : PZN02_001972(hisI) PZN02_003697(hisI)
AGR : AGROH133_06711(hisI)
ALF : CFBP5473_07605(hisI)
AVV : RvVAT039_32550(hisI)
AVF : RvVAR031_19510(hisI)
ASAL : CFBP5507_07365(hisI)
RPUS : CFBP5875_07350(hisI)
ALEG : CFBP4996_07085(hisI)
REC : RHECIAT_CH0002290(hisI)
REL : REMIM1_CH02211(hisI)
REP : IE4803_CH02220(hisI)
REI : IE4771_CH02306(hisI)
RTR : RTCIAT899_CH09380(hisI)
RGA : RGR602_CH02002(hisI)
RPHA : AMC79_CH02340(hisI)
RSUL : N2599_08205(hisI) N2599_19960(hisI)
RLW : RlegWSM1455_10380(hisI)
RBW : RLCC275e_10500(hisI)
NEN : NCHU2750_19240(hisI)
BRJ : BKD03_05995 BKD03_17175
BIO : BR141012304_11680(hisI)
BSEP : HAP48_0045160(hisI)
BCAN : BcanWSM471_24410(hisI)
MAQU : Maq22A_c15535(hisI)
MEE : DA075_32705 DA075_35100 DA075_35130
MMES : MMSR116_09905(hisI)
MICO : GDR74_00155(hisI) GDR74_11790(hisI)
MTUN : MTUNDRAET4_0495(hisI)
FIL : BN1229_v1_2828(hisI)
FIY : BN1229_v1_3086(hisI)
METG : HT051_03985(hisI) HT051_07495(hisI)
HCI : HCDSEM_028(hisI) HCDSEM_049
HCT : HCTETULN_028(hisI) HCTETULN_050
HCD : HCTETUND2_153(hisI) HCTETUND2_171
LABR : CHH27_08215 CHH27_10295
RPOP : K1718_12985(hisI) K1718_14125(hisI)
BVY : NCTC9239_00351(hisE)
TSV : DSM104635_00444(hisE)
RLI : RLO149_c019520(hisL)
PHP : PhaeoP97_01438(hisl)
PPIC : PhaeoP14_01344(hisl)
SINL : DSM14862_01355(hisI)
SPSE : SULPSESMR1_01669(hisI)
RMM : ROSMUCSMR3_03974(hisI)
ROH : FIU89_03620 FIU89_09875
AHT : ANTHELSMS3_03303(hisI)
LALG : LentiSH36_01163(hisl)
DAA : AKL17_1142 AKL17_1953
LVS : LOKVESSMR4R_01468(hisI)
GEH : HYN69_09375 HYN69_19955
NSM : JO391_06410(hisI) JO391_12260(hisI)
AALK : LGT41_0012120(hisI)
RBG : BG454_11010 BG454_17775
SBIN : SBA_ch1_29440(hisI)
SJP : SJA_C1-19030(hisI) SJA_C1-21660(hisI)
SHYD : CJD35_14510 CJD35_16955
SPAG : sphantq_00232(hisI)
SFLA : SPHFLASMR4Y_01228(hisI)
SPHS : ETR14_18210 ETR14_18230(hisD)
ALTN : LBX01_03965(hisI) LBX01_11635(hisI)
CNA : AB433_02530 AB433_08890
GAL : A0U94_04215 A0U94_14325
GSP : IGS75_11480(hisI) IGS75_14215(hisI)
KNA : B0W47_02785 B0W47_15055
ASV : WG31_08970 WG31_14570
APER : A0U91_01215 A0U91_13235
APOM : CPF11_00075 CPF11_11610
ACET : DS739_07410 DS739_08820
ACEK : FLP30_09925(hisI) FLP30_10615(hisI)
NACI : NUH88_03945(hisI) NUH88_16110(hisI)
HCB : HCBAA847_1355(hisIE)
HPUL : NCTC13154_00630(hisIE)
CJV : MTVDSCj20_1561(hisIE)
CFT : CFF04554_0300(hisIE)
CFV : CFVI03293_0301(hisIE)
CFX : CFV97608_0303(hisIE)
CAMP : CFT03427_0308(hisIE)
CCV : CCV52592_0853(hisIE)
CCO : CCC13826_2107(hisIE)
CCOC : CCON33237_0271(hisIE)
CLR : UPTC16701_0113(hisIE)
CLM : UPTC16712_0114(hisIE)
CLQ : UPTC4110_0106(hisIE)
CLN : UPTC3659_0122(hisIE)
CAJ : CIG1485E_0314(hisIE)
CAMR : CAQ16704_0105(hisIE)
CSM : CSUB8521_0116(hisIE)
CSF : CSUB8523_0110(hisIE)
CHV : CHELV3228_0261(hisIE)
CAMZ : CVIC12175_0245(hisIE)
AAQI : AAQM_0124(hisIE) AAQM_0758
ACLO : ACLO_0127(hisIE) ACLO_1748
ALK : ALEK_0168(hisIE) ALEK_0668
SMAB : LN246_01425(hisIE) LN246_13970(hisIE)
GEC : GEO60473_09640(hisI)
GBN : GEOBRER4_07320(hisI)
PCA : Pcar_2024(hisI) Pcar_2683(hisIE)
PACE : A6070_08865 A6070_13190
PPOR : JCM14722_19740(hisI)
BAZ : BAMTA208_17675(hisI)
BTHR : YBT1520_08150(hisI)
BTHU : YBT1518_08080(hisI)
BMET : BMMGA3_08965 BMMGA3_14725
BFD : NCTC4823_03057(hisE)
PARG : PspKH34_03950(hisI)
LYC : FH508_0019965(hisIE)
MLIT : KDJ21_008870(hisIE)
BLEN : NCTC4824_01223(hisE)
AHAL : FTX54_013985(hisIE)
SAX : USA300HOU_2673(hisIE)
SAA : SAUSA300_2605(hisIE)
SUQ : HMPREF0772_10514(hisE)
SUX : SAEMRSA15_25780(hisIE)
SUF : SARLGA251_24450(hisIE)
SAUV : SAI7S6_1020040(hisI)
SAUW : SAI5S5_1019980(hisI)
SAUX : SAI6T6_1019990(hisI)
SAUY : SAI8T7_1020020(hisI)