KEGG   ENZYME: 3.6.1.64
Entry
EC 3.6.1.64                 Enzyme                                 
Name
inosine diphosphate phosphatase;
(deoxy)inosine diphosphatase;
NUDT16
Class
Hydrolases;
Acting on acid anhydrides;
In phosphorus-containing anhydrides
Sysname
inosine diphosphate phosphatase
Reaction(IUBMB)
(1) IDP + H2O = IMP + phosphate [RN:R00961];
(2) dIDP + H2O = dIMP + phosphate [RN:R10235]
Reaction(KEGG)
R00961 R10235
Substrate
IDP [CPD:C00104];
H2O [CPD:C00001];
dIDP [CPD:C01344]
Product
IMP [CPD:C00130];
phosphate [CPD:C00009];
dIMP [CPD:C06196]
Comment
The human enzyme also hydrolyses GDP and dGDP, and to a lesser extent ITP, dITP and XTP.
History
EC 3.6.1.64 created 2013
Pathway
ec00230  Purine metabolism
ec01100  Metabolic pathways
Orthology
K16855  U8 snoRNA-decapping enzyme
Genes
HSA131870(NUDT16)
PTR107966544(NUDT16)
PPS100972453(NUDT16)
GGO101147310(NUDT16) 109026149
PON100433503 100434247
NLE100607601(NUDT16)
MCC717914(NUDT16) 717946
MCF101865654(NUDT16) 102141246
MTHB126947206 126947217
CSAB103241683
CATY105586448 105586449(NUDT16)
PANU101008089(NUDT16)
TGE112617211 112617516 112619589(NUDT16)
RRO104675668(NUDT16)
RBB108522243(NUDT16)
TFN117084192(NUDT16)
PTEH111539517(NUDT16)
CJC100406671 100410770(NUDT16)
SBQ101048719(NUDT16) 101049032
MMUR105872684(NUDT16) 105872691
LCAT123628745 123641286
OGA100961573
MMU73532(Nudt16l2) 75686(Nudt16)
MCAL110301710(Nudt16) 110301971
MPAH110328254(Nudt16) 110328480
RNO363129(Nudt16) 688828
MCOC116072234 116072424
MUN110541621 110552037(Nudt16)
CGE100768978(Nudt16) 100769259
MAUA101823712 101840553
PLEU114693512 114693567
MORG121464346 121464538
MFOT126494427 126499963 126500041
AAMP119809466 119809737
NGI103727278 103727286
HGL101709761(Nudt16) 101717221
CPOC100718426 100718706
CCAN109700639(Nudt16)
DSP122095738(Nudt16)
NCAR124992878 124993228
OCU100338666 100338916
OPI101526244 101526489
TUP102479774(NUDT16)
CFA610721(NUDT16)
CLUD112661184(NUDT16)
VLG121479101(NUDT16)
AML100482941(NUDT16) 117795062
UAH113253933(NUDT16)
UAR123788378(NUDT16)
ELK111155082
LLV125083580 125104573
MPUF101683106(NUDT16)
ORO101364270(NUDT16)
EJU114205733(NUDT16)
ZCA113918099(NUDT16)
MLX118003607(NUDT16)
NSU110570748(NUDT16)
FCA101094947(NUDT16)
PYU121033669(NUDT16)
PBG122491996(NUDT16)
LRUF124526345
PTG102951403(NUDT16)
PPAD109259063(NUDT16)
AJU106971584(NUDT16)
HHV120238464(NUDT16)
BTA512320(NUDT16)
BOM102264435(NUDT16)
BBUB102403661(NUDT16)
CHX102175719(NUDT16)
OAS654329(NUDT16)
ODA120857024 120860385
CCAD122445335(NUDT16)
SSC100152693(NUDT16)
CFR102519457(NUDT16)
CBAI105073871(NUDT16)
CDK105088763(NUDT16)
VPC102534258(NUDT16)
BACU103000667(NUDT16)
LVE103090159(NUDT16)
OOR101280616(NUDT16)
DLE111168182(NUDT16)
PCAD102984260(NUDT16)
PSIU116752825(NUDT16)
ECB100064676(NUDT16)
EPZ103552688(NUDT16)
EAI106841819(NUDT16)
MYB102252289(NUDT16)
MYD102769718(NUDT16)
MMYO118668184(NUDT16)
MLF102437955(NUDT16)
MNA107546077(NUDT16)
PKL118715349(NUDT16)
HAI109378247(NUDT16)
DRO112309712(NUDT16)
SHON118997574(NUDT16)
AJM119048293(NUDT16)
PDIC114501763(NUDT16)
PHAS123830563(NUDT16)
MMF118633175(NUDT16)
RFQ117037219(NUDT16)
PALE102891676(NUDT16)
PGIG120582074(NUDT16)
PVP105303482(NUDT16)
RAY107508467(NUDT16)
MJV108390630(NUDT16)
TOD119256661(NUDT16)
LAV100666216(NUDT16)
TMU101360252
DNM101411803
MDO100029401(NUDT16)
SHR100921288(NUDT16)
PCW110201522(NUDT16)
OAA114812804(NUDT16)
PCOC116240186
MGP104916418
CJO107307442
NMEL110391435
TGU100190266(NUDT16L1)
CCW120412188
ACHC115338235
ASN102373084
AMJ109283987
CPIC101939820
CABI116833504(NUDT16)
MRV120388497(NUDT16)
ACS100563390(nudt16)
PVT110078648
SUND121924144
PBI103066411(NUDT16)
PMUR107284197(NUDT16)
CTIG120301455
TSR106552430
PGUT117675511(NUDT16)
VKO123030047(NUDT16)
PMUA114587400(NUDT16)
ZVI118075415
GJA107108063
STOW125427638
XLA414677(nudt16.L)
XTR100327255(nudt16)
NPR108784477
RTEM120913203
BBUF120977180
BGAR122946138
DRE449987(zgc:103759)
SRX107737722 107741343
SANH107657028 107671960
SGH107562457
CCAR109088229 109093414
CAUA113069121 113071070 113094762
PPRM120462816(zgc:103759)
MAMB125260652(zgc:103759)
IPU108276081(zgc:103759)
PHYP113530952
SMEO124398601(zgc:103759)
TFD113658117(zgc:103759)
AMEX103041050
EEE113587981
TRU101075218
LCO104930759(nudt16)
NCC104952901
CGOB115011407(nudt16)
ELY117257952(zgc:103759)
EFO125891238(zgc:103759)
PLEP121946612(zgc:103759)
SLUC116041066(zgc:103759)
ECRA117948020(zgc:103759)
ESP116691898
PFLV114559197
GAT120828900(zgc:103759)
PPUG119223307(zgc:103759)
MSAM119881932 119916776 119918505
CUD121516982(zgc:103759)
ALAT119022848(zgc:103759)
MZE101466673(nudt16)
ONL100706292(nudt16)
OAU116315623(zgc:103759)
OLA101171079
OML112159327(zgc:103759)
XMA102224429
XCO114148208
XHE116720536
PRET103466890
PFOR103151327
PLAI106947946
PMEI106919608
GAF122831977(zgc:103759)
CTUL119772913(zgc:103759)
GMU124872305(zgc:103759)
NFU107391353
KMR108233051(zgc:103759)
ALIM106522994
NWH119417186(zgc:103759)
AOCE111568682
MCEP125015508(zgc:103759)
CSEM103384574
POV109630913
SSEN122776679(zgc:103759)
HHIP117764281(zgc:103759)
HSP118111677(zgc:103759)
LCF108882689(zgc:103759)
SDU111230747
SLAL111653212
XGL120804372(zgc:103759)
HCQ109511728 109529704
BPEC110158096
MALB109970390
BSPL114859118(zgc:103759)
SASA106581882
STRU115155948
OTW112224924(zgc:103759)
OMY110501384(zgc:103759)
OGO124043699(zgc:103759)
ONE115130849
SALP111959754
SNH120063810(zgc:103759)
CCLU121553256(zgc:103759)
ELS105018732
SFM108918382
PKI111837481
AANG118211242(zgc:103759)
PSPA121329068(zgc:103759)
LCM102358340
CMK103191283(zgc:103759)
BFO118416522
BBEL109477070
CIN100175348 100177159
SCLV120345345
API100166838
DNX107169586
AGS114130925 114130938
RMD113560873
BTAB109032434
CLEC106661250 106669818
HHAL106678633 106678639 106683938
NLU111055328 120348761
PHUPhum_PHUM040630 Phum_PHUM040640
TPAL117646651
ZNE110828423
CSEC111872918
FCD110851310
PVM113814294
PJA122261792
PCHN125044966
HAME121855943
PCLA123745678
PTRU123512954 123513332
HAZT108673432
EAF111711945
DSV119462911
RSAN119395688
RMP119173306
TUT107363439 107364909 107365057
CSCU111626039 111626044
PTEP107452564
SDM118201226
HROHELRODRAFT_69527
LGILOTGIDRAFT_116649
PCAN112571937 112572589
BGT106052081
GAE121369433
HRF124145872
HRJ124270169
CRG109618305
MYI110444005 110464043
PMAX117321138 117332919
MMER123529981
OBI106869713
OSN115218301
LAK106179938 106179941 106179942 106181443
OVIT265_11637
NVE5516494
EPA110242528
ATEN116300004
ADF107343838
AMIL114976049
PDAM113668722
SPIS111334884
DGT114524949
XEN124447167
HMG100204487
AQU100632565
 » show all
Reference
1  [PMID:20385596]
  Authors
Iyama T, Abolhassani N, Tsuchimoto D, Nonaka M, Nakabeppu Y
  Title
NUDT16 is a (deoxy)inosine diphosphatase, and its deficiency induces accumulation of single-strand breaks in nuclear DNA and growth arrest.
  Journal
Nucleic Acids Res 38:4834-43 (2010)
DOI:10.1093/nar/gkq249
  Sequence
[hsa:131870] [mmu:75686]
Other DBs
ExplorEnz - The Enzyme Database: 3.6.1.64
IUBMB Enzyme Nomenclature: 3.6.1.64
ExPASy - ENZYME nomenclature database: 3.6.1.64
BRENDA, the Enzyme Database: 3.6.1.64
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