KEGG   ENZYME: 4.1.1.102
Entry
EC 4.1.1.102                Enzyme                                 
Name
phenacrylate decarboxylase;
FDC1 (gene name);
ferulic acid decarboxylase
Class
Lyases;
Carbon-carbon lyases;
Carboxy-lyases
Sysname
3-phenylprop-2-enoate carboxy-lyase
Reaction(IUBMB)
(1) 4-coumarate = 4-vinylphenol + CO2 [RN:R02952];
(2) trans-cinnamate = styrene + CO2 [RN:R11070];
(3) ferulate = 4-vinylguaiacol + CO2 [RN:R11071]
Reaction(KEGG)
R02952 R11070 R11071;
(other) R03367
Substrate
4-coumarate [CPD:C00811];
trans-cinnamate [CPD:C00423];
ferulate [CPD:C01494]
Product
4-vinylphenol [CPD:C05627];
CO2 [CPD:C00011];
styrene [CPD:C07083];
4-vinylguaiacol [CPD:C17883]
Comment
The enzyme, found in fungi, catalyses the decarboxylation of phenacrylic acids present in plant cell walls. It requires a prenylated flavin cofactor that is produced by EC 2.5.1.129, flavin prenyltransferase.
History
EC 4.1.1.102 created 2015
Pathway
ec00940  Phenylpropanoid biosynthesis
ec01110  Biosynthesis of secondary metabolites
Orthology
K20039  phenacrylate decarboxylase
Genes
PXY: 105396714
QSU: 111991215
SCE: YDR539W(FDC1)
SEUB: DI49_4416
SPAO: SPAR_D07100
ZRO: ZYRO0E10428g
ZMK: HG535_0A09030
DHA: DEHA2G00682g
CAL: CAALFM_C603620CA(CaO19.5730)
CDU: CD36_64160
FGR: FGSG_04669 FGSG_06434
FPU: FPSE_08154
FVR: FVEG_03405 FVEG_05792 FVEG_10483 FVEG_11829
FOX: FOXG_02622 FOXG_04719 FOXG_13395 FOXG_14356 FOXG_15126
NHE: NECHADRAFT_52948 NECHADRAFT_55997 NECHADRAFT_73218 NECHADRAFT_81268
MAW: MAC_08104
MAJ: MAA_01631 MAA_06752
PLJ: VFPFJ_04155
CFJ: CFIO01_10372
CLUP: CLUP02_14534
CHIG: CH63R_09745
SAPO: SAPIO_CDS7959
ELA: UCREL1_1236
PFY: PFICI_01973 PFICI_11103
BFU: BCIN_15g05150
ANI: AN7164.2
NFI: NFIA_026010
AOR: AO090001000093 AO090003000424
ANG: ANI_1_1576034(An03g06590) ANI_1_918084(An09g00030)
AFV: AFLA_001267 AFLA_008428
ALUC: AKAW2_51012A(FDC1)
ACHE: ACHE_80178A(FDC1)
APUU: APUU_80780S(FDC1)
PCS: Pc22g03390
PDP: PDIP_44190
TRG: TRUGW13939_02308 TRUGW13939_08274
BZE: COCCADRAFT_30049
BSC: COCSADRAFT_160246
BOR: COCMIDRAFT_29078
NPA: UCRNP2_4413
CNE: CNH00230
CNG: CNAG_03519
CGI: CGB_G5620W CGB_H0280W
MPR: MPER_02256
MRR: Moror_16770
PSOJ: PHYSODRAFT_258069
 » show all
Reference
1  [PMID:20471595]
  Authors
Mukai N, Masaki K, Fujii T, Kawamukai M, Iefuji H
  Title
PAD1 and FDC1 are essential for the decarboxylation of phenylacrylic acids in Saccharomyces cerevisiae.
  Journal
J Biosci Bioeng 109:564-9 (2010)
DOI:10.1016/j.jbiosc.2009.11.011
  Sequence
[sce:YDR539W]
Reference
2  [PMID:25862228]
  Authors
Bhuiya MW, Lee SG, Jez JM, Yu O
  Title
Structure and Mechanism of Ferulic Acid Decarboxylase (FDC1) from Saccharomyces cerevisiae.
  Journal
Appl Environ Microbiol 81:4216-23 (2015)
DOI:10.1128/AEM.00762-15
  Sequence
[sce:YDR539W]
Reference
3  [PMID:26083754]
  Authors
Payne KA, White MD, Fisher K, Khara B, Bailey SS, Parker D, Rattray NJ, Trivedi DK, Goodacre R, Beveridge R, Barran P, Rigby SE, Scrutton NS, Hay S, Leys D
  Title
New cofactor supports alpha,beta-unsaturated acid decarboxylation via 1,3-dipolar cycloaddition.
  Journal
Nature 522:497-501 (2015)
DOI:10.1038/nature14560
  Sequence
[sce:YDR539W] [cdu:CD36_64160] [ang:ANI_1_1576034]
Other DBs
ExplorEnz - The Enzyme Database: 4.1.1.102
IUBMB Enzyme Nomenclature: 4.1.1.102
ExPASy - ENZYME nomenclature database: 4.1.1.102
BRENDA, the Enzyme Database: 4.1.1.102
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