KEGG   ENZYME: 4.1.1.102
Entry
EC 4.1.1.102                Enzyme                                 

Name
phenacrylate decarboxylase;
FDC1 (gene name);
ferulic acid decarboxylase
Class
Lyases;
Carbon-carbon lyases;
Carboxy-lyases
Sysname
3-phenylprop-2-enoate carboxy-lyase
Reaction(IUBMB)
(1) 4-coumarate = 4-vinylphenol + CO2 [RN:R02952];
(2) trans-cinnamate = styrene + CO2 [RN:R11070];
(3) ferulate = 4-vinylguaiacol + CO2 [RN:R11071]
Reaction(KEGG)
R02952 R11070 R11071;
(other) R03367
Substrate
4-coumarate [CPD:C00811];
trans-cinnamate [CPD:C00423];
ferulate [CPD:C01494]
Product
4-vinylphenol [CPD:C05627];
CO2 [CPD:C00011];
styrene [CPD:C07083];
4-vinylguaiacol [CPD:C17883]
Comment
The enzyme, found in fungi, catalyses the decarboxylation of phenacrylic acids present in plant cell walls. It requires a prenylated flavin cofactor that is produced by EC 2.5.1.129, flavin prenyltransferase.
History
EC 4.1.1.102 created 2015
Pathway
ec00940  Phenylpropanoid biosynthesis
ec01110  Biosynthesis of secondary metabolites
Orthology
K20039  phenacrylate decarboxylase
Genes
PXY: 105396714
QSU: 111991215
SCE: YDR539W(FDC1)
ZRO: ZYRO0E10428g
ZMK: HG535_0A09030
DHA: DEHA2G00682g
CAL: CAALFM_C603620CA(CaO19.5730)
CDU: CD36_64160
FGR: FGSG_04669 FGSG_06434
FPU: FPSE_08154
MAW: MAC_08104
ANI: AN7164.2
ANG: ANI_1_1576034(An03g06590) ANI_1_918084(An09g00030)
CNE: CNH00230
 » show all
Reference
1  [PMID:20471595]
  Authors
Mukai N, Masaki K, Fujii T, Kawamukai M, Iefuji H
  Title
PAD1 and FDC1 are essential for the decarboxylation of phenylacrylic acids in Saccharomyces cerevisiae.
  Journal
J Biosci Bioeng 109:564-9 (2010)
DOI:10.1016/j.jbiosc.2009.11.011
  Sequence
[sce:YDR539W]
Reference
2  [PMID:25862228]
  Authors
Bhuiya MW, Lee SG, Jez JM, Yu O
  Title
Structure and Mechanism of Ferulic Acid Decarboxylase (FDC1) from Saccharomyces cerevisiae.
  Journal
Appl Environ Microbiol 81:4216-23 (2015)
DOI:10.1128/AEM.00762-15
  Sequence
[sce:YDR539W]
Reference
3  [PMID:26083754]
  Authors
Payne KA, White MD, Fisher K, Khara B, Bailey SS, Parker D, Rattray NJ, Trivedi DK, Goodacre R, Beveridge R, Barran P, Rigby SE, Scrutton NS, Hay S, Leys D
  Title
New cofactor supports alpha,beta-unsaturated acid decarboxylation via 1,3-dipolar cycloaddition.
  Journal
Nature 522:497-501 (2015)
DOI:10.1038/nature14560
  Sequence
[sce:YDR539W] [cdu:CD36_64160] [ang:ANI_1_1576034]
Other DBs
ExplorEnz - The Enzyme Database: 4.1.1.102
IUBMB Enzyme Nomenclature: 4.1.1.102
ExPASy - ENZYME nomenclature database: 4.1.1.102
BRENDA, the Enzyme Database: 4.1.1.102
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