Entry
Name
N-acetylneuraminate lyase;
N-acetylneuraminic acid aldolase;
acetylneuraminate lyase;
sialic aldolase;
sialic acid aldolase;
sialate lyase;
N-acetylneuraminic aldolase;
neuraminic aldolase;
N-acetylneuraminate aldolase;
neuraminic acid aldolase;
neuraminate aldolase;
N-acetylneuraminic lyase;
N-acetylneuraminic acid lyase;
NPL;
NALase;
NANA lyase;
acetylneuraminate pyruvate-lyase;
N-acetylneuraminate pyruvate-lyase;
NanA;
N-acetylneuraminate pyruvate-lyase (N-acetyl-D-mannosamine-forming)
Class
Lyases;
Carbon-carbon lyases;
Oxo-acid-lyases
BRITE hierarchy
Sysname
aceneuramate pyruvate-lyase (N-acetyl-D-mannosamine-forming)
Reaction(IUBMB)
aceneuramate = N-acetyl-D-mannosamine + pyruvate [RN:
R12768 ]
Reaction(KEGG)
Substrate
Product
Comment
This enzyme is involved in the degradation of N-acetylneuraminate. It is specific for the open form of the sugar. It also acts on N-glycoloylneuraminate and on O-acetylated sialic acids, other than 4-O-acetylated derivatives.
History
EC 4.1.3.3 created 1961, modified 2021
Pathway
ec00520 Amino sugar and nucleotide sugar metabolism
Orthology
K01639 N-acetylneuraminate lyase
Genes
NGI : 103743787 103745142(Npl)
BOM : 102266056 102270554(NPL)
MYB : 102241283(NPL) 102248929
MRV : 120371163(NPL) 120394268
XLA : 495191(npl.S) 734827(npl.L)
SANH : 107676614 107700206
SGH : 107548793 107585862(npl)
CCAR : 109095363 109095474
CAUA : 113069900 113107207 113107991
ELY : 117253436(npl) 117253462
MSAM : 119900855 119916767
PSPA : 121327333 121330747
BBEL : 109471487 109479995
SCLV : 120326117 120327152
APLC : 110982687 110987397
SKO : 100377673 102804820 102808009 102808494
CCAT : 101456942 101457136 101457317
BOD : 106615285 106615328 106615344
AALB : 109409320 115259985
CNS : 116340872 116340926 116341840 116344459 116347819 116347961 116350255
SOC : 105194749 105194750 105194751
MPHA : 105829081 105831372
ACEP : 105627882 105627883
PBAR : 105422463 105425148
NVI : 100115260 100121176 100124084 100679680
CSOL : 105360966 105360967 105368225
TPRE : 106648290 106653796 106653830 106654583
DPA : 109536458 109542574 109545176
SOY : 115887278 115889117 115889118
CSET : 123306537 123306924
LDC : 111507692 111511184 111515642
APLN : 108739482 108739511 108743640 112903957
PPYR : 116160535 116160536 116160538
BMOR : 101739376 101739517 101739659 101743965 101744495
BMAN : 114243906 114243926 114243932 114243963 114243964
MSEX : 115446799 115446800 115446809 115446822
PRAP : 110997526 110997529 111003276
TNL : 113504787 113504858 113504859
PXY : 105380730 105381854 105398289
LGI : LOTGIDRAFT_176288 LOTGIDRAFT_230121
PCAN : 112562614 112563490
HRF : 124130028 124150538 124152030
CRG : 105326247 105326248 105330010 117681851 117686485
MYI : 110459656 110467336 110467362
PMAX : 117322128 117337144
MMER : 123550380 123554638 123564450 123564451
ATEN : 116291644 116307528
EHX : EMIHUDRAFT_367275 EMIHUDRAFT_437491
ECOO : ECRM13514_4178(nanA)
ECOH : ECRM13516_3982(nanA)
ECW : EcE24377A_3707(nanA)
ECOS : EC958_3301 EC958_3618(nanA)
ECQ : ECED1_3876(nanA) ECED1_4911
EUM : ECUMN_3385 ECUMN_3699(nanA)
EAB : ECABU_c33100(nanA1) ECABU_c36330(nanA2)
EDJ : ECDH1ME8569_3113(nanA)
ELC : i14_3334 i14_3663(nanA)
ELD : i02_3334 i02_3663(nanA)
ECOI : ECOPMV1_03530(nanA)
ECOJ : P423_16505 P423_18060
KOY : J415_00050 J415_05870
KOM : HR38_02445 HR38_08345
KOK : KONIH1_03340 KONIH1_26405
KOC : AB185_07270 AB185_32840
KLL : BJF97_03885 BJF97_26075
KLW : DA718_02970(nanA) DA718_25185
KGR : JJJ10_24620 JJJ10_27805
RTG : NCTC13098_00644(nanA)
BAGE : BADSM9389_04580(nanA) BADSM9389_35140
METY : MRY16398_05560(nanA)
AHN : NCTC12129_00607(nanA_1) NCTC12129_01122(nanA_2)
MTHI : C7M52_02889(nanA_1) C7M52_03382(nanA_2)
ETR : ETAE_0928 ETAE_1381(nanA)
ETE : ETEE_2868(nanA) ETEE_3370(nanA)
ETC : ETAC_04430 ETAC_06530
EDW : QY76_13035 QY76_15530
EDL : AAZ33_04925 AAZ33_07185(nanA)
EHO : A9798_07330 A9798_12130
HIC : NTHIC486_00889(nanA)
HPIT : NCTC13334_00449(nanA)
HHZ : NCTC10839_01816(nanA)
HAEG : NCTC8502_01096(nanA)
PDAG : 4362423_02038(nanA)
AIO : EXH44_00115(nanA) EXH44_10990(nanA)
ALIG : NCTC10568_02130(nanA)
ASEG : NCTC10977_01722(nanA)
AVT : NCTC3438_00944(nanA_1)
RPNE : NCTC8284_03395(nanA)
VNI : VIBNI_A2737 VIBNI_A2738
CHJ : NCTC10426_00701(nanA)
SMEL : SM2011_b20299(nanA)
SFD : USDA257_c27920(nanA)
BKW : BkAM31D_08250(nanA_2)
BLEN : NCTC4824_03976(nanA_2)
SAX : USA300HOU_0335(nanA)
SUQ : HMPREF0772_10180(nanA)
SAUT : SAI1T1_2002410(nanA)
SAUJ : SAI2T2_1002410(nanA)
SAUK : SAI3T3_1002410(nanA)
SAUQ : SAI4T8_1002410(nanA)
SAUV : SAI7S6_1002410(nanA)
SAUW : SAI5S5_1002400(nanA)
SAUX : SAI6T6_1002410(nanA)
SAUY : SAI8T7_1002410(nanA)
SSD : SPSINT_0893 SPSINT_1949
SDP : NCTC12225_00612(nanA_1) NCTC12225_01855(nanA_2)
SSCZ : RN70_03060 RN70_08390
SPIC : SAMEA4384060_0098(nanA)
SSH : NCTC13712_00263(nanA)
SFF : FOB90_04965 FOB90_11620
SSTE : SAMEA4384403_0482(nanA_1)
GMO : NCTC11323_01670(nanA)
GHA : NCTC10459_01746(nanA_4)
POD : PODO_12995 PODO_25225
PAEF : R50345_13165 R50345_24870
PAEJ : H70737_12550 H70737_24850
PIB : BBD41_09015 BBD41_12065
PLW : D5F53_23920 D5F53_26920
PLUT : EI981_21725 EI981_28030
PALR : HGI30_14275 HGI30_19585
CCHL : FPL14_15555 FPL14_18070 FPL14_19830
SPYM : M1GAS476_1739(nanH)
SPH : MGAS10270_Spy0217(nanH)
SPI : MGAS10750_Spy0212(nanH)
SPJ : MGAS2096_Spy0235(nanH)
SPK : MGAS9429_Spy0218(nanH)
STG : MGAS15252_0244(nanH)
SNV : SPNINV200_07980(nanA) SPNINV200_14990(nanH)
SNE : SPN23F12210(nanA) SPN23F16770(nanH)
SNM : SP70585_1374 SP70585_1716
SNI : INV104_07440(nanA) INV104_14270(nanH)
SPNG : HMPREF1038_01317 HMPREF1038_01658
SNB : SP670_0947 SP670_1763
SPNE : SPN034156_05600(nanH)
SPNU : SPN034183_14700(nanH)
SPNM : SPN994038_14590(nanH)
SPNO : SPN994039_14600(nanH)
SMEN : SAMEA4412692_1535(nanA)
SPSU : NCTC13786_01400(nanH)
SPOC : NCTC10925_01773(nanH)
SAUP : NCTC3168_00681(nanH)
SURN : NCTC13766_00157(nanA)
SVF : NCTC3166_00092(nanH)
ECEC : NCTC12421_02415(dapA_2)
JDA : BW727_101433(nanA_2)
CBUT : ATN24_15415 ATN24_16080
ACOL : K5I23_15575 K5I23_15940
BPRO : PMF13cell1_01603(nanA)
LACY : A4V08_12025 A4V08_13205
CSCI : HDCHBGLK_02030(nanA)
CBOL : CGC65_03385 CGC65_04275 CGC65_12465 CGC65_24010
PDF : CD630DERM_22400(nanA)
PHX : KGNDJEFE_01745(nanA)
LASA : L9O85_00730 L9O85_08760
MMYI : mycmycITA_00593(nanA)
MCAP : MCCPF38_00504(nanA)
MCAR : MCCPILRI181_00501(nanA)
MNU : NCTC10166_00256(nanA)
MOE : NCTC10151_00204(nanA)
PCAT : Pcatena_01330(dapA_2)
ABAO : BEQ56_03135 BEQ56_05775
OBT : OPIT5_06590 OPIT5_13835
BVO : Pan97_06100(nanA_1) Pan97_29170(nanA_2)
AMUC : Pan181_22370(nanA_2) Pan181_32020(nanA_3)
PND : Pla175_38950(dapA_3)
AMOB : HG15A2_20960(nanA_1) HG15A2_21470(nanA_2)
PLH : VT85_14820(nanA_1) VT85_16675(nanA_2)
LRS : PX52LOC_04163 PX52LOC_04976
VBC : C5Q97_07890 C5Q97_09125
SGP : SpiGrapes_1317 SpiGrapes_1517
BFS : BF9343_1631 BF9343_3612
BFG : BF638R_1716 BF638R_3788
BFB : VU15_07240 VU15_17665
BOA : Bovatus_00650(nanA_1) Bovatus_01544(nanA_2)
BCAC : CGC64_11145 CGC64_15635
BZG : C4H11_08870 C4H11_13195
PET : PEIBARAKI_5999 PEIBARAKI_6558
PGOL : K6V26_14075 K6V26_22080
PARY : A4V02_00025 A4V02_10370
POC : NCTC13071_00096(nanA)
NSO : NIASO_04185 NIASO_17350
PGS : CPT03_08040 CPT03_13140
SHT : KO02_01195 KO02_14005
SMIZ : 4412673_03729(nanA)
SPHZ : E3D81_00300 E3D81_09390
SDJ : NCTC13534_05184(nanA)
STHA : NCTC11429_02640(nanA_1) NCTC11429_04304(nanA_2)
ZGA : ZOBELLIA_1041(nanA1) ZOBELLIA_1049(nanA3)
AALG : AREALGSMS7_02038 AREALGSMS7_04068
» show all
Taxonomy
Reference
Authors
COMB DG, ROSEMAN S.
Title
The sialic acids. I. The structure and enzymatic synthesis of N-acetylneuraminic acid.
Journal
J Biol Chem 235:2529-37 (1960)
Reference
Authors
Schauer R.
Title
Chemistry, metabolism, and biological functions of sialic acids.
Journal
Reference
Authors
Kentache T, Thabault L, Deumer G, Haufroid V, Frederick R, Linster CL, Peracchi A, Veiga-da-Cunha M, Bommer GT, Van Schaftingen E.
Title
The metalloprotein YhcH is an anomerase providing N-acetylneuraminate aldolase with the open form of its substrate.
Journal
Other DBs
ExplorEnz - The Enzyme Database: 4.1.3.3
ExPASy - ENZYME nomenclature database: 4.1.3.3
BRENDA, the Enzyme Database: 4.1.3.3
LinkDB
All DBs