KEGG   ENZYME: 4.1.3.3
Entry
EC 4.1.3.3                  Enzyme                                 
Name
N-acetylneuraminate lyase;
N-acetylneuraminic acid aldolase;
acetylneuraminate lyase;
sialic aldolase;
sialic acid aldolase;
sialate lyase;
N-acetylneuraminic aldolase;
neuraminic aldolase;
N-acetylneuraminate aldolase;
neuraminic acid aldolase;
neuraminate aldolase;
N-acetylneuraminic lyase;
N-acetylneuraminic acid lyase;
NPL;
NALase;
NANA lyase;
acetylneuraminate pyruvate-lyase;
N-acetylneuraminate pyruvate-lyase;
NanA;
N-acetylneuraminate pyruvate-lyase (N-acetyl-D-mannosamine-forming)
Class
Lyases;
Carbon-carbon lyases;
Oxo-acid-lyases
Sysname
aceneuramate pyruvate-lyase (N-acetyl-D-mannosamine-forming)
Reaction(IUBMB)
aceneuramate = N-acetyl-D-mannosamine + pyruvate [RN:R12768]
Reaction(KEGG)
R12768;
(other) R01811
Substrate
aceneuramate [CPD:C22382]
Product
N-acetyl-D-mannosamine [CPD:C00645];
pyruvate [CPD:C00022]
Comment
This enzyme is involved in the degradation of N-acetylneuraminate. It is specific for the open form of the sugar. It also acts on N-glycoloylneuraminate and on O-acetylated sialic acids, other than 4-O-acetylated derivatives.
History
EC 4.1.3.3 created 1961, modified 2021
Pathway
ec00520  Amino sugar and nucleotide sugar metabolism
ec01100  Metabolic pathways
Orthology
K01639  N-acetylneuraminate lyase
Genes
HSA80896(NPL)
PTR457567(NPL)
PPS100978733(NPL)
GGO101131164(NPL)
PON100171523(NPL)
NLE100605321(NPL)
MCC106994586(NPL)
MCF102145557(NPL)
CSAB103230464(NPL)
CATY105580309(NPL)
PANU101011948(NPL)
TGE112627555(NPL)
RRO104666793(NPL)
RBB108512717(NPL)
TFN117076847(NPL)
PTEH111536955(NPL)
CJC100895053(NPL)
SBQ101037350(NPL)
CSYR103276961(NPL)
MMUR105855068(NPL)
OGA100954272(NPL)
MMU74091(Npl)
MCAL110297974(Npl)
MPAH110322225(Npl)
RNO304860(Npl)
MCOC116101289(Npl)
MUN110546203(Npl)
CGE100766218(Npl)
NGI103743787 103745142(Npl)
HGL101721787(Npl)
CPOC100734839(Npl)
CCAN109690276(Npl)
DORD105985102(Npl)
DSP122103732(Npl)
OPI101524142(NPL)
TUP102497054(NPL)
CFA490313(NPL)
VVP112921804(NPL)
VLG121493329(NPL)
AML100469753(NPL)
UMR103672418(NPL)
UAH113262728(NPL)
UAR123801318(NPL)
ELK111150727
LLV125086098
MPUF101683028(NPL)
ORO101383174(NPL)
EJU114222828(NPL)
ZCA113933063(NPL)
MLX118014366(NPL)
FCA101091498(NPL)
PYU121011820(NPL)
PBG122476563(NPL)
PTG102964881(NPL)
PPAD109253998(NPL)
AJU106966733(NPL)
HHV120245841(NPL)
BTA507597(NPL)
BOM102266056 102270554(NPL)
BIU109570738(NPL)
BBUB102391496(NPL)
CHX102169207(NPL)
OAS101104513(NPL)
ODA120880480(NPL)
CCAD122452397(NPL)
SSC397141(NPL)
CFR102509807(NPL)
CBAI105069027(NPL)
CDK105096232(NPL)
VPC102540096(NPL)
BACU103003468(NPL)
LVE103089058(NPL)
OOR101281507(NPL)
DLE111184633(NPL)
PCAD102980922(NPL)
PSIU116756652(NPL)
ECB100051658(NPL)
EPZ103551930(NPL)
EAI106847451(NPL)
MYB102241283(NPL) 102248929
MYD102752607(NPL)
MMYO118673646(NPL)
MLF102436971(NPL)
MNA107546277(NPL)
PKL118721249(NPL)
HAI109379098(NPL)
DRO112297954(NPL)
SHON118979227(NPL)
AJM119049611(NPL)
PDIC114512003(NPL)
PHAS123818333(NPL)
MMF118637421(NPL)
RFQ117015180(NPL)
PALE102892990(NPL)
PGIG120617584(NPL)
PVP105292829(NPL)
RAY107511289(NPL)
MJV108390002(NPL)
TOD119241202(NPL)
SARA101548770(NPL)
LAV100672144(NPL)
TMU101359533
DNM101444036(NPL)
MDO100023776(NPL)
GAS123243657(NPL)
SHR100920728(NPL)
PCW110206839(NPL)
OAA100085693(NPL)
GGA429074(NPL)
PCOC116230408(NPL)
MGP100538535(NPL)
CJO107317291(NPL)
NMEL110402671(NPL)
APLA101802593(NPL)
ACYG106042503(NPL)
AFUL116491976(NPL)
SCAN103814822(NPL)
PMOA120510489(NPL)
OTC121344601(NPL)
PRUF121360113(NPL)
GFR102037947(NPL)
FAB101810302(NPL)
PHI102100330(NPL)
PMAJ107207932(NPL)
CCAE111932557(NPL)
CCW104693622(NPL)
ETL114061928(NPL)
ZAB102064690(NPL)
FPG101915611(NPL)
FCH102052789(NPL)
CLV102093972(NPL)
EGZ104129708(NPL)
NNI104011321(NPL)
ACUN113483183(NPL)
TALA104367881(NPL)
PADL103917491(NPL)
ACHC115349468(NPL)
AAM106495785(NPL)
NPD112951528(NPL)
DNE112983680(NPL)
ASN102386669(NPL)
AMJ102560627(NPL)
CPOO109307195(NPL)
GGN109286937(NPL)
PSS102463162(NPL)
CMY102944158(NPL)
CPIC101937822(NPL)
TST117881760(NPL)
CABI116824279(NPL)
MRV120371163(NPL) 120394268
ACS100559732(npl)
PVT110077072(NPL)
SUND121929564(NPL)
PBI103051696(NPL)
PMUR107284988(NPL)
TSR106554170(NPL)
PGUT117661125(NPL)
VKO123027876(NPL)
PMUA114598507(NPL)
ZVI118089477(NPL)
GJA107121038(NPL)
XLA495191(npl.S) 734827(npl.L)
XTR496638(npl)
NPR108803422(NPL)
RTEM120945825(NPL)
BBUF120978587(NPL)
BGAR122943228(NPL)
DRE100148292(npl)
SRX107717554 107750814
SANH107676614 107700206
SGH107548793 107585862(npl)
CCAR109095363 109095474
CAUA113069900 113107207 113107991
IPU108265392(npl)
PHYP113535042(npl)
SMEO124399616(npl)
AMEX103030010(npl)
EEE113586335(npl)
TRU101066675(npl)
TNGGSTEN00012651G001
LCO104918425(npl)
NCC104948960(npl)
CGOB115007255(npl)
ELY117253436(npl) 117253462
PLEP121938660(npl)
SLUC116063475(npl)
ECRA117950947(npl)
PFLV114562034(npl)
GAT120824480(npl)
PPUG119216220(npl)
MSAM119900855 119916767
CUD121511972(npl)
MZE101470121(npl)
ONL100698421(npl)
OAU116310066(npl)
OLA101168031(npl)
OML112136954(npl)
XMA102236721(npl)
XCO114150989(npl)
XHE116725840(npl)
PRET103463623(npl)
PFOR103142532(npl)
PLAI106961225(npl)
PMEI106931154(npl)
GAF122838206(npl)
CVG107089704(npl)
CTUL119779397(npl)
GMU124873347(npl)
NFU107393268(npl)
KMR108230539(npl)
ALIM106515050(npl)
NWH119407936(npl)
AOCE111573540(npl)
CSEM103376644(npl)
POV109625864(npl)
SSEN122780875(npl)
HHIP117759777(npl)
LCF108877356(npl)
SDU111232209(npl)
SLAL111656342(npl)
XGL120791233(npl)
HCQ109529735(npl)
BPEC110173993(npl)
MALB109973049(npl)
SASA100194810(npl)
OTW112250923
OMY110524357(npl)
OGO123997024(npl)
ONE115108368(npl)
SALP111975716(npl)
SNH120054812(npl)
ELS105011621(npl)
SFM108919773(npl)
PKI111860259(npl)
AANG118224673(npl)
LOC102696780(npl)
PSPA121327333 121330747
ARUT117413754(npl)
LCM102367679(NPL)
CMK103179995(npl)
RTP109925634(npl)
BFO118406156 118412953
BBEL109471487 109479995
CIN100183785
SCLV120326117 120327152
SPU105444881 586574
APLC110982687 110987397
SKO100377673 102804820 102808009 102808494
DMODmoj_GI15737
DAZ108619427
DNV108656538
DHE111600193
DVI6632161
CCAT101456942 101457136 101457317
BOD106615285 106615328 106615344
AGAAgaP_AGAP007700
ACOZ120953967
AARA120902306
AAG5571760
AALB109409320 115259985
CQUCpipJ_CPIJ000182
CPII120417808
CNS116340872 116340926 116341840 116344459 116347819 116347961 116350255
AME725646
ACER107999049
ALAB122720060
BIM100747751
BBIF117204180
BVK117235775
BVAN117159619
BTER100652226
BPYO122567154
CCAL108632974
OBB114874287 114874312
MGEN117220527
NMEA116427827
CGIG122404515
SOC105194749 105194750 105194751
MPHA105829081 105831372
AEC105151782 105151806
ACEP105627882 105627883
PBAR105422463 105425148
VEM105569390
HST105182317
DQU106741314
CFO105253017
FEX115240052 115244902
LHU105673882 105673883
PGC109855071
OBO105281201
PCF106789775
PFUC122517367
VPS122629355
NVI100115260 100121176 100124084 100679680
CSOL105360966 105360967 105368225
TPRE106648290 106653796 106653830 106654583
MDL103575392
CGLO123262475
FAS105269408 105269409
DAM107042971 107042972
AGIF122850776
CCIN107265433
TCA100142385 660600
DPA109536458 109542574 109545176
SOY115887278 115889117 115889118
ATD109597566 109599497
CSET123306537 123306924
AGB108908875 108916358
LDC111507692 111511184 111515642
NVL108556735 108558113
APLN108739482 108739511 108743640 112903957
PPYR116160535 116160536 116160538
OTU111423913
BMOR101739376 101739517 101739659 101743965 101744495
BMAN114243906 114243926 114243932 114243963 114243964
MSEX115446799 115446800 115446809 115446822
DPLKGM_202692
BANY112046416
PMAC106712071
PPOT106100959
PXU106120308 106120309
PRAP110997526 110997529 111003276
ZCE119828545 119828557
HAW110376430 110376453
TNL113504787 113504858 113504859
OFU114356885 114356911
PXY105380730 105381854 105398289
DCI103517462
CLEC106669431
HHAL106692493
NLU111055228
PHUPhum_PHUM449070
FOC113213536
ZNE110829734
CSEC111866135
PVM113804808 113818954
PJA122263461
HAME121869955
PCLA123746128
PTRU123505414
HAZT108678932
ISCIscW_ISCW019293
DSV119441580
RSAN119386767
RMP119178097
TUT107363749
DFR124492780
CSCU111622937
PTEP107441033
SDM118195837
LGILOTGIDRAFT_176288 LOTGIDRAFT_230121
PCAN112562614 112563490
BGT106066007
GAE121378079 121379659
HRF124130028 124150538 124152030
HRJ124276201 124286452
CRG105326247 105326248 105330010 117681851 117686485
MYI110459656 110467336 110467362
PMAX117322128 117337144
MMER123550380 123554638 123564450 123564451
OBI106875982
OSN115209341
LAK106155637 106181349
NVE5504896 5517314
EPA110241998 110242763
ATEN116291644 116307528
PDAM113666567
SPIS111339376
DGT114535054
AQU100635151
MBRMONBRDRAFT_26275
SREPTSG_03075
ACANACA1_087720
AAFAURANDRAFT_4572
EHXEMIHUDRAFT_367275 EMIHUDRAFT_437491
ECOb3225(nanA)
ECJJW3194(nanA)
ECDECDH10B_3402(nanA)
EBWBWG_2926(nanA)
ECOKECMDS42_2689(nanA)
ECEZ4583(nanA)
ECSECs_4098(nanA)
ECFECH74115_4542(nanA)
ETWECSP_4194(nanA)
ELXCDCO157_3839
EOIECO111_4045(nanA)
EOJECO26_4324(nanA)
EOHECO103_3966(nanA)
ECOOECRM13514_4178(nanA)
ECOHECRM13516_3982(nanA)
ESLO3K_02840
ESOO3O_22805
ESMO3M_02885
ECKEC55989_3638(nanA)
ECGE2348C_3497(nanA)
EOKG2583_3945(nanA)
ELRECO55CA74_18825
ELHETEC_3486
ECWEcE24377A_3707(nanA)
EUNUMNK88_3986(nanA)
ECPECP_3308
ENAECNA114_3298(nanA)
ECOSEC958_3301 EC958_3618(nanA)
ECVAPECO1_3218(nanA)
ECOAAPECO78_19940
ECXEcHS_A3413(nanA)
ECMEcSMS35_3520(nanA)
ECYECSE_3504
ECRECIAI1_3367(nanA)
ECQECED1_3876(nanA) ECED1_4911
EUMECUMN_3385 ECUMN_3699(nanA)
ECTECIAI39_3714(nanA)
EOCCE10_3750(nanA)
EBRECB_03085(nanA)
EBLECD_03085(nanA)
EBEB21_03036(nanA)
EBDECBD_0522
ECIUTI89_C3655(nanA)
EIHECOK1_3639(nanA)
ECZECS88_3602(nanA)
ECCc3639 c3979(nanA)
ELOEC042_3509(nanA)
ELNNRG857_15965
ESEECSF_3050
ECLEcolC_0481
EKOEKO11_0499
EKFKO11_06575(nanA)
EABECABU_c33100(nanA1) ECABU_c36330(nanA2)
EDHEcDH1_0481
EDJECDH1ME8569_3113(nanA)
ELUUM146_00280
ELWECW_m3492(nanA)
ELLWFL_17080(nanA)
ELCi14_3334 i14_3663(nanA)
ELDi02_3334 i02_3663(nanA)
ELPP12B_c3336(nanA)
ELFLF82_1446(nanA)
ECOLLY180_16625
ECOIECOPMV1_03530(nanA)
ECOJP423_16505 P423_18060
EFEEFER_3196(nanA)
EALEAKF1_ch2720(nanA)
EMAC1192_13875(nanA)
ESZFEM44_07120(nanA)
STYSTY3520(nanA)
STTt3256(nanA)
SEXSTBHUCCB_34420
SENTTY21A_16510
STMSTM3339(nanA)
SEOSTM14_4030(nanA)
SEVSTMMW_33381
SEYSL1344_3311(nanA)
SEMSTMDT12_C33970
SEJSTMUK_3325(nanA)
SEBSTM474_3499(nanA)
SEFUMN798_3631(nanA)
SETUSTU288_16905
SETCCFSAN001921_00295
SENRSTMDT2_32311(nanA)
SENDDT104_33321(nanA)
SENICY43_17390
SEENSE451236_22810
SPTSPA3207(nanA)
SEKSSPA2994
SPQSPAB_04163
SEISPC_3409(nanA)
SECSCH_3277(nanA)
SEHSeHA_C3637(nanA)
SHBSU5_03824
SENHCFSAN002069_15470
SEEHSEEH1578_02800
SEESNSL254_A3602(nanA)
SENNSN31241_44630
SEWSeSA_A3532(nanA)
SEASeAg_B3530(nanA)
SENSQ786_16285
SEDSeD_A3699(nanA)
SEGSG3229(nanA)
SELSPUL_3349(nanA)
SEGASPUCDC_3335(nanA)
SETSEN3172(nanA)
SENAAU38_16165
SENOAU37_16365
SENVAU39_16365
SENQAU40_18200
SENLIY59_16775
SENJCFSAN001992_16855
SEECCFSAN002050_23665
SEEBSEEB0189_003165
SEEPI137_15985
SENBBN855_34170(nanA)
SENEIA1_16175
SENCSEET0819_00305
SESSARI_04285
SBGSBG_2968(nanA)
SBZA464_3426
SBVN643_14655
SALZEOS98_02585(nanA)
SFLSF3261(nanA)
SFXS3478(nanA)
SFVSFV_3250(nanA)
SFESFxv_3573(nanA)
SFNSFy_4651
SFSSFyv_4726
SFTNCTC1_03539(nanA)
SSNSSON_3366(nanA)
SBOSBO_3164(nanA)
SBCSbBS512_E3551(nanA)
SDYSDY_3400(nanA)
SDZAsd1617_04512
SHQA0259_19850
ENLA3UG_20415
ECLEECNIH2_20935
ECLXLI66_20190
ECLYLI62_22180
ECLOENC_34680
EHMAB284_05195
ECANCWI88_02300(nanA)
ENTEnt638_3661
EASEntas_3913
LNICWR52_15000(nanA)
ENKLOC22_08245(nanA)
ESAESA_03612
CSKES15_3561(nanA)
CSZCSSP291_16770
CSJCSK29544_00589
KOXKOX_03890 KOX_09640
KOEA225_0628 A225_5236
KOYJ415_00050 J415_05870
KOMHR38_02445 HR38_08345
KOKKONIH1_03340 KONIH1_26405
KOCAB185_07270 AB185_32840
KQUAVR78_02005
EAEEAE_03255
EARCCG33329
KLLBJF97_03885 BJF97_26075
KLWDA718_02970(nanA) DA718_25185
KGRJJJ10_24620 JJJ10_27805
RORRORB6_21275
RONTE10_25095
RPLNB1209_02515
RAODSD31_02680(nanA)
RTGNCTC13098_00644(nanA)
CROROD_45971(nanA)
CKOCKO_04629
CFDCFNIH1_03340
CBRAA6J81_19760(nanA)
CWECO701_00390(nanA)
CYOCD187_02450(nanA)
CPOTFOB25_13855(nanA)
CFQC2U38_23025(nanA)
CSEDJY391_02680(nanA)
CAMAF384_17720
CAFAL524_00390(nanA)
CIFAL515_20930(nanA)
CFARCI104_02600(nanA)
CIRC2U53_06785(nanA)
CIEAN232_07130(nanA)
CPARCUC49_16760(nanA)
CTELGBC03_28320(nanA)
CITZE4Z61_19435(nanA)
CARSE1B03_23655(nanA)
EBTEBL_c19570
KASKATP_35320(nanA)
LAXAPT61_05445
LEIC2U54_22620(nanA)
LEHC3F35_17315(nanA)
LERGNG29_17630(nanA)
LAZA8A57_19025
LEFLJPFL01_3765
LEWDAI21_07080(nanA)
BUFD8682_17915(nanA)
BAGEBADSM9389_04580(nanA) BADSM9389_35140
METYMRY16398_05560(nanA)
AHNNCTC12129_00607(nanA_1) NCTC12129_01122(nanA_2)
YREHEC60_15570(nanA)
SGOEA8O29_003025(nanA)
KINAB182_28235
PDZHHA33_05020(nanA)
IZHFEM41_02940(nanA)
PSGCG163CM_40960(nanA)
EBFD782_0476
EBCC2U52_11185(nanA)
EBUCUC76_18145(nanA)
YPEYPO3024(nanA)
YPKy1458
YPHYPC_1355
YPAYPA_2212
YPNYPN_1361
YPMYP_2647(dapA1)
YPPYPDSF_2129
YPGYpAngola_A2776
YPZYPZ3_2664
YPTA1122_10845
YPDYPD4_2650
YPXYPD8_2644
YPWCH59_3046
YPJCH55_4047
YPVBZ15_504
YPLCH46_2076
YPSYPTB2742(nanA)
YPOBZ17_3887
YPIYpsIP31758_1293
YPYYPK_1400
YPBYPTS_2843
YPQDJ40_3794
YPUBZ21_2047
YPRBZ20_3460
YPCBZ23_2331
YPFBZ19_2112
YENYE1188(nanA)
YEPYE105_C2920
YEYY11_00531
YELLC20_03968
YEWCH47_586(npl)
YETCH48_433
YEFFORC2_1211
YEEYE5303_09471(nanA)
YSIBF17_23215
YFRAW19_354
YKRCH54_1310
YROCH64_1376
YRUBD65_959
YRBUGYR_05385
YAKACZ76_03245
YMADA391_06305
YHID5F51_15670
YCAF0T03_06350
YMOHRD69_19280
SMAFD781_4083
RVCJ9880_05250(nanA)
SODSant_1388
MINTC7M51_04168(nanA)
MTHIC7M52_02889(nanA_1) C7M52_03382(nanA_2)
PMRPMI2973
PMIBBB2000_2986
PVLAOB99_16100
PVGCRN77_04735
PHAUPH4a_06440
PCOLF1325_18465
PCIBF9282_19035
PPEEI6G31_10280
PRGRB151_025140(nanA)
MMKMU9_1230
MWIMNY66_02355
EICNT01EI_1007
ETRETAE_0928 ETAE_1381(nanA)
ETDETAF_0864 ETAF_1284
ETEETEE_2868(nanA) ETEE_3370(nanA)
ETCETAC_04430 ETAC_06530
EDWQY76_13035 QY76_15530
EDLAAZ33_04925 AAZ33_07185(nanA)
EHOA9798_07330 A9798_12130
HAVAT03_18510
HPARAL518_08080(nanA)
OPODSM2777_06890
HINHI_0142
HITNTHI0228(nanA)
HIPCGSHiEE_02575
HIQCGSHiGG_03300
HIFHIBPF_19660
HILHICON_13310
HIUHIB_01950
HIER2846_0495(nanA)
HIZR2866_0445(nanA)
HIKHifGL_000831(nanA)
HIAH733_0026
HIHNF38_04710
HIWNTHI477_01175(nanA)
HICNTHIC486_00889(nanA)
HIXNTHI723_01561(nanA)
HPRPARA_00640
HDUHD_1850(nanA)
HAYC3V42_06680(nanA)
HPITNCTC13334_00449(nanA)
HHZNCTC10839_01816(nanA)
HAEGNCTC8502_01096(nanA)
HPAAE5Q53_09430(nanA)
HSEML3077_04490(nanA)
HAPHAPS_0406(nanA)
HPAZK756_04395
HPASJL26_03895
HPAKJT17_01555
GLECJD39_03360(nanA)
HSOHS_0695(nanA)
HSMHSM_1106
PMUPM1715(nanA)
PMVPMCN06_2142(nanA)
PULNT08PM_2052
PMPPmu_20620(nanA)
PMULDR93_646(nanA)
PDAG4362423_02038(nanA)
PSKYA6B44_00945
PATLKGI96_02385(nanA)
PCAIK7G93_001411(nanA)
MHTD648_700(nanA)
MHQD650_50(nanA)
MHATB824_940(nanA)
MHXMHH_c06030(nanA)
MHAEF382_07790
MHAMJ450_07240
MHAOJ451_08180
MHALN220_00280
MHAQWC39_00030
MHAYVK67_00030
MVRX781_170
MVIX808_20970
MVGX874_19700
MVEX875_280
MANNGM695_02300(nanA)
MGRAA4G16_09740
MBOSICJ55_02185(nanA)
MPEGHV560_02460(nanA)
APLAPL_1754(nanA)
APJAPJL_1789(nanA)
APAAPP7_1839(nanA)
ASIASU2_09840
ASSASU1_09885
AEUACEE_09275
APORDDU33_07380(nanA)
AIOEXH44_00115(nanA) EXH44_10990(nanA)
ALIGNCTC10568_02130(nanA)
AAPNT05HA_0548
AAZADJ80_07005
AATD11S_1580
AAOANH9381_1951
AAND7S_00402
AAHCF65_02466
AACNAANUM_1480
AACTACT75_01610
ASEGNCTC10977_01722(nanA)
GANUMN179_02260
BTOWQG_9600
BTREF542_12440
BTRHF543_13990
BTRAF544_10020
APAGEIA51_02925(nanA)
AVTNCTC3438_00944(nanA_1)
RPNENCTC8284_03395(nanA)
RHEYFEE42_05545(nanA)
RHAEIHV77_03985(nanA)
OOIA6A10_05825
FCLA4G17_08245
BHUDA6A11_08700
VCHVC_1776
VCFIR04_14065
VCSMS6_1549
VCEVch1786_I1270
VCQEN18_12030
VCJVCD_002594
VCIO3Y_08600
VCOVC0395_A1374
VCRVC395_1890
VCMVCM66_1714
VCLVCLMA_A1538
VCZVAB027_2449
VVUVV2_0730
VVYVVA1199
VVMVVMO6_04103
VVLVV93_v1c41260
VNIVIBNI_A2737 VIBNI_A2738
VEUIXK98_05320
VMIAL543_04590
VSCVSVS12_03142(nanA)
VSHBSZ05_25880
VFIVF_0663(nanA)
VFMVFMJ11_0681
VSAVSAL_I0899
PPRPBPRA2287(NANA)
PDSCAY62_04465
SPLSpea_1522
SEURFM038_008010
SGLAFJ709_15295
PHAPSHAb0156(nanA)
PTNPTRA_b0219(nanA)
PSYPCNPT3_12670
PSALPSLF89_804
WOCBA177_03895
RFOREIFOR_02427(nanA)
AHYAHML_07145
AHRV428_07365
AHPV429_07370
AHJV469_16130
CHJNCTC10426_00701(nanA)
SUTRL0B52_09240
BYIBYI23_C001250
BUEBRPE67_CCDS11800
BUOBRPE64_CCDS03040
RHYRD110_24825
RHGEXZ61_13510
MAMOA6B35_14000
NKIKW403_09165
SMESM_b20299(nanA)
SMKSinme_3873
SMQSinmeB_4370
SMXSM11_pD1311(nanA)
SMIBN406_06366(nanA)
SMEGC770_GR4pD1297
SMELSM2011_b20299(nanA)
SMERDU99_31870
SMDSmed_3832
SFDUSDA257_c27920(nanA)
DEQXM25_05300
MMYRMXMO3_02427
YTIFNA67_09070
MEYTM49_06710
MLUTJET14_07725
PARUCYR75_06045
LITFPZ52_12040
BKWBkAM31D_08250(nanA_2)
LGYT479_08705
VIRX953_15365
VHLBME96_14860
VILCFK37_01530
VNECFK40_14540
LAOAOX59_16140
SJEAAV35_002735
PPSRI6J18_09295
PSYHD0S48_20480
SALEEPH95_14845
BLENNCTC4824_03976(nanA_2)
SAUSA0304(nanA)
SAVSAV0315(nanA)
SAWSAHV_0312(nanA)
SAHSaurJH1_0305
SAJSaurJH9_0298
SAMMW0292(nanA)
SASSAS0292
SARSAR0312
SACSACOL0312(nanA)
SAXUSA300HOU_0335(nanA)
SAASAUSA300_0315(nanA)
SAOSAOUHSC_00295
SAENWMN_0257(nanA)
SADSAAV_0282(nanA)
SUUM013TW_0296
SUVSAVC_01325
SUESAOV_0268
SUJSAA6159_00291(nanA)
SUKSAA6008_00291(nanA)
SUCECTR2_275
SUTSAT0131_00319
SUQHMPREF0772_10180(nanA)
SUZMS7_0305(nanA)
SUDST398NM01_0328
SUXSAEMRSA15_02710
SUWSATW20_03200
SUGSAPIG0328
SUFSARLGA251_02770
SAUASAAG_00803
SAUERSAU_000261(nanA)
SAUNSAKOR_00309
SAUSSA40_0273
SAUUSA957_0288
SAUGSA268_0285
SAUZSAZ172_0315
SAUTSAI1T1_2002410(nanA)
SAUJSAI2T2_1002410(nanA)
SAUKSAI3T3_1002410(nanA)
SAUQSAI4T8_1002410(nanA)
SAUVSAI7S6_1002410(nanA)
SAUWSAI5S5_1002400(nanA)
SAUXSAI6T6_1002410(nanA)
SAUYSAI8T7_1002410(nanA)
SAUFX998_0301
SABSAB0252c
SUYSA2981_0314(nanA)
SAUBC248_0304
SAUMBN843_3210
SAUCCA347_329(nanA)
SAURSABB_01533(nanA)
SAUIAZ30_01620
SAUDCH52_04150
SAMSNI36_01485
SUHSAMSHR1132_02890
SHASH0282(nanA)
SHHShL2_00200(nanA)
SSPSSP0375
SCASCA_2389(nanA)
SLGSLGD_00269
SLNSLUG_02680
SSDSPSINT_0893 SPSINT_1949
SDTSPSE_0533 SPSE_1614
SDPNCTC12225_00612(nanA_1) NCTC12225_01855(nanA_2)
SXYBE24_10130
SXLSXYLSMQ121_0398
SXOSXYL_00406(nanA)
SHUSHYC_02985(nanA)
SSCHLH95_02785
SSCZRN70_03060 RN70_08390
SAGQEP23_07105
SEQOSE1039_21860
SSIFAL483_10485
SCVA4G25_08285
SPETCEP67_06415
SLZB5P37_10000
SCOHBZ166_06440
SNLBJD96_02250
SKLC7J89_03650
SFQC7J90_05685
SHOMEGX58_05260
SMUSC7J88_05640
SARLSAP2_04850(nanA)
SPICSAMEA4384060_0098(nanA)
SSHNCTC13712_00263(nanA)
SDBCNQ82_01485
SLLOISP08_02395
SSCUCEP64_02030
SFFFOB90_04965 FOB90_11620
SSTESAMEA4384403_0482(nanA_1)
MLENH3V22_06270
MVTI6J10_08680
GOTAXE85_00550
GMONCTC11323_01670(nanA)
GEQCG018_02305
GSAFOC50_03985
GHANCTC10459_01746(nanA_4)
PJDPjdr2_6208
PODPODO_12995 PODO_25225
PAEFR50345_13165 R50345_24870
PAEJH70737_12550 H70737_24850
PIBBBD41_09015 BBD41_12065
PLWD5F53_23920 D5F53_26920
PLENEIM92_16820
PLUTEI981_21725 EI981_28030
PLYCGXP70_06640
PALRHGI30_14275 HGI30_19585
COHNKCTCHS21_59980
CCHLFPL14_15555 FPL14_18070 FPL14_19830
PLNPlano_2825
PLLI858_008885
PHCBBI08_11340
SPSYAZE41_13795
RSTATY39_00745
VIJJNUCC6_03395
SPYSPy_0257(nanH)
SPZM5005_Spy0217(nanH)
SPYMM1GAS476_1739(nanH)
SPYAA20_0263(nanH)
SPMspyM18_0240
SPGSpyM3_0185(nanH)
SPSSPs0190
SPHMGAS10270_Spy0217(nanH)
SPIMGAS10750_Spy0212(nanH)
SPJMGAS2096_Spy0235(nanH)
SPKMGAS9429_Spy0218(nanH)
SPFSpyM50196(nanH)
SPAM6_Spy0249
SPBM28_Spy0211(nanH)
STGMGAS15252_0244(nanH)
STXMGAS1882_0244(nanA)
SOZSpy49_0216(nanH)
STZSPYALAB49_000250
SPYHL897_01235
SPYOSTAB901_01325
SPNSP_1329 SP_1676
SPDSPD_1163 SPD_1489
SPRspr1186 spr1520
SPWSPCG_0850 SPCG_1648
SJJSPJ_1245 SPJ_1571
SNVSPNINV200_07980(nanA) SPNINV200_14990(nanH)
SPXSPG_1222 SPG_1585
SNTSPT_1615
SNDMYY_1600
SPNNT308_07640
SNESPN23F12210(nanA) SPN23F16770(nanH)
SPVSPH_1471 SPH_1784
SNCHMPREF0837_11918
SNMSP70585_1374 SP70585_1716
SPPSPP_1350 SPP_1694
SNIINV104_07440(nanA) INV104_14270(nanH)
SPNGHMPREF1038_01317 HMPREF1038_01658
SNBSP670_0947 SP670_1763
SNPSPAP_1357 SPAP_1681
SNXSPNOXC14730(nanH)
SNUSPNA45_00565(nanH)
SPNESPN034156_05600(nanH)
SPNUSPN034183_14700(nanH)
SPNMSPN994038_14590(nanH)
SPNOSPN994039_14600(nanH)
SAGSAG0039
SANgbs0038
SAKSAK_0072
SGCA964_0038(nanA)
SAGSSaSA20_0038
SAGLGBS222_0189
SAGMBSA_720
SAGIMSA_750
SAGRSAIL_750
SAGPV193_01185
SAGCDN94_01185
SAGTGBSCOH1_0038
SAGEEN72_00365
SAGGEN73_00365
SAGNW903_0074
SSASSA_0078
SSFSSUA7_0865
SGOSGO_0124
SEZSez_0251(nanA)
SEQSZO_17060
SEZOSeseC_00302(dapA)
SEQUQ426_07965
SEUSEQ_0326
SUBSUB1653(nanH)
SDSSDEG_1953(nanH)
SDGSDE12394_09710
SDAGGS_1778(nanH)
SDCSDSE_2042(nanH)
SDQSDSE167_2019(nanH)
SMBsmi_0608 smi_0794
SORSOR_0557
STKSTP_1679(nanH)
SCPHMPREF0833_11541
SCFSpaf_0070(nanA)
STDSPPN_08165
SIESCIM_0069(nanH)
SIBSIR_0093
SIUSII_0096
SANGSAIN_0089
SANCSANR_0089
SANSDK43_09655
SCGSCI_0117
SCONSCRE_0097
SCOSSCR2_0097
SOII872_00325
SIKK710_1935
SIQDQ08_09135
SIODW64_09115
SIZSI82_09105
SIGN596_07710
SIPN597_09590
STVV470_02480
STRAATM98_07350
STRNSNAG_0549(nanA_3)
SRQSR187_7225
SKID7D50_02690
SPEIEHW89_00460
SGWD7D53_06185
SPLRC0J00_01165
SMENSAMEA4412692_1535(nanA)
SPSUNCTC13786_01400(nanH)
SPOCNCTC10925_01773(nanH)
SLATJ4854_00520
SAUPNCTC3168_00681(nanH)
SURNNCTC13766_00157(nanA)
SVFNCTC3166_00092(nanH)
LPLlp_3568(nanA)
LPJJDM1_2852(nanA)
LPTzj316_0173(nanA)
LPSLPST_C2916(nanA)
LPRLBP_cg2890
LPZLp16_2786
LARGLPA65_15220
LSLLSL_1938(nanA)
LSIHN6_01663(nanA)
LSJLSJ_2192
LMURCPS94_10060
LOLLACOL_1003(nanA)
PPENT256_00905
PACIA4V11_10170
LALWBTM29_03230
LSALCA_1640(nanA)
ESGEsVE80_24210(nanA)
ECECNCTC12421_02415(dapA_2)
VAOFA707_09985
VFVK5K99_05860
ADCFOC79_01580
CAWQ783_10815
JDABW727_101433(nanA_2)
DPMFNV33_08655
CPECPE0185
CPFCPF_0178(nanA)
CPRCPR_0175(nanA)
CBNCbC4_0650
CLBClo1100_3071
CBVU729_2262(nanA)
CBUTATN24_15415 ATN24_16080
CCHVBTM20_03920
CSEPCP523_10750
ASFSFBM_0285(nanA)
ASMMOUSESFB_0261(nanA)
ASOSFBmNL_00305(nanA)
ASBRATSFB_0219(nanA)
PBIFKXZ80_14305
CLOHMPREF0868_0505
FSAC5Q98_04565
FPLAA4U99_07995
FPRFP2_10550
FPAFPR_16180
FPRACG447_00800
ACOLK5I23_15575 K5I23_15940
BYLA4V09_19715
BHANCGC63_00215
BLAUDQQ01_00065
BPROPMF13cell1_01603(nanA)
LACYA4V08_12025 A4V08_13205
CSCIHDCHBGLK_02030(nanA)
CSOCLS_34210
LUAD4A81_11505
ANRAna3638_18190
RTORTO_23820
RGNRGna_08345
CBOLCGC65_03385 CGC65_04275 CGC65_12465 CGC65_24010
DLOK5I24_14925
CDFCD630_22400(nanA)
PDCCDIF630_02473(nanA)
CDCCD196_2096(nanA)
CDLCDR20291_2139(nanA)
PDFCD630DERM_22400(nanA)
PSORRSJ16_02335
ROCHF520_01700
PHXKGNDJEFE_01745(nanA)
ELMELI_4530
IBUIB211_03269
LASAL9O85_00730 L9O85_08760
AVGI6H45_07535
AOBI6H46_01490
MHWACT01_13175
SELEADJ74_04300
SELOAXE86_05630
MFUNGXM21_10685
ERHERH_1249(nanA)
ERSK210_04395
ERIEEI45_03925
FROAALO17_07480
TSGHLK68_00855
MMYMSC_0559(nal)
MMYMMMS_A0611(nanA)
MMYImycmycITA_00593(nanA)
MMLMLC_5370(nanA)
MCPMCAP_0415(nanA)
MCACMCCP01_0496(nanA)
MCAPMCCPF38_00504(nanA)
MCARMCCPILRI181_00501(nanA)
MCAIMCCG_0493
MLCMSB_A0429
MLHMLEA_002290(nanA)
MFERD500_00399(nanA)
MDSMDIS_01470
MNUNCTC10166_00256(nanA)
MOENCTC10151_00204(nanA)
MSYMS53_0198(nanA)
MSOVY93_01140
STURSTURON_00705(nanA)
MIXAB663_000624
MIPAXH82_05105
BRXBH708_15090
CIRALFM56_17780
PSEIGCE65_09510
TESBW730_11875
KFLKfla_0125
SAIUJ4H86_26610
PRYPrubr_64930(nanA)
BEUBE0216_05700
PCATPcatena_01330(dapA_2)
ABAOBEQ56_03135 BEQ56_05775
OBTOPIT5_06590 OPIT5_13835
RUFIK0V07_09330
AMUAmuc_1946
AGLPYTT_0730
ROOG5S37_24060
LUOHHL09_03705
LAMBKBB96_01485
SOAG3M56_010270
RBARB3352(nanA)
PSLPsta_3336
PIRVN12_17370(dapA_3)
RULUC8_49200(nanA)
RMLFF011L_05340(nanA)
AHELQ31a_30830(nanA)
BVOPan97_06100(nanA_1) Pan97_29170(nanA_2)
RLCK227x_40410(nanA)
LPAVPLANPX_4251
AMUCPan181_22370(nanA_2) Pan181_32020(nanA_3)
PNDPla175_38950(dapA_3)
AMOBHG15A2_20960(nanA_1) HG15A2_21470(nanA_2)
PBSPlabr_3142
PLSVT03_06125(nanA)
PLHVT85_14820(nanA_1) VT85_16675(nanA_2)
GESVT84_27435(nanA)
GOGC1280_23910
GMSSOIL9_46870
TIMGMBLW1_47460
LRSPX52LOC_04163 PX52LOC_04976
FTJFTUN_0959
TSPHKIH39_06415
IPAIsop_1578
SACISinac_2107
PBORBSF38_02136(nanA)
AGVOJF2_24040(nanA)
ALUSSTSP2_01851(nanA)
HBSIPV69_21910
VBCC5Q97_07890 C5Q97_09125
TBETrebr_1444
TPAVHRQ91_07360
SBUSpiBuddy_1604
SGPSpiGrapes_1317 SpiGrapes_1517
BHCJFL75_01035
BHYBHWA1_01223
BHDBHYOB78_09945
BRMBmur_2156
BPOBP951000_0924
BPJB2904_orf440
BPIPBPP43_10455
BPWWESB_2246
BIPBint_0630
BHPBHAMNSH16_10335
TALBFTW19_21335
SUSAcid_0192
PFERIRI77_27130
FNUFN1475
FNCHMPREF0946_01165
FNTHMPREF0405_00237
FHWRN87_04330
FVAFV113G1_02170(nanA)
FULC4N20_05225(nanA)
FMOC4N19_02155
FGOC4N16_07135
FNFBSQ88_06515
FCII6I83_10450
LEOAMK43_09045
LGOJCM16774_1716
STRSterm_3485
SMFSmon_1047
BFRBF1706 BF3940
BFSBF9343_1631 BF9343_3612
BFGBF638R_1716 BF638R_3788
BFBVU15_07240 VU15_17665
BHLBache_2789
BXYBXY_03740 BXY_44760
BOABovatus_00650(nanA_1) Bovatus_01544(nanA_2)
BCACCGC64_11145 CGC64_15635
BCAEA4V03_11375
BZGC4H11_08870 C4H11_13195
BHFC3V43_10315
BEGINE88_03329(nanA)
BNOK8P02_05275
BVUBVU_4117
BDOEL88_15480
BDHGV66_21890
PCOPI6J50_17255
PBTING2E5B_2374(nanA)
PMUCING2E5A_0812(Npl)
PETPEIBARAKI_5999 PEIBARAKI_6558
PSACPSM36_2233(Npl)
PDIBDI_2941
PARCCI960_20940
PMERINE87_02675(nanA)
PGOLK6V26_14075 K6V26_22080
PJOLK449_16300
TFOBFO_2202
PARYA4V02_00025 A4V02_10370
COPRCop2CBH44_18930
PMZHMPREF0659_A6643
PDNHMPREF9137_2434
PDTPrede_1038
PROHMPREF0669_00716
PFUSADJ77_09650
PEOAS203_02635
PJECRM71_09435
POCNCTC13071_00096(nanA)
PMUFJ4864_11630
ALQC7Y71_003815
AFDAlfi_0892
AITAI2BBH_05550
RBCBN938_2012
DORIFH5T_13880
MCOSGM418_11585
CHITFW415_22790
COYHF329_09660
NKONiako_0564
NSONIASO_04185 NIASO_17350
NIAA8C56_20465
FGGFSB75_00720
ARKD6B99_12650
PSEGD3H65_00945
PGOFSB84_27465
LACSH4075_08730
HHYHalhy_3293
PHEPhep_2213 Phep_3256
PEPAQ505_14415
PGSCPT03_08040 CPT03_13140
PROEH9L23_05795
PEXIZT61_04605
SHGSph21_4586
SHTKO02_01195 KO02_14005
SPHNBV902_06620
SMIZ4412673_03729(nanA)
SPSCE2P86_07240
SPHZE3D81_00300 E3D81_09390
SPHEGFH32_00790
SDJNCTC13534_05184(nanA)
STHANCTC11429_02640(nanA_1) NCTC11429_04304(nanA_2)
SMUII6J00_22045
SSIYJVX97_26650
MRUBDEO27_011535
MGIKGO620_002245
AGDFRZ59_08685
OLIFKG96_20865
SBXCA265_04835
BBDBelba_3247
EVIEchvi_4343
ESTDN752_04820
SLISlin_2625
DFEDfer_3023
ASWUHUW51_05920
GRSC7S20_18840
COCCoch_2063
CCMCcan_20790
COLAM608_02850
CHGAXF12_07730
CAPNCBG49_11695
CLKCGC53_09525
CSPUCGC55_13490
CCYNCGC48_02365
CAPHCGC49_09930
CSTOCGC58_10525
CAPQCGC52_09855
CAPFFOC45_03370
FBCFB2170_03935
MARTBTR34_05145
ZGAZOBELLIA_1041(nanA1) ZOBELLIA_1049(nanA3)
MRSMurru_0553
POACW731_00455
TMARMARIT_2680(nanA)
SALTAO058_09925
AALGAREALGSMS7_02038 AREALGSMS7_04068
OCIFEZ18_00920
SINHLS482_05955
ZSPMQE36_11625
FBEFF125_09275
ORHOrnrh_2120
ORIQ785_10725
ELTFGE20_11200
 » show all
Reference
1  [PMID:13811398]
  Authors
COMB DG, ROSEMAN S.
  Title
The sialic acids. I. The structure and enzymatic synthesis of N-acetylneuraminic acid.
  Journal
J Biol Chem 235:2529-37 (1960)
Reference
2  [PMID:6762816]
  Authors
Schauer R.
  Title
Chemistry, metabolism, and biological functions of sialic acids.
  Journal
Adv Carbohydr Chem Biochem 40:131-234 (1982)
DOI:10.1016/S0065-2318(08)60109-2
Reference
3  [PMID:33895133]
  Authors
Kentache T, Thabault L, Deumer G, Haufroid V, Frederick R, Linster CL, Peracchi A, Veiga-da-Cunha M, Bommer GT, Van Schaftingen E.
  Title
The metalloprotein YhcH is an anomerase providing N-acetylneuraminate aldolase with the open form of its substrate.
  Journal
J Biol Chem 296:100699 (2021)
DOI:10.1016/j.jbc.2021.100699
Other DBs
ExplorEnz - The Enzyme Database: 4.1.3.3
IUBMB Enzyme Nomenclature: 4.1.3.3
ExPASy - ENZYME nomenclature database: 4.1.3.3
BRENDA, the Enzyme Database: 4.1.3.3
CAS: 9027-60-5
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