| Entry |
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| Name |
long-chain-enoyl-CoA hydratase;
long-chain enoyl coenzyme A hydratase
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| Class |
Lyases;
Carbon-oxygen lyases;
Hydro-lyases
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| Sysname |
long-chain-(3S)-3-hydroxyacyl-CoA hydro-lyase
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| Reaction(IUBMB) |
a long-chain (3S)-3-hydroxyacyl-CoA = a long-chain trans-2-enoyl-CoA + H2O [RN: R02685]
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| Reaction(KEGG) |
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| Substrate |
long-chain (3S)-3-hydroxyacyl-CoA
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| Product |
long-chain trans-2-enoyl-CoA;
H2O [CPD: C00001]
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| Comment |
Acts in the reverse direction. The best substrate is oct-3-enoyl-CoA. Unlike EC 4.2.1.17 enoyl-CoA hydratase, it does not act on crotonoyl-CoA.
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| History |
EC 4.2.1.74 created 1981
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| Pathway |
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| Reference |
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| Authors |
Fong JC, Schulz H. |
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| Title |
Purification and properties of pig heart crotonase and the presence of short chain and long chain enoyl coenzyme A hydratases in pig and guinea pig tissues. |
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| Journal |
J Biol Chem 252:542-7 (1977) |
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| Reference |
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| Authors |
Schulz H. |
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| Title |
Long chain enoyl coenzyme A hydratase from pig heart. |
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| Journal |
J Biol Chem 249:2704-9 (1974) |
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| Other DBs |
| ExplorEnz - The Enzyme Database: | 4.2.1.74 |
| ExPASy - ENZYME nomenclature database: | 4.2.1.74 |
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| LinkDB |
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