KEGG   ENZYME: 4.2.1.74
Entry
EC 4.2.1.74                 Enzyme                                 
Name
long-chain-enoyl-CoA hydratase;
long-chain enoyl coenzyme A hydratase
Class
Lyases;
Carbon-oxygen lyases;
Hydro-lyases
Sysname
long-chain-(3S)-3-hydroxyacyl-CoA hydro-lyase
Reaction(IUBMB)
a long-chain (3S)-3-hydroxyacyl-CoA = a long-chain trans-2-enoyl-CoA + H2O [RN:R02685]
Reaction(KEGG)
R02685 > R04170 R04738 R04740 R04744 R04746 R04749 R07889 R07893 R07897
Substrate
long-chain (3S)-3-hydroxyacyl-CoA
Product
long-chain trans-2-enoyl-CoA;
H2O [CPD:C00001]
Comment
Acts in the reverse direction. The best substrate is oct-3-enoyl-CoA. Unlike EC 4.2.1.17 enoyl-CoA hydratase, it does not act on crotonoyl-CoA.
History
EC 4.2.1.74 created 1981
Pathway
ec00062  Fatty acid elongation
ec00071  Fatty acid degradation
ec01100  Metabolic pathways
Reference
1  [PMID:833142]
  Authors
Fong JC, Schulz H.
  Title
Purification and properties of pig heart crotonase and the presence of short chain and long chain enoyl coenzyme A hydratases in pig and guinea pig tissues.
  Journal
J Biol Chem 252:542-7 (1977)
Reference
2  [PMID:4828315]
  Authors
Schulz H.
  Title
Long chain enoyl coenzyme A hydratase from pig heart.
  Journal
J Biol Chem 249:2704-9 (1974)
Other DBs
ExplorEnz - The Enzyme Database: 4.2.1.74
IUBMB Enzyme Nomenclature: 4.2.1.74
ExPASy - ENZYME nomenclature database: 4.2.1.74
BRENDA, the Enzyme Database: 4.2.1.74
CAS: 62009-81-8
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