Entry
Name
long-chain-enoyl-CoA hydratase;
long-chain enoyl coenzyme A hydratase
Class
Lyases;
Carbon-oxygen lyases;
Hydro-lyases
BRITE hierarchy
Sysname
long-chain-(3S)-3-hydroxyacyl-CoA hydro-lyase
Reaction(IUBMB)
a long-chain (3S)-3-hydroxyacyl-CoA = a long-chain trans-2-enoyl-CoA + H2O [RN:
R02685 ]
Reaction(KEGG)
Substrate
long-chain (3S)-3-hydroxyacyl-CoA
Product
long-chain trans-2-enoyl-CoA;
H2O [CPD:
C00001 ]
Comment
Acts in the reverse direction. The best substrate is oct-3-enoyl-CoA. Unlike EC
4.2.1.17 enoyl-CoA hydratase, it does not act on crotonoyl-CoA.
History
EC 4.2.1.74 created 1981
Pathway
Reference
Authors
Fong JC, Schulz H.
Title
Purification and properties of pig heart crotonase and the presence of short chain and long chain enoyl coenzyme A hydratases in pig and guinea pig tissues.
Journal
J Biol Chem 252:542-7 (1977)
Reference
Authors
Schulz H.
Title
Long chain enoyl coenzyme A hydratase from pig heart.
Journal
J Biol Chem 249:2704-9 (1974)
Other DBs
ExplorEnz - The Enzyme Database: 4.2.1.74
ExPASy - ENZYME nomenclature database: 4.2.1.74
LinkDB
All DBs