KEGG   ENZYME: 4.3.1.4
Entry
EC 4.3.1.4                  Enzyme                                 
Name
formimidoyltetrahydrofolate cyclodeaminase;
formiminotetrahydrofolate cyclodeaminase;
5-formimidoyltetrahydrofolate ammonia-lyase (cyclizing)
Class
Lyases;
Carbon-nitrogen lyases;
Ammonia-lyases
Sysname
5-formimidoyltetrahydrofolate ammonia-lyase (cyclizing; 5,10-methenyltetrahydrofolate-forming)
Reaction(IUBMB)
5-formimidoyltetrahydrofolate = 5,10-methenyltetrahydrofolate + NH3 [RN:R02302]
Reaction(KEGG)
R02302
Substrate
5-formimidoyltetrahydrofolate [CPD:C00664]
Product
5,10-methenyltetrahydrofolate [CPD:C00445];
NH3 [CPD:C00014]
Comment
In eukaroytes, occurs as a bifunctional enzyme that also has glutamate formimidoyltransferase (EC 2.1.2.5) activity.
History
EC 4.3.1.4 created 1961, modified 2000
Pathway
ec00670  One carbon pool by folate
ec01100  Metabolic pathways
Orthology
K01746  formiminotetrahydrofolate cyclodeaminase
K13990  glutamate formiminotransferase / formiminotetrahydrofolate cyclodeaminase
Genes
HSA10841(FTCD)
PTR107966286(FTCD)
PPS100977170(FTCD)
PON100938847(FTCD)
NLE100603041(FTCD)
MCC721818(FTCD)
MCF102134897(FTCD)
MTHB126950601
CSAB103220313(FTCD)
CATY105575558
PANU101006717(FTCD)
TGE112621276(FTCD)
RRO104667617(FTCD)
RBB108512162(FTCD)
TFN117095878(FTCD)
PTEH111527935(FTCD)
CJC100408734(FTCD)
SBQ101051019(FTCD)
CSYR103257840(FTCD)
MMUR105879668(FTCD)
LCAT123630828(FTCD)
OGA100958419(FTCD)
MMU14317(Ftcd)
MCAL110303041(Ftcd)
MPAH110327010(Ftcd)
RNO89833(Ftcd)
MCOC116074842(Ftcd)
MUN110546362(Ftcd)
CGE100754097(Ftcd)
MAUA101839019(Ftcd)
PLEU114696516(Ftcd)
MORG121435557(Ftcd)
MFOT126499375
AAMP119822810(Ftcd)
NGI103739976(Ftcd)
HGL101712457(Ftcd)
CPOC100731799(Ftcd)
CCAN109695887(Ftcd)
DORD105998237(Ftcd)
DSP122121142(Ftcd)
NCAR124992841
OCU100356213(FTCD)
OPI101518331(FTCD)
TUP102471947(FTCD)
CFA607685(FTCD)
CLUD112669239(FTCD)
VVP112909550(FTCD)
VLG121479582(FTCD)
AML100483097(FTCD)
UMR103680733(FTCD)
UAH113259635(FTCD)
UAR123779141(FTCD)
ELK111155802
LLV125093136
MPUF101694507(FTCD)
ORO101375831(FTCD)
EJU114201845(FTCD)
ZCA113917692(FTCD)
MLX118026937(FTCD)
FCA101080907(FTCD)
PYU121035835(FTCD)
PBG122491070(FTCD)
LRUF124526850
PTG102962298(FTCD)
PPAD109258090(FTCD)
AJU106987518(FTCD)
HHV120248661(FTCD)
BTA535816(FTCD)
BOM102278178(FTCD)
BIU109561287(FTCD)
BBUB102396923(FTCD)
CHX102175530(FTCD)
OAS101106741(FTCD)
ODA120881101(FTCD)
CCAD122445443(FTCD)
SSC397517(FTCD)
CFR102517308(FTCD)
CBAI105077991(FTCD)
CDK105090587(FTCD)
VPC102529943(FTCD)
BACU103009100(FTCD)
LVE103077712(FTCD)
OOR101288621(FTCD)
DLE111186370(FTCD)
PCAD102987638(FTCD)
PSIU116752548(FTCD)
ECB100049972(FTCD)
EPZ103558414(FTCD)
EAI106842985(FTCD)
MYB102245572(FTCD)
MYD102761291(FTCD)
MMYO118677267(FTCD)
MLF102418312(FTCD)
MNA107536217(FTCD)
PKL118724660(FTCD)
HAI109373830(FTCD)
DRO112304441(FTCD)
SHON119000239(FTCD)
AJM119058765(FTCD)
PDIC114490873(FTCD)
PHAS123828017(FTCD)
MMF118617592(FTCD)
RFQ117013051(FTCD) 117013316
MJV108409561(FTCD)
TOD119256710(FTCD)
SARA101537614(FTCD)
LAV100661017(FTCD)
TMU101341265
DNM101422645(FTCD)
MDO100026368(FTCD)
SHR100933669(FTCD)
PCW110198883(FTCD)
OAA100083636(FTCD)
GGA395726(FTCD)
PCOC116235986(FTCD)
MGP100547304(FTCD)
CJO107316363(FTCD)
NMEL110399576(FTCD)
APLA101789783(FTCD)
ACYG106049608(FTCD)
AFUL116490975(FTCD)
TGU100221117(FTCD)
LSR110479762(FTCD)
SCAN103814589(FTCD) 103824679
PMOA120498370(FTCD)
OTC121336740(FTCD)
PRUF121355891(FTCD)
GFR102031861(FTCD)
FAB101820680(FTCD)
PHI102106775(FTCD)
PMAJ107207263(FTCD)
CCAE111931826(FTCD)
CCW104694608(FTCD)
CBRC103621841(FTCD)
ETL114068101(FTCD)
ZAB102073555(FTCD)
ACHL103805473(FTCD)
FPG101910482(FTCD)
FCH102051629(FTCD)
CLV102087672(FTCD)
EGZ104122532(FTCD)
NNI104009131(FTCD)
PCRI104023836(FTCD)
PCAO104046025(FTCD)
ACUN113482331(FTCD)
TALA116965208(FTCD)
PADL103914216(FTCD)
AFOR103902136(FTCD)
ACHC115343338(FTCD)
HALD104315254(FTCD)
CCRI104162915(FTCD)
CSTI104560749(FTCD)
EHS104506021(FTCD)
CMAC104477224(FTCD)
MUI104546818(FTCD)
FGA104081040(FTCD)
LDI104349805(FTCD)
MNB103769973(FTCD)
OHA104338962(FTCD)
NNT104409926(FTCD)
DPUB104300196(FTCD)
ACAR104530452(FTCD)
AVIT104266966(FTCD)
CVF104292085(FTCD) 104293790
CUCA104064573(FTCD)
AAM106482291(FTCD)
AROW112975877(FTCD)
NPD112956405(FTCD)
TGT104580941(FTCD)
DNE112987486(FTCD)
SCAM104147738(FTCD)
ASN102375778(FTCD)
AMJ102567824(FTCD)
CPOO109322932(FTCD)
GGN109301918(FTCD)
PSS102463032
CMY102945805(FTCD)
CPIC101930891(FTCD)
TST117870555 117870556
CABI116829073(FTCD)
MRV120375008(FTCD)
ACS100558718(ftcd)
PVT110090942(FTCD)
SUND121919766(FTCD)
PBI103060660(FTCD)
PMUR107296221(FTCD)
CTIG120300416(FTCD)
TSR106545383(FTCD)
PGUT117671168(FTCD)
VKO123024323(FTCD)
PMUA114582310(FTCD)
ZVI118097018(FTCD)
GJA107110724(FTCD)
STOW125440585(FTCD)
XLA379483(ftcd.L)
XTR448617(ftcd)
NPR108793615(FTCD)
RTEM120943925(FTCD)
BBUF121009006(FTCD)
BGAR122945809(FTCD)
DRE394052(ftcd)
SRX107754243
SANH107687873(ftcd)
SGH107586964(ftcd)
CCAR109046911
CAUA113039469 113039563
PPRM120486746(ftcd)
MAMB125254051(ftcd)
IPU108259504(ftcd)
PHYP113524283(ftcd)
SMEO124379695(ftcd)
TFD113651877(ftcd)
AMEX103024962(ftcd)
EEE113586840(ftcd)
TRU101063507(ftcd)
TNGGSTEN00012898G001
CGOB115005331(ftcd)
ELY117249966(ftcd)
EFO125885036(ftcd)
SLUC116055608(ftcd)
ECRA117941203(ftcd)
PFLV114551241
GAT120824943(ftcd)
PPUG119212671(ftcd)
MSAM119905208
CUD121506061(ftcd)
ALAT119015447(ftcd)
MZE101467078(ftcd)
ONL100690779(ftcd)
OAU116329198(ftcd)
OLA101171459(ftcd)
OML112136357(ftcd)
XMA102237820(ftcd)
XCO114140566(ftcd)
XHE116715673(ftcd)
PRET103481118
PFOR103129474(ftcd)
PLAI106957888(ftcd)
PMEI106915705(ftcd)
GAF122827071(ftcd)
CVG107102190(ftcd)
CTUL119773794(ftcd)
GMU124861853(ftcd)
NFU107384588(ftcd)
KMR108229546(ftcd)
ALIM106511228(ftcd)
NWH119428939(ftcd)
AOCE111573008(ftcd)
MCEP125000927(ftcd)
CSEM103389813(ftcd)
POV109648281(ftcd)
SSEN122761018(ftcd)
HHIP117772905(ftcd)
HSP118103529(ftcd)
LCF108874335 108892652
SDU111235556(ftcd)
SLAL111646856(ftcd)
XGL120787541(ftcd)
HCQ109510415(ftcd)
BPEC110173783(ftcd)
MALB109955652(ftcd)
BSPL114846966(ftcd)
SASA100306782(ftcd) 106575213
STRU115179273 115195985
OTW112253782 112266550
OMY110495908 110528815
OGO124008890 124011026(ftcd)
ONE115129674
SALP111953479 111970962 112074004
SNH120033602(ftcd) 120051253
CCLU121568071
ELS105022525(ftcd)
SFM108924266(ftcd)
PKI111845397(ftcd)
AANG118224214(ftcd)
LOC102688465(ftcd)
PSPA121322734(ftcd)
ARUT117412309(ftcd)
LCM102362862(FTCD)
CMK103188928(ftcd)
RTP109935702(ftcd)
BFO118424509
BBEL109478816
CIN100184708
SCLV120342715
SPU580057
APLC110973508
SKO100369906
RZE108371383
NLU111048885
ZNE110837014
CSEC111874903
FCD110847093 110862973
DPXDAPPUDRAFT_300129
DMK116919700
PVM113810735
PJA122246515
PCHN125029752
HAME121854277
PCLA123769008
PTRU123502762
HAZT108671984
EAF111710043
LSM121124164
PPOI119096717 119096863
ISCIscW_ISCW010907
DSV119442274
RSAN119387086
RMP119166904
VDE111244825
VJA111261440
DPTE113792107
DFR124494582
CSCU111625117
PTEP107442201
SDM118187350
HROHELRODRAFT_186115
LGILOTGIDRAFT_139083
PCAN112565050
BGT106070973
GAE121380340
HRF124144311
HRJ124287997
CRG105334085
MYI110465531
PMAX117343548
MMER123532420
OBI106871263
OSN115216718
LAK106175096
NVE5517908
EPA110249093
ATEN116289059
ADF107351438
AMIL114963406
PDAM113676526
SPIS111331227
DGT114519305
XEN124440119
AQU100642146
DDIDDB_G0287977(ftcd)
DPPDICPUDRAFT_54842
DFADFA_02269 DFA_10621(ftcd)
DPSDP2350
DMLDmul_14970(ftcD2)
DATHRM2_43160(ftcD1) HRM2_44060(ftcD2)
DTOTOL2_C11400(ftcD)
DOVDSCO28_45310
DWDDSCW_43640
DALKDSCA_14380
DLIdnl_16130(ftcD)
LPILLIP_0268
HAUHaur_0263
ATMANT_11210
ABATCFX1CAM_0661
PSUBPelsub_P2340
PBFCFX0092_A0599
TTRTter_0694
NPYNPRO_15510
ABAAcid345_2130
SUSAcid_5208
PFERIRI77_18960(ftcD)
THYDTTHT_2091
GAUGAU_0899
GGRHKW67_10395(ftcD)
GBAJ421_2797
DUNFDZ78_09680(ftcD)
OSPOdosp_0734
BUYD8S85_02370(ftcD)
BVIRI6J59_11975(ftcD)
PMZHMPREF0659_A6723(ftcD)
PDNHMPREF9137_1323(ftcD)
PITPIN17_A1822(ftcD)
PFUSADJ77_09620
PEOAS203_00570
PJECRM71_10935(ftcD)
PNIJ5A59_09330(ftcD)
PMUFJ4864_07645(ftcD)
PHISJ5A62_03885(ftcD)
PSCJJ4856_02145(ftcD)
AFDAlfi_3019
ASHAL1_04570
AOKA3BBH6_26830
ADAA5CPEGH6_21080
RBCBN938_0810
TTZFHG85_05330(ftcD)
BLQL21SP5_03905(fchA)
BACCBRDCF_p344(fchA)
DORIFH5T_01095
DRCG0Q07_07740(ftcD)
MCOSGM418_04415(ftcD)
MBASALGA_2664
SGNSGRA_0031
MUCMuYL_1012
MUHHYN43_019730(ftcD)
MGINFRZ54_10445(ftcD)
MGKFSB76_22990(ftcD)
MRUBDEO27_023285(ftcD)
MGOSDIU38_030905(ftcD)
MMABHQ865_16205(ftcD)
FLIFleli_2765
LUTLupro_02365
AUEC5O00_10890(ftcD)
ALTIALE3EI_2614
FBEFF125_14935(ftcD)
BBAUAEM51_01765
IALIALB_1037
CACICLOAM0177(ftcd)
TMATM1560
TMMTmari_1568
TMITHEMA_06480
TMWTHMA_1595
TMQTHMB_1595
TMXTHMC_1595
TPTTpet_1232
TNPTnap_1248
TRQTRQ2_1223
TNACTN_1143
THQT2812B_06135
THZCELL2_06480
THRTRQ7_07195
CABYCabys_2265
NDENIDE4164
NMVNITMOv2_4516
NIONITINOP_1642
NJANSJP_0797
ABIAboo_1135
ACFAciM339_1462
PSYTDSAG12_00815
 » show all
Reference
1
  Authors
Rabinowitz, J.C. and Pricer, W.E.
  Title
Formiminotetrahydrofolic acid and methenyltetrahydrofolic acid as intermediates in the formation of N10-formyltetrahydrofolic acid.
  Journal
J Am Chem Soc 78:5702-5704 (1956)
Other DBs
ExplorEnz - The Enzyme Database: 4.3.1.4
IUBMB Enzyme Nomenclature: 4.3.1.4
ExPASy - ENZYME nomenclature database: 4.3.1.4
BRENDA, the Enzyme Database: 4.3.1.4
CAS: 9032-05-7
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