Entry
Name
coproporphyrin ferrochelatase;
hemH (gene name)
Class
Lyases;
Other lyases;
Sole sub-subclass for lyases that do not belong in the other subclasses
BRITE hierarchy
Sysname
protoheme ferro-lyase (protoporphyrin-forming)
Reaction(IUBMB)
Fe-coproporphyrin III + 2 H+ = coproporphyrin III + Fe2+ [RN:
R11329 ]
Reaction(KEGG)
Substrate
Product
Comment
The enzyme, present in Gram-positive bacteria, participates in heme biosynthesis. It can also catalyse the reaction of EC
4.99.1.1 , protoporphyrin IX ferrochelatase, at a much lower level.
History
EC 4.99.1.9 created 2016
Pathway
ec01110 Biosynthesis of secondary metabolites
Orthology
K01772 protoporphyrin/coproporphyrin ferrochelatase
Genes
MORG : 121438737 121440629
AJM : 119054111(FECH) 119064986
XLA : 108707327(fech.S) 398014(fech.L)
ALIM : 106511235 106530888(fech)
PSPA : 121304527 121318069
DSI : Dsimw501_GD16217(Dsim_GD16217)
AALB : 109398473 109622685 115259613
PPYR : 116182589 116182646
PXY : 105389009 105390036 105391188 105397662
CFEL : 113366450 113366479
CEL : CELE_K07G5.6(fecl-1)
BMY : BM_BM4889(Bma-fecl-1)
PMAX : 117315407 117318700
ATH : AT2G30390(FC2) AT5G26030(FC1)
CSAT : 104700447 104706921 104736630 104749849 104771083 104786621
EUS : EUTSA_v10001248mg EUTSA_v10004150mg
BNA : 106348754 106368532 106415210
RSZ : 108805366 108805381 108854844
CPAP : 110808605 110809148
CIC : CICLE_v10008171mg CICLE_v10025338mg
PVY : 116123290 116129811 116135109 116143966
MINC : 123194717 123199450 123201954 123202101
GRA : 105779977 105785697 105788075 105792971
GHI : 107890717 107902821 107910123 107913582 107932864 107937658 107941132 107956281 121204799
GAB : 108460740 108469898 108473719
GMX : 100780533 100785669 100799066 100803481 100809157 100813423
GSJ : 114408812 114410028 114413280 114414809 114415898 114420952
PVU : PHAVU_002G278100g PHAVU_004G148200g PHAVU_008G0960000 PHAVU_008G0960001 PHAVU_009G157600g PHAVU_009G218100g
VRA : 106752752 106755984 106769019
VAR : 108323905 108331867 108345469
VUN : 114175726 114181788 114195860
CCAJ : 109787794 109796608 109808455
APRC : 113854015 113863936 113866358 113869161
MTR : 11429865 11436819 25489881 25491538
CAM : 101494913 101507238 101509199 101515447
PSAT : 127078922 127087944 127101480
LJA : Lj1g3v1380940.1(Lj1g3v1380940.1) Lj1g3v1785840.1(Lj1g3v1785840.1) Lj1g3v1785840.2(Lj1g3v1785840.2) Lj4g3v2858450.1(Lj4g3v2858450.1) Lj6g3v0338480.1(Lj6g3v0338480.1)
AHF : 112706376 112732989 112764168 112791042
LANG : 109328102 109339428 109343834 109358451
RCN : 112170715 112173143 112194964
PMUM : 103318752 103320534
PAVI : 110744834 110760402
PDUL : 117621954 117630069
MDM : 103410551 103424647 103434245 103451123
PXB : 103930370 103938531 103949649 103951871
CSV : 101216568 101217584(HEMH)
MCHA : 111004735 111018063
CMAX : 111492405 111496575 111499733
CMOS : 111451226 111454682 111462897
CPEP : 111795276 111798095 111805636
HBR : 110637758 110648551 110667402
MESC : 110611834 110629971
POP : 127904820 18097764 18107944 7470718
PEU : 105108599 105116138 105118740 105122225
PALZ : 118030819 118050789 118051945
JRE : 108982043 108984827 109012761
QSU : 111987013 111989931 112000854 112005741
TWL : 119982798 119993101 119997615 120001698
SLY : 101247019 101248153 101263738
SPEN : 107020268 107028737 107028978
SSTN : 125841159 125866817
CANN : 107838934 107870727 107873068
NTA : 107774460 107779891(FeCh) 107817912 107832463
SIND : 105175450 105178020
EGT : 105967046 105976865 105977029
SSPL : 121752995 121768374 121771611 121785367 121811063
APAN : 127248633 127250064
ECAD : 122599299 122603343 122607438
LSV : 111882445 111886658 111894117
CCAV : 112511573 112512928 112529142
DCR : 108196638 108203693 108211272
CSIN : 114265204 114278495 114284682
BVG : 104886500 104888230 104904584
CQI : 110698675 110702609 110703265 110705467 110715658 110728672
NNU : 104599663 104600654 104600774
MING : 122073735 122085494
PSOM : 113284340 113311629 113347963 113349397 113355505
DOSA : Os05t0361200-01(Os05g0361200) Os09t0297000-01(Os09g0297000)
BDI : 100837011 100840234 100843857
TDC : 119267107 119301238 119308773 119330613
TAES : 123043450 123103445 123111647 123117513 123121098 123180821
LPER : 127299758 127300579 127303222
SBI : 8064288 8064655 8085179
ZMA : 100191436 100216845 100284108
SITA : 101764370 101777700
PVIR : 120656088 120660269 120674723 120704950
PHAI : 112881689 112901438
PDA : 103697320 103704785 103712934
EGU : 105038123 105038882 105051677
ZOF : 121970560 121971996 121975633 121977019 121980046 121987827 122051441 122055656
NCOL : 116256195 116258997
SMO : SELMODRAFT_127577(FC1-2) SELMODRAFT_439765(FC2-2) SELMODRAFT_73819(FC2-1) SELMODRAFT_79792(FC1-1)
PPP : 112282151 112288726 112294651
MPP : MICPUCDRAFT_51216(HEMH)
NCS : NCAS_0E04220(NCAS0E04220) NCAS_0F00350(NCAS0F00350)
NDI : NDAI_0K02670(NDAI0K02670)
TPF : TPHA_0K01180(TPHA0K01180)
TBL : TBLA_0A09680(TBLA0A09680)
TDL : TDEL_0G04040(TDEL0G04040)
KAF : KAFR_0G02480(KAFR0G02480)
KNG : KNAG_0M01000(KNAG0M01000)
CAL : CAALFM_C207490WA(HEM15)
NTE : NEUTE1DRAFT116399(NEUTE1DRAFT_116399)
ANG : ANI_1_418134(An15g02690)
ALUC : AKAW2_60429S(HEM15)
ABP : AGABI1DRAFT112668(AGABI1DRAFT_112668)
ABV : AGABI2DRAFT192632(AGABI2DRAFT_192632)
SCM : SCHCO_02634259(SCHCODRAFT_02634259)
PTM : GSPATT00000033001 PTMB.433c
NGD : NGA_0074800(FC_(HEMH))
EHX : EMIHUDRAFT_419645 EMIHUDRAFT_452759 EMIHUDRAFT_456245 EMIHUDRAFT_53434
GTT : GUITHDRAFT_157086 GUITHDRAFT_159124
ECOO : ECRM13514_0368(hemH)
ECOH : ECRM13516_0459(hemH)
ELR : ECO55CA74_02865(hemH)
ECW : EcE24377A_0515(hemH)
ECOA : APECO78_05895(hemH)
EDJ : ECDH1ME8569_0459(hemH)
ECOI : ECOPMV1_00462(hemH)
SEM : STMDT12_C05520(hemH)
SEEH : SEEH1578_11880(hemH)
SENJ : CFSAN001992_08755(hemH)
RTG : NCTC13098_05711(hemH_1)
REE : electrica_03859(hemH)
CLAP : NCTC11466_01084(hemH)
KIE : NCTC12125_02535(hemH)
METY : MRY16398_43430(hemH)
AHN : NCTC12129_03774(hemH)
PTF : PROFFT_A_02850(hemH)
PSHI : SAMEA2665130_2042(hemH)
YPG : YpAngola_A2895(hemH)
YPI : YpsIP31758_3053(hemH)
SMW : SMWW4_v1c10820(hemH)
SERS : SERRSCBI_05120(hemH)
SFJ : SAMEA4384070_1170(hemH)
SOF : NCTC11214_00347(hemH)
PAQU : DMB82_0014950(hemH)
EBI : EbC_10540(hemH) EbC_pEb17200280(hemH)
EHD : ERCIPSTX3056_228(hemH)
PAGC : BEE12_11785 BEE12_19445
PEY : EE896_14500 EE896_19930
PJI : KTJ90_14360(hemH) KTJ90_21320(hemH)
TPTY : NCTC11468_01104(hemH)
PHEI : NCTC12003_01070(hemH)
PRJ : NCTC6933_02971(hemH)
LRI : NCTC12151_01196(hemH)
HIC : NTHIC486_01582(hemH)
HPIT : NCTC13334_01305(hemH_1)
HHZ : NCTC10839_01114(hemH)
HAEG : NCTC8502_01289(hemH_1)
PDAG : 4362423_01085(hemH)
ADP : NCTC12871_01523(hemH)
ALIG : NCTC10568_02332(hemH)
ASEG : NCTC10977_01719(hemH)
AVT : NCTC3438_01649(hemH)
RPNE : NCTC8284_03061(hemH_2)
PAET : NCTC13378_01033(hemH)
XFU : XFF4834R_chr40940(hemH)
XPH : XppCFBP6546_13250(hemH)
XHD : LMG31886_43220(hemH)
LLZ : LYB30171_00120(hemH)
RHD : R2APBS1_2524 R2APBS1_3508
LRZ : BJI69_09505 BJI69_15350
VAU : VANGNB10_cI0860(hemH)
VPL : SA104470976_01783(hemH)
PAEB : NCGM1900_5365(hemH)
PVD : CFBP1590__4390(hemH)
PPRC : PFLCHA0_c51010(hemH)
PFW : PF1751_v1c07250(hemH)
PPUU : PputUW4_04565(hemH)
PKC : PKB_0871(hemh1) PKB_2253(hemh3)
PTRT : HU722_0004970(hemH)
PTW : TUM18999_51340(hemH)
PTAE : NCTC10697_03667(hemH)
PSYC : DABAL43B_0477(hemH)
MCAT : MC25239_00346(hemH)
MCUN : NCTC10297_00017(hemH)
SON : SO_2019(hemH) SO_3348(hemH)
SBM : Shew185_2583 Shew185_3036
SBN : Sbal195_2660 Sbal195_3179
SBP : Sbal223_1342 Sbal223_1801
SBT : Sbal678_2663 Sbal678_3185
SBS : Sbal117_2682 Sbal117_3161
SBB : Sbal175_1324 Sbal175_1783
SPC : Sputcn32_2296 Sputcn32_2683
SHP : Sput200_2322 Sput200_2820
SHE : Shewmr4_1197 Shewmr4_2248
SHM : Shewmr7_1268 Shewmr7_2320
SHN : Shewana3_1198 Shewana3_2440
SHW : Sputw3181_1328 Sputw3181_1712
SHF : CEQ32_06190 CEQ32_22355
SBJ : CF168_08715 CF168_14650
SMAV : CFF01_08080 CFF01_13685
SHEW : CKQ84_14925 CKQ84_17675
SALG : BS332_13645 BS332_21085
SCAA : TUM17387_15260(hemH1) TUM17387_27840(hemH2)
SXM : MKD32_06230(hemH) MKD32_11905(hemH)
SHEJ : MZ182_11525(hemH) MZ182_14070(hemH)
PLZ : S4054249_10715(hemH)
AMC : MADE_000001023525(hemH)
SALH : HMF8227_02638(hemH)
HJA : BST95_01450 BST95_07960
CBS : COXBURSA331_A0153(hemH)
LLG : 44548918_02154(hemH)
LJR : NCTC11533_02183(hemH)
LCJ : NCTC11976_00041(hemH)
LWA : SAMEA4504053_0740(hemH)
LSS : NCTC12082_01241(hemH)
LANT : TUM19329_04730(hemH)
LLY : J2N86_01985(hemH) J2N86_06055(hemH)
MOZ : MoryE10_17770(hemH2)
MISZ : MishRS11D_31220(hemH2)
THIO : AYJ59_02845(hemH) AYJ59_03815(hemH)
TIB : THMIRHAM_19360(hemH2_1) THMIRHAM_21360(hemH2_2)
TSE : THMIRHAS_21790(hemH2)
TZO : THMIRHAT_17120(hemH2)
TNI : TVNIR_3548(hemH_[H])
GAI : IMCC3135_01445(hemH)
THIC : TspCOW1_32310(hemH2)
NJP : NEJAP_0139 NEJAP_3001
AMED : B224_1619 B224_1623
AEL : NCTC12917_01748(hemH)
CHJ : NCTC10426_00888(hemH)
THO : SP60_04935(hemH) SP60_08135(hemH)
CDIZ : CEDIAZO_01615(hemH)
NMM : NMBM01240149_1374(hemH)
NMS : NMBM01240355_0717(hemH)
NMQ : NMBM04240196_1449(hemH)
NMZ : NMBNZ0533_0765(hemH)
NMX : NMA510612_1036(hemH)
NWE : SAMEA3174300_0213(hemH)
NZO : SAMEA4504057_2155(hemH)
NCI : NCTC10296_02156(hemH)
NCZ : NCTC10294_00359(hemH)
NANI : NCTC12227_00449(hemH)
ECOR : SAMEA4412678_1658(hemH)
BMV : BMASAVP1_A0495(hemH)
BML : BMA10229_A1104(hemH)
BPM : BURPS1710b_3326(hemH)
BPL : BURPS1106A_3316(hemH)
BUE : BRPE67_ACDS03760(hemH)
PEW : KZJ38_04765(hemH) KZJ38_32630(hemH)
PLG : NCTC10937_04377(hemH)
LMIR : NCTC12852_02203(hemH)
CABA : SBC2_04870(hemH_1) SBC2_75260(hemH_2)
BUO : BRPE64_ACDS03990(hemH)
BTRM : SAMEA390648700251(hemH)
AXX : ERS451415_01208(hemH)
ADK : Alide2_2120 Alide2_2976
LIM : L103DPR2_02186(hemH)
LIH : L63ED372_01023(hemH)
URU : DSM104443_01603(hemH)
UPL : DSM104440_01509(hemH)
FPHO : SHINM1_004590(hemH)
HPO : HMPREF4655_21269(hemH)
HPX : HMPREF0462_1092(hemH)
HPYA : HPAKL117_05040(hemH)
HPYK : HPAKL86_05530(hemH)
HCL : NCTC13205_00649(hemH)
HSH : NHP194022_12450(hemH)
HPUL : NCTC13154_01449(hemH)
SMAX : FJR03_00980 FJR03_04960
CJV : MTVDSCj20_0523(hemH)
CFV : CFVI03293_0669(hemH)
CAMP : CFT03427_0692(hemH)
CCOC : CCON33237_1236(hemH)
CLR : UPTC16701_1039(hemH)
CLM : UPTC16712_1069(hemH)
CAMR : CAQ16704_1058(hemH)
CSM : CSUB8521_0891 CSUB8521_1234(hemH)
CSF : CSUB8523_1049 CSUB8523_1340(hemH)
CPIN : CPIN18020_0408(hemH)
CAMZ : CVIC12175_1069(hemH)
ACIB : ACBT_0881(hemH1) ACBT_1492(hemH2)
ACRE : ACRYA_0892(hemH1) ACRYA_1451(hemH2)
ANT : Arnit_0384 Arnit_0789
AELL : AELL_0691(hemH1) AELL_1685(hemH2)
AAQI : AAQM_0584(hemH1) AAQM_1525(hemH2)
ASUI : ASUIS_0647(hemH1) ASUIS_1192(hemH2)
ACLO : ACLO_0669(hemH1) ACLO_1496(hemH2)
AVP : AVENP_0783(hemH1) AVENP_1399(hemH2)
ADZ : ADFLV_0683(hemH1) ADFLV_1780(hemH2)
PACO : AACT_0789(hemH1) AACT_1757(hemH2)
ALK : ALEK_0811(hemH1) ALEK_2083(hemH2)
ALP : LPB137_01460 LPB137_03540
AHS : AHALO_0614(hemH1) AHALO_2040(hemH2)
AMAR : AMRN_0673(hemH1) AMRN_2124(hemH2)
ACAA : ACAN_0693(hemH1) ACAN_2162(hemH2)
APAI : APAC_0569(hemH1) APAC_1312(hemH2)
GBN : GEOBRER4_00370(hemH)
RTT : RTTH1527_04195(hemH)
RTB : RTB9991CWPP_04200(hemH)
ERW : ERWE_CDS_06490(hemH)
ERG : ERGA_CDS_06400(hemH)
RBS : RHODOSMS8_03114(hemH)
SMEL : SM2011_c04019(hemH)
SFD : USDA257_c52720(hemH)
SAME : SAMCFNEI73_Ch3226(hemH)
EAH : FA04_15200 FA04_33780
EMX : FKV68_17810 FKV68_21980
REC : RHECIAT_CH0003810(hemH)
REL : REMIM1_CH03627(hemH)
REP : IE4803_CH03932(hemH)
REI : IE4771_CH03870(hemH)
RTR : RTCIAT899_CH15095(hemH)
RGA : RGR602_CH03453(hemH)
RPHA : AMC79_CH03733(hemH)
NGL : RG1141_CH29960(hemH)
NEN : NCHU2750_27600(hemH)
LAS : CLIBASIA_00425(hemH)
BIO : BR141012304_21117(hemH)
OPS : A8A54_11500 A8A54_20680
PSCQ : KHQ08_12560(hemH) KHQ08_13215(hemH)
BRC : BCCGELA001_05595(hemH)
BSEP : HAP48_0021075(hemH)
VGO : GJW-30_1_02506(hemH)
MAQU : Maq22A_1p32650(hemH)
MTUN : MTUNDRAET4_2254(hemH)
FIL : BN1229_v1_2306(hemH)
FIY : BN1229_v1_2305(hemH)
BVY : NCTC9239_03289(hemH)
TSV : DSM104635_03884(hemH)
RLI : RLO149_c041990(hemH)
PHP : PhaeoP97_03474(hemH)
PPIC : PhaeoP14_03283(hemH)
SINL : DSM14862_00048(hemH)
SPSE : SULPSESMR1_03127(hemH)
RMM : ROSMUCSMR3_02097(hemH)
AHT : ANTHELSMS3_00995(hemH)
LVS : LOKVESSMR4R_03547(hemH)
PAMO : BAR1_01545 BAR1_17220
SPHX : E5675_00125 E5675_02695
SBIN : SBA_ch1_13970(hemH)
SFLA : SPHFLASMR4Y_01826(hemH)
ROS : CTJ15_16490 CTJ15_18270(hemH)
RMUC : FOB66_20255(hemH) FOB66_21985
RMT : IAI58_01455(hemH) IAI58_08710
RAP : RHOA_1318(hemH) RHOA_2233(hemH)
RCE : RC1_2797(hemH) RC1_3547(hemH)
ECOG : FIV45_06745 FIV45_17950(hemH)
BLI : BL00949 BL01073(hemH)
BLD : BLi01093(hemH1) BLi04115(hemH2)
BLH : BaLi_c12140(hemH1) BaLi_c41250(hemH2)
BAZ : BAMTA208_04760(hemH)
BSON : S101395_00273(hemH) S101395_03741
BAN : BA_1071(hemH1) BA_1158(hemH2)
BAR : GBAA_1071(hemH1) GBAA_1158(hemH2)
BAH : BAMEG_3424(hemH2) BAMEG_3504(hemH1)
BAI : BAA_1160(hemH1) BAA_1240(hemH2)
BAX : H9401_1012 H9401_1092
BANT : A16_11340 A16_12130
BANR : A16R_11480 A16R_12300
BANS : BAPAT_1016 BAPAT_1095
BANH : HYU01_05630 HYU01_06005
BANV : DJ46_2(hemH) DJ46_5524(hemH)
BCA : BCE_1168(hemH) BCE_1260(hemH)
BCZ : BCE33L0987(hemH) BCE33L1054
BCR : BCAH187_A1231(hemH1) BCAH187_A1311(hemH2)
BCB : BCB4264_A1104(hemH1) BCB4264_A1208(hemH2)
BCU : BCAH820_1153(hemH1) BCAH820_1235(hemH2)
BCG : BCG9842_B4133(hemH2) BCG9842_B4201(hemH1)
BCQ : BCQ_1139(hemH) BCQ_1215(hemH-2)
BCX : BCA_1119(hemH1) BCA_1197(hemH2)
BAL : BACI_c11120(hemH1) BACI_c11920(hemH2)
BCER : BCK_02600 BCK_02975
BCY : Bcer98_0825 Bcer98_0873
BTK : BT9727_0985(hemH) BT9727_1056(hemH)
BTB : BMB171_C0943(hemH) BMB171_C1015(hemH2)
BTHR : YBT1520_06110 YBT1520_06825
BTHI : BTK_06160 BTK_07035
BTC : CT43_CH1022(hemH) CT43_CH1090(hemH2)
BTF : YBT020_06055 YBT020_06430
BTM : MC28_0303(hemH1) MC28_0373(hemH2)
BTG : BTB_c11370(hemH1) BTB_c12070(hemH2)
BTN : BTF1_03105 BTF1_03465
BTHT : H175_ch1035 H175_ch1104
BTHU : YBT1518_06475 YBT1518_06825
BTW : BF38_2312(hemH) BF38_2386(hemH)
BTHY : AQ980_24100 AQ980_24795
BTY : Btoyo_3731 Btoyo_3794
BMYC : DJ92_3711(hemH) DJ92_3772(hemH)
BBY : CY96_04640 CY96_04985
BWD : CT694_05925(hemH) CT694_06285(hemH)
BTRO : FJR70_27585(hemH) FJR70_27980(hemH)
BMOB : MLA2C4_05710(hemH) MLA2C4_06070(hemH)
BNT : GSN03_05595(hemH) GSN03_05940(hemH)
BPAC : LMD38_20665(hemH) LMD38_21110(hemH)
BPAN : NLJ82_05600(hemH) NLJ82_06005(hemH)
BGY : BGLY_1127(hemH) BGLY_4479
BFD : NCTC4823_02833(hemH)
BCO : Bcell_1480 Bcell_3737
PARG : PspKH34_30760(hemH)
LGY : T479_06895 T479_19520
VIG : BKP57_03810 BKP57_09520
VPT : KBP50_04925(hemH) KBP50_20975
PSYH : D0S48_10685(hemH) D0S48_17570(hemH)
PRD : F7984_04175(hemH) F7984_07495
BLEN : NCTC4824_03026(hemH)
STEA : C0679_02085 C0679_05465(hemH)
SAX : USA300HOU_1824(hemH)
SUQ : HMPREF0772_11312(hemH)
SUX : SAEMRSA15_17370(hemH)
SUF : SARLGA251_17160(hemH)
SAUT : SAI1T1_2013540(hemH)