Entry
Name
trans-2,3-dihydro-3-hydroxyanthranilate isomerase;
phzF (gene name);
(5S,6S)-6-amino-5-hydroxycyclohexane-1,3-diene-1-carboxyate isomerase (incorrect)
Class
Isomerases;
Intramolecular oxidoreductases;
Transposing C=C bonds
BRITE hierarchy
Sysname
(5S,6S)-6-amino-5-hydroxycyclohexa-1,3-diene-1-carboxyate isomerase
Reaction(IUBMB)
(5S,6S)-6-amino-5-hydroxycyclohexa-1,3-diene-1-carboxyate = (1R,6S)-6-amino-5-oxocyclohex-2-ene-1-carboxylate [RN:
R09707 ]
Reaction(KEGG)
Substrate
(5S,6S)-6-amino-5-hydroxycyclohexa-1,3-diene-1-carboxyate
Product
(1R,6S)-6-amino-5-oxocyclohex-2-ene-1-carboxylate [CPD:
C19831 ]
Comment
The enzyme is involved in phenazine biosynthesis. The product probably spontaneously dimerises to 1,4,5a,6,9,10a-hexahydrophenazine-1,6-dicarboxylate
History
EC 5.3.3.17 created 2011
Pathway
ec01110 Biosynthesis of secondary metabolites
Orthology
K06998 trans-2,3-dihydro-3-hydroxyanthranilate isomerase
Genes
PDAG : 4362423_01827(phzF)
DYG : DYGSA30_26110(phzF2)
PAE : PA1904(phzF2) PA4215(phzF1)
PAEV : N297_1964(phzF) N297_4347(phzF) N297_4879
PAEI : N296_1964(phzF) N296_4347(phzF) N296_4879
PAU : PA14_09420(phzF1) PA14_39890(phzF2)
PAP : PSPA7_0884 PSPA7_3380
PAG : PLES_07121(phzF1) PLES_34201(phzF2)
PAF : PAM18_0722(phzF1) PAM18_3138(phzF2)
PNC : NCGM2_2821(phzF2) NCGM2_5460(phzF2)
PAEB : NCGM1900_0744(phzF2) NCGM1900_4585(phzF2)
PDK : PADK2_03595 PADK2_16130
PSG : G655_03630 G655_15595
PRP : M062_09940 M062_22205
PAEP : PA1S_03745 PA1S_16420 PA1S_25575
PAER : PA1R_gp2106 PA1R_gp5533
PAEM : U769_03775 U769_16135
PAES : SCV20265_0746 SCV20265_3491
PAEU : BN889_04686(phzF1_1) BN889_05250
PAEG : AI22_00165 AI22_08355 AI22_17570
PAEC : M802_1962(phzF) M802_4345(phzF) M802_4877
PAEO : M801_1963(phzF) M801_4213(phzF) M801_4744
SECH : B18_04220 B18_12380 B18_21410
PPAA : B7D75_03675 B7D75_15420
NWE : SAMEA3174300_1973(phzF)
NZO : SAMEA4504057_0357(phzF)
NCI : NCTC10296_00240(phzF)
IOD : EJO50_10155 EJO50_10670
IFL : C1H71_04730 C1H71_12960
JEU : BJP62_08530 BJP62_08970
DEE : HQN60_09830 HQN60_10650
CHIZ : HQ393_08190 HQ393_09855 HQ393_17400
CFON : HZU75_11195 HZU75_13935
AXX : ERS451415_02093(phzF_2)
JAB : VN23_00085 VN23_13765
URU : DSM104443_04201(phzF)
UPL : DSM104440_03722(phzF)
MESM : EJ066_15615 EJ066_26285
MESP : C1M53_12085 C1M53_23775
SMK : Sinme_2017 Sinme_2823
SMQ : SinmeB_1860 SinmeB_2599
SMX : SM11_chr1282(phzF) SM11_chr2933
SMI : BN406_01860 BN406_02626
SMEL : SM2011_c03984 SM2011_c04271
SMER : DU99_11495 DU99_15320
RHI : NGR_c19260 NGR_c28110
SFH : SFHH103_01857(phzf1) SFHH103_02823(phzf3)
SIX : BSY16_3772 BSY16_738
SAME : SAMCFNEI73_Ch2307 SAMCFNEI73_Ch3184
SINO : SS05631_c20920 SS05631_c32190
ESJ : SJ05684_c20640 SJ05684_c27880
EAK : EKH55_2004 EKH55_2725
EMX : FKV68_13020 FKV68_17605
ENU : PYH37_004480 PYH37_005323
EGI : PZN02_001794 PZN02_002764
SKM : PZL22_002373 PZL22_003072
STEG : QA637_09860 QA637_14020
EAH : FA04_09430 FA04_15000
ECAA : J3R84_09520 J3R84_14850
ENP : JVX98_10140 JVX98_25360
AGR : AGROH133_05795(phzF)
AGC : BSY240_288 BSY240_4024
AVV : RvVAT039_02580 RvVAT039_09830
AVF : RvVAR031_23300 RvVAR031_29760
RET : RHE_CH02720 RHE_CH03501(phzF)
REC : RHECIAT_CH0002863 RHECIAT_CH0003744(phzF)
REL : REMIM1_CH02761 REMIM1_CH03569
REP : IE4803_CH02854 IE4803_CH03858
REI : IE4771_CH02885 IE4771_CH03797
RLT : Rleg2_2476 Rleg2_3243
RLB : RLEG3_24160 RLEG3_28755
RLU : RLEG12_23490 RLEG12_27710
RTR : RTCIAT899_CH10825 RTCIAT899_CH14815
RHL : LPU83_2634 LPU83_3475(phzF)
RGA : RGR602_CH02401 RGR602_CH03404
RHN : AMJ98_CH02880 AMJ98_CH03723
RPHA : AMC79_CH02876 AMC79_CH03669
RHX : AMK02_CH02810 AMK02_CH03612
RHK : Kim5_CH02928 Kim5_CH03829
REZ : AMJ99_CH02879 AMJ99_CH03775
RJG : CCGE525_12315 CCGE525_17120
RHR : CKA34_14265 CKA34_17670
RGR : FZ934_08815 FZ934_13040
RAD : CO657_12525 CO657_16685
RII : FFM53_017145 FFM53_021965
RHID : FFM81_003445 FFM81_007510
RBQ : J2J99_14375 J2J99_18560
RLN : J0663_01130 J0663_05380
RBAN : J2J98_13695 J2J98_17785
RRG : J3P73_16280 J3P73_20720
RLS : HB780_17480 HB780_21320
RROS : D4A92_00790 D4A92_18840
RAW : NE851_25355 NE851_29245
RSUL : N2599_06425 N2599_14490
RLW : RlegWSM1455_13740 RlegWSM1455_17920
RCT : PYR68_12050 PYR68_16040
ARA : Arad_2852 Arad_3737(phzF)
RBW : RLCC275e_13795 RLCC275e_18125
RIF : U5G49_002725 U5G49_003626
RHIZ : QMO80_003382 QMO80_004169
RHIB : I8E17_09320 I8E17_12740
NGL : RG1141_CH19960 RG1141_CH29530
NGG : RG540_CH20890 RG540_CH30300
NEN : NCHU2750_18220(phzF) NCHU2750_27220(phzF)
NPM : QEO92_10705 QEO92_16530
PDES : FE840_000010 FE840_015170
BIC : LMTR13_08245 LMTR13_15845
VGO : GJW-30_1_01905(phzF)
BVV : BHK69_19345 BHK69_24740
BOS : BSY19_2654 BSY19_3464
BOI : BLM15_01930 BLM15_06670
BOF : FQV39_04085 FQV39_28505
BOW : NWE53_04830 NWE53_09575
BOSE : RMR04_09340 RMR04_14765
APOL : K9D25_13340 K9D25_18555
MOC : BB934_19420 BB934_29780 BB934_38640
MLD : U0023_01595 U0023_33665
PLEO : OHA_1_04223(phzF_1)
LAP : ACP90_05890 ACP90_09555 ACP90_20515
LABR : CHH27_11070 CHH27_14735
LABT : FIU93_11525(phzF1) FIU93_15115(phzF2)
LAGG : B0E33_04200 B0E33_17445 B0E33_21490
LIZ : LGH83_08355 LGH83_12345
TSV : DSM104635_02644(phzF)
AHT : ANTHELSMS3_02186(phzF)
SPHD : HY78_15485 HY78_15755
EMV : HQR01_04245 HQR01_07335
SRF : LHU95_05550 LHU95_10330
THAR : T8K17_06100 T8K17_06105
MDG : K8L98_04685 K8L98_11675
NOZ : DMB37_02435 DMB37_35920
NIE : KV110_08545 KV110_33255
STRC : AA958_29965 AA958_30780
STRD : NI25_24420 NI25_26815
SQZ : FQU76_00265 FQU76_33475
SNK : CP967_01660 CP967_31725
SAQU : EJC51_01040 EJC51_43595
SHUN : DWB77_04284(phzF_2)
SCHG : NRO40_23350 NRO40_27010
STP : Strop_0014 Strop_0718
MTEM : GCE86_09440 GCE86_28820
ATL : Athai_16050 Athai_37480 Athai_38900 Athai_43480
ASER : Asera_31160 Asera_36280
PRY : Prubr_32250 Prubr_54090(phzF) Prubr_64730(phzF1)
DVC : Dvina_03975 Dvina_22000
DFU : Dfulv_04460 Dfulv_40555
DROS : Drose_03440 Drose_30765
DMAT : Dmats_03665 Dmats_17615
DACT : KZZ52_04100 KZZ52_52260
BALA : DSM104299_00265(phzF_1)
SYY : SYNGTS_0576(slr1019)
SYT : SYNGTI_0576(slr1019)
SYS : SYNPCCN_0576(slr1019)
SYQ : SYNPCCP_0576(slr1019)
KBS : EPA93_00210 EPA93_02205 EPA93_09165
LOKI : Lokiarch_48980(phzF)
LOB : NEF87_003859 NEF87_003860
» show all
Taxonomy
Reference
Authors
Parsons JF, Song F, Parsons L, Calabrese K, Eisenstein E, Ladner JE
Title
Structure and function of the phenazine biosynthesis protein PhzF from Pseudomonas fluorescens 2-79.
Journal
Sequence
Reference
Authors
Blankenfeldt W, Kuzin AP, Skarina T, Korniyenko Y, Tong L, Bayer P, Janning P, Thomashow LS, Mavrodi DV
Title
Structure and function of the phenazine biosynthetic protein PhzF from Pseudomonas fluorescens.
Journal
Sequence
Reference
Authors
Parsons JF, Calabrese K, Eisenstein E, Ladner JE
Title
Structure of the phenazine biosynthesis enzyme PhzG.
Journal
Reference
Authors
Mavrodi DV, Bleimling N, Thomashow LS, Blankenfeldt W
Title
The purification, crystallization and preliminary structural characterization of PhzF, a key enzyme in the phenazine-biosynthesis pathway from Pseudomonas fluorescens 2-79.
Journal
Reference
Authors
Ahuja EG, Janning P, Mentel M, Graebsch A, Breinbauer R, Hiller W, Costisella B, Thomashow LS, Mavrodi DV, Blankenfeldt W
Title
PhzA/B catalyzes the formation of the tricycle in phenazine biosynthesis.
Journal
Sequence
Other DBs
ExplorEnz - The Enzyme Database: 5.3.3.17
ExPASy - ENZYME nomenclature database: 5.3.3.17
LinkDB
All DBs