Entry
Name
Class
Isomerases;
Intramolecular transferases;
Transferring amino groups
BRITE hierarchy
Sysname
L-lysine 2,3-aminomutase
Reaction(IUBMB)
L-lysine = (3S)-3,6-diaminohexanoate [RN:
R00461 ]
Reaction(KEGG)
Substrate
Product
(3S)-3,6-diaminohexanoate [CPD:
C01142 ]
Comment
This enzyme is a member of the 'AdoMet radical' (radical SAM) family. It contains pyridoxal phosphate and a [4Fe-4S] cluster and binds an exchangeable S-adenosyl-L-methionine molecule. Activity in vitro requires a strong reductant such as dithionite and strictly anaerobic conditions. A 5'-deoxyadenosyl radical is generated during the reaction cycle by reductive cleavage of S-adenosyl-L-methionine, mediated by the iron-sulfur cluster. S-adenosyl-L-methionine is regenerated at the end of the reaction.
History
EC 5.4.3.2 created 1972
Pathway
Orthology
Genes
NTE : NEUTE1DRAFT114872(NEUTE1DRAFT_114872)
SMP : 10808586(SMAC4_04322)
RTHE : 98122829(VTJ83DRAFT_1968)
PTRR : 6344348(PtrM4_101820)
ADAC : 96089234(ACET3X_008912)
FFU : CLAFUR5_04285 CLAFUR5_05560
PCUB : JR316_0012845 JR316_0012857 JR316_0012860
GAI : IMCC3135_04800(kamA)
CHJ : NCTC10426_01833(kamA)
MMEI : LRP31_10065 LRP31_15900
SMK : Sinme_3605 Sinme_6425
SMX : SM11_chr3752(kamA) SM11_pC1246(kamA)
SMEL : SM2011_c00355(kamA)
AGR : AGROH133_08690(kamA)
REC : RHECIAT_CH0004331(kamA)
REL : REMIM1_CH04140(kamA)
REP : IE4803_CH04427(kamA)
REI : IE4771_CH04377(kamA)
RGA : RGR602_CH03920(kamA)
RPHA : AMC79_CH04262(kamA)
RBAN : J2J98_20555 J2J98_26410
RRG : J3P73_23745 J3P73_35830
RHIZ : QMO80_002783 QMO80_006602
NEN : NCHU2750_36270(kamA)
LAS : CLIBASIA_04835(kamA)
BPAH : QA639_20835 QA639_34380
VGO : GJW-30_1_01602(kamA)
MAQU : Maq22A_c26075(kamA)
FIL : BN1229_v1_1843 BN1229_v1_2651
FIY : BN1229_v1_1845 BN1229_v1_3263
CAUB : AMEJIAPC_03028(kamA)
TSV : DSM104635_00054(kamA)
AARE : D3093_09500 D3093_34140(blsG)
GBN : GEOBRER4_22450(yjeK)
GER : KP004_10945 KP004_12025
GSB : GSUB_02220 GSUB_03855 GSUB_05965 GSUB_07355
GHC : L9S41_01645 L9S41_05640 L9S41_07310(ablA)
PCA : Pcar_1401(ablA) Pcar_2387 Pcar_2520(yjeK)
PACE : A6070_02665 A6070_03395 A6070_05730 A6070_06435
PEF : A7E78_02800 A7E78_07825 A7E78_11820 A7E78_13340
DEU : DBW_0848 DBW_1255 DBW_2386 DBW_3001
DVE : DESUT3_13440(kamA) DESUT3_27970(yjeK_1) DESUT3_31190(yjeK_2)
DEP : AOP6_0255 AOP6_0692(ablA) AOP6_1508(yjeK_1) AOP6_2159(yjeK_2)
DES : DSOUD_0973 DSOUD_2506 DSOUD_2698(yjeK)
DFL : DFE_1364 DFE_1412(kamA) DFE_1858
PSYF : N1030_14440(ablA) N1030_15920
DSB : LN040_08055 LN040_09975(ablA)
DSA : Desal_2912 Desal_3316
DAF : Desaf_1116 Desaf_2084
PPOR : JCM14722_25910(kamA)
DBA : Dbac_0035 Dbac_0211 Dbac_1776
DESU : NLA06_08890 NLA06_11895(ablA)
DSF : UWK_00106 UWK_01028 UWK_03167
DLM : DPPLL_14770(yjeK) DPPLL_28040(kamA_1) DPPLL_35990(kamA_2)
DAK : DaAHT2_0565 DaAHT2_1378
DBK : DGMP_01880 DGMP_15710(yjeK)
ECOM : QTN59_03850 QTN59_06025(ablA)
EAJ : Q3M24_17265(ablA) Q3M24_18195
ELAX : KKHLCK_03145 KKHLCK_05950(ablA)
ESD : SD837_13930 SD837_14695(ablA)
DAT : HRM2_03800(kamA1) HRM2_13250(kamA2) HRM2_29300 HRM2_34920
DOV : DSCO28_44610(yjeK) DSCO28_54840(kamA)
DWD : DSCW_20720 DSCW_40890(kamA)
DALK : DSCA_17890 DSCA_32500(yjeK)
DVR : Dvar_25790 Dvar_74200
DML : Dmul_00080(kamA) Dmul_00460(kamA)
DLI : dnl_02010 dnl_02350(kamA1) dnl_25960(kamA2)
DMM : dnm_051080(kamA1) dnm_068000(kamA2)
DEK : DSLASN_19740 DSLASN_35270(yjeK) DSLASN_49440(kamA)
DAX : FDQ92_04350 FDQ92_09195
DMP : FAK_15120(kamA) FAK_24740(kamA)
TAV : G4V39_04930 G4V39_09320
ACP : A2cp1_1402 A2cp1_1403
AFW : Anae109_1315 Anae109_1316
ANK : AnaeK_1301 AnaeK_1302
AORY : AMOR_08190(kamA_1) AMOR_08200(kamA_2)
APAU : AMPC_01680(kamA) AMPC_01690(ablA)
MXA : MXAN_4698(kamA) MXAN_4699
MSD : MYSTI_05154 MYSTI_05155
MFB : MFUL124B02_28325 MFUL124B02_28330
MYX : QEG98_25380 QEG98_25385
MLAN : JY572_00850 JY572_00855
MYM : A176_002193 A176_002194
CCX : COCOR_02697(kamA1) COCOR_02698(kamA)
MFU : LILAB_31440 LILAB_31445
MMAS : MYMAC_004591 MYMAC_004592
PPAK : JY651_08635 JY651_08640
SUR : STAUR_5548(kamA) STAUR_5549
AGE : AA314_04239 AA314_04240 AA314_07042
AVM : JQX13_08445 JQX13_35080 JQX13_35085
MBD : MEBOL_008096 MEBOL_008097
CFUS : CYFUS_006135 CYFUS_006136
VIN : AKJ08_1096 AKJ08_1097
PBRU : LZC95_07185 LZC95_46985
PRUE : LVJ94_08280 LVJ94_47015
PALJ : LZC94_36150 LZC94_43330
SCL : sce2448(kamA1) sce7261(kamA2)
SCU : SCE1572_14735 SCE1572_42310
CCRO : CMC5_039170 CMC5_076260(epmB)
PAUU : E8A73_020040 E8A73_026670
MRM : A7982_01933 A7982_08488
SAMY : DB32_003420 DB32_005585
LLU : AKJ09_01113 AKJ09_03422
NANN : O0S08_21765 O0S08_41655
HAX : BALOs_1592(kamA) BALOs_2519(kamA)
BSTO : C0V70_09335 C0V70_13420
SBF : JCM31447_10720 JCM31447_28690
PIJ : QEJ31_06040 QEJ31_12595
SAQI : AXG55_05260 AXG55_13325
OBG : Verru16b_00738(kamA)
PBS : Plabr_0677 Plabr_4558
ALUS : STSP2_00237(kamA_1)
TAER : GT409_04090(ablA) GT409_14120
LBAC : LJT99_04010(ablA) LJT99_05770
SSM : Spirs_0607 Spirs_3672 Spirs_3983
OCK : EXM22_10175 EXM22_17815
SBU : SpiBuddy_0818 SpiBuddy_2578
SGP : SpiGrapes_0097 SpiGrapes_0923 SpiGrapes_1190
SASS : MUG09_04720 MUG09_13795
LIL : LA_2701(kamA) LB_298(kamA)
LIE : LIF_A2208(kamA) LIF_B239(kamA)
LIC : LIC_11303 LIC_20230(kamA)
LIS : LIL_11427(kamA) LIL_20244(kamA1) LIL_20285(kamA2)
LBJ : LBJ_2006(kamA) LBJ_4222(kamA)
LBL : LBL_1044(kamA) LBL_4236(kamA)
LBI : LEPBI_I1797(kamA) LEPBI_II0202(kamA)
LBF : LBF_1744(kamA) LBF_4195(kamA)
LAJ : A0128_12040 A0128_21430
LMAY : DPV73_11295 DPV73_19475
LKM : EFP84_03965 EFP84_20000
LWL : FHG68_06165 FHG68_20595
LKB : LPTSP3_g17160(kamA) LPTSP3_g38570
LNO : MAL08_06535 MAL08_18340
LKR : FH602_00390 FH602_11785
LMIL : AB3N58_08315 AB3N58_17095
LIOW : AB3N60_08920 AB3N60_18685
LGOR : AB3N59_11520 AB3N59_18495
LMGO : AB3N62_08790 AB3N62_18415
LCIN : AB3N61_06195 AB3N61_18745
PCRE : NCTC12858_01516(kamA)
PCAG : NCTC12856_01005(kamA)
PSOE : CE91St14_15580(kamA)
BACC : BRDCF_p1071 BRDCF_p677(kamA)
DORI : FH5T_01695 FH5T_13980
DRC : G0Q07_07045 G0Q07_15170(ablA)
CPB : Cphamn1_1421 Cphamn1_1649
PROC : Ptc2401_01487(kamA)
PROS : CHL67_03815 CHL67_07360(ablA)
FML : FMIA91_06040(ablA_1) FMIA91_06080(ablA_2)
TAM : Theam_0701 Theam_1077
DAP : Dacet_0802 Dacet_0867
NLI : G3M70_00450 G3M70_11405
BSED : DN745_12025 DN745_13335
PCAY : FRD00_04340 FRD00_14815
BBAE : FRD01_12365 FRD01_20915
DHR : LGS26_01175 LGS26_06415
BAZ : BAMTA208_07265(kamA)
BSTR : QI003_10660(ablA) QI003_14090(ablA)
BARD : QRY57_07120(ablA) QRY57_12775(ablA)
BMQ : BMQ_2377(kamA) BMQ_4040
BMD : BMD_2339(kamA) BMD_4025
BMH : BMWSH_1184 BMWSH_2857(kamA)
BMEG : BG04_4750(ablA) BG04_954(ablA)
CSPG : LS684_12455(ablA) LS684_24030(ablA)
BMUR : ABE28_013255 ABE28_018470
PBUT : DTO10_01450(ablA) DTO10_06470(ablA)
PFRI : L8956_14800(ablA) L8956_20320(ablA)
PERI : RE409_16735(ablA) RE409_22365(ablA)
PERJ : JNUCC41_03000(ablA) JNUCC41_23970(ablA)
NDT : L1999_17875(ablA) L1999_19680(ablA)
MDG : K8L98_03075(ablA) K8L98_14350(ablA)
ECTO : MUG87_02015(ablA) MUG87_02760(ablA)
BLR : BRLA_c010390 BRLA_c044750
BRW : GOP56_14945(ablA) GOP56_21165
BAYD : BSPP4475_00890(ablA)
TUM : CBW65_01255 CBW65_05630 CBW65_10660
TAB : CIG75_01540(ablA) CIG75_17315
KPUL : GXN76_09095(blsG) GXN76_15765(ablA)
KEB : GXN75_13480 GXN75_17100(ablA)
CACE : CACET_c36840(kamA2)
CEU : A7L45_01580 A7L45_04295
CCOH : SAMEA4530647_0744(kamA)
CLOS : DMR38_14950(ablA) DMR38_19195(ablA)
CGEL : psyc5s11_05360(kamA)
VFA : MM35RIKEN_07340(kamA)
VCOP : MM50RIKEN_12210(kamA)
PETR : QKW49_06405(ablA) QKW49_14125(ablA)
SALQ : SYNTR_1221 SYNTR_1223 SYNTR_1330
DOR : Desor_2831 Desor_4631
DRS : DEHRE_00265 DEHRE_04870
TFR : BR63_13955(ablA) BR63_16265(ablA)
FWA : DCMF_01115 DCMF_21065
PHOS : ABFY19_01645(ablA) ABFY19_09995(ablA)
DGI : Desgi_1711 Desgi_2670
HCV : FTV88_2326(kamA) FTV88_2887(ablA)
BPRO : PMF13cell1_00227(kamA)
CSCI : HDCHBGLK_00354(kamA)
CBAR : PATL70BA_2534(kamA)
VGU : HYG85_18190 HYG85_18535(ablA)
VPY : HZI73_17995(ablA) HZI73_18450
AMIC : Ami3637_09140(ablA)
ABUT : Ami103574_15005(ablA)
ETM : CE91St48_07390(kamA) CE91St48_35810
GFE : Gferi_05330 Gferi_11530
TEB : T8CH_0440(kamA) T8CH_2402(kamA)
EAC : EAL2_808p00710(kamA)
DBC : MFMK1_002312(ablA) MFMK1_003526
NTH : Nther_1886 Nther_2886
RCR : NCTC10994_00675(kamA)
SRW : TUE45_pSRc_0464(kamA)
SLX : SLAV_34285(kamA1) SLAV_37380(kamA2)
SQZ : FQU76_03545(blsG) FQU76_28925
STSU : B7R87_14090 B7R87_29075
SPLA : CP981_01905(blsG) CP981_02325
SXT : KPP03845_105561(kamA)
SRPA : HEP86_03170(blsG) HEP86_03775
ACIT : HPK19_03915 HPK19_20035(ablA)
NAQU : ENKNEFLB_02387(kamA)
AWS : ACN3XK_31700 ACN3XK_32845
AMYE : MJQ72_08290 MJQ72_20160
APRE : CNX65_18605 CNX65_22330(blsG)
KPHY : AOZ06_16995 AOZ06_28005
LED : BBK82_35635 BBK82_41165
AAUR : V5P93_004051 V5P93_004237
MSAG : GCM10017556_54710(kamA)
ACTR : Asp14428_06210(kamA)
ASIC : Q0Z83_003630 Q0Z83_010220
DAUR : Daura_26240 Daura_28155
CCAZ : COUCH_16400 COUCH_20850
LET : O77CONTIG1_01249(kamA)
SCYS : NIES4073_45150(kamA)
DEH : cbdbA219(kamA) cbdbA615(kamA)
DEB : DehaBAV1_0133 DehaBAV1_0601
DEV : DhcVS_197(ablAB) DhcVS_569
DEG : DehalGT_0266 DehalGT_0563
DMG : GY50_0220(kamA) GY50_0554(kamA)
DMX : X792_01440 X792_03055
DMY : X793_01030 X793_02800
DMZ : X794_00885 X794_02540
DUC : UCH007_02500(kamA) UCH007_05500(kamA)
FPOL : ERS445057_00493(kamA)
MHAZ : BHR79_01010 BHR79_06475
MPOT : BKM01_02735 BKM01_07400
MZH : Mzhil_0344 Mzhil_1041
MZI : HWN40_06395 HWN40_12610(ablA)
MRTJ : KHC33_05760(ablA) KHC33_05765
MEM : Memar_0215 Memar_1790
MEMA : MMAB1_0138(kamA) MMAB1_0763
MPI : Mpet_0518 Mpet_1023 Mpet_1464
» show all
Taxonomy
Reference
Authors
Zappia V, Barker HA.
Title
Studies on lysine-2,3-aminomutase. Subunit structure and sulfhydryl groups.
Journal
Reference
2
Authors
Aberhart DJ, Lim H-J, Weiller BH.
Title
Stereochemistry of lysine 2,3-aminomutase.
Journal
J Am Chem Soc 103:6750-6752 (1981)
Reference
Authors
Frey PA
Title
Lysine 2,3-aminomutase: is adenosylmethionine a poor man's adenosylcobalamin?
Journal
Reference
Authors
Lieder KW, Booker S, Ruzicka FJ, Beinert H, Reed GH, Frey PA
Title
S-Adenosylmethionine-dependent reduction of lysine 2,3-aminomutase and observation of the catalytically functional iron-sulfur centers by electron paramagnetic resonance.
Journal
Reference
Authors
Lepore BW, Ruzicka FJ, Frey PA, Ringe D
Title
The x-ray crystal structure of lysine-2,3-aminomutase from Clostridium subterminale.
Journal
Reference
Authors
Frey PA, Reed GH
Title
Pyridoxal-5'-phosphate as the catalyst for radical isomerization in reactions of PLP-dependent aminomutases.
Journal
Other DBs
ExplorEnz - The Enzyme Database: 5.4.3.2
ExPASy - ENZYME nomenclature database: 5.4.3.2
BRENDA, the Enzyme Database: 5.4.3.2
LinkDB
All DBs