KEGG   ENZYME: 5.4.99.48
Entry
EC 5.4.99.48                Enzyme                                 
Name
achilleol B synthase
Class
Isomerases;
Intramolecular transferases;
Transferring other groups
Sysname
(3S)-2,3-epoxy-2,3-dihydrosqualene mutase (cyclizing, achilleol-B-forming)
Reaction(IUBMB)
(3S)-2,3-epoxy-2,3-dihydrosqualene = achilleol B [RN:R09908]
Reaction(KEGG)
R09908
Substrate
(3S)-2,3-epoxy-2,3-dihydrosqualene [CPD:C01054]
Product
achilleol B [CPD:C20187]
Comment
Achilleol B is probably formed by cleavage of the 8-14 and 9-10 bonds of (3S)-2,3-epoxy-2,3-dihydrosqualene as part of the cyclization reaction, after formation of the oleanane skeleton.
History
EC 5.4.99.48 created 2011
Pathway
ec00909  Sesquiterpenoid and triterpenoid biosynthesis
Orthology
K19011  achilleol B synthase
Genes
OSA: 4328259 4350288 4350291 4350295 4350734
DOSA: Os02g0140200 Os02g0140400 Os11g0285000 Os11g0286800 Os11g0562100
OBR: 102701306 102701586 102703694
OGL: 127754440 127755054 127755055 127755075 127764028 127774076
BDI: 100827654 100843778
ATS: 109734192 109736669 109739339 109743284 109770264 109777463
TDC: 119284479 119288449 119290044 119293087 119315173 119323019 119323648 119333936 119340556 119361867
TAES: 123043239 123083663 123084663 123088665 123089814 123089815 123095544 123132191 123136222 123141178 123142911 123150783 123154489 123159283 123166066 123170385
TUA: 125516081 125516140 125520744 125522489 125523582 125523738 125524235 125524236 125524237
LPER: 127294856 127299217 127302675 127302864 127316690 127317241 127323218 127329912 127330773 127348620
LRD: 124652282 124657775 124657776 124670152 124675744 124676308 124676542 124676889 124678346 124685309 124699528 124699656 124700808
SBI: 110434442 110436943 8062668 8063842 8064550 8067848 8069958 8072983 8073228
ZMA: 100193317 100285643 103626416 103653555 103654534
MFLO: 136471049 136475673 136476318 136477304 136484038 136500571 136521210 136532235
SITA: 101752607 101756143 101761176 101767046 101769509 101784323 101786482
SVS: 117843020 117851924 117852781 117853708 117855859 117856263 117864379 117864418 117864489
PVIR: 120644241 120644823 120646058 120654626 120669159 120669934 120702021
PHAI: 112874083 112885223 112891129 112899190 112902491
PAUA: 133887485 133889836 133930304
 » show all
Reference
1  [PMID:21526825]
  Authors
Ito R, Mori K, Hashimoto I, Nakano C, Sato T, Hoshino T
  Title
Triterpene cyclases from Oryza sativa L.: cycloartenol, parkeol and achilleol B synthases.
  Journal
Org Lett 13:2678-81 (2011)
DOI:10.1021/ol200777d
  Sequence
[osa:4350288]
Other DBs
ExplorEnz - The Enzyme Database: 5.4.99.48
IUBMB Enzyme Nomenclature: 5.4.99.48
ExPASy - ENZYME nomenclature database: 5.4.99.48
BRENDA, the Enzyme Database: 5.4.99.48
LinkDB

DBGET integrated database retrieval system