KEGG ENZYME: 6.2.1.65

ENZYME: 6.2.1.65

Entry

EC 6.2.1.65                 Enzyme

Name

salicylate---CoA ligase;
sdgA (gene name)

Class

Ligases;
Forming carbon-sulfur bonds;
Acid-thiol ligases

Sysname

salicylate:CoA ligase (AMP-forming)

Reaction(IUBMB)

ATP + salicylate + CoA = AMP + diphosphate + 2-hydroxybenzoyl-CoA (overall reaction) [RN:R12642];
(1a) ATP + salicylate = diphosphate + (2-hydroxybenzoyl)adenylate [RN:R12640];
(1b) (2-hydroxybenzoyl)adenylate + CoA = AMP + 2-hydroxybenzoyl-CoA [RN:R12641]

Reaction(KEGG)

R12640 R12641 R12642

Substrate

ATP [CPD:C00002];
salicylate [CPD:C00805];
CoA [CPD:C00010];
(2-hydroxybenzoyl)adenylate [CPD:C22233]

Product

AMP [CPD:C00020];
diphosphate [CPD:C00013];
2-hydroxybenzoyl-CoA [CPD:C20394];
(2-hydroxybenzoyl)adenylate [CPD:C22233]

Comment

The enzyme, characterized from the bacteria Thauera aromatica and Streptomyces sp. WA46, participates in a salicylate degradation pathway. It activates salicylate by its adenylation to (2-hydroxybenzoyl)adenylate, followed by the transfer of the activated compound to coenzyme A.

History

EC 6.2.1.65 created 2020

Orthology

K24408

salicylate---CoA ligase

Genes