KEGG   ENZYME: 6.3.1.17
Entry
EC 6.3.1.17                 Enzyme                                 
Name
beta-citrylglutamate synthase;
NAAG synthetase I;
NAAGS-I;
RIMKLB (gene name) (ambiguous)
Class
Ligases;
Forming carbon-nitrogen bonds;
Acid-D-ammonia (or amine) ligases (amide synthases)
Sysname
citrate:L-glutamate ligase (ADP-forming)
Reaction(IUBMB)
ATP + citrate + L-glutamate = ADP + phosphate + beta-citryl-L-glutamate [RN:R10677]
Reaction(KEGG)
R10677
Substrate
ATP [CPD:C00002];
citrate [CPD:C00158];
L-glutamate [CPD:C00025]
Product
ADP [CPD:C00008];
phosphate [CPD:C00009];
beta-citryl-L-glutamate [CPD:C20775]
Comment
The enzyme, found in animals, also has the activity of EC 6.3.2.41, N-acetylaspartylglutamate synthase.
History
EC 6.3.1.17 created 2014
Pathway
ec00250  Alanine, aspartate and glutamate metabolism
ec01100  Metabolic pathways
Orthology
K18310  beta-citrylglutamate/N-acetylaspartylglutamate synthase
Genes
HSA57494(RIMKLB)
PTR735860(RIMKLB)
PPS100974820(RIMKLB)
GGO101136567(RIMKLB)
PON100441104(RIMKLB)
NLE100593570(RIMKLB)
HMH116456202 116472644(RIMKLB) 116481450
MCC722261(RIMKLB)
MCF102124154(RIMKLB) 102128847 123572791
MTHB126931378 126935689 126940883
MNI105499881(RIMKLB)
CSAB103218536(RIMKLB)
CATY105587959(RIMKLB)
PANU101024010(RIMKLB)
TGE112635206(RIMKLB)
MLEU105552618(RIMKLB)
RRO104672842(RIMKLB)
RBB108543684(RIMKLB)
TFN117090541(RIMKLB)
PTEH111526616(RIMKLB)
CANG105519900(RIMKLB)
CJC100406491(RIMKLB)
SBQ101033047(RIMKLB)
CIMI108291858(RIMKLB) 108311366
CSYR103251714(RIMKLB)
MMUR105878274(RIMKLB)
LCAT123640042(RIMKLB)
PCOQ105805100(RIMKLB)
OGA100941690(RIMKLB)
MMU108653(Rimklb)
MCAL110296264(Rimklb)
MPAH110316335(Rimklb)
RNO100362344(Rimklbl1) 362428(Rimklb)
MCOC116099539(Rimklb)
ANU117715398(Rimklb)
MUN110556298(Rimklb)
CGE100760031(Rimklb)
MAUA101842752(Rimklb)
PROB127236141(Rimklb)
PLEU114683483(Rimklb)
MORG121438947(Rimklb)
MFOT126514898
AAMP119808422(Rimklb)
NGI103727467(Rimklb)
HGL101706744(Rimklb)
CPOC100732576(Rimklb)
CCAN109697724(Rimklb)
DORD105991108(Rimklb)
DSP122127019(Rimklb)
PLOP125342895(Rimklb)
NCAR124983424
MMMA107159921(Rimklb)
OCU100346793
OPI101523234(RIMKLB)
TUP102472940(RIMKLB)
GVR103597920(RIMKLB)
CFA486698(RIMKLB)
CLUD112675320(RIMKLB)
VVP112917302(RIMKLB)
VLG121479857(RIMKLB)
NPO129517123(RIMKLB)
AML100473320(RIMKLB)
UMR103669163(RIMKLB)
UAH113257923(RIMKLB)
UAR123781552(RIMKLB)
ELK111142053
LLV125106794
MPUF101680352(RIMKLB)
MNP132019465(RIMKLB)
MLK131839093(RIMKLB)
NVS122891599(RIMKLB)
ORO101374535(RIMKLB)
EJU114221687(RIMKLB)
ZCA113921819(RIMKLB)
MLX118025692(RIMKLB)
NSU110580730(RIMKLB)
LWW102741413(RIMKLB)
FCA101097740(RIMKLB)
PYU121022064(RIMKLB)
PCOO112867654(RIMKLB)
PBG122473789(RIMKLB)
PVIV125170874(RIMKLB)
LRUF124502657
PTG102963865(RIMKLB)
PPAD109276058(RIMKLB)
PUC125920076
AJU106965320
HHV120222721(RIMKLB)
BTA538579(RIMKLB)
BOM102269649(RIMKLB)
BIU109559695(RIMKLB)
BBUB102397788(RIMKLB) 112578013
BBIS104995473(RIMKLB)
CHX102176861(RIMKLB)
OAS101102554(RIMKLB)
BTAX128047549(RIMKLB)
ODA120858791(RIMKLB)
CCAD122423372(RIMKLB) 122439954
MBEZ129535835(RIMKLB)
SSC100152915(RIMKLB)
CFR102503881(RIMKLB)
CBAI105062179(RIMKLB)
CDK105098170(RIMKLB)
VPC102526778(RIMKLB)
BACU103019013(RIMKLB)
BMUS118884598 118887952 118902028(RIMKLB)
LVE103069710(RIMKLB)
OOR101273054(RIMKLB)
DLE111176728(RIMKLB)
PCAD102975069 102981532(RIMKLB)
PSIU116746837 116760947(RIMKLB)
NASI112391802(RIMKLB)
ECB100061350(RIMKLB)
EPZ103564581(RIMKLB)
EAI106837431(RIMKLB)
MYB102245342(RIMKLB)
MYD102752373(RIMKLB)
MMYO118650363(RIMKLB)
MLF102441683(RIMKLB)
PKL118728963(RIMKLB)
EFUS103285400(RIMKLB)
MNA107544073(RIMKLB)
DRO112322046(RIMKLB)
SHON119002540(RIMKLB)
AJM119065675(RIMKLB)
PDIC114514072(RIMKLB)
PHAS123819342(RIMKLB)
MMF118624708(RIMKLB)
PPAM129085032(RIMKLB)
HAI109372752(RIMKLB)
RFQ117028564(RIMKLB)
PALE102880426(RIMKLB)
PGIG120611695(RIMKLB)
PVP105295916(RIMKLB)
RAY107501656(RIMKLB)
MJV108396116(RIMKLB)
TOD119247737(RIMKLB)
SARA101554225(RIMKLB)
SETR126006581(RIMKLB)
LAV100657534(RIMKLB)
TMU101361972
ETF101645920(RIMKLB)
DNM101416522(RIMKLB)
MDO100013787(RIMKLB)
GAS123250757(RIMKLB)
SHR100930894(RIMKLB)
AFZ127539203
PCW110213807(RIMKLB)
OAA100090307(RIMKLB)
GGA418255(RIMKLB)
PCOC116240958(RIMKLB)
MGP104916636
CJO107318392(RIMKLB)
TPAI128089909(RIMKLB)
LMUT125687916(RIMKLB)
NMEL110397764(RIMKLB)
APLA101792875(RIMKLB)
ACYG106048091(RIMKLB)
CATA118247607(RIMKLB)
AFUL116490791(RIMKLB)
TGU100220208(RIMKLB)
LSR110472321(RIMKLB)
SCAN103827201(RIMKLB)
PMOA120497743(RIMKLB)
OTC121341027(RIMKLB)
PRUF121349851(RIMKLB)
GFR102035986(RIMKLB)
FAB101814507(RIMKLB)
OMA130255587(RIMKLB)
PHI102111957(RIMKLB)
PMAJ107210434(RIMKLB)
CCAE111925810(RIMKLB)
CCW104690266(RIMKLB)
CBRC103616673(RIMKLB)
ETL114069342(RIMKLB)
ZAB102064947(RIMKLB)
ZLE135451535(RIMKLB)
ACHL103811885(RIMKLB)
SVG106859828(RIMKLB)
MMEA130579182(RIMKLB)
HRT120748584(RIMKLB)
FPG101913481(RIMKLB)
FCH102056126(RIMKLB)
CLV102098362(RIMKLB)
EGZ104122771(RIMKLB)
NNI104014577(RIMKLB)
PCRI104036849(RIMKLA)
PLET104626869(RIMKLB)
EHS104510567(RIMKLB)
PCAO104053397(RIMKLB)
ACUN113491069(RIMKLB)
TALA104365181(RIMKLB)
PADL103915115(RIMKLB)
AFOR103899962(RIMKLB)
ACHC115352600(RIMKLB)
HALD104321852(RIMKLB)
HLE104836674(RIMKLB)
AGEN126047837
GCL127017595
CCRI104158756(RIMKLB)
CSTI104557469(RIMKLB)
CMAC104474785(RIMKLB)
MUI104538317(RIMKLB)
BREG104641295(RIMKLB)
FGA104072777(RIMKLB)
GSTE104257247(RIMKLB)
LDI104343382(RIMKLB)
MNB103775226(RIMKLB)
OHA104332450(RIMKLB)
NNT104411662(RIMKLB)
SHAB115605282(RIMKLB)
DPUB104306895(RIMKLB)
PGUU104458927(RIMKLB)
ACAR104532919(RIMKLB)
CPEA104394530(RIMKLB)
AVIT104268972(RIMKLB)
CVF104294502(RIMKLB)
RTD128902766(RIMKLB)
CUCA104060632(RIMKLB)
TEO104382280
BRHI104488456
AAM106495722(RIMKLB)
AROW112973974(RIMKLB)
NPD112952039(RIMKLB)
TGT104580212(RIMKLB)
DNE112992432(RIMKLB)
SCAM104152046(RIMKLB)
ASN102373845(RIMKLB)
AMJ102576775(RIMKLB)
CPOO109316234(RIMKLB)
GGN109296594(RIMKLB)
PSS102451018(RIMKLB)
CMY102933090(RIMKLB)
CCAY125623379(RIMKLB)
DCC119859155(RIMKLB)
CPIC101943668(RIMKLB)
TST117884982(RIMKLB)
CABI116823843(RIMKLB)
MRV120404562(RIMKLB)
ACS100563778(rimklb)
ASAO132767973(RIMKLB)
PVT110069781(RIMKLB)
SUND121921715(RIMKLB)
PBI103055545(RIMKLB)
PMUR107288539(RIMKLB)
CTIG120318691(RIMKLB)
TSR106544566(RIMKLB)
PGUT117661914(RIMKLB)
APRI131189735(RIMKLB)
PTEX113444557(RIMKLB)
NSS113425290(RIMKLB)
VKO123017759(RIMKLB)
PMUA114588043(RIMKLB)
PRAF128405389(RIMKLB)
ZVI118097943(RIMKLB)
HCG128346831(RIMKLB)
GJA107117747(RIMKLB)
STOW125437091(RIMKLB)
EMC129345231(RIMKLB)
XLA108696039 108697330
XTR100486701(rimklb)
NPR108799485(RIMKLB)
RTEM120946910(RIMKLB)
BBUF121005412(RIMKLB)
BGAR122941782(RIMKLB)
MUO115457690(RIMKLB)
GSH117350096(RIMKLB)
DRE447815(rimkla)
SRX107711947 107717536
SANH107669631
SGH107556480 107591767
CCAR109084979 109084984
CAUA113078389 113093917 113107768
CGIB127964047 128018591
PTET122350397(rimkla)
LROH127170090(rimkla)
OMC131545407(rimkla)
PPRM120483739(rimkla)
RKG130094558(rimkla)
MAMB125279787(rimkla)
CIDE127517732
MASI127414466 127424193
TROS130567859(rimkla)
TDW130439951(rimkla)
MANU129413961(rimkla)
IPU108265850
IFU128607997(rimkla)
PHYP113529230
SMEO124399561(rimkla)
TFD113655760(rimkla)
TVC132853464(rimkla)
TRN134318214(rimkla)
AMEX103035057
CMAO118813696(rimkla)
EEE113572086
CHAR105902183(rimkla)
TRU101062827
TFS130530628(rimkla)
TNGGSTEN00013753G001
LCO104920219
NCC104955181(rimkla)
TBEN117494141(rimkla)
CGOB115011073
PGEO117449663(rimkla)
GACU117541819(rimkla)
EMAC134870674(rimkla)
ELY117258509(rimkla)
EFO125891718(rimkla)
PLEP121947276(rimkla)
SLUC116040663(rimkla)
ECRA117948232(rimkla)
ESP116692402
PFLV114558866
GAT120828693(rimkla)
PPUG119205701 119222662
AFB129100051(rimkla)
CLUM117732964(rimkla)
PSWI130199585(rimkla)
MSAM119905637(rimkla)
SCHU122882832(rimkla)
CUD121518035(rimkla)
ALAT119022909(rimkla)
MZE101477475
ONL100698845
OAU116309725(rimkla)
OLA101169452(rimklb)
OML112159079(rimkla)
CSAI133457317(rimkla)
XMA102218635
XCO114141086
XHE116725681
PRET103467997(rimkla)
PFOR103138952(rimkla)
PLAI106957454(rimkla)
PMEI106907435(rimkla)
GAF122836233(rimkla)
PPRL129372418(rimkla)
CVG107088869(rimkla)
CTUL119797064(rimkla)
GMU124867677(rimkla)
NFU107390714
KMR108236831(rimkla)
ALIM106524174
NWH119417065(rimkla)
AOCE111585273
MCEP124997852(rimkla)
CSEM103384935
POV109630621(rimkla)
SSEN122776960(rimkla)
HHIP117764653(rimkla)
HSP118110963(rimkla)
PPLT128442387(rimkla)
SMAU118317585(rimkla)
LCF108891717
SDU111219047
SLAL111670604
XGL120804092(rimkla)
HCQ109526583
SSCV125988093
SBIA133508604(rimkla)
PEE133405192(rimkla)
PTAO133482673(rimkla)
BPEC110161111
MALB109970719
BSPL114858903(rimkla)
SJO128357364(rimkla)
SASA106567384 106572158
STRU115166047 115168921
OTW112215953 112221609
OMY110491822 110532211
OGO124017459 124031877
ONE115102623 115132092
OKI109869491 109907940
OKE118360188 118361096
SALP111966388 111976646
SNH120059373 120060966
CCLU121538272 121545958
ELS105013808
SFM108918203 108924922
PKI111856970 111859075(rimkla)
AANG118208179(rimkla)
LOC102687393(rimkla)
PSPA121296514 121325367 121328885 121329280
ARUT117424072 117425213 117425745 117432003
PSEX120530966(rimkla) 120535665
LCM102351441(RIMKLB) 102354509(RIMKLA)
CMK103190080(rimkla)
CPLA122540248(rimkla)
HOC132833521(rimkla)
LERI129711474(rimkla)
PMRN116937615 116948844
LRJ133345229
 » show all
Reference
1  [PMID:20657015]
  Authors
Collard F, Stroobant V, Lamosa P, Kapanda CN, Lambert DM, Muccioli GG, Poupaert JH, Opperdoes F, Van Schaftingen E
  Title
Molecular identification of N-acetylaspartylglutamate synthase and beta-citrylglutamate synthase.
  Journal
J Biol Chem 285:29826-33 (2010)
DOI:10.1074/jbc.M110.152629
  Sequence
[mmu:108653]
Other DBs
ExplorEnz - The Enzyme Database: 6.3.1.17
IUBMB Enzyme Nomenclature: 6.3.1.17
ExPASy - ENZYME nomenclature database: 6.3.1.17
BRENDA, the Enzyme Database: 6.3.1.17
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