KEGG ENZYME: 6.3.2.41

ENZYME: 6.3.2.41

Entry

EC 6.3.2.41                 Enzyme

Name

N-acetylaspartylglutamate synthase;
N-acetylaspartylglutamate synthetase;
NAAG synthetase;
NAAGS;
RIMKLA (gene name) (ambiguous);
RIMKLB (gene name) (ambiguous)

Class

Ligases;
Forming carbon-nitrogen bonds;
Acid-D-amino-acid ligases (peptide synthases)

Sysname

N-acetyl-L-aspartate:L-glutamate ligase (ADP, N-acetyl-L-aspartyl-L-glutamate-forming)

Reaction(IUBMB)

ATP + N-acetyl-L-aspartate + L-glutamate = ADP + phosphate + N-acetyl-L-aspartyl-L-glutamate [RN:R10678]

Reaction(KEGG)

R10678

Substrate

ATP [CPD:C00002];
N-acetyl-L-aspartate [CPD:C01042];
L-glutamate [CPD:C00025]

Product

ADP [CPD:C00008];
phosphate [CPD:C00009];
N-acetyl-L-aspartyl-L-glutamate [CPD:C12270]

Comment

The enzyme, found in animals, produces the neurotransmitter N-acetyl-L-aspartyl-L-glutamate. One isoform also has the activity of EC 6.3.1.17, beta-citrylglutamate synthase [2], while another isoform has the activity of EC 6.3.2.42, N-acetylaspartylglutamylglutamate synthase [3].

History

EC 6.3.2.41 created 2014

Pathway

ec00250

Alanine, aspartate and glutamate metabolism

ec01100

Metabolic pathways

Orthology

K18310

beta-citrylglutamate/N-acetylaspartylglutamate synthase

K18311

N-acetylaspartylglutamate/N-acetylaspartylglutamylglutamate synthase

Genes

HSA:	284716(RIMKLA) 57494(RIMKLB)

PTR:	735860(RIMKLB) 748944(RIMKLA)

PPS:	100970527(RIMKLA) 100974820(RIMKLB)

GGO:	101136567(RIMKLB) 101137769(RIMKLA) 129529357

PON:	100441104(RIMKLB) 100457877(RIMKLA)

PPYG:

129009422(RIMKLB) 129011706(RIMKLA)

NLE:	100589997(RIMKLA) 100593570(RIMKLB)

HMH:	116456202 116463700 116463727 116472644(RIMKLB) 116481450

SSYN:

129469175(RIMKLA) 129482966 129483406(RIMKLB) 129490478

MCC:	699767(RIMKLA) 722261(RIMKLB)

MCF:	102124154(RIMKLB) 102128755(RIMKLA) 102128847 135970472

MTHB:

126931378 126935689 126940883 126959995

MNI:	105494839(RIMKLA) 105499881(RIMKLB)

CSAB:

103218536(RIMKLB) 103225007(RIMKLA)

CATY:

105587959(RIMKLB) 105594671(RIMKLA)

PANU:

101017885(RIMKLA) 101024010(RIMKLB)

TGE:	112631615(RIMKLA) 112635206(RIMKLB)

MLEU:

105552618(RIMKLB) 105555114(RIMKLA)

RRO:	104668996(RIMKLA) 104672842(RIMKLB)

RBB:	108530380(RIMKLA) 108543684(RIMKLB)

TFN:	117090541(RIMKLB) 117092770(RIMKLA)

PTEH:

111526616(RIMKLB) 111548818(RIMKLA)

CANG:

105513879(RIMKLA) 105519900(RIMKLB)

CJC:	100400904(RIMKLA) 100406491(RIMKLB)

SBQ:	101028223(RIMKLA) 101033047(RIMKLB)

CIMI:

108291858(RIMKLB) 108311366 108313389(RIMKLA)

ANAN:

105705148(RIMKLA) 105721347(RIMKLB)

CSYR:

103251714(RIMKLB) 103269612(RIMKLA)

MMUR:

105862291(RIMKLA) 105878274(RIMKLB)

LCAT:

123634283(RIMKLA) 123640042(RIMKLB)

PCOQ:

105805100(RIMKLB) 105812355(RIMKLA)

OGA:	100941690(RIMKLB) 100962508(RIMKLA)

MMU:	108653(Rimklb) 194237(Rimkla)

MCAL:

110293598(Rimkla) 110296264(Rimklb)

MPAH:

110316335(Rimklb) 110323614(Rimkla)

RNO:	100362344(Rimklbl1) 313553(Rimkla) 362428(Rimklb)

MCOC:

116096541(Rimkla) 116099539(Rimklb)

ANU:	117709313(Rimkla) 117715398(Rimklb)

MUN:	110547458(Rimkla) 110556298(Rimklb)

CGE:	100759423(Rimkla) 100760031(Rimklb)

MAUA:

101842752(Rimklb) 101843711(Rimkla)

PROB:

127225276(Rimkla) 127236141(Rimklb)

PLEU:

114683483(Rimklb) 114704934(Rimkla)

MORG:

121438947(Rimklb) 121448391(Rimkla)

MFOT:

126513197 126514898

AAMP:

119808422(Rimklb) 119818063(Rimkla)

NGI:	103727467(Rimklb) 103735994(Rimkla)

HGL:	101706744(Rimklb) 101721728(Rimkla)

CPOC:

100713055(Rimkla) 100732576(Rimklb)

CCAN:

109697724(Rimklb) 109702396(Rimkla)

DORD:

105986036(Rimkla) 105991108(Rimklb)

DSP:	122111270(Rimkla) 122127019(Rimklb)

PLOP:

125342895(Rimklb) 125354285(Rimkla)

NCAR:

124969199 124983424

MMMA:

107141636(Rimkla) 107159921(Rimklb)

OCU:	100346793 100356205

OPI:	101523234(RIMKLB) 101536112(RIMKLA)

TUP:	102472940(RIMKLB) 102474653(RIMKLA)

GVR:	103597920(RIMKLB) 103602407(RIMKLA)

CFA:	482445(RIMKLA) 486698(RIMKLB)

CLUD:

112642267(RIMKLA) 112675320(RIMKLB)

VVP:	112908198(RIMKLA) 112917302(RIMKLB)

VLG:	121479857(RIMKLB) 121481599(RIMKLA)

NPO:	129517123(RIMKLB) 129520538(RIMKLA)

AML:	100472546(RIMKLA) 100473320(RIMKLB)

UMR:	103669163(RIMKLB) 103670923(RIMKLA)

UAH:	113254814(RIMKLA) 113257923(RIMKLB)

UAR:	123781552(RIMKLB) 123793822(RIMKLA)

ELK:	111142053 111143454

LLV:	125098454 125106794

MPUF:

101680352(RIMKLB) 101690597(RIMKLA)

MNP:	132000685(RIMKLA) 132019465(RIMKLB)

MLK:	131809477(RIMKLA) 131839093(RIMKLB)

NVS:	122891599(RIMKLB) 122899834(RIMKLA)

ORO:	101368732(RIMKLA) 101374535(RIMKLB)

EJU:	114221687(RIMKLB) 114224206(RIMKLA)

ZCA:	113919895(RIMKLA) 113921819(RIMKLB)

MLX:	118019547(RIMKLA) 118025692(RIMKLB)

NSU:	110575430(RIMKLA) 110580730(RIMKLB)

LWW:	102733401(RIMKLA) 102741413(RIMKLB)

FCA:	101097740(RIMKLB) 101099388(RIMKLA)

PYU:	121022064(RIMKLB) 121026952(RIMKLA)

PCOO:

112863341(RIMKLA) 112867654(RIMKLB)

PBG:	122473789(RIMKLB) 122480352(RIMKLA)

PVIV:

125170874(RIMKLB) 125173105(RIMKLA)

LRUF:

124502657 124514137

PTG:	102959348(RIMKLA) 102963865(RIMKLB)

PPAD:

109254893(RIMKLA) 109276058(RIMKLB)

PUC:	125912708 125920076

AJU:	106965320 106970196

HHV:	120222721(RIMKLB) 120236090(RIMKLA)

BTA:	507323(RIMKLA) 538579(RIMKLB)

BOM:	102269649(RIMKLB) 102285876(RIMKLA)

BIU:	109556903(RIMKLA) 109559695(RIMKLB)

BBUB:

102397788(RIMKLB) 102407086(RIMKLA) 112578013

BBIS:

104995473(RIMKLB) 105004897(RIMKLA)

CHX:	102176861(RIMKLB) 102179728(RIMKLA)

OAS:	101102554(RIMKLB) 101104941(RIMKLA)

BTAX:

128044673(RIMKLA) 128047549(RIMKLB)

ODA:	120856323(RIMKLA) 120858791(RIMKLB)

CCAD:

122423372(RIMKLB) 122437135(RIMKLA) 122439954

MBEZ:

129535835(RIMKLB) 129541522(RIMKLA)

SSC:	100152915(RIMKLB) 100522878(RIMKLA)

CFR:	102503881(RIMKLB) 102522941(RIMKLA)

CBAI:

105062179(RIMKLB) 105072857(RIMKLA)

CDK:	105098170(RIMKLB) 105105491(RIMKLA)

VPC:	102526778(RIMKLB) 102545512(RIMKLA)

BACU:

103018606(RIMKLA) 103019013(RIMKLB)

BMUS:

118884598 118886232(RIMKLA) 118887952 118902028(RIMKLB)

LVE:	103069710(RIMKLB) 103083571(RIMKLA)

OOR:	101273054(RIMKLB) 101275823(RIMKLA)

DLE:	111175673(RIMKLA) 111176728(RIMKLB)

PCAD:

102975069 102981532(RIMKLB) 102982103(RIMKLA)

PSIU:

116746837 116760947(RIMKLB) 116762902(RIMKLA)

NASI:

112391802(RIMKLB) 112399558(RIMKLA)

ECB:	100061350(RIMKLB) 100067475(RIMKLA)

EPZ:	103557317(RIMKLA) 103564581(RIMKLB)

EAI:	106837431(RIMKLB) 106847814(RIMKLA)

MYB:	102245342(RIMKLB) 102249129(RIMKLA)

MYD:	102752373(RIMKLB) 102754710(RIMKLA)

MMYO:

118650363(RIMKLB) 118677485(RIMKLA)

MLF:	102430712(RIMKLA) 102441683(RIMKLB)

MDT:	132227250(RIMKLB) 132231150(RIMKLA)

PKL:	118723941(RIMKLA) 118728963(RIMKLB)

EFUS:

103285400(RIMKLB) 103294846(RIMKLA)

MNA:	107531164(RIMKLA) 107544073(RIMKLB)

DRO:	112299564(RIMKLA) 112322046(RIMKLB)

SHON:

118977580(RIMKLA) 119002540(RIMKLB)

AJM:	119052488(RIMKLA) 119065675(RIMKLB)

PDIC:

114497212(RIMKLA) 114514072(RIMKLB)

PHAS:

123819342(RIMKLB) 123831998(RIMKLA)

MMF:	118624708(RIMKLB) 118627179(RIMKLA)

PPAM:

129069083(RIMKLA) 129085032(RIMKLB)

HAI:	109372752(RIMKLB) 109383339(RIMKLA)

RFQ:	117027770(RIMKLA) 117028564(RIMKLB)

PALE:

102880426(RIMKLB) 102882758(RIMKLA)

PGIG:

120607199(RIMKLA) 120611695(RIMKLB)

PVP:	105295916(RIMKLB) 105304029(RIMKLA)

RAY:	107501656(RIMKLB) 107508299(RIMKLA)

MJV:	108396116(RIMKLB) 108403838(RIMKLA)

TOD:	119236219(RIMKLA) 119247737(RIMKLB)

SARA:

101544446(RIMKLA) 101554225(RIMKLB)

SETR:

126006581(RIMKLB) 126011165(RIMKLA)

LAV:	100657534(RIMKLB) 100664484(RIMKLA)

TMU:	101348075 101361972

ETF:	101645920(RIMKLB) 101661935(RIMKLA)

DNM:	101416522(RIMKLB) 101421529(RIMKLA)

MDO:	100013787(RIMKLB) 100026482(RIMKLA)

GAS:	123243217(RIMKLA) 123250757(RIMKLB)

SHR:	100913508(RIMKLA) 100930894(RIMKLB)

AFZ:	127539203 127555543

PCW:	110206227(RIMKLA) 110213807(RIMKLB)

TVP:	118840184(RIMKLA) 118850782(RIMKLB)

OAA:	100073839(RIMKLA) 100090307(RIMKLB)

GGA:	418255(RIMKLB)

PCOC:

116240958(RIMKLB)

MGP:

104916636

CJO:	107318392(RIMKLB)

TPAI:

128089909(RIMKLB)

LMUT:

125687916(RIMKLB)

NMEL:

110397764(RIMKLB)

APLA:

101792875(RIMKLB)

ACYG:

106048091(RIMKLB)

CATA:

118247607(RIMKLB)

AFUL:

116490791(RIMKLB)

TGU:	100220208(RIMKLB)

LSR:	110472321(RIMKLB)

SCAN:

103827201(RIMKLB)

PMOA:

120497743(RIMKLB)

OTC:	121341027(RIMKLB)

PRUF:

121349851(RIMKLB)

GFR:	102035986(RIMKLB)

FAB:	101814507(RIMKLB)

OMA:	130255587(RIMKLB)

PHI:	102111957(RIMKLB)

PMAJ:

107210434(RIMKLB)

CCAE:

111925810(RIMKLB)

CCW:	104690266(RIMKLB)

CBRC:

103616673(RIMKLB)

ETL:	114069342(RIMKLB)

ZAB:	102064947(RIMKLB)

ZLE:	135451535(RIMKLB)

ACHL:

103811885(RIMKLB)

SVG:	106859828(RIMKLB)

MMEA:

130579182(RIMKLB)

HRT:	120748584(RIMKLB)

SATI:

136375597(RIMKLB)

FPG:	101913481(RIMKLB)

FCH:	102056126(RIMKLB)

CCRI:

104158756(RIMKLB)

NNT:	104411662(RIMKLB)

SHAB:

115605282(RIMKLB)

ACUN:

113491069(RIMKLB)

TALA:

104365181(RIMKLB)

ACHC:

115352600(RIMKLB)

HALD:

104321852(RIMKLB)

HLE:	104836674(RIMKLB)

AGEN:

126047837

GCL:

127017595

CSTI:

104557469(RIMKLB)

LDI:	104343382(RIMKLB)

MNB:	103775226(RIMKLB)

DPUB:

104306895(RIMKLB)

AVIT:

104268972(RIMKLB)

BRHI:

104488456

EGZ:	104122771(RIMKLB)

NNI:	104014577(RIMKLB)

PCRI:

104036849(RIMKLA)

PCAO:

104053397(RIMKLB)

PADL:

103915115(RIMKLB)

AFOR:

103899962(RIMKLB)

FGA:	104072777(RIMKLB)

GSTE:

104257247(RIMKLB)

CLV:	102098362(RIMKLB)

MUI:	104538317(RIMKLB)

PGUU:

104458927(RIMKLB)

PLET:

104626869(RIMKLB)

EHS:	104510567(RIMKLB)

CMAC:

104474785(RIMKLB)

CUCA:

104060632(RIMKLB)

TEO:

104382280

BREG:

104641295(RIMKLB)

OHA:	104332450(RIMKLB)

ACAR:

104532919(RIMKLB)

CPEA:

104394530(RIMKLB)

CVF:	104294502(RIMKLB)

RTD:	128902766(RIMKLB)

AAM:	106495722(RIMKLB)

AROW:

112973974(RIMKLB)

NPD:	112952039(RIMKLB)

TGT:	104580212(RIMKLB)

DNE:	112992432(RIMKLB)

SCAM:

104152046(RIMKLB)

ASN:	102373845(RIMKLB)

AMJ:	102576775(RIMKLB)

CPOO:

109316234(RIMKLB)

GGN:	109296594(RIMKLB)

PSS:	102451018(RIMKLB)

CMY:	102933090(RIMKLB)

CCAY:

125623379(RIMKLB)

DCC:	119859155(RIMKLB)

CPIC:

101943668(RIMKLB)

TST:	117884982(RIMKLB)

CABI:

116823843(RIMKLB)

MRV:	120404562(RIMKLB)

ACS:	100563778(rimklb)

ASAO:

132767973(RIMKLB)

PVT:	110069781(RIMKLB)

SUND:

121921715(RIMKLB)

PBI:	103055545(RIMKLB)

PMUR:

107288539(RIMKLB)

CTIG:

120318691(RIMKLB)

TSR:	106544566(RIMKLB)

PGUT:

117661914(RIMKLB)

APRI:

131189735(RIMKLB)

PTEX:

113444557(RIMKLB)

NSS:	113425290(RIMKLB)

VKO:	123017759(RIMKLB)

PMUA:

114588043(RIMKLB)

PRAF:

128405389(RIMKLB)

ZVI:	118097943(RIMKLB)

HCG:	128346831(RIMKLB)

GJA:	107117747(RIMKLB)

STOW:

125437091(RIMKLB)

EMC:	129345231(RIMKLB)

XLA:	108696039 108696583 108697330

XTR:	100145548(rimkla) 100486701(rimklb)

NPR:	108783941(RIMKLA) 108799485(RIMKLB)

RTEM:

120915609(RIMKLA) 120946910(RIMKLB)

BBUF:

120998179(RIMKLA) 121005412(RIMKLB)

BGAR:

122926877(RIMKLA) 122941782(RIMKLB)

MUO:	115457690(RIMKLB)

GSH:	117350096(RIMKLB)

DRE:	447815(rimkla)

SRX:	107711947 107717536

SANH:

107669631

SGH:	107556480 107591767

CCAR:

109084979 109084984

CAUA:

113078389 113093917 113107768

CGIB:

127964047 128018591

PTET:

122350397(rimkla)

LROH:

127170090(rimkla)

OMC:	131545407(rimkla)

PPRM:

120483739(rimkla)

RKG:	130094558(rimkla)

MAMB:

125279787(rimkla)

CIDE:

127517732

CERY:

137027117(rimkla)

MASI:

127414466 127424193

TROS:

130567859(rimkla)

TDW:	130439951(rimkla)

MANU:

129413961(rimkla)

IPU:

108265850

IFU:	128607997(rimkla)

PHYP:

113529230

SMEO:

124399561(rimkla)

TFD:	113655760(rimkla)

TVC:	132853464(rimkla)

TRN:	134318214(rimkla)

AMEX:

103035057(rimkla)

CMAO:

118813696(rimkla)

EEE:

113572086

CHAR:

105902183(rimkla)

TRU:

101062827

TFS:	130530628(rimkla)

TNG:	GSTEN00013753G001

LCO:

104920219

NCC:	104955181(rimkla)

TBEN:

117494141(rimkla)

CGOB:

115011073

PGEO:

117449663(rimkla)

GACU:

117541819(rimkla)

EMAC:

134870674(rimkla)

ELY:	117258509(rimkla)

EFO:	125891718(rimkla)

PLEP:

121947276(rimkla)

SLUC:

116040663(rimkla)

ECRA:

117948232(rimkla)

ESP:

116692402

PFLV:

114558866

GAT:	120828693(rimkla)

PPUG:

119205701 119222662

AFB:	129100051(rimkla)

CLUM:

117732964(rimkla)

PSWI:

130199585(rimkla)

MSAM:

119905637(rimkla)

SCHU:

122882832(rimkla)

CUD:	121518035(rimkla)

ALAT:

119022909(rimkla)

MZE:

101477475

ONL:

100698845

OAU:	116309725(rimkla)

OLA:	101169452(rimklb)

OML:	112159079(rimkla)

CSAI:

133457317(rimkla)

XMA:

102218635

XCO:

114141086

XHE:

116725681

PRET:

103467997(rimkla)

PFOR:

103138952(rimkla)

PLAI:

106957454(rimkla)

PMEI:

106907435(rimkla)

GAF:	122836233(rimkla)

PPRL:

129372418(rimkla)

CVG:	107088869(rimkla)

CTUL:

119797064(rimkla)

GMU:	124867677(rimkla)

NFU:

107390714

KMR:	108236831(rimkla)

ALIM:

106524174

NWH:	119417065(rimkla)

AOCE:

111585273

MCEP:

124997852(rimkla)

CSEM:

103384935

POV:	109630621(rimkla)

SSEN:

122776960(rimkla)

HHIP:

117764653(rimkla)

HSP:	118110963(rimkla)

PPLT:

128442387(rimkla)

SMAU:

118317585(rimkla)

LCF:

108891717

SDU:

111219047

SLAL:

111670604

XGL:	120804092(rimkla)

HCQ:

109526583

SSCV:

125988093

SBIA:

133508604(rimkla)

PEE:	133405192(rimkla)

PTAO:

133482673(rimkla)

BPEC:

110161111

MALB:

109970719

BSPL:

114858903(rimkla)

SJO:	128357364(rimkla)

SASA:

106567384 106572158

STRU:

115166047 115168921

OTW:	112215953 112221609

OMY:	110491822 110532211

OGO:	124017459 124031877

ONE:	115102623 115132092

OKI:	109869491 109907940

OKE:	118360188 118361096

SALP:

111966388 111976646

SNH:	120059373 120060966

CCLU:

121538272 121545958

ELS:

105013808

SFM:	108918203 108924922

PKI:	111856970 111859075(rimkla)

AANG:

118208179(rimkla)

LOC:	102687393(rimkla)

PSPA:

121296514 121325367 121328885 121329280

ARUT:

117424072 117425213 117425745 117432003

PSEX:

120530966(rimkla) 120535665

LCM:	102351441(RIMKLB) 102354509(RIMKLA)

CMK:	103190080(rimkla)

RTP:	109924989(rimkla)

CPLA:

122540248(rimkla)

HOC:	132833521(rimkla)

LERI:

129711474(rimkla)

PMRN:

116937615 116948844

LRJ:

133345229

» show all

Reference

1 [PMID:20643647]

Authors

Becker I, Lodder J, Gieselmann V, Eckhardt M

Title

Molecular characterization of N-acetylaspartylglutamate synthetase.

Journal

J Biol Chem 285:29156-64 (2010)
DOI:10.1074/jbc.M110.111765

Sequence

[mmu:108653] [hsa:57494]

Reference

2 [PMID:20657015]

Authors

Collard F, Stroobant V, Lamosa P, Kapanda CN, Lambert DM, Muccioli GG, Poupaert JH, Opperdoes F, Van Schaftingen E

Title

Molecular identification of N-acetylaspartylglutamate synthase and beta-citrylglutamate synthase.

Journal

J Biol Chem 285:29826-33 (2010)
DOI:10.1074/jbc.M110.152629

Sequence

[mmu:194237 108653]

Reference

3 [PMID:21454531]

Authors

Lodder-Gadaczek J, Becker I, Gieselmann V, Wang-Eckhardt L, Eckhardt M

Title

N-acetylaspartylglutamate synthetase II synthesizes N-acetylaspartylglutamylglutamate.

Journal

J Biol Chem 286:16693-706 (2011)
DOI:10.1074/jbc.M111.230136

Sequence

[mmu:194237] [hsa:284716]

Other DBs

ExplorEnz - The Enzyme Database:

6.3.2.41

IUBMB Enzyme Nomenclature:

6.3.2.41

ExPASy - ENZYME nomenclature database:

6.3.2.41

BRENDA, the Enzyme Database:

6.3.2.41

LinkDB

DBGET integrated database retrieval system