In Escherichia coli, this enzyme, along with EC 22.214.171.124
, 5-(carboxyamino)imidazole ribonucleotide mutase, is required to carry out the single reaction catalysed by EC 126.96.36.199
, phosphoribosylaminoimidazole carboxylase, in vertebrates. Belongs to the ATP grasp protein superfamily . Carboxyphosphate is the putative acyl phosphate intermediate. Involved in the late stages of purine biosynthesis.