KEGG   DRUG: NaproxenHelp
Entry
D00118                      Drug                                   

Name
Naproxen (JP17/USP/INN);
Naprosyn (TN)
Product
  Generic
NAPROXEN (A-S Medication Solutions), NAPROXEN (A-S Medication Solutions), NAPROXEN (A-S Medication Solutions), NAPROXEN (A-S Medication Solutions), NAPROXEN (A-S Medication Solutions), NAPROXEN (A-S Medication Solutions), NAPROXEN (A-S Medication Solutions), NAPROXEN (A-S Medication Solutions), NAPROXEN (A-S Medication Solutions), NAPROXEN (A-S Medication Solutions), NAPROXEN (Aidarex Pharmaceuticals LLC), NAPROXEN (Aidarex Pharmaceuticals LLC), NAPROXEN (Aidarex Pharmaceuticals LLC), NAPROXEN (Aidarex Pharmaceuticals LLC), NAPROXEN (Aidarex Pharmaceuticals LLC), NAPROXEN (Aidarex Pharmaceuticals LLC), NAPROXEN (American Health Packaging), NAPROXEN (Amneal Pharmaceuticals LLC), NAPROXEN (Amneal Pharmaceuticals of New York LLC), NAPROXEN (Aphena Pharma Solutions - Tennessee), NAPROXEN (Aphena Pharma Solutions - Tennessee), NAPROXEN (Aphena Pharma Solutions - Tennessee), NAPROXEN (Aphena Pharma Solutions - Tennessee), NAPROXEN (Apotheca), NAPROXEN (Apotheca), NAPROXEN (Aurobindo Pharma Limited), NAPROXEN (AvKARE), NAPROXEN (AvKARE), NAPROXEN (AvPAK), NAPROXEN (Avera McKennan Hospital), FLANAX NAPROXEN (Belmora LLC), NAPROXEN (Biomes Pharmaceuticals), NAPROXEN (Blenheim Pharmacal), NAPROXEN (Blenheim Pharmacal), NAPROXEN (Blenheim Pharmacal), NAPROXEN (Blenheim Pharmacal), NAPROXEN (Blenheim Pharmacal), NAPROXEN (Blenheim Pharmacal), NAPROXEN (Blenheim Pharmacal), NAPROXEN (Blenheim Pharmacal), NAPROXEN (Blenheim Pharmacal), NAPROXEN (Bryant Ranch Prepack), NAPROXEN (Bryant Ranch Prepack), NAPROXEN (Bryant Ranch Prepack), NAPROXEN (Bryant Ranch Prepack), NAPROXEN (Bryant Ranch Prepack), NAPROXEN (Bryant Ranch Prepack), NAPROXEN (Bryant Ranch Prepack), NAPROXEN (Bryant Ranch Prepack), NAPROXEN (Bryant Ranch Prepack), NAPROXEN (Cadila Healthcare Limited), NAPROXEN (Camber Pharmaceuticals), NAPROXEN (Camber Pharmaceuticals), NAPROXEN (Carilion Materials Management), NAPROXEN (Carilion Materials Management), NAPROXEN (Carilion Materials Management), NAPROXEN (Cipla USA), NAPROXEN (Cipla USA), NAPROXEN (Citron Pharma LLC), NAPROXEN (Clinical Solutions Wholesale), NAPROXEN (Contract Pharmacy Services-PA), NAPROXEN (DIRECT RX), NAPROXEN (DIRECT RX), NAPROXEN (Denton Pharma), NAPROXEN (Direct RX), NAPROXEN (DirectRX), NAPROXEN (Dispensing Solutions), NAPROXEN (Dispensing Solutions), NAPROXEN (Exelan Pharmaceuticals), NAPROXEN (H.J. Harkins Company), NAPROXEN (H.J. Harkins Company), NAPROXEN (H.J. Harkins Company.), NAPROXEN (KAISER FOUNDATION HOSPITALS), NAPROXEN (Keltman Pharmaceuticals), NAPROXEN (Lake Erie Medical & Surgical Supply DBA Quality Care Products LLC), NAPROXEN (Lake Erie Medical DBA Quality Care Products LLC), NAPROXEN (Lake Erie Medical DBA Quality Care Products LLC), NAPROXEN (Lake Erie Medical DBA Quality Care Products LLC), NAPROXEN (Lake Erie Medical DBA Quality Care Products LLC), NAPROXEN (Lake Erie Medical DBA Quality Care Products LLC), NAPROXEN (Lake Erie Medical DBA Quality Care Products LLC), NAPROXEN (Liberty Pharmaceuticals), NAPROXEN (Liberty Pharmaceuticals), NAPROXEN (Life Line Home Care Services), NAPROXEN (MARKSANS PHARMA LIMITED), NAPROXEN (MAS MANAGEMENT GROUP), NAPROXEN (Major Pharmaceuticals), NAPROXEN (Major Pharmaceuticals), NAPROXEN (McKesson Corporation), NAPROXEN (Medsource Pharmaceuticals), NAPROXEN (NCS HealthCare of KY), NAPROXEN (NCS HealthCare of KY), NAPROXEN (NCS HealthCare of KY), NAPROXEN (NCS HealthCare of KY), NAPROXEN (Northwind Pharmaceuticals), NAPROXEN (NuCare Pharmaceuticals), NAPROXEN (NuCare Pharmaceuticals), NAPROXEN (NuCare Pharmaceuticals), NAPROXEN (NuCare Pharmaceuticals), NAPROXEN (NuCare Pharmaceuticals), NAPROXEN (NuCare Pharmaceuticals), NAPROXEN (NuCare Pharmaceuticals), NAPROXEN (NuCare Pharmaceuticals), NAPROXEN (NuCare Pharmaceuticals), NAPROXEN (NuCare Pharmaceuticals), NAPROXEN (NuCare Pharmaceuticals), NAPROXEN (NuCare Pharmaceuticals), NAPROXEN (NuCare Pharmaceuticals), NAPROXEN (NuCare Pharmaceuticals), NAPROXEN (PD-Rx Pharmaceuticals), NAPROXEN (PD-Rx Pharmaceuticals), NAPROXEN (PD-Rx Pharmaceuticals), NAPROXEN (PD-Rx Pharmaceuticals), NAPROXEN (PD-Rx Pharmaceuticals), NAPROXEN (Palmetto Pharmaceuticals), NAPROXEN (Polygen Pharmaceuticals LLC), NAPROXEN (Preferred Pharmaceuticals), NAPROXEN (Preferred Pharmaceuticals), NAPROXEN (Preferred Pharmaceuticals), NAPROXEN (Preferred Pharmaceuticals), NAPROXEN (Preferred Pharmaceuticals), NAPROXEN (Preferred Pharmaceuticals), NAPROXEN (Preferred Pharmaceuticals), NAPROXEN (Preferred Pharmaceuticals), NAPROXEN (Preferred Pharmaceuticals), NAPROXEN (Preferred Pharmaceuticals), NAPROXEN (Proficient Rx LP), NAPROXEN (Proficient Rx LP), NAPROXEN (Proficient Rx LP), NAPROXEN (Proficient Rx LP), NAPROXEN (Proficient Rx LP), NAPROXEN (QPharma), NAPROXEN (QPharma), NAPROXEN (QPharma), NAPROXEN (QPharma), NAPROXEN (REMEDYREPACK), NAPROXEN (REMEDYREPACK), NAPROXEN (REMEDYREPACK), NAPROXEN (REMEDYREPACK), NAPROXEN (REMEDYREPACK), NAPROXEN (REMEDYREPACK), NAPROXEN (REMEDYREPACK), NAPROXEN (REMEDYREPACK), NAPROXEN (REMEDYREPACK), NAPROXEN (REMEDYREPACK), NAPROXEN (REMEDYREPACK), NAPROXEN (REMEDYREPACK), NAPROXEN (REMEDYREPACK), NAPROXEN (REMEDYREPACK), NAPROXEN (REMEDYREPACK), NAPROXEN (RPK Pharmaceuticals), NAPROXEN (Rebel Distributors Corp), NAPROXEN (Rebel Distributors Corp), NAPROXEN (Rebel Distributors Corp), NAPROXEN (Rebel Distributors Corp.), NAPROXEN (RedPharm Drug), NAPROXEN (RedPharm Drug), NAPROXEN (RedPharm Drug), NAPROXEN (RedPharm Drug), NAPROXEN (RedPharm Drug), NAPROXEN (St. Mary's Medical Park Pharmacy), NAPROXEN (St. Mary's Medical Park Pharmacy), NAPROXEN (St. Mary's Medical Park Pharmacy), NAPROXEN (State of Florida DOH Central Pharmacy), NAPROXEN (State of Florida DOH Central Pharmacy), NAPROXEN (State of Florida DOH Central Pharmacy), NAPROXEN (State of Florida DOH Central Pharmacy), NAPROXEN (TIME CAP LABORATORIES), NAPROXEN (Teva Pharmaceuticals USA), NAPROXEN (Unit Dose Services), NAPROXEN (Unit Dose Services), NAPROXEN (Unit Dose Services), NAPROXEN (Unit Dose Services), NAPROXEN (Unit Dose Services), NAPROXEN (Unit Dose Services), NAPROXEN (West-Ward Pharmaceuticals Corp), NAPROXEN (Zydus Pharmaceuticals (USA)), NAPROXEN DELAYED RELEASE (Northwind Pharmaceuticals), NAPROXEN (DIRECT RX), NAPROXEN SODIUM (Northwind Pharmaceuticals)
Formula
C14H14O3
Exact mass
230.0943
Mol weight
230.2592
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Anti-inflammatory
 DG01908  Antiinflammatory drug, propionic acid derivatives
 DG01504  Nonsteroidal antiinflammatory drug (NSAID)
  DG01908  Antiinflammatory drug, propionic acid derivatives
Remark
Same as: C01517
Therapeutic category: 1149
ATC code: G02CC02 M01AE02 M02AA12
Chemical structure group: DG00455
Product (DG00455): D00118<JP/US> D00970<US>
Efficacy
Analgesic, Anti-inflammatory, Antipyretic, COX inhibitor
Comment
Propionic acid derivative
Target
PTGS1 (COX1) [HSA:5742] [KO:K00509]
PTGS2 (COX2) [HSA:5743] [KO:K11987]
  Pathway
hsa00590  Arachidonic acid metabolism
Interaction
Drug interaction
Structure map
map07048  Antimigraines
map07114  Naphthalene family
map07219  Cyclooxygenase inhibitors
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 G GENITO URINARY SYSTEM AND SEX HORMONES
  G02 OTHER GYNECOLOGICALS
   G02C OTHER GYNECOLOGICALS
    G02CC Antiinflammatory products for vaginal administration
     G02CC02 Naproxen
      D00118  Naproxen (JP17/USP/INN) <JP/US>
 M MUSCULO-SKELETAL SYSTEM
  M01 ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS
   M01A ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS
    M01AE Propionic acid derivatives
     M01AE02 Naproxen
      D00118  Naproxen (JP17/USP/INN) <JP/US>
  M02 TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN
   M02A TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN
    M02AA Antiinflammatory preparations, non-steroids for topical use
     M02AA12 Naproxen
      D00118  Naproxen (JP17/USP/INN) <JP/US>
USP drug classification [BR:br08302]
 Analgesics
  Nonsteroidal Anti-inflammatory Drugs
   Naproxen
    D00118  Naproxen (JP17/USP/INN)
 Anti-inflammatory Agents
  Nonsteroidal Anti-inflammatory Drugs
   Naproxen
    D00118  Naproxen (JP17/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   114  Antipyretics and analgesics, anti-inflammatory agents
    1149  Others
     D00118  Naproxen (JP17/USP/INN)
Target-based classification of drugs [BR:br08310]
 Enzymes
  Oxidoreductases (EC1)
   Prostaglandin synthase
    PTGS1 (COX1)
     D00118  Naproxen (JP17/USP/INN) <JP/US>
    PTGS2 (COX2)
     D00118  Naproxen (JP17/USP/INN) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00118  Naproxen
Drug classes of therapeutic agents [br08360.html]
 Antirheumatic and antigout agents
  D00118
 Anesthetics, analgesics and anti-inflammatory drugs
  D00118
BRITE hierarchy
Other DBs
CAS: 22204-53-1
PubChem: 7847186
ChEBI: 7476
ChEMBL: CHEMBL154
DrugBank: DB00788
PDB-CCD: NPS[PDBj]
LigandBox: D00118
NIKKAJI: J9.289D
LinkDB All DBs
KCF data Show

ATOM        17
            1   C8y C    24.6254  -20.0866
            2   C8y C    24.6254  -21.4127
            3   C8x C    25.8119  -19.3887
            4   C8x C    23.5087  -19.3887
            5   C8x C    23.5087  -22.1106
            6   C8x C    25.8119  -22.1106
            7   C8y C    26.9983  -20.0866
            8   C8x C    22.3222  -20.0866
            9   C8y C    22.3222  -21.4127
            10  C8x C    26.9983  -21.3429
            11  C1c C    28.1848  -19.3887
            12  O2a O    21.1358  -22.1106
            13  C6a C    29.3015  -20.0866
            14  C1a C    28.1848  -18.0626
            15  C1a C    19.4607  -21.0637
            16  O6a O    30.6974  -19.1793
            17  O6a O    29.3015  -21.4127
BOND        18
            1     1   2 2
            2     1   3 1
            3     1   4 1
            4     2   5 1
            5     2   6 1
            6     3   7 2
            7     4   8 2
            8     5   9 2
            9     6  10 2
            10    7  11 1
            11    9  12 1
            12   11  13 1
            13   11  14 1 #Down
            14   12  15 1
            15   13  16 1
            16   13  17 2
            17    7  10 1
            18    8   9 1

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