| Entry |
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| Name |
Naproxen and esomeprazole magnesium;
Vimovo (TN) |
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| Product |
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| Generic |
NAPROXEN AND ESOMEPRAZOLE MAGNESIUM (Ajanta Pharma USA), NAPROXEN AND ESOMEPRAZOLE MAGNESIUM (Asclemed USA), NAPROXEN AND ESOMEPRAZOLE MAGNESIUM (Bryant Ranch Prepack), NAPROXEN AND ESOMEPRAZOLE MAGNESIUM (Bryant Ranch Prepack), NAPROXEN AND ESOMEPRAZOLE MAGNESIUM (Bryant Ranch Prepack), NAPROXEN AND ESOMEPRAZOLE MAGNESIUM (Dr. Reddy's Laboratories Limited), NAPROXEN AND ESOMEPRAZOLE MAGNESIUM (PHOENIX RX LLC), NAPROXEN AND ESOMEPRAZOLE MAGNESIUM (PHOENIX RX LLC), NAPROXEN AND ESOMEPRAZOLE MAGNESIUM (Preferred Pharmaceuticals), NAPROXEN AND ESOMEPRAZOLE MAGNESIUM (Preferred Pharmaceuticals), NAPROXEN AND ESOMEPRAZOLE MAGNESIUM (ScieGen Pharmaceuticals) |
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| Component |
Naproxen [DR: D00118], (Esomeprazole magnesium [DR: D01984] | Esomeprazole magnesium dihydrate [DR: D11114])
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| Class |
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| Remark |
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| Efficacy |
Anti-infammatory, Antirheumatic |
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| Disease |
Gastric ulcer [DS: H01634] Rheumatoid arthritis [DS: H00630] Ankylosing spondylitis [DS: H01674] Juvenile idiopathic arthritis [DS: H01672] |
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| Comment |
Naproxen is a substrate of CYP2C9 and CYP1A2.
Esomeprazole is metabolized by CYP2C19 with some contribution from CYP3A4.
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| Metabolism |
Enzyme: CYP2C9 [HSA: 1559], CYP1A2 [HSA: 1544], CYP2C19 [HSA: 1557]; CYP3A4 [HSA: 1576]
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| Interaction |
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
M MUSCULO-SKELETAL SYSTEM
M01 ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS
M01A ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS
M01AE Propionic acid derivatives
M01AE52 Naproxen and esomeprazole
D11576 Naproxen and esomeprazole magnesium <US>
USP drug classification [BR:br08302]
Analgesics
Nonsteroidal Anti-inflammatory Drugs
Esomeprazole Magnesium/ Naproxen
D11576 Naproxen and esomeprazole magnesium
Drug groups [BR:br08330]
Metabolizing enzyme substrate
DG01892 CYP1A2 substrate
D11576 Naproxen and esomeprazole magnesium
DG01642 CYP2C9 substrate
D11576 Naproxen and esomeprazole magnesium
DG01639 CYP2C19 substrate
D11576 Naproxen and esomeprazole magnesium
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
D11576 Naproxen and esomeprazole magnesium
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D11576
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| Other DBs |
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| LinkDB |
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