KEGG   DRUG: Indomethacin
Entry
D00141                      Drug                                   
Name
Indomethacin (USP);
Indometacin (JP18/INN);
Aconip (TN);
Indocin (TN)
Product
  Generic
INDOMETHACIN (A-S Medication Solutions), INDOMETHACIN (A-S Medication Solutions), INDOMETHACIN (A-S Medication Solutions), INDOMETHACIN (A-S Medication Solutions), INDOMETHACIN (A-S Medication Solutions), INDOMETHACIN (American Health Packaging), INDOMETHACIN (Amneal Pharmaceuticals LLC), INDOMETHACIN (Asclemed USA), INDOMETHACIN (Asclemed USA), INDOMETHACIN (AvPAK), INDOMETHACIN (Bryant Ranch Prepack), INDOMETHACIN (Bryant Ranch Prepack), INDOMETHACIN (Bryant Ranch Prepack), INDOMETHACIN (Bryant Ranch Prepack), INDOMETHACIN (Bryant Ranch Prepack), INDOMETHACIN (Bryant Ranch Prepack), INDOMETHACIN (Bryant Ranch Prepack), INDOMETHACIN (Bryant Ranch Prepack), INDOMETHACIN (Bryant Ranch Prepack), INDOMETHACIN (Bryant Ranch Prepack), INDOMETHACIN (Bryant Ranch Prepack), INDOMETHACIN (Bryant Ranch Prepack), INDOMETHACIN (Bryant Ranch Prepack), INDOMETHACIN (Bryant Ranch Prepack), INDOMETHACIN (Camber Pharmaceuticals), INDOMETHACIN (Camber Pharmaceuticals), INDOMETHACIN (Chartwell RX), INDOMETHACIN (DIRECT RX), INDOMETHACIN (DIRECT RX), INDOMETHACIN (Denton Pharma), INDOMETHACIN (Direct Rx), INDOMETHACIN (Direct_Rx), INDOMETHACIN (Glenmark Pharmaceuticals), INDOMETHACIN (Glenmark Pharmaceuticals), INDOMETHACIN (Ingenus Pharmaceuticals), INDOMETHACIN (Jubilant Cadista Pharmaceuticals), INDOMETHACIN (KVK-Tech), INDOMETHACIN (Lake Erie Medical DBA Quality Care Products LLC), INDOMETHACIN (Lake Erie Medical DBA Quality Care Products LLC), INDOMETHACIN (Northwind Pharmaceuticals), INDOMETHACIN (Northwind Pharmaceuticals), INDOMETHACIN (NuCare Pharmaceuticals), INDOMETHACIN (NuCare Pharmaceuticals), INDOMETHACIN (NuCare Pharmaceuticals), INDOMETHACIN (NuCare Pharmaceuticals), INDOMETHACIN (NuCare Pharmaceuticals), INDOMETHACIN (NuCare Pharmaceuticals), INDOMETHACIN (PD-Rx Pharmaceuticals), INDOMETHACIN (PD-Rx Pharmaceuticals), INDOMETHACIN (PD-Rx Pharmaceuticals), INDOMETHACIN (PD-Rx Pharmaceuticals), INDOMETHACIN (PD-Rx Pharmaceuticals), INDOMETHACIN (PD-Rx Pharmaceuticals), INDOMETHACIN (Preferred Pharmaceuticals), INDOMETHACIN (Preferred Pharmaceuticals), INDOMETHACIN (Preferred Pharmaceuticals), INDOMETHACIN (Preferred Pharmaceuticals), INDOMETHACIN (Proficient Rx LP), INDOMETHACIN (Proficient Rx LP), INDOMETHACIN (Proficient Rx LP), INDOMETHACIN (Proficient Rx LP), INDOMETHACIN (Proficient Rx LP), INDOMETHACIN (REMEDYREPACK), INDOMETHACIN (REMEDYREPACK), INDOMETHACIN (REMEDYREPACK), INDOMETHACIN (REMEDYREPACK), INDOMETHACIN (REMEDYREPACK), INDOMETHACIN (RPK Pharmaceuticals), INDOMETHACIN (RPK Pharmaceuticals), INDOMETHACIN (RPK Pharmaceuticals), INDOMETHACIN (RedPharm Drug), INDOMETHACIN (RedPharm Drug), INDOMETHACIN (RedPharm Drug), INDOMETHACIN (RedPharm Drug), INDOMETHACIN (St. Mary's Medical Park Pharmacy), INDOMETHACIN (Viona Pharmaceuticals), INDOMETHACIN (XLCare Pharmaceuticals), INDOMETHACIN (Zydus Lifesciences Limited), INDOMETHACIN (Zydus Lifesciences Limited), INDOMETHACIN (Zydus Pharmaceuticals (USA)), INDOCIN (Zyla Life Sciences US)
Formula
C19H16ClNO4
Exact mass
357.0768
Mol weight
357.7876
Structure
Simcomp
Class
Anti-inflammatory
 DG01504  Nonsteroidal anti-inflammatory drug (NSAID)
  DG01906  Anti-inflammatory drug, acetic acid derivatives
   DG01899  Anti-inflammatory drug, indoleacetic acid derivatives
Remark
Same as: C01926
Therapeutic category: 1145 2649
ATC code: C01EB03 M01AB01 M02AA23 S01BC01
Chemical structure group: DG00241
Product (DG00241): D00141<JP/US> D01565<JP> D02110<JP/US>
Efficacy
Analgesic, Anti-inflammatory, Antipyretic, COX inhibitor
  Disease
Rheumatoid arthritis [DS:H00630]
Ankylosing spondylitis [DS:H01674]
Acute gouty arthritis [DS:H01532]
Comment
Indole acetic acid derivative
Target
PTGS1 (COX1) [HSA:5742] [KO:K00509]
PTGS2 (COX2) [HSA:5743] [KO:K11987]
  Pathway
hsa00590  Arachidonic acid metabolism
Interaction
Structure map
map07219  Cyclooxygenase inhibitors
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C01 CARDIAC THERAPY
   C01E OTHER CARDIAC PREPARATIONS
    C01EB Other cardiac preparations
     C01EB03 Indometacin
      D00141  Indomethacin (USP) <JP/US>
 M MUSCULO-SKELETAL SYSTEM
  M01 ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS
   M01A ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS
    M01AB Acetic acid derivatives and related substances
     M01AB01 Indometacin
      D00141  Indomethacin (USP) <JP/US>
  M02 TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN
   M02A TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN
    M02AA Antiinflammatory preparations, non-steroids for topical use
     M02AA23 Indometacin
      D00141  Indomethacin (USP) <JP/US>
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01B ANTIINFLAMMATORY AGENTS
    S01BC Antiinflammatory agents, non-steroids
     S01BC01 Indometacin
      D00141  Indomethacin (USP) <JP/US>
USP drug classification [BR:br08302]
 Analgesics
  Nonsteroidal Anti-inflammatory Drugs
   Indomethacin
    D00141  Indomethacin (USP)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   114  Antipyretics and analgesics, anti-inflammatory agents
    1145  Indomethacins
     D00141  Indomethacin (USP); Indometacin (JP18/INN)
 2  Agents affecting individual organs
  26  Epidermides
   264  Analgesics, anti-itchings, astringents, anti-inflammatory agents
    2649  Others
     D00141  Indomethacin (USP); Indometacin (JP18/INN)
Classification of Japanese OTC drugs [BR:br08313]
 Agents for integumentary system
  57 Analgesic, antipruritic, astringent, and anti-inflammatory remedies (incl. gel patches)
   D00141  Indomethacin (USP)
Risk category of Japanese OTC drugs [BR:br08312]
 Second-class OTC drugs
  Inorganic and organic chemicals
   Indometacin
    D00141  Indomethacin (USP)
Drug groups [BR:br08330]
 Anti-inflammatory
  DG01504  Nonsteroidal anti-inflammatory drug (NSAID)
   DG01906  Anti-inflammatory drug, acetic acid derivatives
    DG01899  Anti-inflammatory drug, indoleacetic acid derivatives
     DG00241  Indometacin
      D00141  Indomethacin
Drug classes [BR:br08332]
 Anti-inflammatory
  DG01504  Nonsteroidal anti-inflammatory drug (NSAID)
   D00141  Indomethacin
Target-based classification of drugs [BR:br08310]
 Enzymes
  Oxidoreductases (EC1)
   Prostaglandin synthase
    PTGS1 (COX1)
     D00141  Indomethacin (USP) <JP/US>
    PTGS2 (COX2)
     D00141  Indomethacin (USP) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00141  Indometacin
  D00141  Indometacin capsules
  D00141  Indometacin suppositories
Prodrugs [br08324.html]
 D00141
Rx-to-OTC switch list in Japan [br08314.html]
 D00141
Drug groups [BR:br08330]
 Anti-inflammatory
  DG01504  Nonsteroidal anti-inflammatory drug (NSAID)
   DG01906  Anti-inflammatory drug, acetic acid derivatives
    DG01899  Anti-inflammatory drug, indoleacetic acid derivatives
     DG00241  Indometacin
Other DBs
CAS: 53-86-1
PubChem: 7847209
ChEBI: 49662
PDB-CCD: IMN[PDBj]
LigandBox: D00141
NIKKAJI: J1.368D
LinkDB
KCF data

ATOM        25
            1   C8y C    23.8648  -19.0768
            2   C8y C    23.8564  -20.5490
            3   C1a C    25.1409  -21.2966
            4   C6a C    26.4256  -19.0915
            5   C1b C    25.1494  -18.3439
            6   C8y C    21.5264  -20.4363
            7   C8y C    21.5264  -19.0827
            8   N4y N    22.7025  -21.1172
            9   C8x C    20.3428  -21.1031
            10  C8x C    20.3428  -18.3946
            11  C5a C    22.7118  -22.4351
            12  C8x C    19.1807  -20.4363
            13  C8y C    19.1807  -19.0827
            14  C8y C    21.9087  -22.9293
            15  O2a O    18.0197  -18.4158
            16  C8x C    20.7461  -22.2186
            17  C8x C    21.8611  -24.2805
            18  C1a C    16.8577  -19.0968
            19  C8x C    19.5535  -22.8588
            20  C8x C    20.6841  -24.9202
            21  C8y C    19.5286  -24.2071
            22  X   Cl   18.3219  -24.7917
            23  O6a O    27.7101  -18.3588
            24  O6a O    26.4256  -20.5638
            25  O5a O    23.9557  -23.1242
BOND        27
            1     2   3 1
            2     6   7 2
            3     6   8 1
            4     6   9 1
            5     7   1 1
            6     7  10 1
            7     8   2 1
            8     8  11 1
            9     9  12 2
            10   10  13 2
            11   11  14 1
            12   13  15 1
            13   14  16 2
            14   14  17 1
            15   15  18 1
            16   16  19 1
            17   17  20 2
            18   19  21 2
            19   21  22 1
            20   12  13 1
            21   20  21 1
            22    4   5 1
            23    4  23 1
            24    5   1 1
            25    4  24 2
            26    1   2 2
            27   11  25 2

» Japanese version   » Back

KEGG   DRUG: Indomethacin sodium
Entry
D02110                      Drug                                   
Name
Indomethacin sodium (USP);
Indometacin sodium hydrate (JAN);
Indomethacin sodium trihydrate;
Indometacin sodium;
Indocin I.V. (TN)
Product
  Generic
Formula
C19H15ClNO4. 3H2O. Na
Exact mass
433.0904
Mol weight
433.8153
Structure
Simcomp
Class
Anti-inflammatory
 DG01504  Nonsteroidal anti-inflammatory drug (NSAID)
  DG01906  Anti-inflammatory drug, acetic acid derivatives
   DG01899  Anti-inflammatory drug, indoleacetic acid derivatives
Remark
Therapeutic category: 2190
ATC code: C01EB03 M01AB01 M02AA23 S01BC01
Chemical structure group: DG00241
Product (DG00241): D00141<JP/US> D01565<JP> D02110<JP/US>
Efficacy
Anti-inflammatory, Cardiovascular agent, COX inhibitor
Comment
Indole acetic acid derivative
Target
PTGS1 (COX1) [HSA:5742] [KO:K00509]
PTGS2 (COX2) [HSA:5743] [KO:K11987]
  Pathway
hsa00590  Arachidonic acid metabolism
Interaction
Structure map
map07219  Cyclooxygenase inhibitors
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C01 CARDIAC THERAPY
   C01E OTHER CARDIAC PREPARATIONS
    C01EB Other cardiac preparations
     C01EB03 Indometacin
      D02110  Indomethacin sodium (USP) <JP/US>
 M MUSCULO-SKELETAL SYSTEM
  M01 ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS
   M01A ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS
    M01AB Acetic acid derivatives and related substances
     M01AB01 Indometacin
      D02110  Indomethacin sodium (USP) <JP/US>
  M02 TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN
   M02A TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN
    M02AA Antiinflammatory preparations, non-steroids for topical use
     M02AA23 Indometacin
      D02110  Indomethacin sodium (USP) <JP/US>
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01B ANTIINFLAMMATORY AGENTS
    S01BC Antiinflammatory agents, non-steroids
     S01BC01 Indometacin
      D02110  Indomethacin sodium (USP) <JP/US>
USP drug classification [BR:br08302]
 Analgesics
  Nonsteroidal Anti-inflammatory Drugs
   Indomethacin
    D02110  Indomethacin sodium (USP)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  21  Cardiovascular agents
   219  Miscellaneous
    2190  Miscellaneous
     D02110  Indomethacin sodium (USP); Indometacin sodium hydrate (JAN)
Drug groups [BR:br08330]
 Anti-inflammatory
  DG01504  Nonsteroidal anti-inflammatory drug (NSAID)
   DG01906  Anti-inflammatory drug, acetic acid derivatives
    DG01899  Anti-inflammatory drug, indoleacetic acid derivatives
     DG00241  Indometacin
      D02110  Indomethacin sodium
Drug classes [BR:br08332]
 Anti-inflammatory
  DG01504  Nonsteroidal anti-inflammatory drug (NSAID)
   D02110  Indomethacin sodium
Target-based classification of drugs [BR:br08310]
 Enzymes
  Oxidoreductases (EC1)
   Prostaglandin synthase
    PTGS1 (COX1)
     D02110  Indomethacin sodium (USP) <JP/US>
    PTGS2 (COX2)
     D02110  Indomethacin sodium (USP) <JP/US>
Drug groups [BR:br08330]
 Anti-inflammatory
  DG01504  Nonsteroidal anti-inflammatory drug (NSAID)
   DG01906  Anti-inflammatory drug, acetic acid derivatives
    DG01899  Anti-inflammatory drug, indoleacetic acid derivatives
     DG00241  Indometacin
Other DBs
CAS: 74252-25-8
PubChem: 7849171
LigandBox: D02110
LinkDB
KCF data

ATOM        29
            1   C8y C    21.1257  -17.8394
            2   C8y C    21.1187  -19.3169
            3   C1a C    22.4058  -20.0688
            4   C6a C    23.7002  -17.8586
            5   C1b C    22.4129  -17.1068
            6   C8y C    18.7772  -19.2026
            7   C8y C    18.7772  -17.8443
            8   N4y N    19.9606  -19.8922
            9   C8x C    17.5875  -19.8735
            10  C8x C    17.5875  -17.1557
            11  C5a C    19.9253  -21.2367
            12  C8x C    16.4228  -19.2026
            13  C8y C    16.4228  -17.8443
            14  C8y C    19.1044  -21.6949
            15  O2a O    15.2590  -17.1804
            16  C8x C    17.9102  -21.0300
            17  C8x C    19.1025  -23.0588
            18  C1a C    14.0872  -17.8630
            19  C8x C    16.7373  -21.7153
            20  C8x C    17.9487  -23.7396
            21  C8y C    16.7568  -23.0666
            22  X   Cl   15.6094  -23.7585
            23  O6a O    24.9873  -17.1191 #-
            24  O6a O    23.7002  -19.3362
            25  O5a O    21.1290  -21.9649
            26  Z   Na   26.9719  -17.2204 #+
            27  O0  O    29.4191  -21.3993
            28  O0  O    29.4191  -21.3993
            29  O0  O    29.4191  -21.3993
BOND        27
            1     6   7 2
            2     6   8 1
            3     6   9 1
            4     7   1 1
            5     7  10 1
            6     8   2 1
            7     8  11 1
            8     9  12 2
            9    10  13 2
            10   11  14 1
            11   13  15 1
            12   14  16 2
            13   14  17 1
            14   15  18 1
            15   16  19 1
            16   17  20 2
            17   19  21 2
            18   21  22 1
            19   12  13 1
            20   20  21 1
            21    4   5 1
            22    4  23 1
            23    5   1 1
            24    4  24 2
            25    1   2 2
            26    2   3 1
            27   11  25 2
BRACKET     1    27.5100  -22.1900   27.5100  -20.3000
            1    29.8200  -20.3000   29.8200  -22.1900
            1  3
 ORIGINAL  1   27
 REPEAT    1   28  29

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