KEGG   DRUG: BudesonideHelp
Entry
D00246                      Drug                                   

Name
Budesonide (JAN/USAN/INN);
Entocort EC (TN);
Pulmicort (TN);
Rhinocort (TN);
Uceris (TN)
Product
  Generic
BUDESONIDE (APPCO PHARMA LLC), BUDESONIDE (Actavis Pharma), BUDESONIDE (ENTERIC COATED) (Alvogen), BUDESONIDE (Amneal Pharmaceuticals LLC), BUDESONIDE NASAL (Apotex Corp.), BUDESONIDE (Apotex Corp.), BUDESONIDE (Cadila Healthcare Limited), BUDESONIDE (Carilion Materials Management), BUDESONIDE (Cipla USA), BUDESONIDE (Dispensing Solutions), BUDESONIDE (Golden State Medical Supply), BUDESONIDE INHALATION (Impax Generics), BUDESONIDE (ENTERIC COATED) (Lake Erie Medical DBA Quality Care Products LLC), BUDESONIDE (ENTERIC COATED) (Mayne Pharma), BUDESONIDE (Mylan Institutional), BUDESONIDE (Mylan Pharmaceuticals), BUDESONIDE (Nephron SC), BUDESONIDE (Northstar Rx LLC.), BUDESONIDE (Oceanside Pharmaceuticals), BUDESONIDE (Preferred Pharmaceuticals), BUDESONIDE (Preferred Pharmaceuticals), BUDESONIDE (Preferred Pharmaceuticals), BUDESONIDE INHALATION (Preferred Pharmaceuticals), BUDESONIDE (Preferred Pharmaceuticals), BUDESONIDE (Rising Pharmaceuticals), BUDESONIDE (Sandoz), BUDESONIDE (Teva Pharmaceuticals USA), BUDESONIDE (Teva Pharmaceuticals USA), BUDESONIDE (Teva Pharmaceuticals USA), BUDESONIDE (Zydus Pharmaceuticals (USA))
Formula
C25H34O6
Exact mass
430.2355
Mol weight
430.5339
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Anti-inflammatory
 DG01955  Corticosteroid
  DG02068  Glucocorticoid
Enzyme substrate
 DG01633  CYP3A substrate
Remark
Therapeutic category: 2290 2399
ATC code: A07EA06 D07AC09 R01AD05 R03BA02
Product: D00246<JP/US>
Product (mixture): D09595<JP/US>
Efficacy
Antiasthmatic, Anti-inflammatory, Glucocorticoid receptor agonist
  Disease
Asthma [DS:H00079]
Crohn's disease [DS:H00286]
Perennial allergic rhinitis [DS:H01360]
Distal ulcerative colitis [DS:H01466]
Target
NR3C1 (GR) [HSA:2908] [KO:K05771]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
Metabolism
Enzyme: CYP3A4 [HSA:1576]
Interaction
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A07 ANTIDIARRHEALS, INTESTINAL ANTIINFLAMMATORY/ANTIINFECTIVE AGENTS
   A07E INTESTINAL ANTIINFLAMMATORY AGENTS
    A07EA Corticosteroids acting locally
     A07EA06 Budesonide
      D00246  Budesonide (JAN/USAN/INN) <JP/US>
 D DERMATOLOGICALS
  D07 CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
   D07A CORTICOSTEROIDS, PLAIN
    D07AC Corticosteroids, potent (group III)
     D07AC09 Budesonide
      D00246  Budesonide (JAN/USAN/INN) <JP/US>
 R RESPIRATORY SYSTEM
  R01 NASAL PREPARATIONS
   R01A DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE
    R01AD Corticosteroids
     R01AD05 Budesonide
      D00246  Budesonide (JAN/USAN/INN) <JP/US>
  R03 DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
   R03B OTHER DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES, INHALANTS
    R03BA Glucocorticoids
     R03BA02 Budesonide
      D00246  Budesonide (JAN/USAN/INN) <JP/US>
USP drug classification [BR:br08302]
 Hormonal Agents, Stimulant/Replacement/Modifying (Adrenal)
  Budesonide
   D00246  Budesonide (JAN/USAN/INN)
 Inflammatory Bowel Disease Agents
  Glucocorticoids
   Budesonide
    D00246  Budesonide (JAN/USAN/INN)
 Respiratory Tract/Pulmonary Agents
  Anti-inflammatories, Inhaled Corticosteroids
   Budesonide
    D00246  Budesonide (JAN/USAN/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  22  Respiratory organ agents
   229  Miscellaneous
    2290  Miscellaneous
     D00246  Budesonide (JAN/USAN/INN)
  23  Digestive organ agents
   239  Miscellaneous
    2399  Others
     D00246  Budesonide (JAN/USAN/INN)
Target-based classification of drugs [BR:br08310]
 Nuclear receptors
  Estrogen like receptors
   3-Ketosteroid receptor
    NR3C1 (GR)
     D00246  Budesonide (JAN/USAN/INN) <JP/US>
Drug classes of therapeutic agents [br08360.html]
 Respiratory agents
  D00246
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D00246
Rx-to-OTC switch list in the USA [br08315.html]
 D00246
BRITE hierarchy
Other DBs
CAS: 51333-22-3
PubChem: 7847312
ChEBI: 3207
ChEMBL: CHEMBL1370 CHEMBL2110662
DrugBank: DB01222
PDB-CCD: 8W5[PDBj]
LigandBox: D00246
NIKKAJI: J11.656D
LinkDB All DBs
KCF data Show

ATOM        31
            1   C2x C    16.6600  -25.0600
            2   C5x C    16.6600  -26.4600
            3   C2x C    17.8500  -27.1600
            4   C2y C    19.1100  -26.4600
            5   C1z C    19.1100  -25.0600
            6   C2x C    17.8500  -24.3600
            7   C1x C    20.3000  -27.1600
            8   C1x C    21.4900  -26.4600
            9   C1y C    21.4900  -25.0600
            10  C1y C    20.3000  -24.3600
            11  C1y C    22.7500  -24.3600
            12  C1z C    22.7500  -22.9600
            13  C1x C    21.4900  -22.2600
            14  C1y C    20.3000  -22.9600
            15  C1x C    25.1300  -24.3600
            16  C1y C    25.1300  -22.9600
            17  C1z C    23.9400  -22.2600
            18  O5x O    15.4700  -27.1600
            19  C1a C    19.1100  -23.6600
            20  O1a O    19.1100  -22.2600
            21  C1a C    22.7500  -21.5600
            22  C5a C    23.9400  -20.7200
            23  O2x O    25.1300  -21.5600
            24  O2x O    26.5300  -22.6100
            25  C1y C    26.5300  -21.5600
            26  C1b C    27.7200  -20.8600
            27  C1b C    28.9100  -21.5600
            28  C1a C    30.1000  -20.8600
            29  O5a O    25.1524  -20.0200
            30  C1b C    22.7276  -20.0200
            31  O1a O    21.5321  -20.7104
BOND        35
            1     1   2 1
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 1
            6     1   6 2
            7     4   7 1
            8     7   8 1
            9     8   9 1
            10    9  10 1
            11    5  10 1
            12    9  11 1
            13   11  12 1
            14   12  13 1
            15   13  14 1
            16   10  14 1
            17   11  15 1
            18   15  16 1
            19   16  17 1
            20   12  17 1
            21    2  18 2
            22    5  19 1 #Up
            23   14  20 1 #Up
            24   12  21 1 #Up
            25   17  22 1 #Up
            26   17  23 1 #Down
            27   16  24 1 #Down
            28   23  25 1
            29   25  24 1
            30   26  27 1
            31   26  25 1
            32   27  28 1
            33   22  29 2
            34   22  30 1
            35   30  31 1

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